The Placental Innate Immune System Is Altered in Early-Onset Preeclampsia, but Not in Late-Onset Preeclampsia

Identification, Validation, and Utilization of Immune Cells in Pancreatic Ductal Adenocarcinoma Based on Marker Genes

(2021) Willem de Koning et al.   Frontiers in Immunology

Etiological Value of Sterile Inflammation in Preeclampsia: Is It a Non-Infectious Pregnancy Complication?

(2021) Sayani Banerjee et al.   Frontiers in Cellular and Infection Microbiology

The Function of the Kynurenine Pathway in the Placenta: A Novel Pharmacotherapeutic Target?

(2021) Michelle Broekhuizen et al.   International Journal of Environmental Research and Public Health

Immunology of the Placenta

(2020) Mancy Tong et al.   OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA

Increased placental macrophages and a pro‐inflammatory profile in placentas and maternal serum in infants with a decreased growth rate in the third trimester of pregnancy

(2020) Megan C. Sharps et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

l -Tryptophan–Induced Vasodilation Is Enhanced in Preeclampsia

(2020) Michelle Broekhuizen et al.   HYPERTENSION

RNA from stabilized whole blood enables more comprehensive immune gene expression profiling compared to RNA from peripheral blood mononuclear cells

(2020) Fleur van der Sijde et al.   PLoS One

Dendritic cell vaccination and CD40-agonist combination therapy licenses T cell-dependent antitumor immunity in a pancreatic carcinoma murine model

(2020) Sai Ping Lau et al.   Journal for ImmunoTherapy of Cancer

Abnormal placental CD8 + T‐cell infiltration is a feature of fetal growth restriction and pre‐eclampsia

(2020) Susanne Lager et al.   JOURNAL OF PHYSIOLOGY-LONDON

Altered Levels of Decidual Immune Cell Subsets in Fetal Growth Restriction, Stillbirth, and Placental Pathology

(2020) Romy E. Bezemer et al.   Frontiers in Immunology

Preconditioning of the tumor microenvironment with oncolytic reovirus converts CD3-bispecific antibody treatment into effective immunotherapy

(2020) Christianne Groeneveldt et al.   Journal for ImmunoTherapy of Cancer

Human Tregs at the materno-fetal interface show site-specific adaptation reminiscent of tumor Tregs

(2020) Judith Wienke et al.   JCI Insight

Preeclampsia

(2019) Sarosh Rana et al.   CIRCULATION RESEARCH

Regulation of the complement system and immunological tolerance in pregnancy

(2019) Laura Teirilä et al.   SEMINARS IN IMMUNOLOGY

Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed to hypoxia and endoplasmic reticulum stressors

(2019) Shi-Bin Cheng et al.   Cell Death & Disease

Single cell transcriptional signatures of the human placenta in term and preterm parturition

(2019) Roger Pique-Regi et al.   eLife

Hypertensive Disorders of Pregnancy

(2018) Mark A. Brown et al.   HYPERTENSION

Mast cells as sources of cytokines, chemokines, and growth factors

(2018) Kaori Mukai et al.   IMMUNOLOGICAL REVIEWS

Innate immune cells in the placental bed in healthy pregnancy and preeclampsia

(2018) Marijke M. Faas et al.   PLACENTA

Endothelial indoleamine 2,3-dioxygenase-1 regulates the placental vascular tone and is deficient in intrauterine growth restriction and pre-eclampsia

(2018) Pablo Zardoya-Laguardia et al.   Scientific Reports

Exploring the links between cancer and placenta development

(2018) Vincenzo Costanzo et al.   Open Biology

Integrated Systems Biology Approach Identifies Novel Maternal and Placental Pathways of Preeclampsia

(2018) Nandor Gabor Than et al.   Frontiers in Immunology

Single-cell reconstruction of the early maternal–fetal interface in humans

(2018) Roser Vento-Tormo et al.   NATURE

Intrauterine growth restriction and placental gene expression in severe preeclampsia, comparing early-onset and late-onset forms

(2017) Jaana Nevalainen et al.   JOURNAL OF PERINATAL MEDICINE

Downregulation of indoleamine 2, 3-dioxygenase expression in the villous stromal endothelial cells of placentas with preeclampsia

(2017) Naoyuki Iwahashi et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Uterine NK cells and macrophages in pregnancy

(2017) Marijke M. Faas et al.   PLACENTA

Hypoxia and HIF pathway in cancer and the placenta

(2017) Philip S. Macklin et al.   PLACENTA

Integrative single-cell and cell-free plasma RNA transcriptomics elucidates placental cellular dynamics

(2017) Jason C. H. Tsang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chymase-producing cells of the innate immune system are required for decidual vascular remodeling and fetal growth

(2017) Nicole Meyer et al.   Scientific Reports

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

(2016) Zuguang Gu et al.   BIOINFORMATICS

Specific Features of TLR4 Expression in Structural Elements of Placenta in Patients with Preeclampsia

(2016) G. V. Kulikova et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Maternal Decidual Macrophages Inhibit NK Cell Killing of Invasive Cytotrophoblasts During Human Pregnancy

(2013) E. C. Co et al.   BIOLOGY OF REPRODUCTION

Fractalkine (CX3CL1) and Its Receptor CX3CR1 May Contribute to Increased Angiogenesis in Diabetic Placenta

(2013) Dariusz Szukiewicz et al.   MEDIATORS OF INFLAMMATION

Expression of angiogenesis-related factors and inflammatory cytokines in placenta and umbilical vessels in pregnancies with preeclampsia and chorioamnionitis/funisitis

(2012) Atsuko Taki et al.   CONGENITAL ANOMALIES

Expression and Localization of TLR4 and Its Negative Regulator Tollip in the Placenta of Early-Onset and Late-Onset Preeclampsia

(2012) Li Zhang et al.   HYPERTENSION IN PREGNANCY

Dendritic cells in the circulation of women with preeclampsia demonstrate a pro-inflammatory bias secondary to dysregulation of TLR receptors

(2012) Britta Panda et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Mast Cells and Histamine: Do They Influence Placental Vascular Network and Development in Preeclampsia?

(2012) Grzegorz Szewczyk et al.   MEDIATORS OF INFLAMMATION

Oxidative Damage, Inflammation, and Toll-Like Receptor 4 Pathway Are Increased in Preeclamptic Patients: A Case-Control Study

(2012) Fabiana C. B. Bernardi et al.   Oxidative Medicine and Cellular Longevity

Altered expression of immune-associated genes in first-trimester human decidua of pregnancies later complicated with hypertension or foetal growth restriction

(2012) J.R. Prins et al.   PLACENTA

Elevated Serum Levels of Interleukin-6, Interleukin-1β and Human Chorionic Gonadotropin in Pre-eclampsia

(2011) Michail Kalinderis et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Expression of Toll-like Receptor TLR-2, TLR-3, TLR-4 and TLR-9 Is Increased in Placentas from Patients with Preeclampsia

(2011) Antonio Pineda et al.   ARCHIVES OF MEDICAL RESEARCH

A meta-analysis of tumor necrosis factor-alpha, interleukin-6, and interleukin-10 in preeclampsia

(2011) Cui Xie et al.   CYTOKINE

Role of Complement Component C1q in the Onset of Preeclampsia in Mice

(2011) Jameel Singh et al.   HYPERTENSION

C-reactive protein levels, blood pressure and the risks of gestational hypertensive complications

(2011) Layla L. de Jonge et al.   JOURNAL OF HYPERTENSION

Comparative gene expression profiling of placentas from patients with severe pre-eclampsia and unexplained fetal growth restriction

(2011) Haruki Nishizawa et al.   Reproductive Biology and Endocrinology

Toll-like receptors 2 and 4 and the cryopyrin inflammasome in normal pregnancy and pre-eclampsia

(2010) F Xie et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Circulating cytokines, chemokines and adhesion molecules in normal pregnancy and preeclampsia determined by multiplex suspension array

(2010) Andras Szarka et al.   BMC IMMUNOLOGY

Control of infection by pyroptosis and autophagy: role of TLR and NLR

(2010) Karina R. Bortoluci et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

An Alternative Role of C1q in Cell Migration and Tissue Remodeling: Contribution to Trophoblast Invasion and Placental Development

(2010) C. Agostinis et al.   JOURNAL OF IMMUNOLOGY

Maternal and umbilical serum levels of interleukin-6, interleukin-8, and tumor necrosis factor-α in normal pregnancies and in pregnancies complicated by preeclampsia

(2010) Miğraci Tosun et al.   Journal of Maternal-Fetal & Neonatal Medicine

Pre-eclampsia

(2010) Eric AP Steegers et al.   LANCET

Immune cells in the placental bed

(2009) Judith N. Bulmer et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

Whole-genome microarray and targeted analysis of angiogenesis-regulating gene expression (ENG, FLT1, VEGF, PlGF) in placentas from pre-eclamptic and small-for-gestational-age pregnancies

(2008) Johanne Holm Toft et al.   Journal of Maternal-Fetal & Neonatal Medicine

A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate

(2008) Roberto Romero et al.   Journal of Maternal-Fetal & Neonatal Medicine

Direct multiplexed measurement of gene expression with color-coded probe pairs

(2008) Gary K Geiss et al.   NATURE BIOTECHNOLOGY

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

Maternal TLR4 and NOD2 Gene Variants, Pro-Inflammatory Phenotype and Susceptibility to Early-Onset Preeclampsia and HELLP Syndrome

(2008) Bas B. van Rijn et al.   PLoS One

Activation of fractalkine/CX3CR1 by vascular endothelial cells induces angiogenesis through VEGF-A/KDR and reverses hindlimb ischaemia

(2007) J. Ryu et al.   CARDIOVASCULAR RESEARCH