NKTR-255, a novel polymer-conjugated rhIL-15 with potent antitumor efficacy

Rationale for IL-15 superagonists in cancer immunotherapy

(2020) Karin M. Knudson et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

IL-15 by continuous i.v. infusion to adult patients with solid tumors in a Phase I trial induced dramatic NK cell subset expansion

(2019) Kevin C Conlon et al.   CLINICAL CANCER RESEARCH

Current Clinical Trials in Non-muscle-Invasive Bladder Cancer: Heightened Need in an Era of Chronic BCG Shortage

(2019) Vignesh T. Packiam et al.   Current Urology Reports

Trans-endocytosis of intact IL-15Rα–IL-15 complex from presenting cells into NK cells favors signaling for proliferation

(2019) Olga M. Anton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ALT-803, an IL-15 superagonist, in combination with nivolumab in patients with metastatic non-small cell lung cancer: a non-randomised, open-label, phase 1b trial

(2018) John M Wrangle et al.   LANCET ONCOLOGY

The potential and promise of IL-15 in immuno-oncogenic therapies

(2017) Tanya O. Robinson et al.   IMMUNOLOGY LETTERS

Redistribution, Hyperproliferation, Activation of Natural Killer Cells and CD8 T Cells, and Cytokine Production During First-in-Human Clinical Trial of Recombinant Human Interleukin-15 in Patients With Cancer

(2015) Kevin C. Conlon et al.   JOURNAL OF CLINICAL ONCOLOGY

Comparison of the Superagonist Complex, ALT-803, to IL15 as Cancer Immunotherapeutics in Animal Models

(2015) P. R. Rhode et al.   Cancer Immunology Research

Molecular Pathways: Interleukin-15 Signaling in Health and in Cancer

(2014) A. Mishra et al.   CLINICAL CANCER RESEARCH

Circulating IL-15 exists as heterodimeric complex with soluble IL-15R  in human and mouse serum

(2012) C. Bergamaschi et al.   BLOOD

Activity of Recombinant Human Interleukin-15 against Tumor Recurrence and Metastasis in Mice

(2010) Feng Tang et al.   Cellular & Molecular Immunology

Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15R  complexes

(2010) K. G. Elpek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Safety and immunologic effects of IL-15 administration in nonhuman primates

(2009) C. Berger et al.   BLOOD

The Exon-3-Encoded Domain of IL-15Rα Contributes to IL-15 High-Affinity Binding and Is Crucial for the IL-15 Antagonistic Effect of Soluble IL-15Rα

(2008) Grégory Bouchaud et al.   JOURNAL OF MOLECULAR BIOLOGY