Assessment of the Antimicrobial and Antiproliferative Activities of Chloropyrazine-Tethered Pyrimidine Derivatives: In Vitro, Molecular Docking, and In-Silico Drug-Likeness Studies

Structural and antioxidant properties of guanylhydrazinium pyrazine-2-carboxylate

(2021) S. Packiaraj et al.   Journal of Materials Science: Materials in Electronics

Design, Synthesis and Biological Evaluation of New Pyrimidine Derivatives as Anticancer Agents

(2021) Valentina Noemi Madia et al.   MOLECULES

Design and biological evaluation of a novel type of potential multi-targeting antimicrobial sulfanilamide hybrids in combination of pyrimidine and azoles

(2020) Yan-Fei Sui et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, Synthesis, and Biological Evaluation of Two Series of Novel A-Ring Fused Steroidal Pyrazines as Potential Anticancer Agents

(2020) Shijun Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Eco‐friendly synthesis of novel pyrimidine derivatives as potential anticancer agents

(2020) Eslam M. Abbass et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

One-Pot Multicomponent Synthesis and Cytotoxic Evaluation of Novel 7-Substituted-5-(1H-Indol-3-yl)Tetrazolo[1,5-a] Pyrimidine-6-Carbonitrile

(2020) Mohamed A. A. Radwan et al.   MOLECULES

Biological Evaluation and Molecular Docking with In Silico Physicochemical, Pharmacokinetic and Toxicity Prediction of Pyrazolo[1,5-a]pyrimidines

(2020) Ahmed M. Naglah et al.   MOLECULES

Synthesis of Functionalised Chromonyl‐pyrimidines and Their Potential as Antimycobacterial Agents

(2020) Kristiana T. Santoso et al.   ChemistrySelect

Green synthesis and investigation of antioxidant ability new pyrazines containing pyrrolo[2,1‐a]isoquinolines derivatives

(2020) Seyyed Ali Moghaddas et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Photosensitive and pH-dependent activity of pyrazine-functionalized carbazole derivative as promising antifungal and imaging agent

(2020) Agnieszka Chylewska et al.   Scientific Reports

A convenient synthesis, reactions and biological evaluation of novel pyrazolo[3,4-b]selenolo[3,2-e]pyrazine heterocycles as potential anticancer and antimicrobial agents

(2020) Remon M. Zaki et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis of pyrazinamide analogues and their antitubercular bioactivity

(2020) First A. Wati et al.   MEDICINAL CHEMISTRY RESEARCH

Staphylococcus xylosus VITURAJ10: Pyrrolo [1,2α] pyrazine-1,4-dione, hexahydro-3-(2-methylpropyl) (PPDHMP) producing, potential probiotic strain with antibacterial and anticancer activity

(2020) Upasana Mangrolia et al.   MICROBIAL PATHOGENESIS

Mutually Isomeric 2- and 4-(3-Nitro-1,2,4-triazol-1-yl)pyrimidines Inspired by an Antimycobacterial Screening Hit: Synthesis and Biological Activity against the ESKAPE Panel of Pathogens

(2020) Sergey Chuprun et al.   Antibiotics-Basel

Synthesis, and biological screening of chloropyrazine conjugated benzothiazepine derivatives as potential antimicrobial, antitubercular and cytotoxic agents

(2020) Afzal B. Shaik et al.   Arabian Journal of Chemistry

Catalyst-Free Synthesis of Xanthene and Pyrimidine-Fused Heterocyclic Derivatives at Water-Ethanol Medium and Their Antioxidant Properties

(2019) Reddi Mohan Naidu Kalla et al.   ChemistrySelect

DHFR Inhibitors: Reading the Past for Discovering Novel Anticancer Agents

(2019) Maria Raimondi et al.   MOLECULES

Synthesis, In Vitro Antimicrobial and Cytotoxic Activities of Some New Pyrazolo[1,5-a]pyrimidine Derivatives

(2019) Ahmed Fouda et al.   MOLECULES

Probing the Effects of Pyrimidine Functional Group Switches on Acyclic Fleximer Analogues for Antiviral Activity

(2019) Mary K. Yates et al.   MOLECULES

New pyrimidine-benzoxazole/benzimidazole hybrids: Synthesis, antioxidant, cytotoxic activity, in vitro cyclooxygenase and phospholipase A2-V inhibition

(2019) Mohamed A. Abdelgawad et al.   BIOORGANIC CHEMISTRY

Structure elaboration of isoniazid: synthesis, in silico molecular docking and antimycobacterial activity of isoniazid–pyrimidine conjugates

(2019) Hardeep Kaur et al.   MOLECULAR DIVERSITY

The bioisosteric modification of pyrazinamide derivatives led to potent antitubercular agents: Synthesis via click approach and molecular docking of pyrazine-1,2,3-triazoles

(2019) Rajkumar Reddyrajula et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Expansion of chemical space based on a pyrrolo[1,2-a]pyrazine core: Synthesis and its anticancer activity in prostate cancer and breast cancer cells

(2019) Yohan Seo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Convenient Synthesis, Reactions and Biological Activities of Some Novel Thieno[3,2-e]pyrazolo[3,4-b]pyrazine Compounds as Anti-microbial and Anti-inflammatory agents

(2018) Remon Zaki et al.   CURRENT ORGANIC SYNTHESIS

Ionic Liquid-Promoted Synthesis of Novel Chromone-Pyrimidine Coupled Derivatives, Antimicrobial Analysis, Enzyme Assay, Docking Study and Toxicity Study

(2018) Shailee Tiwari et al.   MOLECULES

Chalcones and their pyrazine analogs: synthesis, inhibition of aldose reductase, antioxidant activity, and molecular docking study

(2018) Marta Kucerova-Chlupacova et al.   MONATSHEFTE FUR CHEMIE

Asymmetric synthesis and antiviral activity of novel chiral amino-pyrimidine derivatives

(2018) Song Bai et al.   TETRAHEDRON LETTERS

Synthesis of Spirooxindole-O-Naphthoquinone-Tetrazolo[1,5-a]Pyrimidine Hybrids as Potential Anticancer Agents

(2018) Liqiang Wu et al.   MOLECULES

Anticancer and Anti-Inflammatory Activities of Some New Pyrazolo[3,4-b]pyrazines

(2018) Hussein El-Kashef et al.   MOLECULES

Acridone-pyrimidine hybrids- design, synthesis, cytotoxicity studies in resistant and sensitive cancer cells and molecular docking studies

(2017) Manikanta Murahari et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Antibacterial Activity of Benzo[4,5]isothiazolo[2,3-a]pyrazine-6,6-dioxide Derivatives

(2017) Jatinder Bassin et al.   MOLECULES

3-Substituted N-Benzylpyrazine-2-carboxamide Derivatives: Synthesis, Antimycobacterial and Antibacterial Evaluation

(2017) Lucia Semelková et al.   MOLECULES

Synthesis and Evaluation of Curcuminoid Analogues as Antioxidant and Antibacterial Agents

(2017) Dalia Emam et al.   MOLECULES

Studies on synthesis of pyrimidine derivatives and their antimicrobial activity

(2017) C. Mallikarjunaswamy et al.   Arabian Journal of Chemistry

An Efficient Synthesis of Novel Pyrazole-Based Heterocycles as Potential Antitumor Agents

(2017) Magda Abdallah et al.   Applied Sciences-Basel

Synthesis and molecular modeling of antimicrobial active fluoroquinolone–pyrazine conjugates with amino acid linkers

(2016) Siva S. Panda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel Halogenated Pyrazine-Based Chalcones as Potential Antimicrobial Drugs

(2016) Marta Kucerova-Chlupacova et al.   MOLECULES

Novel pyrazole-5-carboxamide and pyrazole–pyrimidine derivatives: Synthesis and anticancer activity

(2015) Jing Bo Shi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, and structure–activity relationship for C(4) and/or C(5) thienyl substituted pyrimidines, as a new family of antimycobacterial compounds

(2015) Egor V. Verbitskiy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of N-Alkyl-3-(alkylamino)-pyrazine-2-carboxamides

(2015) Lucia Semelkova et al.   MOLECULES

Utility of 3-Acetyl-6-bromo-2H-chromen-2-one for the Synthesis of New Heterocycles as Potential Antiproliferative Agents

(2015) Sobhi Gomha et al.   MOLECULES

Novel Pyrazine Analogs of Chalcones: Synthesis and Evaluation of Their Antifungal and Antimycobacterial Activity

(2015) Marta Kucerova-Chlupacova et al.   MOLECULES

Synthesis, in vitro anticancer activity and SAR studies of arylated imidazo[1,2-a]pyrazine–coumarin hybrids

(2015) Richa Goel et al.   RSC Advances

Unequivocal Role of Pyrazine Ring in Medicinally Important Compounds: A Review

(2015) Pankaj Miniyar et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Synthesis and cytotoxic evaluation for some new 2,5-disubstituted pyrimidine derivatives for anticancer activity

(2014) Onteddu Surendranatha Reddy et al.   MEDICINAL CHEMISTRY RESEARCH

Heterocycles in drugs and drug discovery

(2012) A. Gomtsyan   Chemistry of Heterocyclic Compounds

In Vitro Antibacterial and Antifungal Activity of Salicylanilide Pyrazine-2- carboxylates

(2012) Martin Kratky et al.   Medicinal Chemistry

Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor

(2010) Jason D. Burch et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS