Review
Immunology
Hai-Di Li, Yong-Ke You, Bao-Yi Shao, Wei-Feng Wu, Yi-Fan Wang, Jian-Bo Guo, Xiao-Ming Meng, Haiyong Chen
Summary: Diabetic nephropathy is the most common chronic kidney disease, and the activation and transition of resident macrophages play a crucial role in causing renal inflammation and fibrosis. Inhibiting macrophage activation and macrophage-cell interactions may be a promising approach to attenuate diabetic nephropathy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Xiaohui Li, Jialu Liu, Mengru Zeng, Kexin Yang, Shumin Zhang, Yifei Liu, Xiangxiang Yin, Chanyue Zhao, Wenpeng Wang, Li Xiao
Summary: This study identified key genes related to macrophage-mediated inflammation in diabetic nephropathy through bioinformatics analysis and experimental validation. These genes, including CASP1, MS4A4A, CD53, and GBP2, may be involved in the progression of diabetic nephropathy. Among them, GBP2 may serve as a prognostic biomarker and intervention target for diabetic nephropathy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell & Tissue Engineering
Yaqi Zhang, Xi Le, Shuo Zheng, Ke Zhang, Jing He, Mengting Liu, Chengshu Tu, Wei Rao, Hongyuan Du, Yu Ouyang, Changyong Li, Dongcheng Wu
Summary: This study demonstrates that MSCs derived from human umbilical cords can protect renal function in rats with diabetic nephropathy by altering macrophage phenotype. UC-MSCs-derived miR-146a-5p promotes the anti-inflammatory phenotype of macrophages by inhibiting the TRAF6/STAT1 signaling pathway and effectively improves renal function.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Engineering, Biomedical
Hao Yang, Liu Song, Bingxue Sun, Di Chu, Leilei Yang, Meng Li, Huan Li, Yun Dai, Zhuo Yu, Jianfeng Guo
Summary: The study confirmed the potential of paeoniflorin (PF) for transitioning macrophages and developed a high molecular weight hyaluronic acid (HA) hydrogel that significantly promoted cutaneous healing in experimental diabetic mice, showing promising clinical translation potential.
MATERIALS TODAY BIO
(2021)
Article
Medicine, Research & Experimental
Ruyu Ma, Yinghao He, Qing Fang, Gaoyu Xie, Minyou Qi
Summary: This study aimed to investigate the nephroprotective effect of ferulic acid (FA) on diabetic nephropathy (DN) and its underlying mechanism using a mouse model. The results showed that FA reduced body weight and fasting blood glucose levels, improved renal organ coefficient, and decreased protein and nitrogen levels in urine and blood, as well as cholesterol levels in serum. Additionally, FA enhanced autophagy and suppressed inflammation in the renal tissues. These findings suggest that FA plays a positive role in alleviating renal injury in DN mice.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Xibao Zhao, Qianqian Di, Han Liu, Jiazheng Quan, Jing Ling, Zizhao Zhao, Yue Xiao, Han Wu, Zherui Wu, Wengang Song, Huazhang An, Weilin Chen
Summary: This study demonstrates the critical role of MEF2C in regulating macrophage polarization, with involvement in inflammation and host defense through promoting the expression of interleukin-12. MEF2C deficiency leads to increased susceptibility to certain infections and protection against certain intestinal diseases.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Cell Biology
Hadeel Al Sadoun
Summary: Macrophage differentiation and polarization are crucial for successful wound healing. Macrophages exhibit plasticity, allowing them to adopt different functional states, contributing to inflammation resolution and tissue regeneration. Reparative macrophages are a source of growth factors, playing a critical role in wound repair. Dysregulation of macrophages is associated with nonhealing wounds and fibrosis. Therapeutic manipulation of macrophages, such as promoting secretion of growth factors, shows promise in promoting wound healing. The example of Hoxa3 overexpression highlights the potential of repolarizing macrophages as a therapeutic strategy.
Article
Biochemistry & Molecular Biology
Yanhong Ma, Fanghao Cai, Xiaohan Huang, Huijing Wang, Binfeng Yu, Junni Wang, Wanyun Nie, Kedan Cai, Yi Yang, Jianghua Chen, Liang Xiao, Fei Han
Summary: Increased serum mannose-binding lectin (MBL) level has been proven to correlate with the development of diabetic nephropathy (DN). This study found that MBL promotes the progression of DN by activating the nuclear factor-kappa B pathway in macrophages. This finding provides a new direction for the treatment of DN patients.
Article
Cell Biology
Miao Chen, Weimin Lin, Rui Ye, Jianru Yi, Zhihe Zhao
Summary: The study found that PPAR beta/delta agonist significantly improved the osteoporotic phenotypes of diabetic mice by modulating macrophage dysfunction to reduce osteoclast activity. Additionally, Angptl4 may act as a target of PPAR beta/delta to regulate macrophage polarization.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Biomedical
Zhipeng Zhou, Tuo Deng, Maixian Tao, Lisha Lin, Luyun Sun, Xuemei Song, Dongxiu Gao, Jixing Li, Zhongjuan Wang, Xingzi Wang, Jinpeng Li, Zexiu Jiang, Lan Luo, Lian Yang, Mingyi Wu
Summary: Diabetic foot ulcers (DFUs) are a severe and rapidly growing diabetic complication. A natural adhesive from snail mucus has been discovered to promote skin wound healing. A double-network hydrogel biomaterial composed of snail glycosaminoglycan (AFG) and methacrylated gelatin (GelMA) was developed, which exhibited strong tissue adhesion, anti-inflammatory activity, and biocompatibility. The AFG/GelMA hydrogel effectively promoted chronic wound healing.
Article
Oncology
Yu Wang, Jingqiu Cui, Ming Liu, Yingqi Shao, Xiaoying Dong
Summary: The study demonstrated that Schisandrin C has protective effects during the treatment of diabetic nephropathy by regulating macrophage polarization and the Swiprosin-1/IFN-gamma-R ss signaling pathway, providing a potential novel strategy for DN therapy.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
M. Amelie Jule, J. Kacie Hoyt, Kevin Wei, Maria Gutierrez-Arcelus, L. Maria Taylor, Julie Ng, A. James Lederer, M. Siobhan Case, H. Margaret Chang, M. Ezra Cohen, Fatma Dedeoglu, M. Melissa Hazen, S. Jonathan Hausmann, Olha Halyabar, Erin Janssen, Jeffrey Lo, S. Mindy Lo, Esra Meidan, E. Jordan Roberts, F. Mary Beth Son, P. Robert Sundel, Y. Pui Lee, Talal Chatila, A. Peter Nigrovic, A. Lauren Henderson
Summary: Oligoarticular juvenile idiopathic arthritis (oligo JIA) is characterized by Th1 polarization, particularly prominent in CD4+ T cells, while not compromising the regulatory identity of Tregs. Single-cell RNA-Seq revealed heterogeneous effector and regulatory subpopulations in synovial fluid, including IFN-induced Tregs, peripheral helper T cells, and cytotoxic CD4+ T cells.
Article
Medicine, Research & Experimental
Jinxiang Li, Shuling Yue, Jingwen Fang, Junling Zeng, Siqi Chen, Jianwei Tian, Sheng Nie, Xiaoting Liu, Hanying Ding
Summary: TGF-beta/Smad signaling is crucial for fibrosis development in DKD, and miR-10a/b can regulate TGFBR1 and TGF-beta/Smad signaling activation to influence fibrosis in DKD.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Medicine, Research & Experimental
Xiaohan Wu, He Li, Zhijie Wan, Ran Wang, Jing Liu, Qingfeng Liu, Haiyun Zhao, Zhehuan Wang, Huiru Zhang, Hui Guo, Caihong Qi, Xiangyue Jiao, Xiaotian Li
Summary: This study investigates the combined effects of ursolic acid and empagliflozin in treating diabetic nephropathy using a diabetic rat model. The results showed that the combination treatment was more effective in improving blood glucose, renal function indicators, inflammation levels, oxidative stress responses, and renal fibrosis compared to monotherapy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Jingbo Zhou, Shu Zhang, Xinyi Sun, Yan Lou, Jinjing Bao, Jiangyi Yu
Summary: The study demonstrated that hyperoside can improve high glucose-induced cell injury and prevent diabetic symptoms and renal dysfunction in mice with diabetic nephropathy. It achieves these effects by targeting the miR-499-5p/APC axis, indicating a potential therapeutic strategy for diabetic nephropathy.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Review
Physiology
Victor Segura-Ibarra, Suhong Wu, Nida Hassan, Jose A. Moran-Guerrero, Mauro Ferrari, Ashrith Guha, Harry Karmouty-Quintana, Elvin Blanco
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Pharmacology & Pharmacy
Yan Ting Liu, Shreya Goel, Megumi Kai, Jose Alberto Moran Guerrero, Thao Nguyen, Junhua Mai, Haifa Shen, Arturas Ziemys, Kenji Yokoi
Summary: Our study showed that tumors derived from different seed and soil sources exhibited varying responses to immunotherapy, with differences in PD-L1 expression, therapeutic delivery, immune cell accumulation, and tumor coagulation. This highlights the importance of understanding organ-specific heterogeneity in the delivery and response to immunotherapy in polyclonal tumors.
Article
Multidisciplinary Sciences
Cuiyan Xin, Jiahui Lei, Qian Wang, Yixia Yin, Xiaoqian Yang, Jose Alberto Moran Guerrero, Venkata Sabbisetti, Xiaoming Sun, Vishal S. Vaidya, Joseph V. Bonventre
Summary: This study demonstrates that targeting SMOC2 can effectively improve inflammation, fibrosis, and kidney function loss in chronic kidney disease, providing a potential approach to prevent disease progression.
Review
Clinical Neurology
Hector R. Martinez, Jose A. Figueroa-Sanchez, Carlos A. Arreola-Aldape, Jose Alberto Moran Guerrero, Ana Luisa Trujillo-Bracho, Alejandro Cantu Lopez
Summary: Capsular warning syndrome (CWS) is characterized by recurrent episodes of unilateral transient motor and/or sensory symptoms without cortical signs, with a high risk of stroke development. Small perforating artery disease is the most common underlying mechanism. This study aimed to assess the risk factors, treatment options, and outcomes in CWS patients. The review found that hypertension, diabetes, and smoking were common risk factors, and dual antiplatelet therapy and anticoagulation therapy showed favorable results.
FRONTIERS IN NEUROLOGY
(2023)