DRD4 (Dopamine D4 Receptor) Mitigate Abdominal Aortic Aneurysm via Decreasing P38 MAPK (mitogen-activated protein kinase)/NOX4 (NADPH Oxidase 4) Axis–Associated Oxidative Stress

Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer

(2020) Eric C. Cheung et al.   CANCER CELL

Crosstalk between mitochondrial hyperacetylation and oxidative stress in vascular dysfunction and hypertension

(2019) Sergey I Dikalov et al.   ANTIOXIDANTS & REDOX SIGNALING

Up regulation of isoleucyl-tRNA synthetase promotes vascular smooth muscle cells dysfunction via p38 MAPK/PI3K signaling pathways

(2019) Bowen Li et al.   LIFE SCIENCES

Obesity, kidney dysfunction and hypertension: mechanistic links

(2019) John E. Hall et al.   Nature Reviews Nephrology

Oxidative stress and vascular stiffness in hypertension: A renewed interest for antioxidant therapies?

(2019) Marika Massaro et al.   VASCULAR PHARMACOLOGY

SGLT-2 (Sodium-Glucose Cotransporter 2) Inhibition Reduces Ang II (Angiotensin II)–Induced Dissecting Abdominal Aortic Aneurysm in ApoE (Apolipoprotein E) Knockout Mice

(2019) Rebeca Ortega et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Age-Related Dopaminergic Innervation Augments T Helper 2-Type Allergic Inflammation in the Postnatal Lung

(2019) Wei Wang et al.   IMMUNITY

An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential

(2018) Liqin Wang et al.   CELL

Inhibition or deletion of angiotensin II type 1 receptor suppresses elastase-induced experimental abdominal aortic aneurysms

(2018) Haojun Xuan et al.   JOURNAL OF VASCULAR SURGERY

Over-expression of a cardiac-specific human dopamine D5 receptor mutation in mice causes a dilated cardiomyopathy through ROS over-generation by NADPH oxidase activation and Nrf2 degradation

(2018) Xiaoliang Jiang et al.   Redox Biology

Exposure to Maternal Diabetes Mellitus Causes Renal Dopamine D 1 Receptor Dysfunction and Hypertension in Adult Rat Offspring

(2018) Hao Luo et al.   HYPERTENSION

Sex- and Strain-related Differences in the Stress Response of Mice to CO2 Euthanasia

(2018) Michelle A Creamer-Hente et al.   Journal of the American Association for Laboratory Animal Science

Inhibitory effects of cycloastragenol on abdominal aortic aneurysm and its related mechanisms

(2018) Yunxia Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hyperglycemia modulates redox, inflammatory and vasoactive markers through specific signaling pathways in cerebral endothelial cells: Insights on insulin protective action

(2018) Angélique Arcambal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Combined NADPH and the NOX inhibitor apocynin provides greater anti-inflammatory and neuroprotective effects in a mouse model of stroke

(2017) Yuan-Yuan Qin et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Future Challenge of Reactive Oxygen Species (ROS) in Hypertension: From Bench to Bed Side

(2017) Gabriele Togliatto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NOX isoforms in the development of abdominal aortic aneurysm

(2017) Kin Lung Siu et al.   Redox Biology

Intermedin 1− 53 Attenuates Abdominal Aortic Aneurysm by Inhibiting Oxidative StressHighlights

(2016) Wei-Wei Lu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells

(2016) Sonam Dolma et al.   CANCER CELL

Matricellular protein CCN3 mitigates abdominal aortic aneurysm

(2016) Chao Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of D4Dopamine Receptors on Insulin Receptor Expression and Effect in Renal Proximal Tubule Cells

(2016) Ye Zhang et al.   Journal of the American Heart Association

Receptor-Interacting Protein Kinase 3 Contributes to Abdominal Aortic Aneurysms via Smooth Muscle Cell Necrosis and Inflammation

(2015) Q. Wang et al.   CIRCULATION RESEARCH

Regulation of Signal Transduction by Reactive Oxygen Species in the Cardiovascular System

(2015) D. I. Brown et al.   CIRCULATION RESEARCH

Leukotriene B4Activates Pulmonary Artery Adventitial Fibroblasts in Pulmonary Hypertension

(2015) Jin Qian et al.   HYPERTENSION

Risk Profiles for Aortic Dissection and Ruptured or Surgically Treated Aneurysms: A Prospective Cohort Study

(2015) M. Landenhed et al.   Journal of the American Heart Association

The NADPH oxidase inhibitor diphenyleneiodonium activates the human TRPA1 nociceptor

(2014) Hiroka Suzuki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

NADPH Oxidase Deficiency Exacerbates Angiotensin II–Induced Abdominal Aortic Aneurysms in Mice

(2014) Yasuyoshi Kigawa et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dopamine receptors - IUPHAR Review 13

(2014) Jean-Martin Beaulieu et al.   BRITISH JOURNAL OF PHARMACOLOGY

A far-upstream AP-1/Smad binding box regulates human NOX4 promoter activation by transforming growth factor-β

(2014) Guangxing Bai et al.   GENE

Oxidative Stress in Hypertension: Role of the Kidney

(2013) Magali Araujo et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH Oxidases in Vascular Pathology

(2013) Anna Konior et al.   ANTIOXIDANTS & REDOX SIGNALING

A Selective Role for Dopamine D4 Receptors in Modulating Reward Expectancy in a Rodent Slot Machine Task

(2013) Paul J. Cocker et al.   BIOLOGICAL PSYCHIATRY

Zoledronate attenuates angiotensin II-induced abdominal aortic aneurysm through inactivation of Rho/ROCK-dependent JNK and NF-κB pathway

(2013) Shih-Hung Tsai et al.   CARDIOVASCULAR RESEARCH

ROS Are Required for Mouse Spermatogonial Stem Cell Self-Renewal

(2013) Hiroko Morimoto et al.   Cell Stem Cell

KLF4 Regulates Abdominal Aortic Aneurysm Morphology and Deletion Attenuates Aneurysm Formation

(2013) M. Salmon et al.   CIRCULATION

Macrophage Mitochondrial Oxidative Stress Promotes Atherosclerosis and Nuclear Factor-κB–Mediated Inflammation in Macrophages

(2013) Ying Wang et al.   CIRCULATION RESEARCH

Hyperhomocysteinemia Exaggerates Adventitial Inflammation and Angiotensin II−Induced Abdominal Aortic Aneurysm in Mice

(2012) Ziyi Liu et al.   CIRCULATION RESEARCH

Paraoxonase 2 decreases renal reactive oxygen species production, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of NADPH oxidase

(2012) Yu Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatocyte growth factor promotes an anti-inflammatory cytokine profile in human abdominal aortic aneurysm tissue

(2011) Yusuke Shintani et al.   ATHEROSCLEROSIS

Nox4 is a Novel Inducible Source of Reactive Oxygen Species in Monocytes and Macrophages and Mediates Oxidized Low Density Lipoprotein–Induced Macrophage Death

(2010) Chi Fung Lee et al.   CIRCULATION RESEARCH

Activation of Dopamine D4 Receptors Is Protective Against Hypoxia/Reoxygenation-Induced Cell Death in HT22 Cells

(2010) Saori Shimada et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Mitochondria-targeted antioxidant effects of S(-) and R(+) pramipexole

(2010) Giulia Ferrari-Toninelli et al.   BMC Pharmacology & Toxicology

Translation-Linked mRNA Destabilization Accompanying Serum-Induced Nox4 Expression in Human Endothelial Cells

(2009) Hitesh Peshavariya et al.   ANTIOXIDANTS & REDOX SIGNALING

Transition from atherosclerosis to aortic aneurysm in humans coincides with an increased expression of RAS components

(2009) Elena Kaschina et al.   ATHEROSCLEROSIS

Monoamine Oxidase A–Mediated Enhanced Catabolism of Norepinephrine Contributes to Adverse Remodeling and Pump Failure in Hearts With Pressure Overload

(2009) Nina Kaludercic et al.   CIRCULATION RESEARCH

Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II–induced aortic aneurysms

(2009) Kimio Satoh et al.   NATURE MEDICINE

Cellular and molecular mechanisms of thoracic aortic aneurysms

(2009) Ismail El-Hamamsy et al.   Nature Reviews Cardiology

Inhibition of reactive oxygen species attenuates aneurysm formation in a murine model

(2008) Wanfen Xiong et al.   ATHEROSCLEROSIS

Reduced tumor growth in a mouse model of schizophrenia, lacking the dopamine transporter

(2008) Masanori Asada et al.   INTERNATIONAL JOURNAL OF CANCER