Mechanism of a COVID-19 nanoparticle vaccine candidate that elicits a broadly neutralizing antibody response to SARS-CoV-2 variants

Rapid Development of SARS-CoV-2 Spike Protein Receptor-Binding Domain Self-Assembled Nanoparticle Vaccine Candidates

(2021) Yin-Feng Kang et al.   ACS Nano

Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

(2021) Philip J.M. Brouwer et al.   CELL

B cell memory: Understanding COVID-19

(2021) Isaak Quast et al.   IMMUNITY

Vaccinology in the post−COVID-19 era

(2021) Rino Rappuoli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

(2021) Jennifer M. Dan et al.   SCIENCE

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

(2021) Tiong Kit Tan et al.   Nature Communications

A Single Immunization with Spike-Functionalized Ferritin Vaccines Elicits Neutralizing Antibody Responses against SARS-CoV-2 in Mice

(2021) Abigail E. Powell et al.   ACS Central Science

No higher infectivity but immune escape of SARS-CoV-2 501Y.V2 variants

(2021) Qianqian Li et al.   CELL

Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera

(2021) Piyada Supasa et al.   CELL

Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

(2021) Wilfredo F. Garcia-Beltran et al.   CELL

Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques immunized with HCV envelope glycoproteins

(2021) Fang Chen et al.   IMMUNITY

SARS-CoV-2 Viral Variants—Tackling a Moving Target

(2021) John R. Mascola et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia

(2021) Denis Y Logunov et al.   LANCET

Safety and immunogenicity of S-Trimer (SCB-2019), a protein subunit vaccine candidate for COVID-19 in healthy adults: a phase 1, randomised, double-blind, placebo-controlled trial

(2021) Peter Richmond et al.   LANCET

Resurgence of COVID-19 in Manaus, Brazil, despite high seroprevalence

(2021) Ester C Sabino et al.   LANCET

Emergence of a SARS-CoV-2 variant of concern with mutations in spike glycoprotein

(2021) Houriiyah Tegally et al.   NATURE

Dynamic regulation of TFH selection during the germinal centre reaction

(2021) Julia Merkenschlager et al.   NATURE

Variant-proof vaccines — invest now for the next pandemic

(2021) Dennis R. Burton et al.   NATURE

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants

(2021) Zijun Wang et al.   NATURE

Assessing the human immune response to SARS-CoV-2 variants

(2021) Roberto Burioni et al.   NATURE MEDICINE

SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

(2021) Constantinos Kurt Wibmer et al.   NATURE MEDICINE

Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England

(2021) Nicholas G. Davies et al.   SCIENCE

S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates

(2021) Joshua G. Liang et al.   Nature Communications

Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study

(2021) Robert Challen et al.   BMJ-British Medical Journal

A lymph node–targeted Amphiphile vaccine induces potent cellular and humoral immunity to SARS-CoV-2

(2021) Martin P. Steinbuck et al.   Science Advances

SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies

(2021) Markus Hoffmann et al.   CELL

Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies

(2021) Delphine Planas et al.   NATURE MEDICINE

Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection

(2021) David S. Khoury et al.   NATURE MEDICINE

Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines

(2021) Linling He et al.   Nature Communications

SARS-CoV-2 evolution and vaccines: cause for concern?

(2021) Thomas C Williams et al.   Lancet Respiratory Medicine

Single-component, self-assembling, protein nanoparticles presenting the receptor binding domain and stabilized spike as SARS-CoV-2 vaccine candidates

(2021) Linling He et al.   Science Advances

Protein-based antigen presentation platforms for nanoparticle vaccines

(2021) Brian Nguyen et al.   npj Vaccines

Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum

(2021) Chang Liu et al.   CELL

Delta coronavirus variant: scientists brace for impact

(2021) Ewen Callaway   NATURE

Safety and Efficacy of NVX-CoV2373 Covid-19 Vaccine

(2021) Paul T. Heath et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prevention and Attenuation of Covid-19 with the BNT162b2 and mRNA-1273 Vaccines

(2021) Mark G. Thompson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neutralizing Antibodies Induced by First-Generation gp41-Stabilized HIV-1 Envelope Trimers and Nanoparticles

(2021) Sonu Kumar et al.   mBio

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Toll-like Receptors and the Control of Immunity

(2020) Katherine A. Fitzgerald et al.   CELL

A human neutralizing antibody targets the receptor binding site of SARS-CoV-2

(2020) Rui Shi et al.   NATURE

Human neutralizing antibodies elicited by SARS-CoV-2 infection

(2020) Bin Ju et al.   NATURE

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

(2020) Dora Pinto et al.   NATURE

A strategic approach to COVID-19 vaccine R&D

(2020) Lawrence Corey et al.   SCIENCE

Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays

(2020) Katharine H. D. Crawford et al.   Viruses-Basel

Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines

(2020) Linling He et al.   Science Advances

Suppressing Subcapsular Sinus Macrophages Enhances Transport of Nanovaccines to Lymph Node Follicles for Robust Humoral Immunity

(2020) Yi-Nan Zhang et al.   ACS Nano

The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity

(2020) Qianqian Li et al.   CELL

Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells

(2020) Yunlong Cao et al.   CELL

COVID-19 vaccine development and a potential nanomaterial path forward

(2020) Matthew D. Shin et al.   Nature Nanotechnology

Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

(2020) Thomas F. Rogers et al.   SCIENCE

Quantitative evaluation of protective antibody response induced by hepatitis E vaccine in humans

(2020) Gui-Ping Wen et al.   Nature Communications

Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo

(2020) Yu Kato et al.   IMMUNITY

Animal models for COVID-19

(2020) César Muñoz-Fontela et al.   NATURE

Whither COVID-19 vaccines?

(2020) Laura DeFrancesco   NATURE BIOTECHNOLOGY

A platform incorporating trimeric antigens into self-assembling nanoparticles reveals SARS-CoV-2-spike nanoparticles to elicit substantially higher neutralizing responses than spike alone

(2020) Baoshan Zhang et al.   Scientific Reports

Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients

(2020) Anita S. Iyer et al.   Science Immunology

Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production

(2020) Yuezhou Chen et al.   CELL

SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation

(2020) Katlyn Lederer et al.   IMMUNITY

Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses

(2020) Xiancai Ma et al.   IMMUNITY

Eliciting B cell immunity against infectious diseases using nanovaccines

(2020) Ankur Singh   Nature Nanotechnology

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Self-Assembling Nanoparticles Usher in a New Era of Vaccine Design

(2019) Rino Rappuoli et al.   CELL

Nanoparticle Size Influences Antigen Retention and Presentation in Lymph Node Follicles for Humoral Immunity

(2019) Yi-Nan Zhang et al.   NANO LETTERS

Induction of broadly neutralizing antibodies in Germinal Centre simulations

(2018) Philippe A Robert et al.   CURRENT OPINION IN BIOTECHNOLOGY

Immunization with tumor neoantigens displayed on T7 phage nanoparticles elicits plasma antibody and vaccine-draining lymph node B cell responses

(2018) Girja S. Shukla et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Glycoconjugate vaccines: Principles and mechanisms

(2018) Rino Rappuoli   Science Translational Medicine

Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers

(2018) Talar Tokatlian et al.   SCIENCE

An accelerated rabies vaccine schedule based on toll-like receptor 3 (TLR3) agonist PIKA adjuvant augments rabies virus specific antibody and T cell response in healthy adult volunteers

(2017) Limin Wijaya et al.   VACCINE

Differential Antibody Responses to Conserved HIV-1 Neutralizing Epitopes in the Context of Multivalent Scaffolds and Native-Like gp140 Trimers

(2017) Charles D. Morris et al.   mBio

Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design

(2016) Dennis R. Burton et al.   Annual Review of Immunology

Programming of donor T cells using allogeneic  -like ligand 4-positive dendritic cells to reduce GVHD in mice

(2016) K. Mochizuki et al.   BLOOD

Germinal Center B Cell Dynamics

(2016) Luka Mesin et al.   IMMUNITY

Overcoming CD4 Th1 Cell Fate Restrictions to Sustain Antiviral CD8 T Cells and Control Persistent Virus Infection

(2016) Laura M. Snell et al.   Cell Reports

Self-assembling protein nanoparticles in the design of vaccines

(2016) Jacinto López-Sagaseta et al.   Computational and Structural Biotechnology Journal

Vaccine Adjuvant MF59 Promotes Retention of Unprocessed Antigen in Lymph Node Macrophage Compartments and Follicular Dendritic Cells

(2015) Rocco Cantisani et al.   JOURNAL OF IMMUNOLOGY

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Immunological mechanisms of vaccination

(2011) Bali Pulendran et al.   NATURE IMMUNOLOGY

Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity

(2011) Tracy L Flach et al.   NATURE MEDICINE

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Use of defined TLR ligands as adjuvants within human vaccines

(2010) Malcolm S. Duthie et al.   IMMUNOLOGICAL REVIEWS

B cell follicles and antigen encounters of the third kind

(2010) Jason G Cyster   NATURE IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Cloning and expression of murine Ig genes from single B cells

(2009) Thomas Tiller et al.   JOURNAL OF IMMUNOLOGICAL METHODS