Genetic Knockouts Indicate That the ABCC2 Protein in the Bollworm Helicoverpa zea Is Not a Major Receptor for the Cry1Ac Insecticidal Protein

Mechanisms of Resistance to Insecticidal Proteins from Bacillus thuringiensis

(2021) Juan Luis Jurat-Fuentes et al.   Annual Review of Entomology

The Essential and Enigmatic Role of ABC Transporters in Bt Resistance of Noctuids and Other Insect Pests of Agriculture

(2021) David G. Heckel   Insects

SfABCC2 transporter extracellular loops 2 and 4 are responsible for the Cry1Fa insecticidal specificity against Spodoptera frugiperda

(2021) Yuanyuan Liu et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Synergistic resistance of Helicoverpa armigera to Bt toxins linked to cadherin and ABC transporters mutations

(2021) Dandan Zhang et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mutations in a Novel Cadherin Gene Associated with Bt Resistance in Helicoverpa zea

(2020) Megan L. Fritz et al.   G3-Genes Genomes Genetics

Functional redundancy of two ABC transporter proteins in mediating toxicity of Bacillus thuringiensis to cotton bollworm

(2020) Jing Wang et al.   PLoS Pathogens

Resistance to Bacillus thuringiensis Cry1Ac toxin requires mutations in two Plutella xylostella ATP-binding cassette transporter paralogs

(2020) Zhaoxia Liu et al.   PLoS Pathogens

The Spodoptera exigua ABCC2 Acts as a Cry1A Receptor Independently of its Nucleotide Binding Domain II

(2019) Daniel Pinos et al.   Toxins

Differences between two populations of bollworm, Helicoverpa zea (Lepidoptera: Noctuidae), with variable measurements of laboratory susceptibilities to Bt toxins exposed to non-Bt and Bt cottons in large field cages

(2019) Nathan S. Little et al.   PLoS One

CRISPR/Cas9-mediated knockout of both the PxABCC2 and PxABCC3 genes confers high-level resistance to Bacillus thuringiensis Cry1Ac toxin in the diamondback moth, Plutella xylostella (L.)

(2019) Zhaojiang Guo et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

The Cadherin Cry1Ac Binding-Region is Necessary for the Cooperative Effect with ABCC2 Transporter Enhancing Insecticidal Activity of Bacillus thuringiensis Cry1Ac Toxin

(2019) Ma et al.   Toxins

A single amino acid polymorphism in ABCC2 loop 1 is responsible for differential toxicity of Bacillus thuringiensis Cry1Ac toxin in different Spodoptera (Noctuidae) species

(2018) Leilei Liu et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

CRISPR/Cas9 mediated high efficiency knockout of the eye color gene Vermillion in Helicoverpa zea (Boddie)

(2018) Omaththage P. Perera et al.   PLoS One

Mutational disruption of the ABCC2 gene in fall armyworm, Spodoptera frugiperda, confers resistance to the Cry1Fa and Cry1A.105 insecticidal proteins

(2018) Lex Flagel et al.   Scientific Reports

Decreased Cry1Ac activation by midgut proteases associated with Cry1Ac resistance in Helicoverpa zea

(2018) Min Zhang et al.   PEST MANAGEMENT SCIENCE

ALP2 is a functional receptor of Cry1Ac but not Cry2Ab in Helicoverpa zea

(2018) Jizhen Wei et al.   INSECT MOLECULAR BIOLOGY

Bombyx mori ABC transporter C2 structures responsible for the receptor function of Bacillus thuringiensis Cry1Aa toxin

(2017) Shiho Tanaka et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

ABCC2 is associated with Bacillus thuringiensis Cry1Ac toxin oligomerization and membrane insertion in diamondback moth

(2017) Josue Ocelotl et al.   Scientific Reports

Mechanism and DNA-based detection of field-evolved resistance to transgenic Bt corn in fall armyworm (Spodoptera frugiperda)

(2017) Rahul Banerjee et al.   Scientific Reports

TheSpodoptera exigua(Lepidoptera: Noctuidae) ABCC2 Mediates Cry1Ac Cytotoxicity and, in Conjunction with Cadherin, Contributes to Enhance Cry1Ca Toxicity in Sf9 Cells

(2016) Xiang-Liang Ren et al.   JOURNAL OF ECONOMIC ENTOMOLOGY

Identification of ABCC2 as a binding protein of Cry1Ac on brush border membrane vesicles fromHelicoverpa armigeraby an improved pull-down assay

(2016) Zishan Zhou et al.   MicrobiologyOpen

MAPK Signaling Pathway Alters Expression of Midgut ALP and ABCC Genes and Causes Resistance to Bacillus thuringiensis Cry1Ac Toxin in Diamondback Moth

(2015) Zhaojiang Guo et al.   PLoS Genetics

Alternative Splicing and Highly Variable Cadherin Transcripts Associated with Field-Evolved Resistance of Pink Bollworm to Bt Cotton in India

(2014) Jeffrey A. Fabrick et al.   PLoS One

Mis-splicing of the ABCC2 gene linked with Bt toxin resistance in Helicoverpa armigera

(2014) Yutao Xiao et al.   Scientific Reports

Analysis of resistance to Cry1Ac in field-collected pink bollworm,Pectinophora gossypiella(Lepidoptera:Gelechiidae), populations

(2014) Abhishek Ojha et al.   GM Crops & Food-Biotechnology in Agriculture and the Food Chain

The ATP-binding cassette transporter subfamily C member 2 inBombyx morilarvae is a functional receptor for Cry toxins fromBacillus thuringiensis

(2013) Shiho Tanaka et al.   FEBS Journal

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

(2013) Prashant Mali et al.   NATURE BIOTECHNOLOGY

DNA targeting specificity of RNA-guided Cas9 nucleases

(2013) Patrick D Hsu et al.   NATURE BIOTECHNOLOGY

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Binding Sites for Bacillus thuringiensis Cry2Ae Toxin on Heliothine Brush Border Membrane Vesicles Are Not Shared with Cry1A, Cry1F, or Vip3A Toxin

(2011) C. Gouffon et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

SMART 7: recent updates to the protein domain annotation resource

(2011) I. Letunic et al.   NUCLEIC ACIDS RESEARCH

Field-evolved resistance to Bt toxin Cry1Ac in the pink bollworm, Pectinophora gossypiella (Saunders) (Lepidoptera: Gelechiidae), from India

(2011) Sanyasi Dhurua et al.   PEST MANAGEMENT SCIENCE

Reduced Levels of Membrane-Bound Alkaline Phosphatase Are Common to Lepidopteran Strains Resistant to Cry Toxins from Bacillus thuringiensis

(2011) Juan Luis Jurat-Fuentes et al.   PLoS One

An ABC Transporter Mutation Is Correlated with Insect Resistance to Bacillus thuringiensis Cry1Ac Toxin

(2010) Linda J. Gahan et al.   PLoS Genetics

Cloning and characterization of the Cry1Ac-binding alkaline phosphatase (HvALP) from Heliothis virescens

(2009) Omaththage P. Perera et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Insect resistance to Bt crops: evidence versus theory

(2008) Bruce E Tabashnik et al.   NATURE BIOTECHNOLOGY