Review
Biochemistry & Molecular Biology
Somayyeh Ghareghomi, Faezeh Moosavi-Movahedi, Luciano Saso, Mehran Habibi-Rezaei, Ali Khatibi, Jun Hong, Ali A. Moosavi-Movahedi
Summary: Oxidative stresses play a pivotal role in various pathophysiological conditions. The Keap1/Nrf2 pathway is a dual-edged sword with beneficial effects on both normal and cancer cells by regulating endogenous antioxidant enzymes. Targeting the Nrf2/HO-1 axis is considered a novel strategy for cancer treatment, especially in lung cancer.
Article
Biochemistry & Molecular Biology
Xiangyun Li, Jianbo Yu, Lirong Gong, Yuan Zhang, Shuan Dong, Jia Shi, Cui Li, Yuting Li, Yanfang Zhang, Haibo Li
Summary: Sepsis-induced acute lung injury leads to oxidative stress, inflammation, apoptosis, and changes in Golgi morphology. Activating the HO-1 pathway can alleviate Golgi stress and oxidative stress, providing a therapeutic target for treating acute lung injury.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Yumin Wang, Luyan Gao, Jichao Chen, Qiang Li, Liang Huo, Yanchao Wang, Hongquan Wang, Jichen Du
Summary: Parkinson's disease is a complex neurodegenerative disorder characterized by the loss of dopaminergic neurons in the brain. Oxidative stress has been implicated in its pathogenesis, with the transcription factor Nrf2 playing a key role in activating protective genes against oxidative stress. Recent studies have shown that bioactive compounds can activate Nrf2 and ameliorate neurotoxins associated with PD, suggesting a potential therapeutic target for the treatment of the disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Maria G. Detsika, Elias A. Lianos
Summary: Heme oxygenase-1 has a new cytoprotective role by regulating the complement control protein, which helps prevent kidney injury. Targeting HO-1 induction in specific cells could be a novel approach to attenuate complement-dependent kidney diseases.
Article
Biochemistry & Molecular Biology
Yingjie Zhu, Chunyan Wang, Jingjing Luo, Shucheng Hua, Dan Li, Liping Peng, Hongmei Liu, Lei Song
Summary: Zingerone treatment alleviated oxidative stress and inflammation in asthma models by upregulating the AMPK/Nrf2/HO-1 signaling pathway.
Article
Multidisciplinary Sciences
Zhen Liang, Zhaoshi Zheng, Qi Guo, Meng Tian, Jing Yang, Xiu Liu, Xiaojuan Zhu, Songyan Liu
Summary: This study investigates the role of hypoxia-inducible factor (HIF)-1 alpha/heme oxygenase (HO)-1 in hippocampal neuron ferroptosis during epilepsy. The results suggest that there are metabolic differences between epilepsy patients and healthy individuals, with increased oxidative stress, heightened bilirubin, and augmented iron metabolism in epileptic blood. The active HIF-1 pathway in epileptic pathogenesis and perturbations in HIF-1 alpha signaling are reinforced by the analysis. The study implicates that HIF-1 alpha/HO-1 potentially regulates hippocampal neuronal ferroptosis, iron metabolism, and oxidative stress, thereby promoting the propagation of epilepsy.
Article
Biochemistry & Molecular Biology
Maria Teresa Bayo Jimenez, Katie Frenis, Swenja Kroller-Schon, Marin Kuntic, Paul Stamm, Miroslava Kvandova, Matthias Oelze, Huige Li, Sebastian Steven, Thomas Munzel, Andreas Daiber
Summary: This study investigated the protective effects of HO-1 inducer and NRF2 activator on mice exposed to aircraft noise, showing that these treatments can mitigate the adverse effects of noise on vascular function by normalizing arterial hypertension and vascular dysfunction, as well as reducing oxidative stress and inflammation levels triggered by noise exposure. The study identifies new potential targets for mitigating the health effects of environmental noise exposure, suggesting that natural dietary constituents with HO-1 and NRF2 induction properties could be promising for preventive measures.
Article
Biochemistry & Molecular Biology
Yang Huang, Zi Ye, Yujing Yin, Tianju Ma, Qi Zhang, Kun Shang, Wenqian Chen, Zhaohui Li
Summary: The loss of HO-1 enzymatic activity induces early-onset nuclear cataracts by activating oxidative stress and ER stress.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Ayleen Fernandez-Fierro, Samanta C. Funes, Mariana Rios, Camila Covian, Jorge Gonzalez, Alexis M. Kalergis
Summary: The heme oxygenase (HO) system involves three isoforms, with HO-1 being the most studied and overexpression of this enzyme promoting anti-inflammatory products. However, overexpression of HO leading to neonatal jaundice has prompted the development of inhibitors. Various types of inhibitors have been identified, including competitive and non-competitive ones, with potential medical implications in metabolic diseases and immune-mediated diseases such as cancer and Alzheimer's disease. Selective inhibition of HO isoforms may contribute to the treatment of these ailments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Akihiro Yachie
Summary: HO-1 is crucial in protecting tissues and organs from oxidative stress and excessive inflammatory reactions. Deficiency in HO-1 leads to dysfunction in monocytes, macrophages, and endothelial cells, resulting in systemic inflammatory response syndrome. Therapeutic induction of HO-1 production through pharmacological intervention shows promise in controlling inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Hye-Eun Choi, Eun Jeong Jeon, Dong Young Kim, Mi Jin Choi, Hana Yu, Jea Il Kim, Hyae Gyeong Cheon
Summary: This study investigated the effects of sodium salicylate on adipocyte browning and found that it can induce browning by up-regulating HO-1 and promoting M2 polarization.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Physiology
Marta Martinez-Casales, Raquel Hernanz, Maria J. Alonso
Summary: Hypertension is considered an inflammatory disease with elevated cytokine levels and oxidative stress. In hypertension, the polarization of macrophages to the M1 phenotype plays a key role in producing inflammatory cytokines and oxidative stress.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Lina Zhang, Xuece Zhang, Ting Wu, Xu Pan, Zhi Wang
Summary: 0.7% ISO exerts neuroprotective effects in SAE by activating HO-1 and demonstrating anti-inflammatory, antioxidative, and anti-apoptotic properties.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Finn Jochims, Rebecca Strohm, Claudia von Montfort, Chantal-Kristin Wenzel, Niklas Klahm, Arun Kumar Kondadi, Wilhelm Stahl, Andreas S. Reichert, Peter Brenneisen
Summary: This study investigated the selectivity of artesunate (ART) on melanoma cells and further elucidated its mechanism, finding that ART induces oxidative stress and upregulates heme oxygenase 1 (HO-1), which subsequently affects its toxicity. This new finding may provide new perspectives in cancer therapy.
Article
Cardiac & Cardiovascular Systems
Marwa M. M. Refaie, Sayed Shehata, Randa Ahmed Ibrahim, Asmaa M. A. Bayoumi, Seham A. Abdel-Gaber
Summary: The study demonstrated that hemin can reduce doxorubicin-induced cardiotoxicity in rats by modulating specific signaling pathways, with antioxidant, anti-inflammatory, and anti-apoptotic effects in a dose-dependent manner.
CARDIOVASCULAR TOXICOLOGY
(2021)
Article
Microbiology
Manish Goyal, Adina Heinberg, Vera Mitesser, Sofiya Kandelis-Shalev, Brajesh Kumar Singh, Ron Dzikowski
Summary: The study reveals that Plasmodium falciparum phosphorylates its canonical core histone PfH2A in response to DNA damage, which is then recruited to damaged chromatin sites. This phosphorylation is dynamic and eventually removed as the repair mechanism is activated, providing insight into a novel direct DNA repair assay for the parasite.
Review
Immunology
Zahra Gholizadeh, Mohd. Shameel Iqbal, Rui Li, Fabio Romerio
Summary: Viruses have developed creative ways of encoding multiple proteins within the same genomic region by using overprinting. The complex retrovirus HIV-1 expresses multiple proteins from different reading frames, including the poorly understood Antisense Protein (ASP) gene. The role and function of ASP in the virus lifecycle remain a topic of ongoing research.
Article
Parasitology
Mamta Gangwar, Ruchi Jha, Manish Goyal, Mrigank Srivastava
Summary: Characterization of Wolbachia proteins helps in understanding the immunopathogenesis of lymphatic filariasis. The study showed that Recombinase A is widely expressed in different life stages of filarial nematodes and inhibitors can effectively impact its activity in killing microfilariae.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2021)
Article
Cell Biology
Manish Goyal, Brajesh Kumar Singh, Karina Simantov, Yotam Kaufman, Shiri Eshar, Ron Dzikowski
Summary: Plasmodium falciparum, the parasite responsible for the deadliest form of human malaria, has evolved unique mechanisms to maintain genome integrity under harsh conditions. A highly conserved RNA splicing factor, PfSR1, plays a crucial role in DNA repair in malaria parasites, particularly in recovery from damage caused by antimalarial drugs.
JOURNAL OF CELL SCIENCE
(2021)
Article
Parasitology
Arif Jamal Siddiqui, Jyoti Bhardwaj, Walid Sabri Hamadou, Manish Goyal, Sadaf Jahan, Syed Amir Ashraf, Arshad Jamal, Pankaj Sharma, Manojkumar Sachidanandan, Riadh Badraoui, Mejdi Snoussi, Mohd Adnan
Summary: In this study, we investigated the role of the antimalarial drug halofantrine (HF) in inducing sterile protection against challenges with Plasmodium yoelii sporozoites. We found that repetitive sporozoite inoculation under HF treatment resulted in delayed blood-stage infection and a decline in liver stage parasite load in mice. Additionally, HF treatment up-regulated the expression of pro-inflammatory cytokines and down-regulated anti-inflammatory cytokines in hepatic mononuclear cells and spleen cells.
FOLIA PARASITOLOGICA
(2022)
Correction
Cell Biology
Manish Goyal, Brajesh Kumar Singh, Karina Simantov, Yotam Kaufman, Shiri Eshar, Ron Dzikowski
JOURNAL OF CELL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Adina Heinberg, Inbar Amit-Avraham, Vera Mitesser, Karina Simantov, Manish Goyal, Yuval Nevo, Sofia Kandelis-Shalev, Emilie Thompson, Ron Dzikowski
Summary: This study reveals that the deadliest form of human malaria, caused by Plasmodium falciparum, is able to evade the human immune response by selectively expressing a single variant of a surface antigen. The researchers found that a long noncoding RNA (lncRNA) transcribed from an intron of an active gene is implicated in the choice of the single active variant. They also identified a protein called PfTPx-1, which interacts with the lncRNA and is involved in gene activation. Furthermore, they show that PfTPx-1 plays a role in providing a redox-controlled nuclear microenvironment ideal for active transcription.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Microbiology
Karina Simantov, Manish Goyal, Ron Dzikowski
Summary: Noncoding RNAs (ncRNAs) play important regulatory roles in eukaryotic organisms, including gene expression regulation at various levels. Protozoan parasites have been found to encode diverse ncRNAs, but little is known about their cellular functions. This review focuses on the long noncoding RNAs (lncRNAs) of the human malaria parasite Plasmodium falciparum and highlights their cellular functions and potential mechanisms of action.
Review
Medicine, Research & Experimental
Somnath Mazumder, Samik Bindu, Rudranil De, Subhashis Debsharma, Saikat Pramanik, Uday Bandyopadhyay
Summary: Gastroduodenal inflammation and ulcerative injuries are increasing due to various factors such as socio-economic stress, unhealthy habits, and the use of certain medications. The COVID-19 pandemic has also led to gastrointestinal complications, posing a challenge to healthcare systems. Mitochondrial dysfunctions play a significant role in the pathogenesis of diseases and can be targeted for prevention and treatment. Oxidative and nitrosative stress cause mitochondrial injury, leading to tissue damage and inflammation. Understanding the molecular events and factors affecting mitochondria is important for understanding gastrointestinal mucosal pathogenesis and developing new drugs.
Review
Microbiology
Manish Goyal, Karina Simantov, Ron Dzikowski
Summary: SR proteins play an important role in eukaryotic gene expression by regulating splicing events and acting as key regulators of RNA metabolism. Plasmodium parasites encode several SR proteins, which might have noncanonical functions in addition to splicing regulation.
CURRENT OPINION IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rui Li, Isabella Caico, Ziyan Xu, Mohammad Shameel Iqbal, Fabio Romerio
Summary: Nucleosomes on the HIV-1 5 ' LTR regulate sense transcription and latency, while the NSP in the 3 ' LTR expresses antisense transcripts. Epigenetic regulation of NSP activity was investigated using two chronically infected T cell lines. Histone acetylation and methylation were found to regulate both sense and antisense transcription, with the latter potentially limiting the efficacy of latency-reversing agents in HIV-1 cure strategies.
Article
Pharmacology & Pharmacy
Subhashis Debsharma, Saikat Pramanik, Samik Bindu, Somnath Mazumder, Troyee Das, Debanjan Saha, Rudranil De, Shiladitya Nag, Chinmoy Banerjee, Asim Azhar Siddiqui, Zhumur Ghosh, Uday Bandyopadhyay
Summary: This study investigated the effects of honokiol, a phytochemical, on gastric injury caused by non-steroidal anti-inflammatory drugs (NSAIDs). The results showed that honokiol protected against NSAID-induced gastric injury by stimulating the activity of Sirtuin-3 and maintaining mitochondrial integrity. This provides a basis for a novel gastroprotective strategy.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Chinmoy Banerjee, Shiladitya Nag, Manish Goyal, Debanjan Saha, Asim Azhar Siddiqui, Somnath Mazumder, Subhashis Debsharma, Saikat Pramanik, Uday Bandyopadhyay
Summary: This study reveals the nuclease activity of PfAlba3 in response to DNA damage and its potential role in Plasmodium pathogenicity.
Article
Medicine, General & Internal
Arif Jamal Siddiqui, Mohammad Faheem Khan, Walid Sabri Hamadou, Manish Goyal, Sadaf Jahan, Arshad Jamal, Syed Amir Ashraf, Pankaj Sharma, Manojkumar Sachidanandan, Riadh Badraoui, Kundan Kumar Chaubey, Mejdi Snoussi, Mohd Adnan
Summary: This study screened three repurposing drugs as potent candidates against Schistosoma-associated bladder cancer (SABC) in humans using computational methods. Ivermectin displayed promising inhibition of bladder cancer cells targeting VEGF and GSTs signaling.
MEDICINA-LITHUANIA
(2021)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)