Tofacitinib Suppresses Natural Killer Cells In Vitro and In Vivo: Implications for Amyotrophic Lateral Sclerosis

Natural killer cells associate with amyotrophic lateral sclersois in a sex- and age-dependent manner

(2021) Benjamin J. Murdock et al.   JCI Insight

Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis

(2020) Stefano Garofalo et al.   Nature Communications

Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury

(2019) Alexander J. Davies et al.   CELL

Dose-Dependent Pharmacokinetics of Tofacitinib in Rats: Influence of Hepatic and Intestinal First-Pass Metabolism

(2019) Ji Sang Lee et al.   Pharmaceutics

JAK inhibitors alter NK cell functions and may impair immunosurveillance against lymphomagenesis

(2019) Gaetane Nocturne et al.   Cellular & Molecular Immunology

Temporal evolution of the microbiome, immune system and epigenome with disease progression in ALS mice

(2019) Claudia Figueroa-Romero et al.   Disease Models & Mechanisms

Ca 2+ -activated K + channels modulate microglia affecting motor neuron survival in hSOD1 G93A mice

(2018) Germana Cocozza et al.   BRAIN BEHAVIOR AND IMMUNITY

Abnormal RNA stability in amyotrophic lateral sclerosis

(2018) E. M. Tank et al.   Nature Communications

Evaluation of the Short‐, Mid‐, and Long‐term Effects of Tofacitinib on Lymphocytes in Patients with Rheumatoid Arthritis

(2018) Ronald van Vollenhoven et al.   Arthritis & Rheumatology

Tofacitinib for Psoriatic Arthritis in Patients with an Inadequate Response to TNF Inhibitors

(2017) Dafna Gladman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis

(2017) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comprehensive immune profiling reveals substantial immune system alterations in a subset of patients with amyotrophic lateral sclerosis

(2017) Michael P. Gustafson et al.   PLoS One

A cytokine signal inhibitor for rheumatoid arthritis enhances cancer metastasis via depletion of NK cells in an experimental lung metastasis mouse model of colon cancer

(2017) Hideki Shimaoka et al.   Oncology Letters

Correlation of Peripheral Immunity With Rapid Amyotrophic Lateral Sclerosis Progression

(2017) Benjamin J. Murdock et al.   JAMA Neurology

Peripheral monocytes are functionally altered and invade the CNS in ALS patients

(2016) Lisa Zondler et al.   ACTA NEUROPATHOLOGICA

Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis

(2016) SungWon Song et al.   NATURE MEDICINE

Major Histocompatibility Complex I Expression by Motor Neurons and Its Implication in Amyotrophic Lateral Sclerosis

(2016) Giovanni Nardo et al.   Frontiers in Neurology

The dual roles of immunity in ALS: Injury overrides protection

(2015) Benjamin J. Murdock et al.   NEUROBIOLOGY OF DISEASE

Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis

(2015) Kristopher G. Hooten et al.   Neurotherapeutics

Simultaneous inhibition of JAK and SYK kinases ameliorates chronic and destructive arthritis in mice

(2015) Alba Llop-Guevara et al.   ARTHRITIS RESEARCH & THERAPY

The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis

(2014) D L Boyle et al.   ANNALS OF THE RHEUMATIC DISEASES

Tofacitinib versus Methotrexate in Rheumatoid Arthritis

(2014) Eun Bong Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of tofacitinib on lymphocytes in rheumatoid arthritis: relation to efficacy and infectious adverse events

(2014) Koshiro Sonomoto et al.   RHEUMATOLOGY

Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits

(2013) Yuanchao Xue et al.   CELL

Homeostasis of Human NK Cells Is Not IL-15 Dependent

(2013) H. Lebrec et al.   JOURNAL OF IMMUNOLOGY

Immune-mediated Mechanisms in the Pathoprogression of Amyotrophic Lateral Sclerosis

(2013) Weihua Zhao et al.   Journal of Neuroimmune Pharmacology

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS

(2012) Oleg Butovsky et al.   JOURNAL OF CLINICAL INVESTIGATION

The effects of repeated oral gavage on the health of male CD-1 mice

(2012) Regina Arantes-Rodrigues et al.   LAB ANIMAL

Human NK Cells Proliferate and Die In Vivo More Rapidly than T Cells in Healthy Young and Elderly Adults

(2011) C. T. Lutz et al.   JOURNAL OF IMMUNOLOGY

Abnormal Changes in NKT Cells, the IGF-1 Axis, and Liver Pathology in an Animal Model of ALS

(2011) Arseny Finkelstein et al.   PLoS One

The Jak Inhibitor CP-690,550 Preserves the Function of CD4+CD25brightFoxP3+ Regulatory T Cells and Inhibits Effector T Cells

(2010) V. D. K. D. Sewgobind et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence

(2010) T. Strowig et al.   BLOOD

Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection

(2010) Mark E. Flanagan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Extracellular mutant SOD1 induces microglial-mediated motoneuron injury

(2009) Weihua Zhao et al.   GLIA

Bilirubin selectively inhibits cytochromecoxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid

(2009) Ana Rita Vaz et al.   JOURNAL OF NEUROCHEMISTRY

Phase 1 Dose-Escalation Study of CP-690 550 in Stable Renal Allograft Recipients: Preliminary Findings of Safety, Tolerability, Effects on Lymphocyte Subsets and Pharmacokinetics

(2008) E. van Gurp et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY

CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS

(2008) D. R. Beers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS

(2008) I. M. Chiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis

(2008) Anthony J Milici et al.   ARTHRITIS RESEARCH & THERAPY