Article
Rheumatology
Paola Ghanem, Joseph C. Murray, Kristen A. Marrone, Susan C. Scott, Josephine L. Feliciano, Vincent K. Lam, Christine L. Hann, David S. Ettinger, Benjamin P. Levy, Patrick M. Forde, Ami A. Shah, Christopher Mecoli, Julie Brahmer, Laura C. Cappelli
Summary: Lung cancer patients with concomitant autoimmune rheumatic diseases (ARD) have different tumor characteristics and clinical outcomes compared to those without ARD. Patients with ARD are more likely to be diagnosed with early-stage lung cancer and have a longer overall survival (OS).
Review
Chemistry, Multidisciplinary
Miao-miao Lin, Na Liu, Zheng-hong Qin, Yan Wang
Summary: Both mitochondrial dysfunction and neuroinflammation play significant roles in neurodegeneration and neurodegenerative diseases. There are multiple links between mitochondrial dysfunction and neuroinflammation, and their interaction is a complex and dynamic process. Understanding the specific molecular mechanisms associated with mitochondrial dysfunction and the progression of neuroinflammation in neurodegenerative diseases is of great importance for the identification of new therapeutic targets.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Immunology
Christine Gaboriaud, Marie Lorvellec, Veronique Rossi, Chantal Dumestre-Perard, Nicole M. Thielens
Summary: Our immune system responds to infectious and tissue damage signals, with the complement system and HMGB1 playing important roles. These systems involve molecular cascades and amplification loops, initially acting as alarm systems but eventually contributing to inflammation resolution and homeostasis. However, when these defense systems go out of control, they can cause serious cellular and tissue damage. The interaction between complement and HMGB1 pathways, as well as their traditional and non-canonical roles, functioning, and impact in different systems are described.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Helena Block, Jan Rossaint, Alexander Zarbock
Summary: The innate immune system acts as the first line of defense against invading pathogens or sterile injuries. Neutrophils play a crucial role in fighting infection and healing injuries, with the release of neutrophil extracellular traps (NETs) being an important mechanism. Recent studies have shown that NETs can have detrimental effects in certain diseases.
Article
Immunology
Tahereh Hojjatipour, Saeed Aslani, Sevda Salimifard, Haleh Mikaeili, Maryam Hemmatzadeh, Jamshid Gholizadeh Navashenaq, Elham Ahangar Parvin, Farhad Jadidi-Niaragh, Hamed Mohammadi
Summary: NK cells play a critical role in the pathogenesis of autoimmune diseases, bridging the innate and adaptive immune responses. Their functions in regulating immune responses and affecting various immune cells have been investigated. NK cells can have both harmful and protective effects depending on the subset of NK cells, disease microenvironment, and disease phase or stimuli. Understanding the role of NK cells in autoimmune diseases can provide insights for therapeutic strategies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Dmitry V. Sverchinsky, Bashar A. Alhasan, Marina A. Mikeladze, Vladimir F. Lazarev, Liubov S. Kuznetcova, Alisa V. Morshneva, Alina D. Nikotina, Amr Ziewanah, Lidia V. Koludarova, Tatiana Y. Starkova, Boris A. Margulis, Irina V. Guzhova
Summary: Cancer recurrence is regulated by factors such as heat shock protein 70 (Hsp70) signaling. The abundance of Hsp70-HMGB1 complex in the extracellular matrix may serve as a novel marker of cancer relapse state, and targeting this complex could be a promising treatment for cancers with a high risk of recurrence.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Livia S. A. Passos, Prabhash K. Jha, Dakota Becker-Greene, Mark C. Blaser, Dayanna Romero, Adrien Lupieri, Galina K. Sukhova, Peter Libby, Sasha A. Singh, Walderez O. Dutra, Masanori Aikawa, Robert A. Levine, Maria C. P. Nunes, Elena Aikawa
Summary: Proteomics analysis revealed ProTα as a protein associated with rheumatic heart valve disease (RHVD). ProTα may be involved in regulating the sex predisposition in RHVD by influencing the activity of CD8(+) T cells and the immune response of valvular cells. In addition, molecular mimicry between human and bacterial proteins was found.
Review
Biochemistry & Molecular Biology
Julie Sarrand, Laurie Baglione, Dorian Parisis, Muhammad Soyfoo
Summary: Sjogren's syndrome is a chronic autoimmune disease that primarily affects exocrine glands. It is characterized by lymphoplasmacytic infiltration and dysfunction of the glandular tissues. In addition to dry eyes and dry mouth, patients commonly experience fatigue, pain, and other systemic symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rheumatology
Teresa Carbone, Valentina Picerno, Vito Pafundi, Ernesto Esposito, Pietro Leccese, Angela Anna Padula, Salvatore D'Angelo
Summary: The COVID-19 pandemic has significantly impacted rheumatological clinical practice and autoimmunity testing demands, resulting in a decrease in laboratory test volumes and first rheumatological visits and diagnoses in 2020. However, an equivalent or higher percentage of positive autoimmunity results were recorded in outpatient services during 2020 compared to the prepandemic state, with new diagnoses mainly affected by less severe diseases.
JOURNAL OF RHEUMATOLOGY
(2022)
Review
Rheumatology
Sakir Ahmed, Olena Zimba, Armen Yuri Gasparyan
Summary: COVID-19 can lead to various autoimmune disorders, post-COVID-19 syndromes, and multi-system inflammatory syndrome. The infection of SARS-CoV-2 may cause endotheliitis and thrombosis, activate immune systems, and result in the formation of autoantibodies. It is important to monitor recovery patients for autoimmune manifestations and production of autoantibodies in the context of rheumatic diseases.
CLINICAL RHEUMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Erick J. Rodriguez-Palma, Isabel Velazquez-Lagunas, Ana Belen Salinas-Abarca, Guadalupe C. Vidal-Cantu, Maria J. Escoto-Rosales, Gabriela Castaneda-Corral, Alonso Fernandez-Guasti, Vinicio Granados-Soto
Summary: Chronic stress can trigger behavioral disorders such as nociceptive hypersensitivity and anxiety, but the mechanisms behind these disorders are not fully understood. This study investigated the role of HMGB1 and TLR4 in chronic stress-induced nociceptive hypersensitivity. The results showed that chronic stress induced tactile allodynia, anxiety-like behaviors, and activation of spinal microglia. HMGB1 and TLR4 expression was increased in the dorsal root ganglion. Blocking HMGB1 and TLR4 reduced nociceptive hypersensitivity and anxiety-like behaviors induced by chronic stress. TLR4 deletion diminished chronic stress-induced tactile allodynia in both male and female mice. The findings suggest that TLR4 could be a potential target for treating nociceptive hypersensitivity associated with chronic pain.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Immunology
Christoph Brieske, Peter Lamprecht, Anja Kerstein-Staehle
Summary: Cell death and dysregulated clearance of dead cells play crucial roles in chronic inflammatory processes and autoimmune diseases. This review discusses how regulated cell death and the release of damage-associated molecular patterns (DAMP) contribute to the granulomatous tissue inflammation and autoimmune responses in granulomatosis with polyangiitis (GPA).
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Bo Li, Xin Peng, He Li, Fei Chen, Yuxia Chen, Yingqian Zhang, Kai Le
Summary: HMGB1 is a protein that plays a regulatory role in both the cell nucleus and extracellular space, with significant clinical and scientific significance in the field of pediatrics, potentially serving as a diagnostic biomarker and therapeutic target for pediatric diseases.
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Article
Rheumatology
Bingxia Ming, Yaowu Zhu, Jixin Zhong, Lingli Dong
Summary: Sjögren's syndrome is a systemic autoimmune disorder that affects salivary and lacrimal glands, characterized by focal lymphocyte infiltration and autoantibody inflammatory response. Danger-associated molecular patterns (DAMPs) play a role in disease progression, and inhibiting DAMPs may serve as a novel therapeutic strategy for SS.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2022)
Article
Allergy
Yudong Liu, Mariana J. Kaplan
Summary: Neutrophils contribute to the initiation, promotion, and perpetuation of immune dysregulation in systemic rheumatic diseases, making them potential targets for therapeutic interventions to improve clinical outcomes.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuxue Chen, Lu Liu, Mengzhu Li, Ensheng Yao, Jiahuan Hao, Yuanji Dong, Xiaolong Zheng, Xinghua Liu
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Clinical Neurology
Chen Bo, Qin Chuan, Tao Ran, Dong Yuan-Ji, Ma Xue, Chen Man, Wu Long-Jun, Bu Bi-Tao, Tian Dai-Shi
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2020)
Article
Rheumatology
Yu Chen, Yuanji Dong, Shaozhe Cai, Cong Ye, Lingli Dong
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2020)
Article
Medicine, General & Internal
Peng Hu, Bingxia Ming, Xuefen Wu, Shaozhe Cai, Jungen Tang, Yuanji Dong, Tianshu Zhou, Zheng Tan, Jixin Zhong, Fang Zheng, Lingli Dong
Summary: The study found that intratracheal administration of poly(I:C) aggravated the reduction of saliva flow rate in NOD mice and worsened the histopathological lesions and inflammatory cells infiltration in SMG. Furthermore, it promoted the expression of IL-33 and increased T cells proportion in the lung.
FRONTIERS IN MEDICINE
(2021)
Review
Medicine, General & Internal
Yuanji Dong, Jixin Zhong, Lingli Dong
Summary: IL-33 plays a crucial role in activating various immune cells, while the IL-33/ST2 axis has a dual effect in rheumatic diseases, showing both detrimental and protective roles.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Qian Mo, Yuanji Dong, Cong Ye, Jixin Zhong, Shaozhe Cai, Min Wang, Lingli Dong
Summary: The study found that gradually reducing TNFi dosage (instead of complete withdrawal) can reduce disease activity and relapse rate in axSpA patients, while being associated with slower progression of chronic bone erosion. Maintaining an average DQ over 30 or 25 is a feasible strategy, particularly for patients needing TNFi reduction.
FRONTIERS IN MEDICINE
(2021)
Article
Rheumatology
Rongfen Gao, Jungen Tang, Yuanji Dong, Bingxia Ming, Zhihua Yu, Jixin Zhong, Lingli Dong
Summary: This study preliminarily addressed the levels of DCN and its potential roles in pSS. The results showed a significant elevation of DCN in the salivary glands of ESS mice model and pSS patients. Bioinformatics analysis revealed that DCN levels in the parotid glands of pSS patients positively correlated with several chemokines, IL1-beta, and caspase3, but negatively correlated with the proliferation relative gene MKI67. Furthermore, DCN was found to induce apoptosis in salivary gland epithelial cells and polarization of macrophages towards the pro-inflammatory M1 phenotype.
MODERN RHEUMATOLOGY
(2023)
Review
Immunology
Yuanji Dong, Jixin Zhong, Lingli Dong
Summary: Decorin is an extracellular matrix protein involved in collagen fibril formation and various biological processes. It has important characteristics and potential roles in immune and inflammatory diseases.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
