A very long-acting IL-15: implications for the immunotherapy of cancer

Heterodimeric IL-15 in Cancer Immunotherapy

(2021) Cristina Bergamaschi et al.   Cancers

Attenuation of the Reaction of Michael Acceptors with Biologically Important Nucleophiles

(2021) Brian R. Hearn et al.   BIOCONJUGATE CHEMISTRY

NKTR-255, a novel polymer-conjugated rhIL-15 with potent antitumor efficacy

(2021) Takahiro Miyazaki et al.   Journal for ImmunoTherapy of Cancer

Short-course IL-15 given as a continuous infusion led to a massive expansion of effective NK cells: implications for combination therapy with antitumor antibodies

(2021) Sigrid P Dubois et al.   Journal for ImmunoTherapy of Cancer

The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques

(2020) Gabriela M. Webb et al.   PLoS Pathogens

IL-15 in the Combination Immunotherapy of Cancer

(2020) Thomas A. Waldmann et al.   Frontiers in Immunology

Interleukin 15 Pharmacokinetics and Consumption by a Dynamic Cytokine Sink

(2020) John A. Hangasky et al.   Frontiers in Immunology

Engineering IL-2 to Give New Life to T Cell Immunotherapy

(2020) Willem W. Overwijk et al.   Annual Review of Medicine

In Vitro-In Vivo Correlation for the Degradation of Tetra-PEG Hydrogel Microspheres with Tunable β-Eliminative Crosslink Cleavage Rates

(2019) Jeff Henise et al.   International Journal of Polymer Science

IL-15 by continuous i.v. infusion to adult patients with solid tumors in a Phase I trial induced dramatic NK cell subset expansion

(2019) Kevin C Conlon et al.   CLINICAL CANCER RESEARCH

Interleukin-15 (dys)regulation of lymphoid homeostasis: Implications for therapy of autoimmunity and cancer

(2019) Thomas A. Waldmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation

(2018) Rizwan Romee et al.   BLOOD

Evaluation of the biological activities of the IL-15 superagonist complex, ALT-803, following intravenous versus subcutaneous administration in murine models

(2018) Bai Liu et al.   CYTOKINE

Optimized administration of hetIL-15 expands lymphocytes and minimizes toxicity in rhesus macaques

(2018) Cristina Bergamaschi et al.   CYTOKINE

Emergence of NK Cell Hyporesponsiveness after Two IL-15 Stimulation Cycles

(2018) Marie Frutoso et al.   JOURNAL OF IMMUNOLOGY

IL-15 enhanced antibody-dependent cellular cytotoxicity mediated by NK cells and macrophages

(2018) Meili Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The potential and promise of IL-15 in immuno-oncogenic therapies

(2017) Tanya O. Robinson et al.   IMMUNOLOGY LETTERS

Approach for Half-Life Extension of Small Antibody Fragments That Does Not Affect Tissue Uptake

(2016) Eric L. Schneider et al.   BIOCONJUGATE CHEMISTRY

Targeting natural killer cells in cancer immunotherapy

(2016) Camille Guillerey et al.   NATURE IMMUNOLOGY

Biodegradable Tetra-PEG Hydrogels as Carriers for a Releasable Drug Delivery System

(2015) Jeff Henise et al.   BIOCONJUGATE CHEMISTRY

Redistribution, Hyperproliferation, Activation of Natural Killer Cells and CD8 T Cells, and Cytokine Production During First-in-Human Clinical Trial of Recombinant Human Interleukin-15 in Patients With Cancer

(2015) Kevin C. Conlon et al.   JOURNAL OF CLINICAL ONCOLOGY

Characterization and Favorablein VivoProperties of Heterodimeric Soluble IL-15·IL-15Rα Cytokine Compared to IL-15 Monomer

(2013) Elena Chertova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic Model of Natural Killer Cell Proliferative Response to IL-15 Receptor Stimulation

(2013) Yun M. Zhao et al.   PLoS Computational Biology

Augmented IL-15R  Expression by CD40 Activation Is Critical in Synergistic CD8 T Cell-Mediated Antitumor Activity of Anti-CD40 Antibody with IL-15 in TRAMP-C2 Tumors in Mice

(2012) M. Zhang et al.   JOURNAL OF IMMUNOLOGY

Predictable and tunable half-life extension of therapeutic agents by controlled chemical release from macromolecular conjugates

(2012) D. V. Santi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-15 administered by continuous infusion to rhesus macaques induces massive expansion of CD8+ T effector memory population in peripheral blood

(2011) M. C. Sneller et al.   BLOOD

IL-15:IL-15 receptor alpha superagonist complex: High-level co-expression in recombinant mammalian cells, purification and characterization

(2011) Kai-ping Han et al.   CYTOKINE

Characterization of Recombinant Human IL-15 Deamidation and Its Practical Elimination through Substitution of Asparagine 77

(2011) David F. Nellis et al.   PHARMACEUTICAL RESEARCH

Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15R  complexes

(2010) K. G. Elpek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MTS dye based colorimetric CTLL-2 cell proliferation assay for product release and stability monitoring of Interleukin-15: Assay qualification, standardization and statistical analysis

(2009) Gopalan Soman et al.   JOURNAL OF IMMUNOLOGICAL METHODS

High antitumor activity of RLI, an interleukin-15 (IL-15)-IL-15 receptor   fusion protein, in metastatic melanoma and colorectal cancer

(2009) A. Bessard et al.   MOLECULAR CANCER THERAPEUTICS