Primary vulvar squamous cell carcinomas with high T cell infiltration and active immune signaling are potential candidates for neoadjuvant PD-1/PD-L1 immunotherapy

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LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy

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Looking past PD-L1: expression of immune checkpoint TIM-3 and its ligand galectin-9 in cervical and vulvar squamous neoplasia

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Performance of the Pattern Based Interpretation of p53 Immunohistochemistry as a Surrogate for TP53 Mutations in Vulvar Squamous Cell Carcinoma

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Pre-existing inflammatory immune microenvironment predicts the clinical response of vulvar high-grade squamous intraepithelial lesions to therapeutic HPV16 vaccination

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Neoadjuvant and Adjuvant Pembrolizumab in Resectable Locally Advanced, Human Papillomavirus-Unrelated Head and Neck Cancer: A Multicenter, Phase 2 Trial

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Vulvar cancer subclassification by HPV and p53 status results in three clinically distinct subtypes

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Lack of myeloid cell infiltration as an acquired resistance strategy to immunotherapy

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(2019) Jérôme Galon et al.   NATURE REVIEWS DRUG DISCOVERY

A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma

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Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis

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Recurrent genetic alterations and biomarker expression in primary and metastatic squamous cell carcinomas of the vulva

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Safety and Efficacy of Nivolumab Monotherapy in Recurrent or Metastatic Cervical, Vaginal, or Vulvar Carcinoma: Results From the Phase I/II CheckMate 358 Trial

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Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell–mediated tumor regression

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High numbers of activated helper T cells are associated with better clinical outcome in early stage vulvar cancer, irrespective of HPV or p53 status

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Tumor-intrinsic signaling pathways: key roles in the regulation of the immunosuppressive tumor microenvironment

(2019) Li Yang et al.   Journal of Hematology & Oncology

ILT4 functions as a potential checkpoint molecule for tumor immunotherapy

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Pembrolizumab in Recurrent Squamous Cell Carcinoma of the Vulva: Case Report and Review of the Literature

(2018) Lisa B.E. Shields et al.   GYNECOLOGIC AND OBSTETRIC INVESTIGATION

Pan-cancer adaptive immune resistance as defined by the Tumor Inflammation Signature (TIS): results from The Cancer Genome Atlas (TCGA)

(2018) Patrick Danaher et al.   Journal for ImmunoTherapy of Cancer

TIGIT: a novel immunotherapy target moving from bench to bedside

(2018) Benjamin L. Solomon et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

PD-L1 and IDO Expression in Cervical and Vulvar Invasive and Intraepithelial Squamous Neoplasias: Implications for Combination Immunotherapy

(2018) Zachary Chinn et al.   HISTOPATHOLOGY

Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity

(2018) Hui-Ming Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

T-Cell–Inflamed Gene-Expression Profile, Programmed Death Ligand 1 Expression, and Tumor Mutational Burden Predict Efficacy in Patients Treated With Pembrolizumab Across 20 Cancers: KEYNOTE-028

(2018) Patrick A. Ott et al.   JOURNAL OF CLINICAL ONCOLOGY

LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration

(2018) Mi Deng et al.   NATURE

IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade

(2017) Mark Ayers et al.   JOURNAL OF CLINICAL INVESTIGATION

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(2017) Daniel S. Chen et al.   NATURE

The immune contexture in cancer prognosis and treatment

(2017) Wolf H. Fridman et al.   Nature Reviews Clinical Oncology

PD-L1 expression on immune cells is a favorable prognostic factor for vulvar squamous cell carcinoma patients

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Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

Vaccine-induced tumor regression requires a dynamic cooperation between T cells and myeloid cells at the tumor site

(2015) Maxime Thoreau et al.   Oncotarget

Therapeutic Peptide Vaccine-Induced CD8 T Cells Strongly Modulate Intratumoral Macrophages Required for Tumor Regression

(2015) T. C. van der Sluis et al.   Cancer Immunology Research

Lymphocyte Activation Gene 3 (LAG-3) Modulates the Ability of CD4 T-cells to Be Suppressed In Vivo

(2014) Nicholas M. Durham et al.   PLoS One

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(2013) Jérôme Galon et al.   IMMUNITY

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TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines

(2009) William D. Hastings et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A suggested modification to FIGO stage III vulvar cancer

(2008) Roman Rouzier et al.   GYNECOLOGIC ONCOLOGY