Th17 CD4+ T-Cell as a Preferential Target for HIV Reservoirs

LILAC pilot study: Effects of metformin on mTOR activation and HIV reservoir persistence during antiretroviral therapy

(2021) Delphine Planas et al.   EBioMedicine

Differences in HIV burden in the inflamed and non-inflamed colon from a person living with HIV and ulcerative colitis

(2021) Xiaorong Peng et al.   Journal of Virus Eradication

Gut Leakage of Fungal‐Related Products: Turning Up the Heat for HIV Infection

(2021) Stéphane Isnard et al.   Frontiers in Immunology

Upregulated IL-32 Expression And Reduced Gut Short Chain Fatty Acid Caproic Acid in People Living With HIV With Subclinical Atherosclerosis

(2021) Mohamed El-Far et al.   Frontiers in Immunology

Mapping the extent of heterogeneity of human CCR5+ CD4 T-cells in peripheral blood and lymph nodes

(2020) John Zaunders et al.   AIDS

HIV-1 elite controllers present a high frequency of activated regulatory T and Th17 cells

(2020) Diogo G. Caetano et al.   PLoS One

Preferential infection of α4β7+ memory CD4+ T cells during early acute HIV-1 infection

(2020) Andrey Tokarev et al.   CLINICAL INFECTIOUS DISEASES

Modulation of mTORC1 Signaling Pathway by HIV-1

(2020) Burkitkan Akbay et al.   Cells

HIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus

(2020) Elias K. Halvas et al.   JOURNAL OF CLINICAL INVESTIGATION

Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection

(2019) Marion Pardons et al.   PLoS Pathogens

Impact of HIV-ART on the restoration of Th17 and Treg cells in blood and female genital mucosa

(2019) María Paula Caruso et al.   Scientific Reports

SIV infects functionally polarized memory CD4 T cells equivalently in vivo

(2019) Stephen Lai et al.   JOURNAL OF VIROLOGY

IL-7 induced proliferation of peripheral Th17 cells is impaired in HAART controlled HIV infection

(2019) Sandra C. Côté et al.   AIDS

The IL-17 Family of Cytokines in Health and Disease

(2019) Mandy J. McGeachy et al.   IMMUNITY

Altered differentiation is central to HIV-specific CD4+ T cell dysfunction in progressive disease

(2019) Antigoni Morou et al.   NATURE IMMUNOLOGY

Proliferative memory SAMHD1low CD4+ T cells harbour high levels of HIV-1 with compartmentalized viral populations

(2019) Lylia Hani et al.   PLoS Pathogens

CD161+ CD4+ T Cells Harbor Clonally Expanded Replication-Competent HIV-1 in Antiretroviral Therapy-Suppressed Individuals

(2019) Xiaomin Li et al.   mBio

Anti-apoptotic Protein BIRC5 Maintains Survival of HIV-1-Infected CD4 + T Cells

(2018) Hsiao-Hsuan Kuo et al.   IMMUNITY

HIV-specific CD4+Th17 cells from HIV infected long-term non-progressors exhibit lower CTLA-4 expression and reduced apoptosis

(2018) Vandana Saxena et al.   IMMUNOBIOLOGY

Effects of Th17/Treg cell imbalance on HIV replication in patients with AIDS complicated with tuberculosis

(2018) Yanshuang Li et al.   Experimental and Therapeutic Medicine

New Th17-specific therapeutic strategies for HIV remission

(2018) Delphine Planas et al.   Current Opinion in HIV and AIDS

Role of autophagy in HIV infection and pathogenesis

(2017) R. Nardacci et al.   JOURNAL OF INTERNAL MEDICINE

The Th17 Lineage: From Barrier Surfaces Homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis

(2017) Vanessa Wacleche et al.   Viruses-Basel

The mTOR Complex Controls HIV Latency

(2016) Emilie Besnard et al.   Cell Host & Microbe

Parallel assessment of Th17 cell frequencies by surface marker co-expression versus ex vivo IL-17 production in HIV-1 infection

(2016) Gábor A. Dunay et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Human Th17 Cells Lack HIV-Inhibitory RNases and Are Highly Permissive to Productive HIV Infection

(2016) Aaron Christensen-Quick et al.   JOURNAL OF VIROLOGY

Toll-Like Receptor 2 Ligation Enhances HIV-1 Replication in Activated CCR6 + CD4 + T Cells by Increasing Virus Entry and Establishing a More Permissive Environment to Infection

(2016) Jean-François Bolduc et al.   JOURNAL OF VIROLOGY

MAIT cells reside in the female genital mucosa and are biased towards IL-17 and IL-22 production in response to bacterial stimulation

(2016) A Gibbs et al.   Mucosal Immunology

New insights into the heterogeneity of Th17 subsets contributing to HIV-1 persistence during antiretroviral therapy

(2016) Vanessa Sue Wacleche et al.   Retrovirology

Low SAMHD1 expression following T-cell activation and proliferation renders CD4+ T cells susceptible to HIV-1

(2015) Nicolas Ruffin et al.   AIDS

Early HIV-1 Infection Is Associated With Reduced Frequencies of Cervical Th17 Cells

(2015) Lyle R. McKinnon et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Immunosuppressive Tryptophan Catabolism and Gut Mucosal Dysfunction Following Early HIV Infection

(2015) Mohammad-Ali Jenabian et al.   JOURNAL OF INFECTIOUS DISEASES

Th1/17 Polarization of CD4 T Cells Supports HIV-1 Persistence during Antiretroviral Therapy

(2015) Hong Sun et al.   JOURNAL OF VIROLOGY

Identification of novel HIV-1 dependency factors in primary CCR4+CCR6+Th17 cells via a genome-wide transcriptional approach

(2015) Aurélie Cleret-Buhot et al.   Retrovirology

New Insights about Treg and Th17 Cells in HIV Infection and Disease Progression

(2015) Jacqueline María Valverde-Villegas et al.   Journal of Immunology Research

Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids

(2014) Radha Ramesh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: NKT Cells Constitutively Express IL-23 Receptor and ROR t and Rapidly Produce IL-17 upon Receptor Ligation in an IL-6-Independent Fashion

(2014) A. V. Rachitskaya et al.   JOURNAL OF IMMUNOLOGY

Phenotype and susceptibility to HIV infection of CD4+ Th17 cells in the human female reproductive tract

(2014) M Rodriguez-Garcia et al.   Mucosal Immunology

Functional heterogeneity of human memory CD4+ T cell clones primed by pathogens or vaccines

(2014) S. Becattini et al.   SCIENCE

Role of PI3K/Akt and mTOR complexes in Th17 cell differentiation

(2013) Shigenori Nagai et al.   Annals of the New York Academy of Sciences

Restrictions to HIV-1 replication in resting CD4+ T lymphocytes

(2013) Xiaoyu Pan et al.   CELL RESEARCH

Mucosal Th17 Cell Function Is Altered during HIV Infection and Is an Independent Predictor of Systemic Immune Activation

(2013) C. J. Kim et al.   JOURNAL OF IMMUNOLOGY

Preferential HIV Infection of CCR6+ Th17 Cells Is Associated with Higher Levels of Virus Receptor Expression and Lack of CCR5 Ligands

(2013) Y. Alvarez et al.   JOURNAL OF VIROLOGY

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

(2013) Noriko Komatsu et al.   NATURE MEDICINE

Distinct Tryptophan Catabolism and Th17/Treg Balance in HIV Progressors and Elite Controllers

(2013) Mohammad-Ali Jenabian et al.   PLoS One

Kruppel-like Factor 2 Modulates CCR5 Expression and Susceptibility to HIV-1 Infection

(2012) M. W. Richardson et al.   JOURNAL OF IMMUNOLOGY

Human Th17 Cells Express High Levels of Enzymatically Active Dipeptidylpeptidase IV (CD26)

(2012) B. Bengsch et al.   JOURNAL OF IMMUNOLOGY

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

(2012) Hichem Lahouassa et al.   NATURE IMMUNOLOGY

Stem Cell Factor Receptor/c-Kit: From Basic Science to Clinical Implications

(2012) Johan Lennartsson et al.   PHYSIOLOGICAL REVIEWS

Marking and Quantifying IL-17A-Producing Cells In Vivo

(2012) April E. Price et al.   PLoS One

The natural and the inducible: interleukin (IL)-17-producing γδ T cells

(2012) Yueh-hsiu Chien et al.   TRENDS IN IMMUNOLOGY

PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation by Regulating Gfi1 Expression and Nuclear Translocation of RORγ

(2012) Yutaka Kurebayashi et al.   Cell Reports

Sigmoid Th17 populations, the HIV latent reservoir, and microbial translocation in men on long-term antiretroviral therapy

(2011) Duncan Chege et al.   AIDS

A Randomized Case–Control Study of Dynamic Changes in Peripheral Blood Th17/Treg Cell Balance and Interleukin-17 Levels in Highly Active Antiretroviral-Treated HIV Type 1/AIDS Patients

(2011) Yan He et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Evidence of the transient nature of the Th17 phenotype of CD4+CD161+ T cells in the synovial fluid of patients with juvenile idiopathic arthritis

(2011) Lorenzo Cosmi et al.   ARTHRITIS AND RHEUMATISM

HIV-1 Tat binds to SH3 domains: Cellular and viral outcome of Tat/Grb2 interaction

(2011) Slava Rom et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

CCR6 as a mediator of immunity in the lung and gut

(2011) Toshihiro Ito et al.   EXPERIMENTAL CELL RESEARCH

The Role of Retinoic Acid in Tolerance and Immunity

(2011) Jason A. Hall et al.   IMMUNITY

Th17 Cells Are Long Lived and Retain a Stem Cell-like Molecular Signature

(2011) Pawel Muranski et al.   IMMUNITY

Low Level of Regulatory T Cells and Maintenance of Balance Between Regulatory T Cells and TH17 Cells in HIV-1–Infected Elite Controllers

(2011) Lea Brandt et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Proinflammatory Environment Dictates the IL-17-Producing Capacity of Human Invariant NKT Cells

(2011) L. Moreira-Teixeira et al.   JOURNAL OF IMMUNOLOGY

Characterization of a Human Cervical CD4+ T Cell Subset Coexpressing Multiple Markers of HIV Susceptibility

(2011) L. R. McKinnon et al.   JOURNAL OF IMMUNOLOGY

Memory CCR6+CD4+ T Cells Are Preferential Targets for Productive HIV Type 1 Infection Regardless of Their Expression of Integrin  7

(2011) P. Monteiro et al.   JOURNAL OF IMMUNOLOGY

HIV-1 envelope, integrins and co-receptor use in mucosal transmission of HIV

(2011) Claudia Cicala et al.   Journal of Translational Medicine

Frequency of Circulating Regulatory T Cells Increases during Chronic HIV Infection and Is Largely Controlled by Highly Active Antiretroviral Therapy

(2011) Pietro Presicce et al.   PLoS One

CD161-Expressing Human T Cells

(2011) Joannah R. Fergusson et al.   Frontiers in Immunology

HIV-1 infection is characterized by profound depletion of CD161+ Th17 cells and gradual decline in regulatory T cells

(2010) Andrew Prendergast et al.   AIDS

Early Events in Sexual Transmission of HIV and SIV and Opportunities for Interventions

(2010) Ashley T. Haase   Annual Review of Medicine

Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells

(2010) M. Dusseaux et al.   BLOOD

Wnt/ -Catenin Signaling in T-Cell Immunity and Cancer Immunotherapy

(2010) L. Gattinoni et al.   CLINICAL CANCER RESEARCH

CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC

(2010) Laura Maggi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Retinoic Acid Determines the Precise Tissue Tropism of Inflammatory Th17 Cells in the Intestine

(2010) C. Wang et al.   JOURNAL OF IMMUNOLOGY

Susceptibility of Human Th17 Cells to Human Immunodeficiency Virus and Their Perturbation during Infection

(2010) Aimee El Hed et al.   JOURNAL OF INFECTIOUS DISEASES

An emerging role for p21-activated kinases (Paks) in viral infections

(2010) Celine Van den Broeke et al.   TRENDS IN CELL BIOLOGY

Th17 cell dynamics in HIV infection

(2010) Nichole R Klatt et al.   Current Opinion in HIV and AIDS

Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection

(2009) Lishomwa C Ndhlovu et al.   AIDS

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Precarious Balance: Th17 Cells in Host Defense

(2009) A. Peck et al.   INFECTION AND IMMUNITY

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages

(2009) George B. Kyei et al.   JOURNAL OF CELL BIOLOGY

Peripheral Blood CCR4+CCR6+ and CXCR3+CCR6+ CD4+ T Cells Are Highly Permissive to HIV-1 Infection

(2009) A. Gosselin et al.   JOURNAL OF IMMUNOLOGY

Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa

(2009) S A Khader et al.   Mucosal Immunology

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells

(2009) Thomas Duhen et al.   NATURE IMMUNOLOGY

Host Cell Factors in HIV Replication: Meta-Analysis of Genome-Wide Studies

(2009) Frederic D. Bushman et al.   PLoS Pathogens

Autocrine Production of β-Chemokines Protects CMV-Specific CD4+ T Cells from HIV Infection

(2009) Joseph P. Casazza et al.   PLoS Pathogens

Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections

(2008) J. M. Brenchley et al.   BLOOD

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

(2008) Ivaylo I. Ivanov et al.   Cell Host & Microbe

The canonical Wnt signaling pathway plays an important role in lymphopoiesis and hematopoiesis

(2008) Frank J. T. Staal et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-17/IL-23 : une nouvelle piste thérapeutique dans les maladies inflammatoires chroniques intestinales

(2008) G. Malamut   GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

(2008) Xuexian O. Yang et al.   IMMUNITY

Human interleukin 17–producing cells originate from a CD161+CD4+T cell precursor

(2008) Lorenzo Cosmi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Persistence of HIV in Gut‐Associated Lymphoid Tissue despite Long‐Term Antiretroviral Therapy

(2008) Tae‐Wook Chun et al.   JOURNAL OF INFECTIOUS DISEASES

Effective CD4+ T-cell restoration in gut-associated lymphoid tissue of HIV-infected patients is associated with enhanced Th17 cells and polyfunctional HIV-specific T-cell responses

(2008) M Macal et al.   Mucosal Immunology

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

(2008) Liang Zhou et al.   NATURE

HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells

(2008) James Arthos et al.   NATURE IMMUNOLOGY

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

(2008) S. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA