Obesity causes selective and long-lasting desensitization of AgRP neurons to dietary fat

Need-based prioritization of behavior

(2019) C Joseph Burnett et al.   eLife

Sustained NPY signaling enables AgRP neurons to drive feeding

(2019) Yiming Chen et al.   eLife

Obesity remodels activity and transcriptional state of a lateral hypothalamic brake on feeding

(2019) Mark A. Rossi et al.   SCIENCE

High fat diet attenuates cholecystokinin-induced cFos activation of prolactin-releasing peptide-expressing A2 noradrenergic neurons in the caudal nucleus of the solitary tract

(2019) Kaylee D. Wall et al.   NEUROSCIENCE

Genetic Identification of Vagal Sensory Neurons That Control Feeding

(2019) Ling Bai et al.   CELL

Persistent effects of obesity: a neuroplasticity hypothesis

(2018) Bridget A. Matikainen-Ankney et al.   Annals of the New York Academy of Sciences

Evidence for a Non-leptin System that Defends against Weight Gain in Overfeeding

(2018) Yann Ravussin et al.   Cell Metabolism

AgRP Neurons Can Increase Food Intake during Conditions of Appetite Suppression and Inhibit Anorexigenic Parabrachial Neurons

(2017) Rachel A. Essner et al.   JOURNAL OF NEUROSCIENCE

Homeostatic circuits selectively gate food cue responses in insular cortex

(2017) Yoav Livneh et al.   NATURE

Toward a Wiring Diagram Understanding of Appetite Control

(2017) Mark L. Andermann et al.   NEURON

Dynamics of Gut-Brain Communication Underlying Hunger

(2017) Lisa R. Beutler et al.   NEURON

Nutritive, Post-ingestive Signals Are the Primary Regulators of AgRP Neuron Activity

(2017) Zhenwei Su et al.   Cell Reports

Making sense of the sensory regulation of hunger neurons

(2016) Yiming Chen et al.   BIOESSAYS

Persistent metabolic adaptation 6 years after “The Biggest Loser” competition

(2016) Erin Fothergill et al.   Obesity

Obesity Impairs the Action of the Neuroendocrine Ghrelin System

(2016) Jeffrey M. Zigman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Hunger neurons drive feeding through a sustained, positive reinforcement signal

(2016) Yiming Chen et al.   eLife

Obesogenic memory can confer long-term increases in adipose tissue but not liver inflammation and insulin resistance after weight loss

(2016) J. Schmitz et al.   Molecular Metabolism

Sensory Detection of Food Rapidly Modulates Arcuate Feeding Circuits

(2015) Yiming Chen et al.   CELL

Palatability Can Drive Feeding Independent of AgRP Neurons

(2015) Raphaël G.P. Denis et al.   Cell Metabolism

Diet-Induced Obese Mice Retain Endogenous Leptin Action

(2015) Nickki Ottaway et al.   Cell Metabolism

Biologic Responses to Weight Loss and Weight Regain: Report From an American Diabetes Association Research Symposium

(2015) Rudolph L. Leibel et al.   DIABETES

Altered gut and adipose tissue hormones in overweight and obese individuals: cause or consequence?

(2015) M E J Lean et al.   INTERNATIONAL JOURNAL OF OBESITY

Neurons for hunger and thirst transmit a negative-valence teaching signal

(2015) J. Nicholas Betley et al.   NATURE

Diet composition, not calorie intake, rapidly alters intrinsic excitability of hypothalamic AgRP/NPY neurons in mice

(2015) Wei Wei et al.   Scientific Reports

Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales

(2015) Yael Mandelblat-Cerf et al.   eLife

Natural Neural Projection Dynamics Underlying Social Behavior

(2014) Lisa A. Gunaydin et al.   CELL

Evidence That Diet-Induced Hyperleptinemia, but Not Hypothalamic Gliosis, Causes Ghrelin Resistance in NPY/AgRP Neurons of Male Mice

(2014) Dana I. Briggs et al.   ENDOCRINOLOGY

Leptin Modulates the Intrinsic Excitability of AgRP/NPY Neurons in the Arcuate Nucleus of the Hypothalamus

(2014) S. B. Baver et al.   JOURNAL OF NEUROSCIENCE

The role of gastrointestinal vagal afferent fibres in obesity

(2014) Stephen J. Kentish et al.   JOURNAL OF PHYSIOLOGY-LONDON

Calorie-Restricted Weight Loss Reverses High-Fat Diet-Induced Ghrelin Resistance, Which Contributes to Rebound Weight Gain in a Ghrelin-Dependent Manner

(2013) Dana I. Briggs et al.   ENDOCRINOLOGY

Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin

(2013) Qian Wang et al.   Molecular Metabolism

From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior

(2012) Kevin W Williams et al.   NATURE NEUROSCIENCE

Mouse intragastric infusion (iG) model

(2012) Akiko Ueno et al.   Nature Protocols

Fasting Activation of AgRP Neurons Requires NMDA Receptors and Involves Spinogenesis and Increased Excitatory Tone

(2012) Tiemin Liu et al.   NEURON

Altered hypothalamic function in diet-induced obesity

(2011) L A Velloso et al.   INTERNATIONAL JOURNAL OF OBESITY

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

(2011) Michael J. Krashes et al.   JOURNAL OF CLINICAL INVESTIGATION

Diet-Induced Obesity Attenuates Fasting-Induced Hyperphagia

(2011) D. I. Briggs et al.   JOURNAL OF NEUROENDOCRINOLOGY

Impaired intestinal afferent nerve satiety signalling and vagal afferent excitability in diet induced obesity in the mouse

(2011) Donna M. Daly et al.   JOURNAL OF PHYSIOLOGY-LONDON

AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

(2011) Yexica Aponte et al.   NATURE NEUROSCIENCE

Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons

(2011) Linh Vong et al.   NEURON

Reduced fasting-induced activation of hypothalamic arcuate neurons is associated with hyperleptinemia and increased leptin sensitivity in obese mice

(2010) Csilla Becskei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Diet-Induced Obesity Causes Ghrelin Resistance in Arcuate NPY/AgRP Neurons

(2010) Dana I. Briggs et al.   ENDOCRINOLOGY

Hyperleptinemia Is Required for the Development of Leptin Resistance

(2010) Zachary A. Knight et al.   PLoS One

Obesity and leptin resistance: distinguishing cause from effect

(2010) Martin G. Myers et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM