Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine’s rewarding effects but preserves natural reward processing

From signaling molecules to circuits and behaviors: cell-type-specific adaptations to psychostimulant exposure in the striatum

(2019) Marine Salery et al.   BIOLOGICAL PSYCHIATRY

Detecting G protein-coupled receptor complexes in postmortem human brain with proximity ligation assay and a Bayesian classifier

(2019) Ying Zhu et al.   BIOTECHNIQUES

Disruption of A2AR-D2R Heteroreceptor Complexes After A2AR Transmembrane 5 Peptide Administration Enhances Cocaine Self-Administration in Rats

(2018) Dasiel O. Borroto-Escuela et al.   MOLECULAR NEUROBIOLOGY

Stochastic synaptic plasticity underlying compulsion in a model of addiction

(2018) Vincent Pascoli et al.   NATURE

Modulation and functions of dopamine receptor heteromers in drugs of abuse-induced adaptations

(2018) Andry Andrianarivelo et al.   NEUROPHARMACOLOGY

GluN1 deletions in D1- and A2A-expressing cell types reveal distinct modes of behavioral regulation

(2017) Max E. Joffe et al.   NEUROPHARMACOLOGY

Cocaine self-administration specifically increases A2AR-D2R and D2R-sigma1R heteroreceptor complexes in the rat nucleus accumbens shell. Relevance for cocaine use disorder

(2017) Dasiel O. Borroto-Escuela et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Blunted Dopamine Transmission in Addiction: Potential Mechanisms and Implications for Behavior

(2017) Pierre Trifilieff et al.   SEMINARS IN NUCLEAR MEDICINE

Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease

(2017) Dasiel O. Borroto-Escuela et al.   Frontiers in Cellular Neuroscience

Convergence of Reinforcing and Anhedonic Cocaine Effects in the Ventral Pallidum

(2016) Meaghan Creed et al.   NEURON

The Brain on Drugs: From Reward to Addiction

(2015) Nora D. Volkow et al.   CELL

Evidence against dopamine D1/D2 receptor heteromers

(2015) A L Frederick et al.   MOLECULAR PSYCHIATRY

Cell-Type Specific Insertion of GluA2-Lacking AMPARs with Cocaine Exposure Leading to Sensitization, Cue-Induced Seeking and Incubation of Craving

(2015) Jean Terrier et al.   NEUROPSYCHOPHARMACOLOGY

Extracellular Signal-Regulated Protein Kinases 1 and 2 Activation by Addictive Drugs: A Signal Toward Pathological Adaptation

(2014) Vincent Pascoli et al.   BIOLOGICAL PSYCHIATRY

D1R/GluN1 complexes in the striatum integrate dopamine and glutamate signalling to control synaptic plasticity and cocaine-induced responses

(2014) E Cahill et al.   MOLECULAR PSYCHIATRY

Contrasting forms of cocaine-evoked plasticity control components of relapse

(2014) Vincent Pascoli et al.   NATURE

Cocaine exposure reorganizes cell type– and input-specific connectivity in the nucleus accumbens

(2014) Andrew F MacAskill et al.   NATURE NEUROSCIENCE

A critical time window for dopamine actions on the structural plasticity of dendritic spines

(2014) S. Yagishita et al.   SCIENCE

Optogenetics reveals a role for accumbal medium spiny neurons expressing dopamine D2 receptors in cocaine-induced behavioral sensitization

(2014) Shelly Sooyun Song et al.   Frontiers in Behavioral Neuroscience

Addiction: failure of control over maladaptive incentive habits

(2013) David Belin et al.   CURRENT OPINION IN NEUROBIOLOGY

 FosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli

(2013) M. K. Lobo et al.   JOURNAL OF NEUROSCIENCE

Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use

(2013) Roland Bock et al.   NATURE NEUROSCIENCE

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Moonlighting Proteins and Protein–Protein Interactions as Neurotherapeutic Targets in the G Protein-Coupled Receptor Field

(2013) Kjell Fuxe et al.   NEUROPSYCHOPHARMACOLOGY

 FosB differentially modulates nucleus accumbens direct and indirect pathway function

(2013) B. A. Grueter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection of antigen interactions ex vivo by proximity ligation assay: endogenous dopamine D2-adenosine A2A receptor complexes in the striatum

(2012) Pierre Trifilieff et al.   BIOTECHNIQUES

Interactions between NMDA and dopamine receptors: A potential therapeutic target

(2012) Min Wang et al.   BRAIN RESEARCH

Distinct roles for direct and indirect pathway striatal neurons in reinforcement

(2012) Alexxai V Kravitz et al.   NATURE NEUROSCIENCE

Cell Type-Specific Alterations in the Nucleus Accumbens by Repeated Exposures to Cocaine

(2011) Juhyun Kim et al.   BIOLOGICAL PSYCHIATRY

Differential regulation of motor control and response to dopaminergic drugs by D1R and D2R neurons in distinct dorsal striatum subregions

(2011) Pierre F Durieux et al.   EMBO JOURNAL

Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviour

(2011) Vincent Pascoli et al.   NATURE

Drug-Evoked Synaptic Plasticity in Addiction: From Molecular Changes to Circuit Remodeling

(2011) Christian Lüscher et al.   NEURON

Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization

(2011) L. R. Beutler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Addiction: Beyond dopamine reward circuitry

(2011) N. D. Volkow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adenosine A2A Receptors and A2A Receptor Heteromers as Key Players in Striatal Function

(2011) Sergi Ferré et al.   Frontiers in Neuroanatomy

The Striatal Balancing Act in Drug Addiction: Distinct Roles of Direct and Indirect Pathway Medium Spiny Neurons

(2011) Mary Kay Lobo et al.   Frontiers in Neuroanatomy

Cyclic Adenosine Monophosphate–Independent Tyrosine Phosphorylation of NR2B Mediates Cocaine-Induced Extracellular Signal-Regulated Kinase Activation

(2010) Vincent Pascoli et al.   BIOLOGICAL PSYCHIATRY

Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization

(2010) Susan M Ferguson et al.   NATURE NEUROSCIENCE

Distinct Roles of Synaptic Transmission in Direct and Indirect Striatal Pathways to Reward and Aversive Behavior

(2010) Takatoshi Hikida et al.   NEURON

Cell Type-Specific Loss of BDNF Signaling Mimics Optogenetic Control of Cocaine Reward

(2010) M. K. Lobo et al.   SCIENCE

PSD-95 regulates D1 dopamine receptor resensitization, but not receptor-mediated Gs-protein activation

(2009) Peihua Sun et al.   CELL RESEARCH

Prolonged Withdrawal from Repeated Noncontingent Cocaine Exposure Increases NMDA Receptor Expression and ERK Activity in the Nucleus Accumbens

(2009) J. Schumann et al.   JOURNAL OF NEUROSCIENCE

PSD-95 Uncouples Dopamine-Glutamate Interaction in the D1/PSD-95/NMDA Receptor Complex

(2009) J. Zhang et al.   JOURNAL OF NEUROSCIENCE

D2R striatopallidal neurons inhibit both locomotor and drug reward processes

(2009) Pierre F Durieux et al.   NATURE NEUROSCIENCE

Opposing Patterns of Signaling Activation in Dopamine D1 and D2 Receptor-Expressing Striatal Neurons in Response to Cocaine and Haloperidol

(2008) J. Bertran-Gonzalez et al.   JOURNAL OF NEUROSCIENCE