Morphological Characterization of Antibiotic Combinations

High-Content Imaging to Phenotype Antimicrobial Effects on Individual Bacteria at Scale

(2021) Sushmita Sridhar et al.   mSystems

Transfer Learning with Deep Convolutional Neural Networks for Classifying Cellular Morphological Changes

(2019) Alexander Kensert et al.   SLAS Discovery

Prediction of ultra-high-order antibiotic combinations based on pairwise interactions

(2019) Itay Katzir et al.   PLoS Computational Biology

Drug combinations: a strategy to extend the life of antibiotics in the 21st century

(2019) Mike Tyers et al.   NATURE REVIEWS MICROBIOLOGY

Bacterial Cytological Profiling as a Tool To Study Mechanisms of Action of Antibiotics That Are Active against Acinetobacter baumannii

(2019) Htut Htut Htoo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Morphological Deconvolution of Beta-Lactam Polyspecificity in E. coli

(2019) William J. Godinez et al.   ACS Chemical Biology

Pretomanid: First Approval

(2019) Susan J. Keam   DRUGS

A deep learning and novelty detection framework for rapid phenotyping in high-content screening

(2017) Christoph Sommer et al.   MOLECULAR BIOLOGY OF THE CELL

Automated analysis of high‐content microscopy data with deep learning

(2017) Oren Z Kraus et al.   Molecular Systems Biology

Data-analysis strategies for image-based cell profiling

(2017) Juan C Caicedo et al.   NATURE METHODS

Bacteria Getting into Shape: Genetic Determinants of E. coli Morphology

(2017) Shawn French et al.   mBio

Game Changers: New β-Lactamase Inhibitor Combinations Targeting Antibiotic Resistance in Gram-Negative Bacteria

(2017) Karen Bush   ACS Infectious Diseases

CellProfiler Analyst: interactive data exploration, analysis and classification of large biological image sets

(2016) David Dao et al.   BIOINFORMATICS

Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes

(2016) Mark-Anthony Bray et al.   Nature Protocols

Azithromycin Synergizes with Cationic Antimicrobial Peptides to Exert Bactericidal and Therapeutic Activity Against Highly Multidrug-Resistant Gram-Negative Bacterial Pathogens

(2015) Leo Lin et al.   EBioMedicine

Antagonism between Bacteriostatic and Bactericidal Antibiotics Is Prevalent

(2014) Paolo S. Ocampo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Efflux Inhibitor Phenylalanine-Arginine Beta-Naphthylamide (PAβN) Permeabilizes the Outer Membrane of Gram-Negative Bacteria

(2013) Ryan P. Lamers et al.   PLoS One

Bacterial cytological profiling rapidly identifies the cellular pathways targeted by antibacterial molecules

(2013) P. Nonejuie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relevant role of efflux pumps in high levels of rifaximin resistance in Escherichia coli clinical isolates

(2013) C. Gomes et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

A Forward Chemical Screen Identifies Antibiotic Adjuvants in Escherichia coli

(2012) Patricia L. Taylor et al.   ACS Chemical Biology

Combination Therapy for Treatment of Infections with Gram-Negative Bacteria

(2012) P. D. Tamma et al.   CLINICAL MICROBIOLOGY REVIEWS

Pyridone Methylsulfone Hydroxamate LpxC Inhibitors for the Treatment of Serious Gram-Negative Infections

(2012) Justin I. Montgomery et al.   JOURNAL OF MEDICINAL CHEMISTRY

Defining Fractional Inhibitory Concentration Index Cutoffs for Additive Interactions Based on Self-Drug Additive Combinations, Monte Carlo Simulation Analysis, and In Vitro-In Vivo Correlation Data for Antifungal Drug Combinations against Aspergillus fumigatus

(2009) J. Meletiadis et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

CellClassifier: supervised learning of cellular phenotypes

(2009) Pauli Rämö et al.   BIOINFORMATICS