Nuclear Receptor PXR in Drug-Induced Hypercholesterolemia

Activation of nuclear receptor PXR induces atherogenic lipids and PCSK9 through SREBP2‐mediated mechanism

(2021) Mikko Karpale et al.   BRITISH JOURNAL OF PHARMACOLOGY

The xenobiotic receptors PXR and CAR in liver physiology, an update

(2021) Xinran Cai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases

(2021) Yongfeng Song et al.   Cell Metabolism

Pharmacokinetic Drug–Drug Interaction of Apalutamide, Part 1: Clinical Studies in Healthy Men and Patients with Castration-Resistant Prostate Cancer

(2020) Ignacio Duran et al.   CLINICAL PHARMACOKINETICS

Pregnane X Receptor Activator Rifampin Increases Blood Pressure and Stimulates Plasma Renin Activity

(2020) Fatemeh Hassani‐Nezhad‐Gashti et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Changes in PCSK9 and LDL cholesterol concentrations by everolimus treatment and their effects on polymorphisms in PCSK9 and mTORC1

(2020) Shiori Sato et al.   Pharmacological Reports

4β-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters

(2020) Tuire Salonurmi et al.   Frontiers in Pharmacology

Metabolic and hormonal side effects of mitotane treatment for adrenocortical carcinoma: A retrospective study in 50 Danish patients

(2020) Malene Elbæk Vikner et al.   CLINICAL ENDOCRINOLOGY

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

(2020) Theo Vos et al.   LANCET

Levomepromazine and clozapine induce the main human cytochrome P450 drug metabolizing enzyme CYP3A4

(2020) Przemysław J. Danek et al.   Pharmacological Reports

Characterization of human pregnane X receptor activators identified from a screening of the Tox21 compound library

(2020) Caitlin Lynch et al.   BIOCHEMICAL PHARMACOLOGY

Non-nucleoside reverse transcriptase inhibitor efavirenz activates PXR to induce hypercholesterolemia and hepatic steatosis

(2019) Taesik Gwag et al.   JOURNAL OF HEPATOLOGY

The PCSK9 revolution: Current status, controversies, and future directions

(2019) Bruce A. Warden et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Gene Expression Profiling Reveals that PXR Activation Inhibits Hepatic PPARα Activity and Decreases FGF21 Secretion in Male C57Bl6/J Mice

(2019) Sharon Ann Barretto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanistic Insights of Phenobarbital-Mediated Activation of Human but Not Mouse Pregnane X Receptor

(2019) Linhao Li et al.   MOLECULAR PHARMACOLOGY

2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk

(2019) François Mach et al.   EUROPEAN HEART JOURNAL

Atherosclerosis

(2019) Peter Libby et al.   Nature Reviews Disease Primers

Nuclear receptors are important targets of environmental disrupting compounds

(2019) Lucia Toporova et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Nutritional status modifies pregnane X receptor regulated transcriptome

(2019) Fatemeh Hassani-Nezhad-Gashti et al.   Scientific Reports

Mechanisms and regulation of cholesterol homeostasis

(2019) Jie Luo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evaluation of modafinil as a perpetrator of metabolic drug-drug interactions using a model informed cocktail reaction phenotyping trial protocol

(2018) Angela Rowland et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis

(2017) Ngee Kiat Chua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SREBP-regulated lipid metabolism: convergent physiology — divergent pathophysiology

(2017) Hitoshi Shimano et al.   Nature Reviews Endocrinology

Exploring the Carbamazepine Interaction with Human Pregnane X Receptor and Effect on ABCC2 Using in Vitro and in Silico Approach

(2017) Gurpreet K Grewal et al.   PHARMACEUTICAL RESEARCH

Epidemiology of ischemic heart disease in HIV

(2017) Virginia A. Triant et al.   Current Opinion in HIV and AIDS

Low-Density Lipoprotein Receptor–Dependent and Low-Density Lipoprotein Receptor–Independent Mechanisms of Cyclosporin A–Induced DyslipidemiaHighlights

(2016) Maaike Kockx et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lipids in liver transplant recipients

(2016) Anna Hüsing et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Sirolimus Therapy Is Associated with Elevation in Circulating PCSK9 Levels in Cardiac Transplant Patients

(2016) Vinaya Simha et al.   Journal of Cardiovascular Translational Research

Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice

(2015) Z. Lin et al.   CIRCULATION

Effect of statin therapy on plasma proprotein convertase subtilisin kexin 9 (PCSK9) concentrations: a systematic review and meta-analysis of clinical trials

(2015) A. Sahebkar et al.   DIABETES OBESITY & METABOLISM

Drugs Commonly Associated With Weight Change: A Systematic Review and Meta-analysis

(2015) Juan Pablo Domecq et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Reduction of Inflammation Drives Lipid Changes in Ankylosing Spondylitis

(2015) S. C. Heslinga et al.   JOURNAL OF RHEUMATOLOGY

Intestinal Pregnane X Receptor Links Xenobiotic Exposure and Hypercholesterolemia

(2015) Yipeng Sui et al.   MOLECULAR ENDOCRINOLOGY

A new model of reverse cholesterol transport: enTICEing strategies to stimulate intestinal cholesterol excretion

(2015) Ryan E. Temel et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

mTOR inhibitors and dyslipidemia in transplant recipients: A cause for concern?

(2015) Hallvard Holdaas et al.   Transplantation Reviews

A potential mechanism underlying atypical antipsychotics-induced lipid disturbances

(2015) H L Cai et al.   Translational Psychiatry

Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms

(2014) Andreas Bitter et al.   ARCHIVES OF TOXICOLOGY

Validation of 4β-hydroxycholesterol and evaluation of other endogenous biomarkers for the assessment of CYP3A activity in healthy subjects

(2014) Sreeneeranj Kasichayanula et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

PCSK9

(2014) Nabil G. Seidah et al.   CIRCULATION RESEARCH

HIV infection and cardiovascular disease

(2014) L. G. Hemkens et al.   EUROPEAN HEART JOURNAL

Atherosclerotic risk among children taking antiepileptic drugs

(2014) Tomasz Jakubus et al.   Pharmacological Reports

Omeprazole and Lansoprazole Enantiomers Induce CYP3A4 in Human Hepatocytes and Cell Lines via Glucocorticoid Receptor and Pregnane X Receptor Axis

(2014) Aneta Novotna et al.   PLoS One

The effects of antiepileptic drugs on vascular risk factors: A narrative review

(2014) Niki Katsiki et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Phase I and pharmacokinetic study of bexarotene in combination with gefitinib in the third-line treatment of non-small-cell lung cancer

(2013) Sukhmani K. Padda et al.   ANTI-CANCER DRUGS

Agonism of human pregnane X receptor by rilpivirine and etravirine: Comparison with first generation non-nucleoside reverse transcriptase inhibitors

(2013) Devinder Sharma et al.   BIOCHEMICAL PHARMACOLOGY

Profiling of enantiopure drugs towards aryl hydrocarbon (AhR), glucocorticoid (GR) and pregnane X (PXR) receptors in human reporter cell lines

(2013) Aneta Novotna et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Pregnane X Receptor Agonists Impair Postprandial Glucose Tolerance

(2013) J Rysä et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The effect of single- and multiple-dose etravirine on a drug cocktail of representative cytochrome P450 probes and digoxin in healthy subjects

(2013) Thomas N. Kakuda et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Changes in lipid levels with inflammation and therapy in RA: a maturing paradigm

(2013) Jamie Robertson et al.   Nature Reviews Rheumatology

Effects of switching from olanzapine, quetiapine, and risperidone to aripiprazole on 10-year coronary heart disease risk and metabolic syndrome status: Results from a randomized controlled trial

(2013) T. Scott Stroup et al.   SCHIZOPHRENIA RESEARCH

Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

(2012) Nathanael J. Spann et al.   CELL

Connecting mTORC1 signaling to SREBP-1 activation

(2012) Inan Bakan et al.   CURRENT OPINION IN LIPIDOLOGY

PXR-mediated P-glycoprotein induction by small molecule tyrosine kinase inhibitors

(2012) S. Harmsen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Mitotane Therapy in Adrenocortical Cancer Induces CYP3A4 and Inhibits 5α-Reductase, Explaining the Need for Personalized Glucocorticoid and Androgen Replacement

(2012) Vasileios Chortis et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Chronic Exposure to Rifaximin Causes Hepatic Steatosis in Pregnane X Receptor-Humanized Mice

(2012) Jie Cheng et al.   TOXICOLOGICAL SCIENCES

Niemann-Pick C1-Like 1 (NPC1L1) Protein in Intestinal and Hepatic Cholesterol Transport

(2011) Lin Jia et al.   Annual Review of Physiology

Constitutive Androstane Receptor Activation Decreases Plasma Apolipoprotein B–Containing Lipoproteins and Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice

(2011) Anne-Laure Sberna et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nuclear receptor PXR, transcriptional circuits and metabolic relevance

(2011) Chibueze A. Ihunnah et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The effect of bexarotene on atorvastatin pharmacokinetics: results from a phase I trial of bexarotene plus chemotherapy in patients with advanced non-small cell lung cancer

(2011) Heather A. Wakelee et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Cholesterol-Dependent Degradation of Squalene Monooxygenase, a Control Point in Cholesterol Synthesis beyond HMG-CoA Reductase

(2011) Saloni Gill et al.   Cell Metabolism

Drug interactions with mitotane by induction of CYP3A4 metabolism in the clinical management of adrenocortical carcinoma

(2011) Matthias Kroiss et al.   CLINICAL ENDOCRINOLOGY

Mitotane has a strong and a durable inducing effect on CYP3A4 activity

(2011) Nielka P van Erp et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

PXR Prevents Cholesterol Gallstone Disease by Regulating Biosynthesis and Transport of Bile Salts

(2011) Jinhan He et al.   GASTROENTEROLOGY

Changes in Serum Triglyceride and Cholesterol Levels during Long-Term Phenytoin Treatment for Epilepsy

(2010) P. V. Luoma et al.   ACTA MEDICA SCANDINAVICA

Serum elevation of high density lipoprotein (HDL) cholesterol in epileptic patients taking carbamazepine or phenytoin

(2010) B. O'Neill et al.   ACTA NEUROLOGICA SCANDINAVICA

4β-hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans

(2010) Ulf Diczfalusy et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Identification and Validation of Novel Human Pregnane X Receptor Activators among Prescribed Drugs via Ligand-Based Virtual Screening

(2010) Y. Pan et al.   DRUG METABOLISM AND DISPOSITION

Identification of Clinically Used Drugs That Activate Pregnane X Receptors

(2010) S. J. Shukla et al.   DRUG METABOLISM AND DISPOSITION

Explaining variability in ciclosporin exposure in adult kidney transplant recipients

(2010) Rogier R. Press et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Nuclear Receptor-Mediated Induction of CYP450 by Antiretrovirals: Functional Consequences of NR1I2 (PXR) Polymorphisms and Differential Prevalence in Whites and Sub-Saharan Africans

(2010) Jenny Svärd et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Effect of Antipsychotic Medications on Glucose and Lipid Levels

(2010) Parminder S. Chaggar et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Constitutive androstane receptor activation stimulates faecal bile acid excretion and reverse cholesterol transport in mice

(2010) Anne Laure Sberna et al.   JOURNAL OF HEPATOLOGY

Strong induction of PCSK9 gene expression through HNF1α and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters

(2010) Bin Dong et al.   JOURNAL OF LIPID RESEARCH

The PXR is a drug target for chronic inflammatory liver disease

(2010) Karen Wallace et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The potential influence of genetic variants in genes along bile acid and bile metabolic pathway on blood cholesterol levels in the population

(2009) Yingchang Lu et al.   ATHEROSCLEROSIS

Clinical Pharmacokinetics and Pharmacodynamics of Etravirine

(2009) Monika Schöller-Gyüre et al.   CLINICAL PHARMACOKINETICS

Retinoids induce cytochrome P450 3A4 through RXR/VDR-mediated pathway

(2008) Kun Wang et al.   BIOCHEMICAL PHARMACOLOGY

The Influence of CYP3A5 Genotype on Dexamethasone Induction of CYP3A Activity in African Americans

(2008) P. J. Roberts et al.   DRUG METABOLISM AND DISPOSITION

Regulatory Cross-Talk between Drug Metabolism and Lipid Homeostasis: Constitutive Androstane Receptor and Pregnane X Receptor Increase Insig-1 Expression

(2008) A. Roth et al.   MOLECULAR PHARMACOLOGY

Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?

(2008) S Le Hellard et al.   MOLECULAR PSYCHIATRY