Chinese Herbal Preparation SaiLuoTong Alleviates Brain Ischemia via Nrf2 Antioxidation Pathway–Dependent Cerebral Microvascular Protection

Protective effect of epigallocatechin gallate on endothelial disorders in atherosclerosis

(2020) Kazuo Yamagata   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Occludin degradation makes brain microvascular endothelial cells more vulnerable to reperfusion injury in vitro

(2020) Yuan Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Therapeutic targets of oxidative/nitrosative stress and neuroinflammation in ischemic stroke: Applications for natural product efficacy with omics and systemic biology

(2020) Hansen Chen et al.   PHARMACOLOGICAL RESEARCH

Endothelial Targets in Stroke

(2019) Anuska V. Andjelkovic et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sailuotong Capsule Prevents the Cerebral Ischaemia-Induced Neuroinflammation and Impairment of Recognition Memory through Inhibition of LCN2 Expression

(2019) Yehao Zhang et al.   Oxidative Medicine and Cellular Longevity

Protective effect of edaravone on blood-brain barrier by affecting NRF-2/HO-1 signaling pathway

(2019) Jing Liu et al.   Experimental and Therapeutic Medicine

Cryptotanshinone Attenuates Oxidative Stress and Inflammation through the Regulation of Nrf-2 and NF-κB in Mice with Unilateral Ureteral Obstruction

(2018) Wei Wang et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Astragaloside IV protects blood-brain barrier integrity from LPS-induced disruption via activating Nrf2 antioxidant signaling pathway in mice

(2018) Hongli Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Study protocol for a randomised, double-blind, placebo-controlled 12-week pilot phase II trial of Sailuotong (SLT) for cognitive function in older adults with mild cognitive impairment

(2018) Genevieve Z. Steiner et al.   Trials

Stroke and dementia risk: A systematic review and meta-analysis

(2018) Elżbieta Kuźma et al.   Alzheimers & Dementia

Claudin-1 dependent destabilization of the blood-brain barrier in chronic stroke

(2018) Nikola Sladojevic et al.   JOURNAL OF NEUROSCIENCE

Panax notoginseng Saponins Protect Cerebral Microvascular Endothelial Cells against Oxygen-Glucose Deprivation/Reperfusion-Induced Barrier Dysfunction via Activation of PI3K/Akt/Nrf2 Antioxidant Signaling Pathway

(2018) Shaonan Hu et al.   MOLECULES

Sailuotong Prevents Hydrogen Peroxide (H2O2)-Induced Injury in EA.hy926 Cells

(2017) Sai Seto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Crocin protects against cerebral- ischemia-induced damage in aged rats through maintaining the integrity of blood-brain barrier

(2017) Xuan Zhang et al.   RESTORATIVE NEUROLOGY AND NEUROSCIENCE

Defenders and Challengers of Endothelial Barrier Function

(2017) Nader Rahimi   Frontiers in Immunology

Immortalized endothelial cell lines for in vitro blood–brain barrier models: A systematic review

(2016) Nurul Adhwa Rahman et al.   BRAIN RESEARCH

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

(2016) Agnieszka Loboda et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nrf2—a Promising Therapeutic Target for Defensing Against Oxidative Stress in Stroke

(2016) Rongrong Zhang et al.   MOLECULAR NEUROBIOLOGY

Genetic elimination of Nrf2 aggravates secondary complications except for vasospasm after experimental subarachnoid hemorrhage in mice

(2014) Tao Li et al.   BRAIN RESEARCH

Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral ischemia

(2014) Ghorbangol Ashabi et al.   METABOLIC BRAIN DISEASE

Posttreatment with 11-Keto-β-Boswellic Acid Ameliorates Cerebral Ischemia–Reperfusion Injury: Nrf2/HO-1 Pathway as a Potential Mechanism

(2014) Yi Ding et al.   MOLECULAR NEUROBIOLOGY

Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood–brain barrier disruption and neurological deficits in stroke

(2013) Alessio Alfieri et al.   FREE RADICAL BIOLOGY AND MEDICINE

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Potential Therapeutic Effects of Natural Heme Oxygenase-1 Inducers in Cardiovascular Diseases

(2012) Ignazio Barbagallo et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative stress and cerebral endothelial cells: Regulation of the blood–brain-barrier and antioxidant based interventions

(2011) Linnea R. Freeman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The role of free radical generation in increasing cerebrovascular permeability

(2011) Paul A. Fraser   FREE RADICAL BIOLOGY AND MEDICINE

Specific Role of Tight Junction Proteins Claudin-5, Occludin, and ZO-1 of the Blood–Brain Barrier in a Focal Cerebral Ischemic Insult

(2011) Haixia Jiao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Reactive oxygen species and ischemic cerebrovascular disease

(2011) Inan Olmez et al.   NEUROCHEMISTRY INTERNATIONAL

The complexity of neurobiological processes in acute ischemic stroke

(2009) R. Brouns et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Src Activity Decreases Tyrosine Phosphorylation of Occludin in Brain Capillaries and Attenuates Increase in Permeability of the Blood-Brain Barrier after Transient Focal Cerebral Ischemia

(2009) Yuji Takenaga et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

(2008) C.J. Harvey et al.   FREE RADICAL BIOLOGY AND MEDICINE

Stroke

(2008) Geoffrey A Donnan et al.   LANCET

Blood-brain barrier tight junction permeability and ischemic stroke

(2008) Karin E. Sandoval et al.   NEUROBIOLOGY OF DISEASE