Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.
Article
Oncology
Jun Li, Lusong Tian, Zongpan Jing, Zhengguang Guo, Peng Nan, Fang Liu, Shuangmei Zou, Lijun Yang, Xiufeng Xie, Ying Zhu, Yue Zhao, Wei Sun, Yulin Sun, Xiaohang Zhao
Summary: The study revealed that RAD23B interacts with CORO1C to promote invasion and metastasis in CRC cells, with elevated levels of RAD23B associated with poor prognosis and liver metastasis in patients.
Article
Biochemistry & Molecular Biology
Jiachen Lu, Ruilin Chu, Yi Yin, Huijie Yu, Qinwen Xu, Bo Yang, Yifan Sun, Jing Song, Qiubo Wang, Jiahui Xu, Feng Lu, Yang Cheng
Summary: This study identifies an important mechanism of parasite invasion into host erythrocytes by discovering the specific receptor, ankyrin 1 and band 3 membrane protein, that interacts with the erythrocyte binding protein GAMA. The study also shows the sensitivity of the GAMA interaction with band 3 to the protease chymotrypsin. Additionally, the study demonstrates the inhibitory effect of antibodies against band 3 loop 5 on GAMA binding to erythrocytes and the invasion of Plasmodium falciparum merozoites.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Oncology
Sean McCutcheon, David C. Spray
Summary: The invasive nature of glioblastoma multiforme (GBM) is a major factor contributing to its poor survival rates. Research suggests that connexin 43 (Cx43) has opposing roles in GBM migration. Through a Cx43-dependent mechanism, miRNAs associated with cell-matrix adhesion are transferred from GBM cells to astrocytes, promoting invasion.
MOLECULAR CANCER RESEARCH
(2022)
Article
Oncology
Ji-Yu Bai, Ben Jin, Jian-Bin Ma, Tian-Jie Liu, Chao Yang, Yue Chong, Xinyang Wang, Dalin He, Peng Guo
Summary: In renal cell carcinoma (RCC), the interaction between long non-coding RNA (lncRNA) HOTAIR and androgen receptor (AR) forms a feedback loop that promotes tumor angiogenesis, with HOTAIR enhancing GLI2 expression by cooperatively binding to its promoter with AR. These findings suggest that HOTAIR and GLI2 could serve as novel therapeutic targets against RCC.
Article
Biochemistry & Molecular Biology
Phatcharida Jantaree, Supattra Chaithongyot, Olga Sokolova, Michael Naumann
Summary: Helicobacter pylori infection is associated with the development of gastric diseases, including cancer. NF-κB and DUB USP48 play important roles in this process. USP48 stabilizes NF-κB activity by deubiquitination, enhancing its transcriptional activity and reducing apoptotic cell death. This finding provides new insights into the cell survival mechanism in H. pylori infection.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Liang Wang, Jiayi Wang, Xiaolin Yin, Xin Guan, Ying Li, Chenqi Xin, Jing Liu
Summary: High expression of GIPC2 is significantly associated with distant metastasis and poor prognosis in prostate cancer. GIPC2, as an exosomal molecule, promotes metastatic capabilities of prostate cancer cells. By binding to the WNT co-receptor, GIPC2 activates WNT signaling pathway, thereby stimulating prostate cancer metastasis.
Article
Biochemistry & Molecular Biology
Ave Eesmaa, Li-Ying Yu, Helka Goos, Tatiana Danilova, Kristofer Noges, Emmi Pakarinen, Markku Varjosalo, Maria Lindahl, Paivi Lindholm, Mart Saarma
Summary: This study investigates the mechanism of action of CDNF by analyzing the involvement of UPR signaling in its anti-apoptotic function. The findings suggest that CDNF expression is regulated by ER stress and the involvement of UPR pathways is important for its neuroprotective function. Additionally, novel binding partners of CDNF are identified.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Huili Ren, Yingxiang Chen, Zhou Ao, Qi Cheng, Xiaoyan Yang, Hua Tao, Lixin Zhao, Ao Shen, Peiyuan Li, Qin Fu
Summary: This study reveals that the expression of phosphodiesterase 4D (PDE4D) is positively correlated with poor survival in hepatocellular carcinoma (HCC) patients. PDE4D binds to and interacts with Yes-associated protein (YAP) to promote HCC progression. Targeting the PDE4D-YAP interaction may be an effective strategy for the treatment of HCC.
Article
Oncology
Shupeng Li, Ziwei Li, Xinyu Wang, Junzhe Zhong, Daohan Yu, Hao Chen, Wenbin Ma, Lingling Liu, Minghuang Ye, Ruofei Shen, Chuanlu Jiang, Xiangqi Meng, Jinquan Cai
Summary: The study revealed that HK3 significantly promotes immune cell infiltration in glioma, and its expression level is closely related to tumor grade and prognosis.
CANCER CELL INTERNATIONAL
(2023)
Article
Immunology
Takaaki Yuguchi, Bernard N. Kanoi, Hikaru Nagaoka, Toyokazu Miura, Daisuke Ito, Hiroyuki Takeda, Takafumi Tsuboi, Eizo Takashima, Hitoshi Otsuki
Summary: Erythrocyte recognition and invasion play a critical role in the intra-erythrocytic development of Plasmodium spp. parasites, with EBL proteins involved in tight junction formation. PyEBL was found to specifically interact with basigin, shedding light on its role in modulating the virulence of P. yoelii. This discovery offers new insights into the mechanisms of malaria infection and potential interventions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiaxian Zhu, Ting Long, Lingfang Gao, Yan Zhong, Ping Wang, Xiaoyan Wang, Zuguo Li, Zhiyan Hu
Summary: In this study, RPL21 was found to be involved in promoting CRC metastasis by regulating FA formation in a LAMP3-dependent manner. The interaction between RPL21 and LAMP3 may serve as a potential therapeutic target against CRC.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Oncology
Shi Du, Jiaxian Qian, Shuran Tan, Wenhan Li, Pan Liu, Jing Zhao, Ya Zeng, Linjuan Xu, Zehua Wang, Jing Cai
Summary: In this study, it was found that the number of TEMs increased in cervical cancer tissues with high TIE2 expression and was associated with shorter survival. Further experiments revealed that exosomes derived from TIE2-high cervical cancer cells transported TIE2 protein directly to macrophages, leading to the induction of TEMs. These TEMs promoted tumor angiogenesis and exhibited an M2-like phenotype.
Article
Biology
Yong Huang, Rut Tejero, Vivian K. Lee, Concetta Brusco, Theodore Hannah, Taylor B. Bertucci, Chrystian Junqueira Alves, Igor Katsyv, Michael Kluge, Ramsey Foty, Bin Zhang, Caroline C. Friedel, Guohao Dai, Hongyan Zou, Roland H. Friedel
Summary: The study demonstrates that glioblastoma cells elevate axon guidance molecule Plexin-B2 to increase invasiveness, and through modulating cellular biomechanics, Plexin-B2 promotes glioblastoma cell infiltration along axon fiber tracts in intracranial transplant models.
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
Shasha Liu, Chaoqi Zhang, Boqiao Wang, Huanyu Zhang, Guohui Qin, Congcong Li, Ling Cao, Qun Gao, Yu Ping, Kai Zhang, Jingyao Lian, Qitai Zhao, Dan Wang, Zhen Zhang, Xuan Zhao, Li Yang, Lan Huang, Bo Yang, Yi Zhang
Summary: The intense infiltration of regulatory T cells (Tregs) facilitates the qualities of glioma stem cells (GSCs) through TGF-beta secretion and NF-κB-IL6-STAT3 signaling pathway, leading to increased cancer stemness and tumorigenic potential. Blocking the IL6 receptor can mitigate the promotion effect of Tregs on glioma growth, and the expression levels of CD133, IL6, and TGF-beta could serve as prognosis markers for glioma patients.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Stephen J. Haggarty, Rakesh Karmacharya, Roy H. Perlis
Summary: Bipolar disorder presents a significant unmet medical need, with challenges in effective treatment and prevention. Despite more than 50 years since the introduction of lithium, understanding of its mechanisms and the pathophysiology of bipolar disorder remains limited, hindering the development of new treatments. Progress has been made in understanding the genetic complexity of bipolar disorder, but effective treatments for acute bipolar depression are still lacking. New therapeutic strategies based on defined molecular mechanisms and neural circuits may offer promise for improving the treatment of bipolar disorder.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Debasis Patnaik, Ping-Chieh Pao, Wen-Ning Zhao, M. Catarina Silva, Norma K. Hylton, Peter S. Chindavong, Ling Pan, Li-Huei Tsai, Stephen J. Haggarty
Summary: Genomic instability caused by DNA damage response deficiency is linked to age-related cognitive decline and neurodegenerative diseases. HDAC1 has been identified as a critical factor in protecting neurons from DNA damage, and exifone has been shown to activate HDAC1 deacetylase activity, potentially offering a new therapeutic lead for neuroprotection in the context of neurodegeneration and aging.
ACS CHEMICAL NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Manali Tilak, Jennifer Holborn, Laura A. New, Jasmin Lalonde, Nina Jones
Summary: Glioblastoma multiforme (GBM) is a deadly cancer with limited response to existing therapies. Subtypes of GBM with distinct genetic signatures show aberrant activation of signal transduction pathways. Current research focuses on understanding these molecular alterations to develop more efficient targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Kathryn R. Bowles, M. Catarina Silva, Kristen Whitney, Taylor Bertucci, Joshua E. Berlind, Jesse D. Lai, Jacob C. Garza, Nathan C. Boles, Sidhartha Mahali, Kevin H. Strang, Jacob A. Marsh, Cynthia Chen, Derian A. Pugh, Yiyuan Liu, Ronald E. Gordon, Susan K. Goderie, Rebecca Chowdhury, Steven Lotz, Keith Lane, John F. Crary, Stephen J. Haggarty, Celeste M. Karch, Justin K. Ichida, Alison M. Goate, Sally Temple
Summary: Frontotemporal dementia (FTD) caused by MAPT mutation leads to tau accumulation and glutamatergic neuronal death. Using human iPSC-derived cerebral organoids, this study identified molecular changes preceding neurodegeneration, highlighting glutamate signaling pathways as potential therapeutic targets for FTD.
Article
Neurosciences
Tiziana Petrozziello, Evan A. Bordt, Alexandra N. Mills, Spencer E. Kim, Ellen Sapp, Benjamin A. Devlin, Abigail A. Obeng-Marnu, Sali M. K. Farhan, Ana C. Amaral, Simon Dujardin, Patrick M. Dooley, Christopher Henstridge, Derek H. Oakley, Andreas Neueder, Bradley T. Hyman, Tara L. Spires-Jones, Staci D. Bilbo, Khashayar Vakili, Merit E. Cudkowicz, James D. Berry, Marian DiFiglia, M. Catarina Silva, Stephen J. Haggarty, Ghazaleh Sadri-Vakili
Summary: Research suggests that increased levels of hyperphosphorylated tau may lead to mitochondrial fragmentation and oxidative stress in amyotrophic lateral sclerosis (ALS); reducing tau levels could potentially alleviate mitochondrial dysfunction in ALS.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Cell Biology
Alexander K. Hafez, Amber J. Zimmerman, Grigorios Papageorgiou, Jayapriya Chandrasekaran, Stephen K. Amoah, Rixing Lin, Evelyn Lozano, Caroline Pierotti, Michela Dell'Orco, Brigham J. Hartley, Begum Alural, Jasmin Lalonde, John Matthew Esposito, Sabina Berretta, Alessio Squassina, Caterina Chillotti, Georgios Voloudakis, Zhipin Shao, John F. Fullard, Kristen J. Brennand, Gustavo Turecki, Panos Roussos, Roy H. Perlis, Stephen J. Haggarty, Nora Perrone-Bizzozero, Jonathan L. Brigman, Nikolaos Mellios
Summary: In this study, the researchers found that circHomer1 is inversely associated with HOMER1B mRNA levels in the brains of individuals with psychiatric disorders. They also demonstrated that circHomer1 knockdown inhibits the synaptic expression of Homer1b mRNA, while Homer1b knockdown increases synaptic circHomer1 levels and improves behavioral flexibility. Moreover, the combined knockdown of circHomer1 and Homer1b completely rescues the alterations in learning and synaptic gene expression associated with circHomer1.
Article
Biochemistry & Molecular Biology
Daniel M. Fass, Michael C. Lewis, Rushdy Ahmad, Matthew J. Szucs, Qiangge Zhang, Morgan Fleishman, Dongqing Wang, Myung Jong Kim, Jonathan Biag, Steven A. Carr, Edward M. Scolnick, Richard T. Premont, Stephen J. Haggarty
Summary: This study aims to elucidate the molecular and cellular basis of cognitive deficits in schizophrenia. The research found that genetic variations in a set of genes involved in regulating neuroplasticity may contribute to cognitive deficits and exert their effects by perturbing the networks of these genes.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
M. Catarina Silva, Ghata Nandi, Katherine A. Donovan, Quan Cai, Bethany C. Berry, Radoslaw P. Nowak, Eric S. Fischer, Nathanael S. Gray, Fleur M. Ferguson, Stephen J. Haggarty
Summary: Accumulation of misfolded, aggregating proteins concurrent with disease onset and progression is a hallmark of neurodegenerative proteinopathies. In this study, FTD-patient induced pluripotent stem cells (iPSC)-derived neurons were used as models for driving a medicinal chemistry campaign around tau targeting degrader series. Three lead compounds with tau degradation activity in mutant neurons were identified, establishing potential disease relevance and driving future studies on specificity and pharmacological properties.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Thomas Parmentier, Fiona M. K. James, Elizabeth Hewitson, Craig Bailey, Nicholas Werry, Steven D. Sheridan, Roy H. Perlis, Melissa L. Perreault, Luis Gaitero, Jasmin Lalonde, Jonathan LaMarre
Summary: Activity-induced neurogenesis has been widely studied in rodents but less in humans. In this study, neuronal activity and associated neurogenesis were investigated in cerebral spheroids derived from human induced pluripotent stem cells (iPSCs). The results show that 4AP increases neuronal activity, promotes the generation of new neurons, and reduces the number of new glial cells. Furthermore, the expression of miR-135a, a key regulator of exercise-induced neurogenesis, was significantly decreased, suggesting its involvement in the process. These findings highlight the potential of iPSC-derived cerebral spheroids as a model for studying activity-induced neurogenesis.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Sameena Parveen, Amrita Khamari, Jyothikamala Raju, Marc G. Coppolino, Sunando Datta
Summary: This study identifies STX7 as a key player in invadopodia formation and protease trafficking during cancer cell invasion.
JOURNAL OF CELL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ashwani Kumar, Galina Aglyamova, Yun Young Yim, Aaron O. Bailey, Haley M. Lynch, Reid T. Powell, Nghi D. Nguyen, Zachary Rosenthal, Wen-Ning Zhao, Yi Li, Jianping Chen, Shanghua Fan, Hubert Lee, William K. Russell, Clifford Stephan, Alfred J. Robison, Stephen J. Haggarty, Eric J. Nestler, Jia Zhou, Mischa Machius, Gabby Rudenko
Summary: The AP1 transcription factor Delta FOSB, a splice variant of FOSB, accumulates in the brain in response to chronic insults and mediates subsequent long-term neuroadaptations. The structural basis of its redox switch has been revealed, providing potential targets for modulating its biological functions.
NUCLEIC ACIDS RESEARCH
(2022)