Intelligent lesion blood brain barrier targeting nano-missiles for Alzheimer's disease treatment by anti-neuroinflammation and neuroprotection

Rethinking CRITID Procedure of Brain Targeting Drug Delivery: Circulation, Blood Brain Barrier Recognition, Intracellular Transport, Diseased Cell Targeting, Internalization, and Drug Release

(2021) Shaobo Ruan et al.   Advanced Science

The protein corona hampers the transcytosis of transferrin-modified nanoparticles through blood–brain barrier and attenuates their targeting ability to brain tumor

(2021) Wei Xiao et al.   BIOMATERIALS

pH/ATP cascade-responsive nano-courier with efficient tumor targeting and siRNA unloading for photothermal-immunotherapy

(2021) Xian Tang et al.   Nano Today

A nanocleaner specifically penetrates the blood‒brain barrier at lesions to clean toxic proteins and regulate inflammation in Alzheimer’s disease

(2021) Ting Lei et al.   Acta Pharmaceutica Sinica B

Smart Tumor Microenvironment-Responsive Nanotheranostic Agent for Effective Cancer Therapy

(2020) Shi-yan Guo et al.   ADVANCED FUNCTIONAL MATERIALS

The construction of in vitro nasal cavity-mimic M-cell model, design of M cell-targeting nanoparticles and evaluation of mucosal vaccination by nasal administration

(2020) Xiaotong Yang et al.   Acta Pharmaceutica Sinica B

Endo/Lysosome‐Escapable Delivery Depot for Improving BBB Transcytosis and Neuron Targeted Therapy of Alzheimer's Disease

(2020) Lulu Cai et al.   ADVANCED FUNCTIONAL MATERIALS

β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia

(2020) Lea L. Friker et al.   Cell Reports

The physiological roles of tau and Aβ: implications for Alzheimer’s disease pathology and therapeutics

(2020) Sarah A. Kent et al.   ACTA NEUROPATHOLOGICA

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

(2020) Fangda Leng et al.   Nature Reviews Neurology

Alzheimer's Disease: Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia (Adv. Sci. 4/2019)

(2019) Yifei Lu et al.   Advanced Science

A reactive oxygen species-responsive dendrimer with low cytotoxicity for efficient and targeted gene delivery

(2019) Yueqi Wang et al.   CHINESE CHEMICAL LETTERS

Neuroinflammation in mild cognitive impairment and Alzheimer’s disease: A meta-analysis

(2019) Steven Bradburn et al.   AGEING RESEARCH REVIEWS

Local delivery of FK506 to injured peripheral nerve enhances axon regeneration after surgical nerve repair in rats

(2019) Kasra Tajdaran et al.   Acta Biomaterialia

What Does Nanoparticle Stability Mean?

(2019) Hoa T Phan et al.   Journal of Physical Chemistry C

Tumour microenvironment responsive nanoconstructs for cancer theranostic

(2019) Arif Gulzar et al.   Nano Today

Internal structure and mechanical property of an anisotropic hydrogel with electrostatic repulsion between nanosheets

(2019) Koki Sano et al.   POLYMER

Alzheimer’s Disease, Dendritic Spines, and Calcineurin Inhibitors: A New Approach?

(2018) Melissa A. O’Neal et al.   ACS Chemical Neuroscience

Acid-Responsive Transferrin Dissociation and GLUT Mediated Exocytosis for Increased Blood-Brain Barrier Transcytosis and Programmed Glioma Targeting Delivery

(2018) Shaobo Ruan et al.   ADVANCED FUNCTIONAL MATERIALS

Rapamycin and FK506 derivative TH2849 could ameliorate neurodegenerative diseases through autophagy with low immunosuppressive effect

(2018) Li Ding et al.   CNS Neuroscience & Therapeutics

The impact of protein corona on the behavior and targeting capability of nanoparticle-based delivery system

(2018) Wei Xiao et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Tumor Microenvironment Responsive Nanogel for the Combinatorial Antitumor Effect of Chemotherapy and Immunotherapy

(2017) Qingle Song et al.   NANO LETTERS

Mitochondria-Targeting Ceria Nanoparticles as Antioxidants for Alzheimer’s Disease

(2016) Hyek Jin Kwon et al.   ACS Nano

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

(2016) Valeria Calsolaro et al.   Alzheimers & Dementia

Chemopreventive action of non-steroidal anti-inflammatory drugs on the inflammatory pathways in colon cancer

(2016) Preety Ghanghas et al.   BIOMEDICINE & PHARMACOTHERAPY

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

(2016) H. Lian et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Reactive Oxygen Species (ROS) Responsive Polymers for Biomedical Applications

(2016) Qinghua Xu et al.   MACROMOLECULAR BIOSCIENCE

The road to restoring neural circuits for the treatment of Alzheimer's disease

(2016) Rebecca G. Canter et al.   NATURE

Reactive oxygen species (ROS) responsive PEG–PCL nanoparticles with pH-controlled negative-to-positive charge reversal for intracellular delivery of doxorubicin

(2015) Hongzhang Deng et al.   Journal of Materials Chemistry B

Nonsteroidal anti-inflammatory drug induces proinflammatory damage in gastric mucosa through NF-κB activation and neutrophil infiltration: Anti-inflammatory role of heme oxygenase-1 against nonsteroidal anti-inflammatory drug

(2013) Samik Bindu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cytotoxic role of advanced glycation end-products in PC12 cells treated with β-amyloid peptide

(2013) FU-LING YAN et al.   Molecular Medicine Reports

S100P-Derived RAGE Antagonistic Peptide Reduces Tumor Growth and Metastasis

(2012) T. Arumugam et al.   CLINICAL CANCER RESEARCH

c-Src dependency of NSAID-induced effects on NF- B-mediated apoptosis in colorectal cancer cells

(2011) R. R. W. Brady et al.   CARCINOGENESIS

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease

(2011) Chia-Hsiung Chen et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

RAGE: a single receptor fits multiple ligands

(2011) Günter Fritz   TRENDS IN BIOCHEMICAL SCIENCES

NO-releasing NSAIDs suppress NF-κB signaling in vitro and in vivo through S-nitrosylation

(2010) Mitali Chattopadhyay et al.   CANCER LETTERS

Orally delivered thioketal nanoparticles loaded with TNF-α–siRNA target inflammation and inhibit gene expression in the intestines

(2010) D. Scott Wilson et al.   NATURE MATERIALS

Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice

(2010) Anete Rozkalne et al.   NEUROBIOLOGY OF DISEASE

Effects of ginkgo biloba extract EGb761 on expression of RAGE and LRP-1 in cerebral microvascular endothelial cells under chronic hypoxia and hypoglycemia

(2008) Fu-Ling Yan et al.   ACTA NEUROPATHOLOGICA

Ibuprofen reduces Aβ, hyperphosphorylated tau and memory deficits in Alzheimer mice

(2008) Ann C. McKee et al.   BRAIN RESEARCH