CD3+CD4-CD8- (Double-Negative) T Cells in Inflammation, Immune Disorders and Cancer

Venetoclax enhances T cell-mediated anti-leukemic activity by increasing ROS production

(2021) JongBok Lee et al.   BLOOD

Shaping of T Cell Functions by Trogocytosis

(2021) Masafumi Nakayama et al.   Cells

Transcriptome landscape of double negative T cells by single-cell RNA sequencing

(2021) Lu Yang et al.   JOURNAL OF AUTOIMMUNITY

NKG2D Enhances Double-Negative T Cell Regulation of B Cells

(2021) Shi-hua Hu et al.   Frontiers in Immunology

TCR‐α/β CD4 − CD8 − double negative T cells arise from CD8 + T cells

(2020) Noé Rodríguez‐Rodríguez et al.   JOURNAL OF LEUKOCYTE BIOLOGY

MHC-Independent Thymic Selection of CD4 and CD8 Coreceptor Negative αβ T Cells

(2020) Roxanne Collin et al.   JOURNAL OF IMMUNOLOGY

Systemic lupus erythematosus favors the generation of IL-17 producing double negative T cells

(2020) Hao Li et al.   Nature Communications

CRISPR screen identifies genes that sensitize AML cells to double negative T cell therapy

(2020) Fraser Soares et al.   BLOOD

Developing allogeneic double negative T cells as a novel off-the-shelf adoptive cellular therapy for cancer

(2019) Jong Bok Lee et al.   CLINICAL CANCER RESEARCH

Human double negative T cells target lung cancer via ligand-dependent mechanisms that can be enhanced by IL-15

(2019) Junlin Yao et al.   Journal for ImmunoTherapy of Cancer

Targeting late-stage non-small cell lung cancer with a combination of DNT cellular therapy and PD-1 checkpoint blockade

(2019) Linan Fang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Human Double-Negative Regulatory T-Cells Induce a Metabolic and Functional Switch in Effector T-Cells by Suppressing mTOR Activity

(2019) Tabea Haug et al.   Frontiers in Immunology

Double-negative T Cells Inhibit Proliferation and Invasion of Human Pancreatic Cancer Cells in Co-culture

(2019) YIN LU et al.   ANTICANCER RESEARCH

Double negative T cells mediate Lag3-dependent antigen-specific protection in allergic asthma

(2019) Dan Tian et al.   Nature Communications

Targeting chemotherapy-resistant leukemia by combining DNT cellular therapy with conventional chemotherapy

(2018) Branson Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Critical role of OX40 in the expansion and survival of CD4 T-cell-derived double-negative T cells

(2018) Guangyong Sun et al.   Cell Death & Disease

Double negative T cells levels correlate with chronic graft-versus-host disease severity

(2018) Erin E. Hillhouse et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Infusion of ex-vivo expanded human TCR-αβ+ double-negative regulatory T cells delays onset of xenogeneic graft-versus -host disease

(2018) P. Achita et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Ox40 regulates the conversion and suppressive function of double-negative regulatory T cells

(2018) Kai Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia

(2018) Courtney D. DiNardo et al.   BLOOD

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia

(2018) Daniel A. Pollyea et al.   NATURE MEDICINE

Antipancreatic cancer effect of DNT cells and the underlying mechanism

(2018) Jiong Chen et al.   PANCREATOLOGY

Computational Immune Monitoring Reveals Abnormal Double-Negative T Cells Present across Human Tumor Types

(2018) Allison R. Greenplate et al.   Cancer Immunology Research

Potential role of IL-17-producing CD4/CD8 double negative αβ T cells in psoriatic skin inflammation in a TPA-induced STAT3C transgenic mouse model

(2017) Azumi Ueyama et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Tumor-infiltrating lymphocytes (TILs) from patients with glioma

(2017) Zhenjiang Liu et al.   OncoImmunology

Increased TCR signal strength in DN thymocytes promotes development of gut TCRαβ(+)CD8αα(+) intraepithelial lymphocytes

(2017) Capucine L. Grandjean et al.   Scientific Reports

A novel differentiation pathway from CD4+ T cells to CD4− T cells for maintaining immune system homeostasis

(2016) X Zhao et al.   Cell Death & Disease

Expansion of tumor-infiltrating lymphocytes (TIL) from human pancreatic tumors

(2016) MacLean Hall et al.   Journal for ImmunoTherapy of Cancer

CD4/CD8 Double-negative T-cell Lymphoma: A Variant of Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T-cell Lymphoma?

(2015) T Miyauchi et al.   ACTA DERMATO-VENEREOLOGICA

A77 1726, the active metabolite of leflunomide, attenuates lupus nephritis by promoting the development of regulatory T cells and inhibiting IL-17-producing double negative T cells

(2015) Guilin Qiao et al.   CLINICAL IMMUNOLOGY

IL-7 Abrogates the Immunosuppressive Function of Human Double-Negative T Cells by Activating Akt/mTOR Signaling

(2015) Andrea Allgäuer et al.   JOURNAL OF IMMUNOLOGY

Double-Negative    T Cells Are Early Responders to AKI and Are Found in Human Kidney

(2015) M. N. Martina et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Subset of CD4/CD8 Double-Negative T Cells Expresses HIV Proteins in Patients on Antiretroviral Therapy

(2015) Laura K. DeMaster et al.   JOURNAL OF VIROLOGY

Double-negative T resident memory cells of the lung react to influenza virus infection via CD11chi dendritic cells

(2015) K Neyt et al.   Mucosal Immunology

The production of alpha/beta and gamma/delta double negative (DN) T-cells and their role in the maintenance of pregnancy

(2015) John C. Chapman et al.   Reproductive Biology and Endocrinology

Abnormally differentiated CD4+ or CD8+ T cells with phenotypic and genetic features of double negative T cells in human Fas deficiency

(2014) A. Rensing-Ehl et al.   BLOOD

Transcriptional Profiling of Melanoma Sentinel Nodes Identify Patients with Poor Outcome and Reveal an Association of CD30+ T Lymphocytes with Progression

(2014) V. Vallacchi et al.   CANCER RESEARCH

Double Negative (DN) αβ T Cells: misperception and overdue recognition

(2014) Maria N Martina et al.   IMMUNOLOGY AND CELL BIOLOGY

CD4−CD8− T-cells in primary Sjögren's syndrome: Association with the extent of glandular involvement

(2014) Alessia Alunno et al.   JOURNAL OF AUTOIMMUNITY

Human TCR  / + CD4-CD8- Double-Negative T Cells in Patients with Autoimmune Lymphoproliferative Syndrome Express Restricted V  TCR Diversity and Are Clonally Related to CD8+ T Cells

(2014) A. Bristeau-Leprince et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: In Vivo Trogocytosis as a Mechanism of Double Negative Regulatory T Cell-Mediated Antigen-Specific Suppression

(2014) M. S. Ford McIntyre et al.   JOURNAL OF IMMUNOLOGY

Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys

(2014) J. C. Crispin et al.   JOURNAL OF IMMUNOLOGY

Role of gamma-delta (γδ ) T cells in autoimmunity

(2014) Sourav Paul et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The role of intrahepatic CD3+/CD4−/CD8− double negative T (DN T) cells in enhanced acetaminophen toxicity

(2014) Yonas Getachew et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

MHC Class II Restricted Innate-Like Double Negative T Cells Contribute to Optimal Primary and Secondary Immunity to Leishmania major

(2014) Zhirong Mou et al.   PLoS Pathogens

Identification of CD3 + CD4 − CD8 − T Cells as Potential Regulatory Cells in an Experimental Murine Model of Graft-Versus-Host Skin Disease (GVHD)

(2013) Fumi Miyagawa et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Multifunctional Double-negative T Cells in Sooty Mangabeys Mediate T-helper Functions Irrespective of SIV Infection

(2013) Vasudha Sundaravaradan et al.   PLoS Pathogens

CD4/CD8 Double Negative Mycosis Fungoides With PD-1 (CD279) Expression—A Disease of Follicular Helper T-Cells?

(2012) Werner Kempf et al.   AMERICAN JOURNAL OF DERMATOPATHOLOGY

IL-17-producing CD4−CD8−T cells are expanded in the peripheral blood, infiltrate salivary glands and are resistant to corticosteroids in patients with primary Sjögren's syndrome

(2012) Alessia Alunno et al.   ANNALS OF THE RHEUMATIC DISEASES

Clonal deletion and the fate of autoreactive thymocytes that survive negative selection

(2012) Leonid A Pobezinsky et al.   NATURE IMMUNOLOGY

CD4-CD8-αβ and γδ T Cells Display Inflammatory and Regulatory Potentials during Human Tuberculosis

(2012) Melina B. Pinheiro et al.   PLoS One

Autocrine IFNγ Controls the Regulatory Function of Lymphoproliferative Double Negative T Cells

(2012) Stephen C. Juvet et al.   PLoS One

Level of double negative T cells, which produce TGF-β and IL-10, predicts CD8 T-cell activation in primary HIV-1 infection

(2011) Gaël Petitjean et al.   AIDS

Fas death receptor signalling: roles of Bid and XIAP

(2011) T Kaufmann et al.   CELL DEATH AND DIFFERENTIATION

Characterization of the immunoregulatory function of human TCR-αβ+ CD4−CD8− double-negative T cells

(2011) Simon Voelkl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of antigen-expressing dendritic cells by double negative regulatory T cells

(2011) Julia Fang Gao et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Phenotypic and functional evaluation of CD3+CD4-CD8- T cells in human CD8 immunodeficiency

(2011) I. Bernardo et al.   HAEMATOLOGICA

Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4+ T cell loss is associated with double-negative T cells

(2011) Jeffrey M. Milush et al.   JOURNAL OF CLINICAL INVESTIGATION

CD4-Like Immunological Function by CD4- T Cells in Multiple Natural Hosts of Simian Immunodeficiency Virus

(2011) C. Vinton et al.   JOURNAL OF VIROLOGY

Anti-leukemia effect of ex vivo expanded DNT cells from AML patients: a potential novel autologous T-cell adoptive immunotherapy

(2011) S Merims et al.   LEUKEMIA

Peripheral T-cell Lymphoma With a Regulatory T-cell Phenotype

(2011) Brady E. Beltran et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Analysis of gene profile, steady state proliferation and apoptosis of double-negative T cells in the periphery and gut epithelium provides new insights into the biological functions of the Fas pathway

(2010) Abdel Rahim A. Hamad   IMMUNOLOGIC RESEARCH

Interleukin-10 limits the expansion of immunoregulatory CD4− CD8− T cells in autoimmune-prone non-obese diabetic mice

(2010) Erin E Hillhouse et al.   IMMUNOLOGY AND CELL BIOLOGY

Lung CD4-CD8- Double-Negative T Cells Are Prominent Producers of IL-17A and IFN-  during Primary Respiratory Murine Infection with Francisella tularensis Live Vaccine Strain

(2010) S. C. Cowley et al.   JOURNAL OF IMMUNOLOGY

The Fas–FADD death domain complex structure reveals the basis of DISC assembly and disease mutations

(2010) Liwei Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Double Negative (CD3+4−8−) TCRαβ Splenic Cells from Young NOD Mice Provide Long-Lasting Protection against Type 1 Diabetes

(2010) Beverly Duncan et al.   PLoS One

The Role of IL-23/IL-17 Axis in Lupus Nephritis

(2009) Z. Zhang et al.   JOURNAL OF IMMUNOLOGY

Human TCR-  + CD4- CD8- T Cells Can Derive from CD8+ T Cells and Display an Inflammatory Effector Phenotype

(2009) J. C. Crispin et al.   JOURNAL OF IMMUNOLOGY

Double-negative regulatory T cells induce allotolerance when expanded after allogeneic haematopoietic stem cell transplantation

(2008) Z. McIver et al.   BRITISH JOURNAL OF HAEMATOLOGY

Normal mouse kidneys contain activated and CD3+ CD4− CD8− double-negative T lymphocytes with a distinct TCR repertoire

(2008) Dolores B. Ascon et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Fas-Mediated Apoptosis Regulates the Composition of Peripheral αβ T Cell Repertoire by Constitutively Purging Out Double Negative T Cells

(2008) Abdiaziz S. Mohamood et al.   PLoS One