The combination of ursolic acid and empagliflozin relieves diabetic nephropathy by reducing inflammation, oxidative stress and renal fibrosis

Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice

(2020) Yanyan Zhu et al.   PHARMACOLOGICAL RESEARCH

Korean red ginseng attenuates hyperglycemia-induced renal inflammation and fibrosis via accelerated autophagy and protects against diabetic kidney disease

(2020) Shanika Karunasagara et al.   JOURNAL OF ETHNOPHARMACOLOGY

Potential application of nanoemulsified garlic oil blend in mitigating the progression of type 2 diabetes-mediated nephropathy in Wistar rats

(2020) Muralidaran Yuvashree et al.   3 Biotech

The TGF-β profibrotic cascade targets ecto-5′-nucleotidase gene in proximal tubule epithelial cells and is a traceable marker of progressive diabetic kidney disease

(2020) Claudio Cappelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Nepeta angustifolia C. Y. Wu improves renal injury in HFD/STZ-induced diabetic nephropathy and inhibits oxidative stress-induced apoptosis of mesangial cells

(2020) Shan Huang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Baicalin attenuates fibrogenic process in human renal proximal tubular cells (HK−2) exposed to diabetic milieu

(2020) Jung Eun Nam et al.   LIFE SCIENCES

Hirudin reduces nephropathy microangiopathy in STZ-induced diabetes rats by inhibiting endothelial cell migration and angiogenesis

(2020) Xinxin Pang et al.   LIFE SCIENCES

Tetrandrine mediates renal function and redox homeostasis in a streptozotocin-induced diabetic nephropathy rat model through Nrf2/HO-1 reactivation

(2020) Luyu Su et al.   Annals of Translational Medicine

Erianin protects against high glucose-induced oxidative injury in renal tubular epithelial cells

(2019) Mei-Fen Chen et al.   FOOD AND CHEMICAL TOXICOLOGY

GdCl3 attenuates the glomerular sclerosis of streptozotocin (STZ) induced diabetic rats via inhibiting TGF-β/Smads signal pathway

(2019) Jialin Li et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

All-Trans Retinoic Acid Attenuates Fibrotic Processes by Downregulating TGF-β1/Smad3 in Early Diabetic Nephropathy

(2019) Edith Sierra-Mondragon et al.   Biomolecules

Bergenin impedes the generation of extracellular matrix in glomerular mesangial cells and ameliorates diabetic nephropathy in mice by inhibiting oxidative stress via the mTOR/β-TrcP/Nrf2 pathway

(2019) Simiao Qiao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Gentiopicroside activates the bile acid receptor Gpbar1 (TGR5) to repress NF-kappaB pathway and ameliorate diabetic nephropathy

(2019) Haiming Xiao et al.   PHARMACOLOGICAL RESEARCH

Ginger alleviates hyperglycemia-induced oxidative stress, inflammation and apoptosis and protects rats against diabetic nephropathy

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Urinary IgG4 and Smad1 Are Specific Biomarkers for Renal Structural and Functional Changes in Early Stages of Diabetic Nephropathy

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Ursolic acid in health and disease

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(2017) Yan Zheng et al.   Nature Reviews Endocrinology

Simvastatin Ameliorates Diabetic Cardiomyopathy by Attenuating Oxidative Stress and Inflammation in Rats

(2017) Nawal M. Al-Rasheed et al.   Oxidative Medicine and Cellular Longevity

The protective effect of betulinic acid (BA) diabetic nephropathy on streptozotocin (STZ)-induced diabetic rats

(2017) Rui Xie et al.   Food & Function

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SGLT2 Inhibitors and the Diabetic Kidney

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Anti-Diabetic Agent Sodium Tungstate Induces the Secretion of Pro- and Anti-Inflammatory Cytokines by Human Kidney Cells

(2016) Romina Bertinat et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and GRAP pathways

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The Protective Effect of Beraprost Sodium on Diabetic Nephropathy by Inhibiting Inflammation and p38 MAPK Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Rats

(2016) Li Peng et al.   International Journal of Endocrinology

Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice

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Nitrate/Nitrite as Critical Mediators to Limit Oxidative Injury and Inflammation

(2015) Paul Waltz et al.   ANTIOXIDANTS & REDOX SIGNALING

NZ suppresses TLR4/NF-κB signalings and NLRP3 inflammasome activation in LPS-induced RAW264.7 macrophages

(2015) Pengjun Xiang et al.   INFLAMMATION RESEARCH

Relevance of TNF-α in the context of other inflammatory cytokines in the progression of diabetic nephropathy

(2015) Lin Sun et al.   KIDNEY INTERNATIONAL

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Ursolic Acid Provides Kidney Protection in Diabetic Rats

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Kidney-targeting Smad7 gene transfer inhibits renal TGF-β/MAD homologue (SMAD) and nuclear factor κB (NF-κB) signalling pathways, and improves diabetic nephropathy in mice

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Effects of Panax notoginoside on the expression of TGF-β1 and Smad-7 in renal tissues of diabetic rats

(2011) Qingnian Tu et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

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Effects of α-lipoic acid on transforming growth factor β1–p38 mitogen-activated protein kinase–fibronectin pathway in diabetic nephropathy

(2009) Seong Jin Lee et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Oxidative Stress as a Major Culprit in Kidney Disease in Diabetes

(2008) J. M. Forbes et al.   DIABETES

A copper(II)-selective chelator ameliorates diabetes-evoked renal fibrosis and albuminuria, and suppresses pathogenic TGF-β activation in the kidneys of rats used as a model of diabetes

(2008) D. Gong et al.   DIABETOLOGIA

Bone Morphogenetic Protein-2 Antagonizes Renal Interstitial Fibrosis by Promoting Catabolism of Type I Transforming Growth Factor-β Receptors

(2008) Yu-Lin Yang et al.   ENDOCRINOLOGY

Ursolic acid: An anti- and pro-inflammatory triterpenoid

(2008) Yasutaka Ikeda et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The pathogenesis of diabetic nephropathy

(2008) Suma Dronavalli et al.   Nature clinical practice. Endocrinology & metabolism