Optimization and Validation of a Novel Three-Dimensional Co-Culture System in Decellularized Human Liver Scaffold for the Study of Liver Fibrosis and Cancer

AICAR and Compound C negatively modulate HCC-induced primary human hepatic stellate cell activation in vitro

(2021) Katrin Böttcher et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Analysis of Liver Cancer Cell Lines Identifies Agents With Likely Efficacy Against Hepatocellular Carcinoma and Markers of Response

(2019) Stefano Caruso et al.   GASTROENTEROLOGY

Cirrhotic Human Liver Extracellular Matrix 3D Scaffolds Promote Smad-Dependent TGF-β1 Epithelial Mesenchymal Transition

(2019) Giuseppe Mazza et al.   Cells

STAT3 aggravates TGF-β1-induced hepatic epithelial-to-mesenchymal transition and migration

(2018) Bin Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

SHP-1 acts as a Tumor Suppressor in Hepatocarcinogenesis and HCC Progression

(2018) Liang-Zhi Wen et al.   CANCER RESEARCH

P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts

(2018) Changwei Dou et al.   GASTROENTEROLOGY

Dual targeting of histone methyltransferase G9a and DNA-methyltransferase 1 for the treatment of experimental hepatocellular carcinoma

(2018) Marina Bárcena-Varela et al.   HEPATOLOGY

The adenosine monophosphate-activated protein kinase-vacuolar adenosine triphosphatase-pH axis: A key regulator of the profibrogenic phenotype of human hepatic stellate cells

(2018) Giusi Marrone et al.   HEPATOLOGY

Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine

(2018) Naoto Fujiwara et al.   JOURNAL OF HEPATOLOGY

EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma

(2018) Peter R. Galle et al.   JOURNAL OF HEPATOLOGY

Three Dimensional Mixed-Cell Spheroids Mimic Stroma-Mediated Chemoresistance and Invasive Migration in hepatocellular carcinoma

(2018) Iftikhar Ali Khawar et al.   NEOPLASIA

AASLD guidelines for the treatment of hepatocellular carcinoma

(2017) Julie K. Heimbach et al.   HEPATOLOGY

Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial

(2017) Jordi Bruix et al.   LANCET

SHP-1 is a negative regulator of epithelial-mesenchymal transition in hepatocellular carcinoma

(2017) L-C Fan et al.   ONCOGENE

Three‑dimensional cell culture: A powerful tool in tumor research and drug discovery (Review)

(2017) Donglai Lv et al.   Oncology Letters

Serum fibronectin distinguishes the early stages of hepatocellular carcinoma

(2017) Hyunsoo Kim et al.   Scientific Reports

Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress.

(2017) Tahir Mehmood et al.   Journal of Cancer

Three-Dimensional Cell Cultures in Drug Discovery and Development

(2017) Ye Fang et al.   SLAS Discovery

Pro-fibrotic compounds induce stellate cell activation, ECM-remodelling and Nrf2 activation in a human 3D-multicellular model of liver fibrosis

(2017) Vincenzo Prestigiacomo et al.   PLoS One

A novel three-dimensional culture system maintaining the physiological extracellular matrix of fibrotic model livers accelerates progression of hepatocellular carcinoma cells

(2017) Yuya Miyauchi et al.   Scientific Reports

Rapid production of human liver scaffolds for functional tissue engineering by high shear stress oscillation-decellularization

(2017) Giuseppe Mazza et al.   Scientific Reports

Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro

(2016) Sofia B. Leite et al.   BIOMATERIALS

Role of epithelial to mesenchymal transition in hepatocellular carcinoma

(2016) Gianluigi Giannelli et al.   JOURNAL OF HEPATOLOGY

Regorafenib (Stivarga) pharmacologically targets epithelial-mesenchymal transition in colorectal cancer

(2016) Li-Ching Fan et al.   Oncotarget

Three-dimensional Organotypic Culture Models of Human Hepatocellular Carcinoma

(2016) Atsushi Takai et al.   Scientific Reports

Activated hepatic stellate cells play pivotal roles in hepatocellular carcinoma cell chemoresistance and migration in multicellular tumor spheroids

(2016) Yeonhwa Song et al.   Scientific Reports

Three-dimensional (3D) spheroid cultures improve the metabolic gene expression profiles of HepaRG cells

(2015) Yu Takahashi et al.   BIOSCIENCE REPORTS

Structural and functional hepatocyte polarity and liver disease

(2015) Paul Gissen et al.   JOURNAL OF HEPATOLOGY

Sorafenib and its derivative SC-1 exhibit antifibrotic effects through signal transducer and activator of transcription 3 inhibition

(2015) Tung-Hung Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regorafenib impairs mitochondrial functions, activates AMP-activated protein kinase, induces autophagy, and causes rat hepatocyte necrosis

(2015) Zuquan Weng et al.   TOXICOLOGY

Decellularized human liver as a natural 3D-scaffold for liver bioengineering and transplantation

(2015) Giuseppe Mazza et al.   Scientific Reports

Role of three-dimensional matrix stiffness in regulating the chemoresistance of hepatocellular carcinoma cells

(2014) Chang Liu et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Transforming Growth Factor-  as a Therapeutic Target in Hepatocellular Carcinoma

(2014) G. Giannelli et al.   CANCER RESEARCH

Sorafenib Inhibition of Hepatic Stellate Cell Proliferation in Tumor Microenvironment of Hepatocellular Carcinoma: A Study of the Sorafenib Mechanisms

(2014) Zhi-min Geng et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

STAT3 Mediates Regorafenib-Induced Apoptosis in Hepatocellular Carcinoma

(2014) W.-T. Tai et al.   CLINICAL CANCER RESEARCH

A multicellular 3D heterospheroid model of liver tumor and stromal cells in collagen gel for anti-cancer drug testing

(2013) Derek Yip et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of the Microenvironment in the Pathogenesis and Treatment of Hepatocellular Carcinoma

(2013) Virginia Hernandez–Gea et al.   GASTROENTEROLOGY

Genetic Characteristics of the Human Hepatic Stellate Cell Line LX-2

(2013) Ralf Weiskirchen et al.   PLoS One

TGF-β in Epithelial to Mesenchymal Transition and Metastasis of Liver Carcinoma

(2012) Patrick Reichl et al.   CURRENT PHARMACEUTICAL DESIGN

Antifibrotic Activity of Sorafenib in Experimental Hepatic Fibrosis: Refinement of Inhibitory Targets, Dosing, and Window of Efficacy In Vivo

(2012) Feng Hong et al.   DIGESTIVE DISEASES AND SCIENCES

Monocyte-endothelium-smooth muscle cell interaction in co-culture: Proliferation and cytokine productions in response to advanced glycation end products

(2011) Mi-Hyun Nam et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Complementary vascular and matrix regulatory pathways underlie the beneficial mechanism of action of sorafenib in liver fibrosis

(2011) Dominique Thabut et al.   HEPATOLOGY

Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity

(2010) Scott M. Wilhelm et al.   INTERNATIONAL JOURNAL OF CANCER

New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis

(2010) Yan Wang et al.   JOURNAL OF HEPATOLOGY

Activated hepatic stellate cells promote tumorigenicity of hepatocellular carcinoma

(2009) Thomas Amann et al.   CANCER SCIENCE

The niche of stellate cells within rat liver

(2009) Iris Sawitza et al.   HEPATOLOGY

Hep G2 is a hepatoblastoma-derived cell line

(2009) Dolores López-Terrada et al.   HUMAN PATHOLOGY

Sorafenib attenuates the portal hypertensive syndrome in partial portal vein ligated rats

(2009) Thomas Reiberger et al.   JOURNAL OF HEPATOLOGY

Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats

(2008) Marc Mejias et al.   HEPATOLOGY

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE