Role of Extracellular Vesicle-Based Cell-to-Cell Communication in Multiple Myeloma Progression

Human myeloma cell‐ and plasma‐derived extracellular vesicles contribute to functional regulation of stromal cells

(2021) Antonia Reale et al.   PROTEOMICS

The Immune Microenvironment in Multiple Myeloma: Friend or Foe?

(2021) Raquel Lopes et al.   Cancers

Analysis of Amount, Size, Protein Phenotype and Molecular Content of Circulating Extracellular Vesicles Identifies New Biomarkers in Multiple Myeloma

(2021) Ilaria Laurenzana et al.   International Journal of Nanomedicine

Ribosomal proteins as distinct “passengers” of microvesicles: new semantics in myeloma and mesenchymal stem cells' communication

(2021) Mahmoud Dabbah et al.   Translational Research

Recent Progress of Exosomes in Multiple Myeloma: Pathogenesis, Diagnosis, Prognosis and Therapeutic Strategies

(2021) Xi Wang et al.   Cancers

Apoptotic Extracellular Vesicles Ameliorate Multiple Myeloma by Restoring Fas-Mediated Apoptosis

(2021) Juan Wang et al.   ACS Nano

Exosomes as mediators of intercellular crosstalk in metabolism

(2021) Roi Isaac et al.   Cell Metabolism

Exosome-derived miR-let-7c promotes angiogenesis in multiple myeloma by polarizing M2 macrophages in the bone marrow microenvironment

(2021) Xiangyu Tian et al.   LEUKEMIA RESEARCH

Realization of Osteolysis, Angiogenesis, Immunosuppression, and Drug Resistance by Extracellular Vesicles: Roles of RNAs and Proteins in Their Cargoes and of Ectonucleotidases of the Immunosuppressive Adenosinergic Noncanonical Pathway in the Bone Marrow Niche of Multiple Myeloma

(2021) Takashi Watanabe   Cancers

Formation of a protein corona on the surface of extracellular vesicles in blood plasma

(2021) Eszter Á. Tóth et al.   Journal of Extracellular Vesicles

Extracellular Vesicle microRNAs Contribute to the Osteogenic Inhibition of Mesenchymal Stem Cells in Multiple Myeloma

(2020) Stefania Raimondo et al.   Cancers

Mechanisms of Resistance to Anti-CD38 Daratumumab in Multiple Myeloma

(2020) Ilaria Saltarella et al.   Cells

Recent advances in single extracellular vesicle detection methods

(2020) Su Wang et al.   BIOSENSORS & BIOELECTRONICS

Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours

(2020) David S. Hong et al.   BRITISH JOURNAL OF CANCER

MicroRNAs-Based Nano-Strategies as New Therapeutic Approach in Multiple Myeloma to Overcome Disease Progression and Drug Resistance

(2020) Vanessa Desantis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characterizing Extracellular Vesicles and Their Diverse RNA Contents

(2020) Eren M. Veziroglu et al.   Frontiers in Genetics

Multiple Myeloma-Derived Extracellular Vesicles Induce Osteoclastogenesis through the Activation of the XBP1/IRE1α Axis

(2020) Lavinia Raimondi et al.   Cancers

Extracellular vesicles from human plasma and serum are carriers of extravesicular cargo—Implications for biomarker discovery

(2020) Mari Palviainen et al.   PLoS One

Flow Cytometry Analysis of Circulating Extracellular Vesicle Subtypes from Fresh Peripheral Blood Samples

(2020) Marco Marchisio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Raman Spectroscopic Stratification of Multiple Myeloma Patients Based on Exosome Profiling

(2020) Mario Russo et al.   ACS Omega

Exosome-Transmitted PSMA3 and PSMA3-AS1 Promotes Proteasome Inhibitors Resistance in Multiple Myeloma

(2019) Hongxia Xu et al.   CLINICAL CANCER RESEARCH

Inhibition of multiple myeloma‑derived exosomes uptake suppresses the functional response in bone marrow stromal cell

(2019) Yongjiang Zheng et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Multiple myeloma-derived exosomes are enriched of amphiregulin (AREG) and activate the epidermal growth factor pathway in the bone microenvironment leading to osteoclastogenesis

(2019) Stefania Raimondo et al.   Journal of Hematology & Oncology

Connexins and Integrins in Exosomes

(2019) Motomu Shimaoka et al.   Cancers

Exosomes: biogenesis, biologic function and clinical potential

(2019) Yuan Zhang et al.   Cell and Bioscience

piRNA-823 delivered by multiple myeloma-derived extracellular vesicles promoted tumorigenesis through re-educating endothelial cells in the tumor environment

(2019) Beibei Li et al.   ONCOGENE

Serum exosomal microRNAs as novel biomarkers for multiple myeloma

(2019) Zhi‐yao Zhang et al.   HEMATOLOGICAL ONCOLOGY

Extracellular Vesicles as Biological Shuttles for Targeted Therapies

(2019) Stefania Raimondo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Expression of small heat shock proteins in exosomes from patients with gynecologic cancers

(2019) Aleksandra Wyciszkiewicz et al.   Scientific Reports

Multiple myeloma-derived exosomes inhibit osteoblastic differentiation and improve IL-6 secretion of BMSCs from multiple myeloma

(2019) Zhaoyun Liu et al.   JOURNAL OF INVESTIGATIVE MEDICINE

The many functions of ESCRTs

(2019) Marina Vietri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Detailed analysis of the plasma extracellular vesicle proteome after separation from lipoproteins

(2018) Nasibeh Karimi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Exosome-mediated transfer of lncRUNX2-AS1 from multiple myeloma cells to MSCs contributes to osteogenesis

(2018) Bingzong Li et al.   ONCOGENE

Biogenesis and function of extracellular vesicles in cancer

(2018) Maarten P. Bebelman et al.   PHARMACOLOGY & THERAPEUTICS

Molecular interactions at the surface of extracellular vesicles

(2018) Edit I. Buzás et al.   Seminars in Immunopathology

Pathogenesis of bone disease in multiple myeloma: from bench to bedside

(2018) Evangelos Terpos et al.   Blood Cancer Journal

Microvesicles released from multiple myeloma cells are equipped with ectoenzymes belonging to canonical and non-canonical adenosinergic pathways and produce adenosine from ATP and NAD+

(2018) F. Morandi et al.   OncoImmunology

Circulating exosomal long noncoding RNA PRINS-First findings in monoclonal gammopathies

(2018) Lenka Sedlarikova et al.   HEMATOLOGICAL ONCOLOGY

Circular RNA IARS (circ-IARS) secreted by pancreatic cancer cells and located within exosomes regulates endothelial monolayer permeability to promote tumor metastasis

(2018) Jie Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Bone marrow fibroblasts overexpress miR-27b and miR-214 in step with multiple myeloma progression, dependent on tumour cell-derived exosomes

(2018) Maria Antonia Frassanito et al.   JOURNAL OF PATHOLOGY

Exosomes play a role in multiple myeloma bone disease and tumor development by targeting osteoclasts and osteoblasts

(2018) Sylvia Faict et al.   Blood Cancer Journal

Isolation of High-Purity Extracellular Vesicles by the Combination of Iodixanol Density Gradient Ultracentrifugation and Bind-Elute Chromatography From Blood Plasma

(2018) Zsófia Onódi et al.   Frontiers in Physiology

Tracing Cellular Origin of Human Exosomes Using Multiplex Proximity Extension Assays

(2017) Pia Larssen et al.   MOLECULAR & CELLULAR PROTEOMICS

Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23

(2017) Yao Wei et al.   Nature Communications

Multiple Myeloma-Derived Exosomes Regulate the Functions of Mesenchymal Stem Cells Partially via Modulating miR-21 and miR-146a

(2017) Qian Cheng et al.   Stem Cells International

The Multifaceted Role of SNARE Proteins in Membrane Fusion

(2017) Jing Han et al.   Frontiers in Physiology

Roles and Modalities of Ectonucleotidases in Remodeling the Multiple Myeloma Niche

(2017) Antonella Chillemi et al.   Frontiers in Immunology

T cells in multiple myeloma display features of exhaustion and senescence at the tumor site

(2016) Claudia Zelle-Rieser et al.   Journal of Hematology & Oncology

Multiple myeloma exosomes establish a favourable bone marrow microenvironment with enhanced angiogenesis and immunosuppression

(2016) Jinheng Wang et al.   JOURNAL OF PATHOLOGY

Microenvironment drug resistance in multiple myeloma: emerging new players

(2016) Lucia Di Marzo et al.   Oncotarget

Potential role of exosome-associated microRNA panels and in vivo environment to predict drug resistance for patients with multiple myeloma

(2016) Li Zhang et al.   Oncotarget

Effective internalization of U251-MG-secreted exosomes into cancer cells and characterization of their lipid components

(2015) Yuki Toda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Myeloma cells act as tolerogenic antigen-presenting cells and induce regulatory T cellsin vitro

(2015) Maria Antonia Frassanito et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Halting pro-survival autophagy by TGFβ inhibition in bone marrow fibroblasts overcomes bortezomib resistance in multiple myeloma patients

(2015) M A Frassanito et al.   LEUKEMIA

CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA

(2015) Alice Conigliaro et al.   Molecular Cancer

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

The bone marrow microenvironment enhances multiple myeloma progression by exosome-mediated activation of myeloid-derived suppressor cells

(2015) Jinheng Wang et al.   Oncotarget

Involvement of multiple myeloma cell-derived exosomes in osteoclast differentiation

(2015) Lavinia Raimondi et al.   Oncotarget

Isolation of Exosomes from Blood Plasma: Qualitative and Quantitative Comparison of Ultracentrifugation and Size Exclusion Chromatography Methods

(2015) Tamás Baranyai et al.   PLoS One

Oncogenic ras-driven cancer cell vesiculation leads to emission of double-stranded DNA capable of interacting with target cells

(2014) Tae Hoon Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells

(2014) J. Wang et al.   BLOOD

Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1

(2014) T. Umezu et al.   BLOOD

Formation and role of exosomes in cancer

(2014) Lindsey T. Brinton et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Biogenesis and secretion of exosomes

(2014) Joanna Kowal et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of exosome release from mammary epithelial and breast cancer cells – A new regulatory pathway

(2014) Andrew Riches et al.   EUROPEAN JOURNAL OF CANCER

Immune biomarkers: how well do they serve prognosis in human cancers?

(2014) Constantin N Baxevanis et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Identification of Double-stranded Genomic DNA Spanning All Chromosomes with MutatedKRASandp53DNA in the Serum Exosomes of Patients with Pancreatic Cancer

(2014) Christoph Kahlert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosome Uptake through Clathrin-mediated Endocytosis and Macropinocytosis and Mediating miR-21 Delivery

(2014) Tian Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myeloid derived suppressor cells are numerically, functionally and phenotypically different in patients with multiple myeloma

(2014) James Favaloro et al.   LEUKEMIA & LYMPHOMA

Proteomics of extracellular vesicles: Exosomes and ectosomes

(2014) Dong-Sic Choi et al.   MASS SPECTROMETRY REVIEWS

Sorting it out: Regulation of exosome loading

(2014) Carolina Villarroya-Beltri et al.   SEMINARS IN CANCER BIOLOGY

Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2

(2014) Rania Ghossoub et al.   Nature Communications

Tetraspanins in Extracellular Vesicle Formation and Function

(2014) Zoraida Andreu et al.   Frontiers in Immunology

Nucleic acids in exosomes: Disease markers and intercellular communication molecules

(2013) O. N. Gusachenko et al.   BIOCHEMISTRY-MOSCOW

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

(2013) Yanhua Tian et al.   BIOMATERIALS

HIF-1  of Bone Marrow Endothelial Cells Implies Relapse and Drug Resistance in Patients with Multiple Myeloma and May Act as a Therapeutic Target

(2013) R. Ria et al.   CLINICAL CANCER RESEARCH

Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1

(2013) Katrin J. Svensson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparanase Regulates Secretion, Composition, and Function of Tumor Cell-derived Exosomes

(2013) Camilla A. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Intracellular Interactome of Tetraspanin-enriched Microdomains Reveals Their Function as Sorting Machineries toward Exosomes

(2013) Daniel Perez-Hernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

(2013) Marina Colombo et al.   JOURNAL OF CELL SCIENCE

BM mesenchymal stromal cell–derived exosomes facilitate multiple myeloma progression

(2013) Aldo M. Roccaro et al.   JOURNAL OF CLINICAL INVESTIGATION

Bone marrow fibroblasts parallel multiple myeloma progression in patients and mice: in vitro and in vivo studies

(2013) M A Frassanito et al.   LEUKEMIA

Exosome Secretion Is Enhanced by Invadopodia and Drives Invasive Behavior

(2013) Daisuke Hoshino et al.   Cell Reports

Clinical impact of serum exosomal microRNA-21 as a clinical biomarker in human esophageal squamous cell carcinoma

(2012) Youhei Tanaka et al.   CANCER

Bone Marrow Microenvironment in Multiple Myeloma Progression

(2012) S. Manier et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Improved Flow Cytometric Assessment Reveals Distinct Microvesicle (Cell-Derived Microparticle) Signatures in Joint Diseases

(2012) Bence György et al.   PLoS One

Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands

(2012) Stephan Munich et al.   OncoImmunology

Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM): novel biological insights and development of early treatment strategies

(2011) N. Korde et al.   BLOOD

SST0001, a Chemically Modified Heparin, Inhibits Myeloma Growth and Angiogenesis via Disruption of the Heparanase/Syndecan-1 Axis

(2011) Joseph P. Ritchie et al.   CLINICAL CANCER RESEARCH

The ESCRT Pathway

(2011) William M. Henne et al.   DEVELOPMENTAL CELL

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

(2011) D. Fitzner et al.   JOURNAL OF CELL SCIENCE

Potential role of HER2-overexpressing exosomes in countering trastuzumab-based therapy

(2011) Valentina Ciravolo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences

(2011) Leonora Balaj et al.   Nature Communications

Elevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma

(2010) R. H. Prabhala et al.   BLOOD

Tumor Necrosis Factor Gene-Engineered J558 Tumor Cell–Released Exosomes Stimulate Tumor Antigen P1A-Specific CD8+ CTL Responses and Antitumor Immunity

(2010) Yufeng Xie et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity

(2010) Gaelle Lachenal et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Cellular Internalization of Exosomes Occurs Through Phagocytosis

(2010) Du Feng et al.   TRAFFIC

Membrane-bound HSP70-engineered myeloma cell-derived exosomes stimulate more efficient CD8+ CTL- and NK-mediated antitumour immunity than exosomes released from heat-shocked tumour cells expressing cytoplasmic HSP70

(2009) Yufeng Xie et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Tumor-Derived Microvesicles Promote Regulatory T Cell Expansion and Induce Apoptosis in Tumor-Reactive Activated CD8+ T Lymphocytes

(2009) E. U. Wieckowski et al.   JOURNAL OF IMMUNOLOGY

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer

(2008) Douglas D. Taylor et al.   GYNECOLOGIC ONCOLOGY

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

(2008) Khalid Al-Nedawi et al.   NATURE CELL BIOLOGY

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE