Electrochemical synthesis of functionalized gem-difluoroalkenes with diverse alkyl sources via a defluorinative alkylation process

Synthesis of gem-Difluoroalkenes through Nickel-Promoted Electrochemical Reductive Cross-Coupling

(2022) Zhe Chang et al.   CHINESE JOURNAL OF ORGANIC CHEMISTRY

Generation of Alkyl Radicals from Thiols via Zinc Thiolates: Application for the Synthesis of gem ‐Difluorostyrenes

(2021) Vyacheslav I. Supranovich et al.   ADVANCED SYNTHESIS & CATALYSIS

Site-Selective Defluorinative sp3 C–H Alkylation of Secondary Amides

(2021) Wen-Jun Yue et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reductive Arylation of Aliphatic and Aromatic Aldehydes with Cyanoarenes by Electrolysis for the Synthesis of Alcohols

(2021) Xiao Zhang et al.   ORGANIC LETTERS

Chromium-Catalyzed Allylic Defluorinative Ketyl Olefin Coupling

(2021) Chang Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent Advances in the Electrochemical Synthesis and Functionalization of Indole Derivatives

(2020) Keyin Ye et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalyzing the Hydrodefluorination of CF3-Substituted Alkenes by PhSiH3. H• Transfer from a Nickel Hydride

(2020) Chengbo Yao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visible-Light-Mediated β-C–H gem-Difluoroallylation of Aldehydes and Cyclic Ketones through C–F Bond Cleavage of 1-Trifluoromethyl Alkenes

(2020) Devireddy Anand et al.   ORGANIC LETTERS

Visible-Light-Induced Deoxygenation/Defluorination Protocol for Synthesis of γ,γ-Difluoroallylic Ketones

(2020) Yuan-Qiang Guo et al.   ORGANIC LETTERS

Merger of C–F and C–N Bond Cleavage in Cross-Electrophile Coupling for the Synthesis of gem-Difluoroalkenes

(2020) Youxiang Jin et al.   ORGANIC LETTERS

The coupling of alkylboronic acids with α-(trifluoromethyl)styrenes by Lewis base/photoredox dual catalysis

(2020) Yuefeng Chen et al.   TETRAHEDRON LETTERS

Powering the Future: How Can Electrochemistry Make a Difference in Organic Synthesis?

(2020) Tjark H. Meyer et al.   Chem

Electroreductive Carbofunctionalization of Alkenes with Alkyl Bromides via a Radical-Polar Crossover Mechanism

(2020) Wen Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of gem-Difluoroalkenes by Merging Ni-Catalyzed C–F and C–C Bond Activation in Cross-Electrophile Coupling

(2019) Decai Ding et al.   ORGANIC LETTERS

Visible-Light-Promoted Redox Neutral γ,γ-Difluoroallylation of Cycloketone Oxime Ethers with Trifluoromethyl Alkenes via C–C and C–F Bond Cleavage

(2019) Yuwei He et al.   ORGANIC LETTERS

Photocatalytic, Phosphoranyl Radical-Mediated N–O Cleavage of Strained Cycloketone Oximes

(2019) Peng-Ju Xia et al.   ORGANIC LETTERS

The Electrogenerated Cyanomethyl Anion: An Old Base Still Smart

(2019) Isabella Chiarotto et al.   ACCOUNTS OF CHEMICAL RESEARCH

Site-Selective Catalytic Deaminative Alkylation of Unactivated Olefins

(2019) Shang-Zheng Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visible-Light-Induced Selective Defluoroborylation of Polyfluoroarenes, gem -Difluoroalkenes, and Trifluoromethylalkenes

(2019) Wengang Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cu-Catalyzed tertiary alkylation of α-(trifluoromethyl)styrenes with tertiary alkylmagnesium reagents

(2018) Wenpeng Dai et al.   Organic Chemistry Frontiers

Visible Light-Mediated Trifluoromethylation of Fluorinated Alkenes via C−F Bond Cleavage

(2018) Liu-Hai Wu et al.   ADVANCED SYNTHESIS & CATALYSIS

Synthesis of gem-Difluoroalkenes via Nickel-Catalyzed Allylic Defluorinative Reductive Cross-Coupling

(2018) Yun Lan et al.   ACS Catalysis

Copper-Catalyzed Asymmetric Defluoroborylation of 1-(Trifluoromethyl)Alkenes

(2018) Pan Gao et al.   Chem

Synthesis of gem-Difluoroalkenes via Nickel-Catalyzed Reductive C–F and C–O Bond Cleavage

(2018) Zhiyang Lin et al.   ACS Catalysis

Harnessing Alkyl Amines as Electrophiles for Nickel-Catalyzed Cross Couplings via C–N Bond Activation

(2017) Corey H. Basch et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Decarboxylative alkenylation

(2017) Jacob T. Edwards et al.   NATURE

Synthesis of gem-Difluoroallylboronates via FeCl2-Catalyzed Boration/β-Fluorine Elimination of Trifluoromethyl Alkenes

(2017) Yang Liu et al.   ORGANIC LETTERS

Photoinduced decarboxylative borylation of carboxylic acids

(2017) Alexander Fawcett et al.   SCIENCE

Recent advances in the synthesis and CF functionalization of gem-difluoroalkenes

(2017) Xuxue Zhang et al.   TETRAHEDRON LETTERS

Synthesis of Functionalized gem-Difluoroalkenes via a Photocatalytic Decarboxylative/Defluorinative Reaction

(2016) Tiebo Xiao et al.   JOURNAL OF ORGANIC CHEMISTRY

Decarboxylative Cross-Electrophile Coupling of N-Hydroxyphthalimide Esters with Aryl Iodides

(2016) Kierra M. M. Huihui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents

(2016) T. Qin et al.   SCIENCE

Constructing Quaternary Carbons from N-(Acyloxy)phthalimide Precursors of Tertiary Radicals Using Visible-Light Photocatalysis

(2015) Gerald Pratsch et al.   JOURNAL OF ORGANIC CHEMISTRY

Nickel-Catalyzed Allylic C(sp3)–F Bond Activation of Trifluoromethyl Groups via β-Fluorine Elimination: Synthesis of Difluoro-1,4-dienes

(2015) Tomohiro Ichitsuka et al.   ACS Catalysis

Difluoromethyl 2-pyridyl sulfone: a versatile carbonyl gem-difluoroolefination reagent

(2015) Bing Gao et al.   Organic Chemistry Frontiers

Synthesis and decarboxylative Wittig reaction of difluoromethylene phosphobetaine

(2013) Jian Zheng et al.   CHEMICAL COMMUNICATIONS

Substitution of Two Fluorine Atoms in a Trifluoromethyl Group: Regioselective Synthesis of 3-Fluoropyrazoles

(2012) Kohei Fuchibe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Difluoromethyl 2-Pyridyl Sulfone: A Newgem-Difluoroolefination Reagent for Aldehydes and Ketones

(2010) Yanchuan Zhao et al.   ORGANIC LETTERS