Alternative Splicing, Epigenetic Modifications and Cancer: A Dangerous Triangle, or a Hopeful One?

Hypoxia-induced suppression of alternative splicing of MBD2 promotes breast cancer metastasis via activation of FZD1

(2021) Zhaoji Liu et al.   CANCER RESEARCH

Short H2A histone variants are expressed in cancer

(2021) Guo-Liang Chew et al.   Nature Communications

The Role of H3K4 Trimethylation in CpG Islands Hypermethylation in Cancer

(2021) Giuseppe Zardo   Biomolecules

JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer

(2021) Alec Paschalis et al.   CANCER RESEARCH

Kaempferol Reverses Aerobic Glycolysis via miR-339-5p-Mediated PKM Alternative Splicing in Colon Cancer Cells

(2021) Haili Wu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

BRG1 knockdown inhibits proliferation through multiple cellular pathways in prostate cancer

(2021) Katherine A. Giles et al.   Clinical Epigenetics

Precision medicine in 2030—seven ways to transform healthcare

(2021) Joshua C. Denny et al.   CELL

RNA-Targeting Splicing Modifiers: Drug Development and Screening Assays

(2021) Zhichao Tang et al.   MOLECULES

lncRNA PCAT6 facilitates cell proliferation and invasion via regulating the miR‑326/hnRNPA2B1 axis in liver cancer

(2021) Jun Luo et al.   Oncology Letters

Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth

(2021) Wen-juan Li et al.   Nature Communications

Genetic variant rs10251977 (G>A) in EGFR-AS1 modulates the expression of EGFR isoforms A and D

(2021) Shankar Dhamodharan et al.   Scientific Reports

On the function and relevance of alternative 3′‐ UTRs in gene expression regulation

(2021) Isabel Pereira‐Castro et al.   Wiley Interdisciplinary Reviews-RNA

Epigenetic Mechanisms Are Involved in the Oncogenic Properties of ZNF518B in Colorectal Cancer

(2021) Francisco Gimeno-Valiente et al.   Cancers

Regulation of RNA Splicing: Aberrant Splicing Regulation and Therapeutic Targets in Cancer

(2021) Koji Kitamura et al.   Cells

UHRF1 regulates alternative splicing by interacting with splicing factors and U snRNAs in a H3R2me involved manner

(2021) Peng Xu et al.   HUMAN MOLECULAR GENETICS

A 5′-tRNA halve, tiRNA-Gly promotes cell proliferation and migration via binding to RBM17 and inducing alternative splicing in papillary thyroid cancer

(2021) Litao Han et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

CD44 alternative splicing senses intragenic DNA methylation in tumors via direct and indirect mechanisms

(2021) Eric Batsché et al.   NUCLEIC ACIDS RESEARCH

PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma

(2021) Virginia Giuliani et al.   Nature Communications

lncRNA TRMP-S directs dual mechanisms to regulate p27-mediated cellular senescence

(2021) Tian Shuai et al.   Molecular Therapy-Nucleic Acids

E2F1 and epigenetic modifiers orchestrate breast cancer progression by regulating oxygen-dependent ESRP1 expression

(2021) Cheemala Ashok et al.   Oncogenesis

SETD2 mutation in renal clear cell carcinoma suppress autophagy via regulation of ATG12

(2020) Patricia González-Rodríguez et al.   Cell Death & Disease

Transcription and splicing: A two‐way street

(2020) Michael Tellier et al.   Wiley Interdisciplinary Reviews-RNA

High expression of ESRP1 regulated by circ-0005585 promotes cell colonization in ovarian cancer

(2020) Guanming Deng et al.   Cancer Cell International

Chromatin structure regulates cancer-specific alternative splicing events in primary HPV-related oropharyngeal squamous cell carcinoma

(2020) Theresa Guo et al.   Epigenetics

Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy

(2020) Yuanjun Lu et al.   Molecular Cancer

The expanding regulatory mechanisms and cellular functions of circular RNAs

(2020) Ling-Ling Chen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Specific histone modifications associate with alternative exon selection during mammalian development

(2020) Qiwen Hu et al.   NUCLEIC ACIDS RESEARCH

LARP1 isoform expression in human cancer cell lines

(2020) Hagen Schwenzer et al.   RNA Biology

Proteomics-Based Characterization of miR-574-5p Decoy to CUGBP1 Suggests Specificity for mPGES-1 Regulation in Human Lung Cancer Cells

(2020) Anne C. Emmerich et al.   Frontiers in Pharmacology

A novel miR-206/hnRNPA1/PKM2 axis reshapes the Warburg effect to suppress colon cancer growth

(2020) Rong Fu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The different flavors and splices of MCL

(2020) Oliver Weigert   BLOOD

Exercise-mediated downregulation of MALAT1 expression and implications in primary and secondary cancer prevention

(2020) Maria Paola Paronetto et al.   FREE RADICAL BIOLOGY AND MEDICINE

Comprehensive Network Analysis Reveals Alternative Splicing-Related lncRNAs in Hepatocellular Carcinoma

(2020) Junqing Wang et al.   Frontiers in Genetics

Innovative Therapeutic and Delivery Approaches Using Nanotechnology to Correct Splicing Defects Underlying Disease

(2020) Marc Suñé-Pou et al.   Frontiers in Genetics

Linking transcription, RNA polymerase II elongation and alternative splicing

(2020) Luciana E. Giono et al.   BIOCHEMICAL JOURNAL

Epigenetic regulation of osteopontin splicing isoform c defines its role as a microenvironmental factor to promote the survival of colon cancer cells from 5-FU treatment

(2020) Siyuan Chang et al.   Cancer Cell International

PTBP1 ‐targeting microRNAs regulate cancer‐specific energy metabolism through the modulation of PKM1/M2 splicing

(2020) Kohei Taniguchi et al.   CANCER SCIENCE

Mammalian SWI/SNF Chromatin Remodeling Complexes: Emerging Mechanisms and Therapeutic Strategies

(2020) Richard C. Centore et al.   TRENDS IN GENETICS

Apoptosis in Cancer Cells Is Induced by Alternative Splicing of hnRNPA2/B1 Through Splicing of Bcl-x, a Mechanism that Can Be Stimulated by an Extract of the South African Medicinal Plant, Cotyledon orbiculata

(2020) Tshepiso Jan Makhafola et al.   Frontiers in Oncology

Low DAPK1 expression correlates with poor prognosis and sunitinib resistance in clear cell renal cell carcinoma

(2020) Zhengshuai Song et al.   Aging-US

Use of DNA methylation profiling in translational oncology

(2020) Vanessa Ortiz-Barahona et al.   SEMINARS IN CANCER BIOLOGY

QKI-5 regulates the alternative splicing of cytoskeletal gene ADD3 in lung cancer

(2020) Jin-Zhu Wang et al.   Journal of Molecular Cell Biology

Multiple Alternative Promoters and Alternative Splicing Enable Universal Transcription-Based Logic Computation in Mammalian Cells

(2020) Jiten Doshi et al.   Cell Reports

Widespread Aberrant Alternative Splicing despite Molecular Remission in Chronic Myeloid Leukaemia Patients

(2020) Ulf Schmitz et al.   Cancers

Obesity-induced MBD2_v2 expression promotes tumor-initiating triple negative breast cancer stem cells

(2019) Emily A. Teslow et al.   Molecular Oncology

miR-574-5p as RNA decoy for CUGBP1 stimulates human lung tumor growth by mPGES-1 induction

(2019) Meike J. Saul et al.   FASEB JOURNAL

RNA Splicing of the BHC80 Gene Contributes to Neuroendocrine Prostate Cancer Progression

(2019) Yinan Li et al.   EUROPEAN UROLOGY

ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer

(2019) Laura Cato et al.   CANCER CELL

The long non-coding RNA ANRASSF1 in the regulation of alternative protein-coding transcripts RASSF1A and RASSF1C in human breast cancer cells: implications to epigenetic therapy

(2019) Naiade Calanca et al.   Epigenetics

Acetylation of PHF5A Modulates Stress Responses and Colorectal Carcinogenesis through Alternative Splicing-Mediated Upregulation of KDM3A

(2019) Zhe Wang et al.   MOLECULAR CELL

More than a messenger: Alternative splicing as a therapeutic target

(2019) A.J. Black et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss

(2019) Andrew Fedoriw et al.   CANCER CELL

Epidrugs: targeting epigenetic marks in cancer treatment

(2019) Cristiana Libardi Miranda Furtado et al.   Epigenetics

Hsa‐miR‐139‐5p is a prognostic thyroid cancer marker involved in HNRNPF‐mediated alternative splicing

(2019) Cristina Montero‐Conde et al.   INTERNATIONAL JOURNAL OF CANCER

EWS–FLI1 modulated alternative splicing of ARID1A reveals novel oncogenic function through the BAF complex

(2019) Saravana P Selvanathan et al.   NUCLEIC ACIDS RESEARCH

Epigenetic inactivation of the splicing RNA-binding protein CELF2 in human breast cancer

(2019) Laia Piqué et al.   ONCOGENE

Nascent RNA and the Coordination of Splicing with Transcription

(2019) Karla M. Neugebauer   Cold Spring Harbor Perspectives in Biology

The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer

(2019) Raheleh Amirkhah et al.   Cells

Dietary-phytochemical mediated reversion of cancer-specific splicing inhibits Warburg effect in head and neck cancer

(2019) Sandhya Yadav et al.   BMC CANCER

Enhanced osteopontin splicing regulated by RUNX2 is HDAC-dependent and induces invasive phenotypes in NSCLC cells

(2019) Jing Huang et al.   Cancer Cell International

PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia

(2019) Aliaksandra Radzisheuskaya et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DAPK1 loss triggers tumor invasion in colorectal tumor cells

(2019) Sara Steinmann et al.   Cell Death & Disease

BRM: the core ATPase subunit of SWI/SNF chromatin-remodelling complex—a tumour suppressor or tumour-promoting factor?

(2019) Iga Jancewicz et al.   Epigenetics & Chromatin

Understanding aberrant RNA splicing to facilitate cancer diagnosis and therapy

(2019) Xuesen Dong et al.   ONCOGENE

Integrated Analysis of Structural Variation and RNA Expression of FGFR2 and Its Splicing Modulator ESRP1 Highlight the ESRP1amp-FGFR2norm-FGFR2-IIIchigh Axis in Diffuse Gastric Cancer

(2019) Sara Pinto Teles et al.   Cancers

The Latest Twists in Chromatin Remodeling

(2018) Ralf Blossey et al.   BIOPHYSICAL JOURNAL

PHF5A Epigenetically Inhibits Apoptosis to Promote Breast Cancer Progression.

(2018) Yi-Zi Zheng et al.   CANCER RESEARCH

miR‐200/375 control epithelial plasticity‐associated alternative splicing by repressing the RNA‐binding protein Quaking

(2018) Katherine A Pillman et al.   EMBO JOURNAL

Global cancer incidence in older adults, 2012 and 2035: A population-based study

(2018) Sophie Pilleron et al.   INTERNATIONAL JOURNAL OF CANCER

Alternative Splicing as a Target for Cancer Treatment

(2018) Nancy Martinez-Montiel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interferon regulatory factor 1 and a variant of heterogeneous nuclear ribonucleoprotein L coordinately silence the gene for adhesion protein CEACAM1

(2018) Kenneth J. Dery et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exogenous IL-6 induces mRNA splice variant MBD2_v2 to promote stemness in TP53 wild-type, African American PCa cells

(2018) Emily A. Teslow et al.   Molecular Oncology

Splicing regulation by long noncoding RNAs

(2018) Natali Romero-Barrios et al.   NUCLEIC ACIDS RESEARCH

Histone demethylase JMJD1A promotes alternative splicing of AR variant 7 (AR-V7) in prostate cancer cells

(2018) Lingling Fan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of epigenetic factors in the selection of the alternative splicing isoforms of human KRAS in colorectal cancer cell lines

(2018) Ángela L. Riffo-Campos et al.   Oncotarget

Integrative analysis reveals functional and regulatory roles of H3K79me2 in mediating alternative splicing

(2018) Tianbao Li et al.   Genome Medicine

Cancer epigenetics: Moving forward

(2018) Angela Nebbioso et al.   PLoS Genetics

SKI controls MDS-associated chronic TGFβ signaling, aberrant splicing, and stem cell fitness

(2018) David E. Muench et al.   BLOOD

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Cancer-associated MORC2 mutant M276I regulates an hnRNPM-mediated CD44 splicing switch to promote invasion and metastasis in triple-negative breast cancer

(2018) Fang-Lin Zhang et al.   CANCER RESEARCH

Up-regulated miR-133a orchestrates epithelial-mesenchymal transition of airway epithelial cells

(2018) Linjie Chen et al.   Scientific Reports

SF3B4 is regulated by microRNA-133b and promotes cell proliferation and metastasis in hepatocellular carcinoma

(2018) Zhiyong Liu et al.   EBioMedicine

Hypomethylation of BORIS is a promising prognostic biomarker in hepatocellular carcinoma

(2017) Jingyang He et al.   GENE

A novel splicing isoform of protein arginine methyltransferase 1 (PRMT1) that lacks the dimerization arm and correlates with cellular malignancy

(2017) Odysseas Patounas et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis

(2017) Huairui Yuan et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of a novel leukemic-specific splice variant of DNMT3B and its stability

(2017) Prachi Singh et al.   MEDICAL ONCOLOGY

miR-30c suppresses prostate cancer survival by targeting the ASF/SF2 splicing factor oncoprotein

(2017) Ya-Qiang Huang et al.   Molecular Medicine Reports

DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats

(2017) David Brocks et al.   NATURE GENETICS

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

(2017) Rajesha Rupaimoole et al.   NATURE REVIEWS DRUG DISCOVERY

Body-hypomethylated human genes harbor extensive intragenic transcriptional activity and are prone to cancer-associated dysregulation

(2017) Isabel Mendizabal et al.   NUCLEIC ACIDS RESEARCH

Intragenic DNA methylation and BORIS-mediated cancer-specific splicing contribute to the Warburg effect

(2017) Smriti Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic plasticity and the hallmarks of cancer

(2017) William A. Flavahan et al.   SCIENCE

Effect of histone modifications on hMLH1 alternative splicing in gastric cancer

(2017) Jin-Xuan Zhao et al.   TUMOR BIOLOGY

Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment

(2017) Justin J. -L. Wong et al.   Nature Communications

Alternative Splicing of EZH2 pre-mRNA by SF3B3 Contributes to the Tumorigenic Potential of Renal Cancer

(2016) Ke Chen et al.   CLINICAL CANCER RESEARCH

Overexpression of LARP1 predicts poor prognosis of colorectal cancer and is expected to be a potential therapeutic target

(2016) Ling Ye et al.   TUMOR BIOLOGY

Histone Modifications and Cancer

(2016) James E. Audia et al.   Cold Spring Harbor Perspectives in Biology

The PWWP domain of the human oncogene WHSC1L1/NSD3 induces a metabolic shift toward fermentation

(2016) Germana B. Rona et al.   Oncotarget

Regulation of Alternative Splicing Through Coupling with Transcription and Chromatin Structure

(2015) Shiran Naftelberg et al.   Annual Review of Biochemistry

Mechanisms and Regulation of Alternative Pre-mRNA Splicing

(2015) Yeon Lee et al.   Annual Review of Biochemistry

Epigenetic regulation of CDH1 exon 8 alternative splicing in gastric cancer

(2015) Xiao-Wei Li et al.   BMC CANCER

Intron retention is a widespread mechanism of tumor-suppressor inactivation

(2015) Hyunchul Jung et al.   NATURE GENETICS

The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer

(2015) Thomas G. Hopkins et al.   NUCLEIC ACIDS RESEARCH

HP1 Is Involved in Regulating the Global Impact of DNA Methylation on Alternative Splicing

(2015) Ahuvi Yearim et al.   Cell Reports

EGF-Induced Acetylation of Heterogeneous Nuclear Ribonucleoproteins Is Dependent on KRAS Mutational Status in Colorectal Cancer Cells

(2015) Desamparados Roda et al.   PLoS One

LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression

(2014) M Mura et al.   ONCOGENE

Interplay between the Cancer Genome and Epigenome

(2013) Hui Shen et al.   CELL

Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects

(2013) J. M. Simon et al.   GENOME RESEARCH

DNA Methylation Regulated Nucleosome Dynamics

(2013) Isabel Jimenez-Useche et al.   Scientific Reports

Combinations of Histone Modifications Mark Exon Inclusion Levels

(2012) Stefan Enroth et al.   PLoS One

Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completion

(2012) Cyrille Girard et al.   Nature Communications

MORC2 Signaling Integrates Phosphorylation-Dependent, ATPase-Coupled Chromatin Remodeling during the DNA Damage Response

(2012) Da-Qiang Li et al.   Cell Reports

Complex Alternative Splicing of the Smarca2 Gene Suggests the Importance of Smarca2-B Variants

(2012) Min Yang et al.   Journal of Cancer

Long non-coding RNA modifies chromatin

(2011) Alka Saxena et al.   BIOESSAYS

PHD Finger Recognition of Unmodified Histone H3R2 Links UHRF1 to Regulation of Euchromatic Gene Expression

(2011) Eerappa Rajakumara et al.   MOLECULAR CELL

CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing

(2011) Sanjeev Shukla et al.   NATURE

Cancer epigenetics reaches mainstream oncology

(2011) Manuel Rodríguez-Paredes et al.   NATURE MEDICINE

Expression of Androgen Receptor Splice Variants in Prostate Cancer Bone Metastases is Associated with Castration-Resistance and Short Survival

(2011) Emma Hörnberg et al.   PLoS One

The importance of CELF control: molecular and biological roles of the CUG-BP, Elav-like family of RNA-binding proteins

(2011) Twishasri Dasgupta et al.   Wiley Interdisciplinary Reviews-RNA

The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation

(2010) Vidisha Tripathi et al.   MOLECULAR CELL

Relationship between nucleosome positioning and DNA methylation

(2010) Ramakrishna K. Chodavarapu et al.   NATURE

DNMT3AMutations in Acute Myeloid Leukemia

(2010) Timothy J. Ley et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Biology of Chromatin Remodeling Complexes

(2009) Cedric R. Clapier et al.   Annual Review of Biochemistry

An operational definition of epigenetics

(2009) S. L. Berger et al.   GENES & DEVELOPMENT

Non-redundancy within the RAS oncogene family: Insights into mutational disparities in cancer

(2009) Ken S. Lau et al.   MOLECULES AND CELLS

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells

(2009) Madeleine P Ball et al.   NATURE BIOTECHNOLOGY

CTCFL/BORIS Is a Methylation-Independent DNA-Binding Protein That Preferentially Binds to the Paternal H19 Differentially Methylated Region

(2008) P. Nguyen et al.   CANCER RESEARCH

Ligand-Independent Androgen Receptor Variants Derived from Splicing of Cryptic Exons Signify Hormone-Refractory Prostate Cancer

(2008) R. Hu et al.   CANCER RESEARCH