Article
Physiology
Wenmin Dong, Huiqian Zhang, Cheng Zhao, Yun Luo, Ying Chen
Summary: The study revealed that silencing miR-150-5p played a protective role in the kidneys of DN mice by targeting SIRT1, leading to activation of AMPK-dependent autophagy.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cell Biology
Shiqi Jin, Yu Song, Li Zhou, Wei Jiang, Liping Qin, Yufeng Wang, Ruiqi Yu, Yuting Liu, Yujie Diao, Fan Zhang, Kaixuan Liu, Peishan Li, Huili Hu, Baichun Jiang, Wei Tang, Fan Yi, Yaoqin Gong, Guangyi Liu, Gongping Sun
Summary: Diabetic kidney disease (DKD) is the most prevalent chronic kidney disease, and macrophage infiltration plays a critical role in its progression. This study reveals that myeloid deficiency of CUL4B alleviates diabetes-induced renal injury and fibrosis. The mechanism involves the CUL4B/miR-194-5p/ITGA9 axis, where CUL4B promotes migration and adhesion of macrophages by repressing miR-194-5p expression and increasing ITGA9 levels.
Article
Integrative & Complementary Medicine
Rong Zheng, Weijie Zhang, Jufang Song, Yifei Zhong, Rong Zhu
Summary: The study found that cordycepin produced by Cordyceps militaris can alleviate oxidative stress and inflammation in diabetic nephropathy by regulating the expression of the miR-193b-5p/MCL-1 axis.
Article
Endocrinology & Metabolism
Li Zhao, Huaqian Chen, Lin Wu, Zhengdong Li, Ren Zhang, Yan Zeng, Tao Yang, Hualing Ruan
Summary: This study revealed that upregulated KCNQ1OT1 in DN patients and cell models inhibited cell proliferation and fibrosis while inducing apoptosis. It was found that miR-93-5p is a direct target of KCNQ1OT1, and targeting ROCK2, miR-93-5p overexpression can suppress cell proliferation and fibrosis. KCNQ1OT1 regulates ROCK2 expression by binding to miR-93-5p, providing potential value for DN treatment.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Endocrinology & Metabolism
W. Zhang, L. Zhang, Q. Dong, X. Wang, Z. Li, Q. Wang
Summary: Diabetic nephropathy (DN) is a complication of diabetes with high mortality, but its specific pathogenesis is unclear. Recent studies have shown the involvement of circRNAs in DN, but the functional mechanism of circ_0003928 remains unknown and further investigation is needed to understand its significance in DN prevention.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Cell Biology
DongWei Liu, FengXun Liu, ZhengYong Li, ShaoKang Pan, JunWei Xie, ZiHao Zhao, ZhenJie Liu, JiaHui Zhang, ZhangSuo Liu
Summary: This study found that miR-483-5p is decreased in kidney tissues of diabetic mice and in tubular epithelial cells stimulated with high glucose, but increased in exosomes derived from diabetic mouse kidney tissues. miR-483-5p inhibits fibrosis-related gene expressions by binding to TIMP2 and MAPK1, thus alleviating the progression of DN-induced renal interstitial fibrosis.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Natalia Baulina, Maria Pisklova, Ivan Kiselev, Olga Chumakova, Dmitry Zateyshchikov, Olga Favorova
Summary: This study analyzed the levels of miRNAs in the plasma of hypertrophic cardiomyopathy (HCM) patients and identified miR-499a-5p as a dysregulated miRNA in HCM. Further investigation showed that carriers of pathogenic/likely pathogenic variants in the MYH7 gene had higher levels of miR-499a-5p compared to controls and carriers of MYBPC3 gene variants. The study suggests that miR-499a-5p could serve as a circulating biomarker for HCM caused by MYH7 gene variants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Qin Li, Xiangjian Meng, Qiang Hua
Summary: In this study, the role of circ ASAP2 in diabetes nephropathy (DN) was investigated. It was found that circ ASAP2 can regulate inflammation and ferroptosis in DN. Inhibition of ASAP2 aggravated renal injury and promoted inflammation and oxidative stress in mice model. Additionally, miR-770-5p was shown to have a negative effect in DN, exacerbating renal injury.
ACTA DIABETOLOGICA
(2023)
Article
Cell Biology
Yi-Chun Tsai, Mei-Chuan Kuo, Wei-Wen Hung, Ping-Hsun Wu, Wei-An Chang, Ling-Yu Wu, Su-Chu Lee, Ya-Ling Hsu
Summary: Diabetic nephropathy (DN) is a growing concern for human health and is considered to be the main cause of end-stage renal disease worldwide. The role of exosomes in DN is still unclear, but they may play a crucial role in cross-talk among kidney cells.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Immunology
Hongqiang An, Chu Chu, Zhen Zhang, Yunhong Zhang, Ran Wei, Bin Wang, Ke Xu, Lihua Li, Yonglin Liu, Gang Li, Xia Li
Summary: This study found a negative correlation between miR-19a-5p and IL-17A in postmenopausal osteoporosis. miR-19a-5p can directly bind to the 3' UTR region of IL-17A to regulate its expression. The herbal medicine Hyperoside, used for treating postmenopausal osteoporosis, can improve bone structure in mice by enhancing miR-19a-5p-mediated IL-17A downregulation.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Farnoush Kiyanpour, Maryam Abedi, Yousof Gheisari
Summary: miR-802-5p plays a critical role in diabetic kidney disease by participating in the renin-angiotensin pathway and inflammatory pathways, contributing to disease pathogenesis.
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
(2023)
Article
Cell Biology
Hui Chen, Yuan Guo, Xingbo Cheng
Summary: This research investigated the impact of long non-coding RNA XIST on diabetic nephropathy (DN). The study demonstrated that XIST depletion suppressed cell proliferation and induced apoptosis via the miR-423-5p/HMGA2 axis in high-glucose-treated human kidney cells, suggesting a potential therapeutic target for DN.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Cell Biology
Yu-Rui Duan, Bao-Ping Chen, Fang Chen, Su-Xia Yang, Chao-Yang Zhu, Ya-Li Ma, Yang Li, Jun Shi
Summary: The study showed that lncRNA lnc-ISG20 is up-regulated in the glomerular of patients with diabetic nephropathy (DN). Silencing lnc-ISG20 alleviated fibrosis in kidney cells and delayed renal fibrosis in DN mice. The downstream miRNA of lnc-ISG20, miR-486-5p, was found to inhibit NFAT5 expression by binding to its 3'UTR.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Genetics & Heredity
Yi-Fan Liu, Ming Zhang, Yan-Ju Shan, Li-Chuan Pang, Gai-Ge Ji, Xiao-Jun Ju, Yun-Jie Tu, Shi-Ying Shi, Hao Bai, Jian-Min Zou, Jing-Ting Shu
Summary: This study investigates the effects of miR-499-5p and SOX6 on muscle fiber type and their regulatory mechanism. miR-499-5p overexpression leads to significant changes in gene expression, including genes related to slow-twitch muscle. Functional enrichment analysis shows that differentially expressed genes are mostly associated with muscle development and fiber-related processes.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Rong Fang, Xiangchang Cao, Yaping Zhu, Qiming Chen
Summary: This study found that hsa_circ_0037128 promotes high glucose-induced podocyte injury by regulating the miR-31-5p/KLF9 axis, suggesting that hsa_circ_0037128 may be a target for DN treatment.