Time and metabolic state-dependent effects of GLP-1R agonists on NPY/AgRP and POMC neuronal activity in vivo

Hypothalamic detection of macronutrients via multiple gut-brain pathways

(2021) Nitsan Goldstein et al.   Cell Metabolism

STEP 1 for Effective Weight Control — Another First Step?

(2021) Julie R. Ingelfinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Once-Weekly Semaglutide in Adults with Overweight or Obesity

(2021) John P.H. Wilding et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting

(2021) Nasim Biglari et al.   NATURE NEUROSCIENCE

Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined

(2021) Julie R. Lundgren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glucagon‐like Peptide‐1 (GLP‐1) Signaling in the Brain: From Neural Circuits and Metabolism to Therapeutics

(2021) Anita Kabahizi et al.   BRITISH JOURNAL OF PHARMACOLOGY

PERK in POMC neurons connects celastrol with metabolism

(2021) Zhenyan He et al.   JCI Insight

GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats

(2020) Samantha M. Fortin et al.   Science Translational Medicine

Paraventricular, subparaventricular and periventricular hypothalamic IRS4-expressing neurons are required for normal energy balance

(2020) Amy K. Sutton et al.   Scientific Reports

High-fat food biases hypothalamic and mesolimbic expression of consummatory drives

(2020) Christopher M. Mazzone et al.   NATURE NEUROSCIENCE

Obesity causes selective and long-lasting desensitization of AgRP neurons to dietary fat

(2020) Lisa R Beutler et al.   eLife

Effects of metabolic state on the regulation of melanocortin circuits

(2020) Linh Lieu et al.   PHYSIOLOGY & BEHAVIOR

Regulation of substrate utilization and adiposity by Agrp neurons

(2019) João Paulo Cavalcanti-de-Albuquerque et al.   Nature Communications

Long-Acting Neurotensin Synergizes With Liraglutide to Reverse Obesity Through a Melanocortin-Dependent Pathway

(2019) Cecilia Ratner et al.   DIABETES

From the Incretin Concept and the Discovery of GLP-1 to Today's Diabetes Therapy

(2019) Jens Juul Holst   Frontiers in Endocrinology

Direct and indirect effects of liraglutide on hypothalamic POMC and NPY/AgRP neurons – Implications for energy balance and glucose control

(2019) Zhenyan He et al.   Molecular Metabolism

Glucagon-like peptide 1 (GLP-1)

(2019) T.D. Müller et al.   Molecular Metabolism

Role of POMC and AgRP neuronal activities on glycaemia in mice

(2019) Aykut Göktürk Üner et al.   Scientific Reports

Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1

(2018) Daniel J. Drucker   Cell Metabolism

Liraglutide Modulates Appetite and Body Weight Through Glucagon-Like Peptide 1 Receptor–Expressing Glutamatergic Neurons

(2018) Jessica M. Adams et al.   DIABETES

Determination of liraglutide in rat plasma by a selective liquid chromatography-tandem mass spectrometry method: Application to a pharmacokinetics study

(2018) Shiqi Dong et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Cellular and synaptic reorganization of arcuate NPY/AgRP and POMC neurons after exercise

(2018) Zhenyan He et al.   Molecular Metabolism

Oxytocin-receptor-expressing neurons in the parabrachial nucleus regulate fluid intake

(2017) Philip J. Ryan et al.   NATURE NEUROSCIENCE

Dynamics of Gut-Brain Communication Underlying Hunger

(2017) Lisa R. Beutler et al.   NEURON

TrpC5 Mediates Acute Leptin and Serotonin Effects via Pomc Neurons

(2017) Yong Gao et al.   Cell Reports

Nutritive, Post-ingestive Signals Are the Primary Regulators of AgRP Neuron Activity

(2017) Zhenwei Su et al.   Cell Reports

GLP-1 and weight loss: unraveling the diverse neural circuitry

(2016) Scott E. Kanoski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue

(2016) Sophie M. Steculorum et al.   CELL

The Hypothalamic Glucagon-Like Peptide 1 Receptor Is Sufficient but Not Necessary for the Regulation of Energy Balance and Glucose Homeostasis in Mice

(2016) Melissa A. Burmeister et al.   DIABETES

Near-normalization of glycaemic control with glucagon-like peptide-1 receptor agonist treatment combined with exercise in patients with type 2 diabetes

(2016) P. Mensberg et al.   DIABETES OBESITY & METABOLISM

Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons

(2016) Jia Sun et al.   Molecular Metabolism

Sensory Detection of Food Rapidly Modulates Arcuate Feeding Circuits

(2015) Yiming Chen et al.   CELL

Intact-Brain Analyses Reveal Distinct Information Carried by SNc Dopamine Subcircuits

(2015) Talia N. Lerner et al.   CELL

Liraglutide in Type 2 Diabetes Mellitus: Clinical Pharmacokinetics and Pharmacodynamics

(2015) Lisbeth V. Jacobsen et al.   CLINICAL PHARMACOKINETICS

A neural basis for melanocortin-4 receptor–regulated appetite

(2015) Alastair S Garfield et al.   NATURE NEUROSCIENCE

Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales

(2015) Yael Mandelblat-Cerf et al.   eLife

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

(2014) Anna Secher et al.   JOURNAL OF CLINICAL INVESTIGATION

An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger

(2014) Michael J. Krashes et al.   NATURE

Glucagon-Like Peptide-1 Receptor Signaling in the Lateral Parabrachial Nucleus Contributes to the Control of Food Intake and Motivation to Feed

(2014) Amber L Alhadeff et al.   NEUROPSYCHOPHARMACOLOGY

Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis

(2013) Eric D. Berglund et al.   JOURNAL OF CLINICAL INVESTIGATION

Acute and Long-Term Suppression of Feeding Behavior by POMC Neurons in the Brainstem and Hypothalamus, Respectively

(2013) C. Zhan et al.   JOURNAL OF NEUROSCIENCE

Fasting Activation of AgRP Neurons Requires NMDA Receptors and Involves Spinogenesis and Increased Excitatory Tone

(2012) Tiemin Liu et al.   NEURON

Peripheral and Central GLP-1 Receptor Populations Mediate the Anorectic Effects of Peripherally Administered GLP-1 Receptor Agonists, Liraglutide and Exendin-4

(2011) Scott E. Kanoski et al.   ENDOCRINOLOGY

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

(2011) Michael J. Krashes et al.   JOURNAL OF CLINICAL INVESTIGATION

The Pharmacokinetics, Pharmacodynamics, and Tolerability of Liraglutide, a Once-Daily Human GLP-1 Analogue, After Multiple Subcutaneous Administration in Healthy Chinese Male Subjects

(2011) Ji Jiang et al.   JOURNAL OF CLINICAL PHARMACOLOGY

AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

(2011) Yexica Aponte et al.   NATURE NEUROSCIENCE

Comparative Effects of the Long-Acting GLP-1 Receptor Ligands, Liraglutide and Exendin-4, on Food Intake and Body Weight Suppression in Rats

(2011) Matthew R. Hayes et al.   Obesity

Metabolism and Excretion of the Once-Daily Human Glucagon-Like Peptide-1 Analog Liraglutide in Healthy Male Subjects and Its In Vitro Degradation by Dipeptidyl Peptidase IV and Neutral Endopeptidase

(2010) M. Malm-Erjefalt et al.   DRUG METABOLISM AND DISPOSITION

Population Pharmacokinetics of Liraglutide, a Once-Daily Human Glucagon-Like Peptide-1 Analog, in Healthy Volunteers and Subjects With Type 2 Diabetes, and Comparison to Twice-Daily Exenatide

(2010) Estelle Watson et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Essential Role for TRPC5 in Amygdala Function and Fear-Related Behavior

(2009) Antonio Riccio et al.   CELL

Neuromedin B and Gastrin-Releasing Peptide Excite Arcuate Nucleus Neuropeptide Y Neurons in a Novel Transgenic Mouse Expressing Strong Renilla Green Fluorescent Protein in NPY Neurons

(2009) A. N. van den Pol et al.   JOURNAL OF NEUROSCIENCE

Arcuate Glucagon-Like Peptide 1 Receptors Regulate Glucose Homeostasis but Not Food Intake

(2008) D. A. Sandoval et al.   DIABETES