Thermostable ionizable lipid-like nanoparticle (iLAND) for RNAi treatment of hyperlipidemia

The Importance of Apparent pKa in the Development of Nanoparticles Encapsulating siRNA and mRNA

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Ionizable lipid-assisted efficient hepatic delivery of gene editing elements for oncotherapy

(2021) Chunhui Li et al.   Bioactive Materials

The challenge and prospect of mRNA therapeutics landscape

(2020) Yuhua Weng et al.   BIOTECHNOLOGY ADVANCES

Role of angiopoietin-like protein 3 in sugar-induced dyslipidemia in rhesus macaques: suppression by fish oil or RNAi

(2020) Andrew A. Butler et al.   JOURNAL OF LIPID RESEARCH

Mechanisms underlying direct actions of hyperlipidemia on myocardium: an updated review

(2020) Yu Si Yao et al.   Lipids in Health and Disease

Efficient hepatic delivery and protein expression enabled by optimized mRNA and ionizable lipid nanoparticle

(2020) Tongren Yang et al.   Bioactive Materials

RNAi therapeutic and its innovative biotechnological evolution

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Clinical advances of siRNA therapeutics

(2019) Bo Hu et al.   JOURNAL OF GENE MEDICINE

Gadofullerene Nanoparticles Reverse Dysfunctions of Pancreas and Improve Hepatic Insulin Resistance for Type 2 Diabetes Mellitus Treatment

(2019) Xue Li et al.   ACS Nano

Regulating intracellular fate of siRNA by endoplasmic reticulum membrane-decorated hybrid nanoplexes

(2019) Chong Qiu et al.   Nature Communications

Pharmacological lipid-modification therapies for prevention of ischaemic heart disease: current and future options

(2019) Kausik K Ray et al.   LANCET

Efficient and innocuous delivery of small interfering RNA to microglia using an amphiphilic dendrimer nanovector

(2019) Aleksandra Ellert-Miklaszewska et al.   Nanomedicine

A NEW DAWN FOR MANAGING DYSLIPIDEMIAS: THE ERA OF RNA-BASED THERAPIES

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siRNA Knockdown of RRM2 Effectively Suppressed Pancreatic Tumor Growth Alone or Synergistically with Doxorubicin

(2018) Shuquan Zheng et al.   Molecular Therapy-Nucleic Acids

Safety and efficacy of statin therapy

(2018) Bhavin B. Adhyaru et al.   Nature Reviews Cardiology

Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome

(2018) Gregory G. Schwartz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

ANGPTL3 Inhibition in Homozygous Familial Hypercholesterolemia

(2017) Daniel Gaudet et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides

(2017) Mark J. Graham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates

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(2016) Ryan J. Koene et al.   CIRCULATION

ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors

(2016) Philip L.S.M. Gordts et al.   JOURNAL OF CLINICAL INVESTIGATION

Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model

(2016) Kejin Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacokinetic Behaviors of Intravenously Administered siRNA in Glandular Tissues

(2016) Yuanyu Huang et al.   Theranostics

Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

(2015) Anders Wittrup et al.   NATURE BIOTECHNOLOGY

Knocking down disease: a progress report on siRNA therapeutics

(2015) Anders Wittrup et al.   NATURE REVIEWS GENETICS

Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia

(2015) Daniel Gaudet et al.   NEW ENGLAND JOURNAL OF MEDICINE

Systemic Administration of siRNA via cRGD-containing Peptide

(2015) Yuanyu Huang et al.   Scientific Reports

Liver histology during Mipomersen therapy for severe hypercholesterolemia

(2014) Nikroo Hashemi et al.   Journal of Clinical Lipidology

Loss-of-Function Mutations in APOC3 and Risk of Ischemic Vascular Disease

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Targeting APOC3 in the Familial Chylomicronemia Syndrome

(2014) Daniel Gaudet et al.   NEW ENGLAND JOURNAL OF MEDICINE

Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease

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Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

(2014) Y. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

(2014) Kathryn A. Whitehead et al.   Nature Communications

Shielding of Lipid Nanoparticles for siRNA Delivery: Impact on Physicochemical Properties, Cytokine Induction, and Efficacy

(2014) Varun Kumar et al.   Molecular Therapy-Nucleic Acids

Intracellular cleavable poly(2-dimethylaminoethyl methacrylate) functionalized mesoporous silica nanoparticles for efficient siRNA delivery in vitro and in vivo

(2013) Daoshu Lin et al.   Nanoscale

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

(2013) Gaurav Sahay et al.   NATURE BIOTECHNOLOGY

Mutant KRAS is a druggable target for pancreatic cancer

(2013) E. Zorde Khvalevsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

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Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

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A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo

(2012) Yusuke Sato et al.   JOURNAL OF CONTROLLED RELEASE

Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: a phase 2 randomised controlled trial

(2012) Evan A Stein et al.   LANCET

Influence of cationic lipid composition on uptake and intracellular processing of lipid nanoparticle formulations of siRNA

(2012) Paulo J.C. Lin et al.   Nanomedicine-Nanotechnology Biology and Medicine

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(2010) Gaurav Sahay et al.   JOURNAL OF CONTROLLED RELEASE

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

Elimination Pathways of Systemically Delivered siRNA

(2010) Yuanyu Huang et al.   MOLECULAR THERAPY

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY