Reagents and models for detecting endogenous GLP1R and GIPR

Decreased expression of the GLP-1 receptor after segmental artery injury in mice.

(2021) Katrine Dahl Bjørnholm et al.   JOURNAL OF ENDOCRINOLOGY

Once-Weekly Semaglutide in Adults with Overweight or Obesity

(2021) John P.H. Wilding et al.   NEW ENGLAND JOURNAL OF MEDICINE

CRISPR-based genome editing in primary human pancreatic islet cells

(2021) Romina J. Bevacqua et al.   Nature Communications

GIP Receptor Agonism Attenuates GLP-1 Receptor Agonist Induced Nausea and Emesis in Preclinical Models

(2021) Tito Borner et al.   DIABETES

Acylation of the incretin peptide exendin-4 directly impacts GLP-1 receptor signalling and trafficking

(2021) Maria Lucey et al.   MOLECULAR PHARMACOLOGY

Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes

(2021) Juan P. Frías et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural and compositional diversity in the kainate receptor family

(2021) Purushotham Selvakumar et al.   Cell Reports

Differential importance of endothelial and hematopoietic cell GLP-1Rs for cardiometabolic versus hepatic actions of semaglutide

(2021) Brent A. McLean et al.   JCI Insight

Signalling, trafficking and glucoregulatory properties of glucagon‐like peptide‐1 receptor agonists exendin‐4 and lixisenatide

(2020) Philip Pickford et al.   BRITISH JOURNAL OF PHARMACOLOGY

GIP as a therapeutic target in diabetes and obesity: insight from incretin co-agonists

(2020) Jens Juul Holst et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Mammalian Crumbs Complex Defines a Distinct Polarity Domain Apical of Epithelial Tight Junctions

(2020) Benedict Tan et al.   CURRENT BIOLOGY

Discordance between GLP-1R gene and protein expression in mouse pancreatic islet cells

(2020) Sarah M Gray et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetically encoded tags for direct synthesis of EM-visible gold nanoparticles in cells

(2020) Zhaodi Jiang et al.   NATURE METHODS

Optoacoustic imaging of Glucagon-like Peptide 1 Receptor with a near-infrared exendin-4 analog

(2020) Sheryl Roberts et al.   JOURNAL OF NUCLEAR MEDICINE

Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism

(2020) Elizabeth A. Killion et al.   Nature Communications

Distribution and ultrastructural localization of the glucagon-like peptide-1 receptor (GLP-1R) in the rat brain

(2020) Erzsébet Farkas et al.   Brain Structure & Function

Using a reporter mouse to map known and novel sites of GLP-1 receptor expression in peripheral tissues of male mice

(2020) Daniel B Andersen et al.   ENDOCRINOLOGY

3D FIB-SEM reconstruction of microtubule–organelle interaction in whole primary mouse β cells

(2020) Andreas Müller et al.   JOURNAL OF CELL BIOLOGY

Visualizing subcellular rearrangements in intact β cells using soft x-ray tomography

(2020) Kate L. White et al.   Science Advances

A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis

(2020) Philip N. Newsome et al.   NEW ENGLAND JOURNAL OF MEDICINE

Function and mechanisms of enteroendocrine cells and gut hormones in metabolism

(2019) Fiona M. Gribble et al.   Nature Reviews Endocrinology

Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake

(2019) Alice E. Adriaenssens et al.   Cell Metabolism

Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells

(2019) Teresa Buenaventura et al.   PLOS BIOLOGY

AutoCLEM: An Automated Workflow for Correlative Live-Cell Fluorescence Microscopy and Cryo-Electron Tomography

(2019) Xiaofeng Fu et al.   Scientific Reports

Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction

(2018) John R. Ussher et al.   Cell Metabolism

Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1

(2018) Daniel J. Drucker   Cell Metabolism

Targeting GLP-1 receptor trafficking to improve agonist efficacy

(2018) Ben Jones et al.   Nature Communications

The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates

(2018) Violeta Georgieva Tsonkova et al.   Molecular Metabolism

Conditional and Reversible Activation of Class A and B G Protein-Coupled Receptors Using Tethered Pharmacology

(2018) Tom Podewin et al.   ACS Central Science

Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models

(2018) Elizabeth A. Killion et al.   Science Translational Medicine

Massively parallel single-nucleus RNA-seq with DroNc-seq

(2017) Naomi Habib et al.   NATURE METHODS

Electron microscopy using the genetically encoded APEX2 tag in cultured mammalian cells

(2017) Jeffrey D Martell et al.   Nature Protocols

Dual optical control and mechanistic insights into photoswitchable group II and III metabotropic glutamate receptors

(2017) Joshua Levitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Global Approach for Quantitative Super Resolution and Electron Microscopy on Cryo and Epoxy Sections Using Self-labeling Protein Tags

(2017) Andreas Müller et al.   Scientific Reports

Fluorescent proteins such as eGFP lead to catalytic oxidative stress in cells

(2017) Douglas Ganini et al.   Redox Biology

Use of CRISPR/Cas9-engineered INS-1 pancreatic   cells to define the pharmacology of dual GIPR/GLP-1R agonists

(2016) J. Naylor et al.   BIOCHEMICAL JOURNAL

Sensory Neurons that Detect Stretch and Nutrients in the Digestive System

(2016) Erika K. Williams et al.   CELL

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes

(2016) Åsa Segerstolpe et al.   Cell Metabolism

Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets

(2016) Alice E. Adriaenssens et al.   DIABETOLOGIA

Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study

(2016) Matthew James Armstrong et al.   LANCET

Reappraisal of GIP Pharmacology for Metabolic Diseases

(2016) Brian Finan et al.   TRENDS IN MOLECULAR MEDICINE

Downregulation of a GPCR by β-Arrestin2-Mediated Switch from an Endosomal to a TGN Recycling Pathway

(2016) Nazish Abdullah et al.   Cell Reports

The incretin effect in healthy individuals and those with type 2 diabetes: physiology, pathophysiology, and response to therapeutic interventions

(2016) Michael A Nauck et al.   Lancet Diabetes & Endocrinology

Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets

(2016) Michael R. DiGruccio et al.   Molecular Metabolism

Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets

(2015) David M. Blodgett et al.   DIABETES

TCF1 links GIPR signaling to the control of beta cell function and survival

(2015) Jonathan E Campbell et al.   NATURE MEDICINE

Beta cell specific probing with fluorescent exendin-4 is progressively reduced in type 2 diabetic mouse models

(2015) Janne Lehtonen et al.   Islets

Rapid, high efficiency isolation of pancreatic ß-cells

(2015) Susan M. Clardy et al.   Scientific Reports

A human beta cell line with drug inducible excision of immortalizing transgenes

(2015) Marion Benazra et al.   Molecular Metabolism

GLP-1 Receptor Localization in Monkey and Human Tissue: Novel Distribution Revealed With Extensively Validated Monoclonal Antibody

(2014) Charles Pyke et al.   ENDOCRINOLOGY

Functional Consequences of Glucagon-like Peptide-1 Receptor Cross-talk and Trafficking

(2014) Sarah Noerklit Roed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

(2014) Anna Secher et al.   JOURNAL OF CLINICAL INVESTIGATION

A Naturally Occurring GIP Receptor Variant Undergoes Enhanced Agonist-Induced Desensitization, Which Impairs GIP Control of Adipose Insulin Sensitivity

(2014) S. Mohammad et al.   MOLECULAR AND CELLULAR BIOLOGY

Genetic targeting of chemical indicators in vivo

(2014) Guoying Yang et al.   NATURE METHODS

Fluorescent Exendin-4 Derivatives for Pancreatic β-Cell Analysis

(2013) Susan M. Clardy et al.   BIOCONJUGATE CHEMISTRY

Identification and Characterization of GLP-1 Receptor-Expressing Cells Using a New Transgenic Mouse Model

(2013) P. Richards et al.   DIABETES

Vertical Sleeve Gastrectomy Is Effective in Two Genetic Mouse Models of Glucagon-Like Peptide 1 Receptor Deficiency

(2013) H. E. Wilson-Perez et al.   DIABETES

Lipotoxicity disrupts incretin-regulated human β cell connectivity

(2013) David J. Hodson et al.   JOURNAL OF CLINICAL INVESTIGATION

Cryo FIB-SEM: Volume imaging of cellular ultrastructure in native frozen specimens

(2013) Andreas Schertel et al.   JOURNAL OF STRUCTURAL BIOLOGY

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

(2013) B. Finan et al.   Science Translational Medicine

The Glucagon-Like Peptide-1 Receptor—or Not?

(2012) Charles Pyke et al.   ENDOCRINOLOGY

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

(2011) Philippe Ravassard et al.   JOURNAL OF CLINICAL INVESTIGATION

Accurate measurement of pancreatic islet  -cell mass using a second-generation fluorescent exendin-4 analog

(2011) T. Reiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Near-Infrared Fluorescent Probe for Imaging of Pancreatic β Cells

(2010) Thomas Reiner et al.   BIOCONJUGATE CHEMISTRY

Role of the signal peptide in the synthesis and processing of the glucagon-like peptide-1 receptor

(2009) Y Huang et al.   BRITISH JOURNAL OF PHARMACOLOGY

HaloTag: A Novel Protein Labeling Technology for Cell Imaging and Protein Analysis

(2008) Georgyi V. Los et al.   ACS Chemical Biology

An Engineered Protein Tag for Multiprotein Labeling in Living Cells

(2008) Arnaud Gautier et al.   CHEMISTRY & BIOLOGY