Occludin degradation makes brain microvascular endothelial cells more vulnerable to reperfusion injury in vitro

Gasdermin D serves as a key executioner of pyroptosis in experimental cerebral ischemia and reperfusion model both in vivo and in vitro

(2019) Dongping Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Glibenclamide ameliorates the disrupted blood-brain barrier in experimental intracerebral hemorrhage by inhibiting the activation of NLRP3 inflammasome

(2019) Fulin Xu et al.   Brain and Behavior

The pathological role of NLRs and AIM2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury

(2018) Xintong Ge et al.   BRAIN RESEARCH

Suppression of NLRP3 attenuates hemorrhagic transformation after delayed rtPA treatment in thromboembolic stroke rats: Involvement of neutrophil recruitment

(2018) Zhiliang Guo et al.   BRAIN RESEARCH BULLETIN

Ulinastatin protects brain against cerebral ischemia/reperfusion injury through inhibiting MMP-9 and alleviating loss of ZO-1 and occludin proteins in mice

(2018) Xiao-Fang Li et al.   EXPERIMENTAL NEUROLOGY

Evidence that NLRC4 Inflammasome Mediates Apoptotic and Pyroptotic Microglial Death Following Ischemic Stroke

(2018) Luting Poh et al.   BRAIN BEHAVIOR AND IMMUNITY

Cell permeable HMGB1-binding heptamer peptide ameliorates neurovascular complications associated with thrombolytic therapy in rats with transient ischemic stroke

(2018) Miaodan Li et al.   Journal of Neuroinflammation

Sustained (S)-roscovitine delivery promotes neuroprotection associated with functional recovery and decrease in brain edema in a randomized blind focal cerebral ischemia study

(2017) Estelle Rousselet et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Homocysteine exaggerates microglia activation and neuroinflammation through microglia localized STAT3 overactivation following ischemic stroke

(2017) Shuang Chen et al.   Journal of Neuroinflammation

Evidence that NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke

(2017) David Yang-Wei Fann et al.   MOLECULAR NEUROBIOLOGY

Normobaric Hyperoxia Reduces Blood Occludin Fragments in Rats and Patients With Acute Ischemic Stroke

(2017) Shuhai Shi et al.   STROKE

Blood Occludin Level as a Potential Biomarker for Early Blood Brain Barrier Damage Following Ischemic Stroke

(2017) Rong Pan et al.   Scientific Reports

c-Yes enhances tumor migration and invasion via PI3K/AKT pathway in epithelial ovarian cancer

(2016) Yunfeng Jin et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Managing Post-tPA Intracranial Hemorrhage: Time Is Still Brain

(2016) Tariq K. Halasa et al.   World Neurosurgery

Instigation of endothelial Nlrp3 inflammasome by adipokine visfatin promotes inter-endothelial junction disruption: role of HMGB1

(2015) Yang Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Early Ischemic Blood Brain Barrier Damage: A Potential Indicator for Hemorrhagic Transformation Following Tissue Plasminogen Activator (tPA) Thrombolysis?

(2014) Xinchun Jin et al.   CURRENT NEUROVASCULAR RESEARCH

Blood—Brain Barrier Breakdown Involves Four Distinct Stages of Vascular Damage in Various Models of Experimental Focal Cerebral Ischemia

(2014) Martin Krueger et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions

(2014) Claire L. Gibson et al.   JOURNAL OF NEUROCHEMISTRY

Pathogenesis of acute stroke and the role of inflammasomes

(2013) David Yang-Wei Fann et al.   AGEING RESEARCH REVIEWS

Hemoglobin-Induced Nitric Oxide Synthase Overexpression and Nitric Oxide Production Contribute to Blood–Brain Barrier Disruption in the Rat

(2013) Shuo Yang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Ischemic neurons activate astrocytes to disrupt endothelial barrier via increasing VEGF expression

(2013) Ying-Na Li et al.   JOURNAL OF NEUROCHEMISTRY

Global and regional burden of stroke during 1990–2010: findings from the Global Burden of Disease Study 2010

(2013) Valery L Feigin et al.   LANCET

Reactive Oxygen Species-Caspase-3 Relationship in Mediating Blood-Brain Barrier Endothelial Cell Hyperpermeability Following Oxygen-Glucose Deprivation and Reoxygenation

(2013) Himakarnika Alluri et al.   MICROCIRCULATION

Matrix metalloproteinase-2 deletions protect against hemorrhagic transformation after 1h of cerebral ischemia and 23h of reperfusion

(2013) A. Lu et al.   NEUROSCIENCE

Guidelines for the Early Management of Patients With Acute Ischemic Stroke

(2013) Edward C. Jauch et al.   STROKE

c-Yes regulates cell adhesion at the apical ectoplasmic specialization-blood-testis barrier axis via its effects on protein recruitment and distribution

(2012) Xiang Xiao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Connexin43 mimetic peptide reduces vascular leak and retinal ganglion cell death following retinal ischaemia

(2012) Helen V. Danesh-Meyer et al.   BRAIN

Matrix Metalloproteinase-2-Mediated Occludin Degradation and Caveolin-1-Mediated Claudin-5 Redistribution Contribute to Blood-Brain Barrier Damage in Early Ischemic Stroke Stage

(2012) J. Liu et al.   JOURNAL OF NEUROSCIENCE

Spatiotemporal evolution of blood brain barrier damage and tissue infarction within the first 3h after ischemia onset

(2012) Xinchun Jin et al.   NEUROBIOLOGY OF DISEASE

The role of tumor necrosis factor-α and TNF-α receptors in cerebral arteries following cerebral ischemia in rat

(2011) Aida Maddahi et al.   Journal of Neuroinflammation

Occludin: One Protein, Many Forms

(2011) P. M. Cummins   MOLECULAR AND CELLULAR BIOLOGY

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

(2011) J. I. Alvarez et al.   SCIENCE

Oxygen Therapy Reduces Secondary Hemorrhage after Thrombolysis in Thromboembolic Cerebral Ischemia

(2010) Li Sun et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Disruption of occludin function in polarized epithelial cells activates the extrinsic pathway of apoptosis leading to cell extrusion without loss of transepithelial resistance

(2009) Neal E Beeman et al.   BMC CELL BIOLOGY

Normobaric Hyperoxia Reduces the Neurovascular Complications Associated With Delayed Tissue Plasminogen Activator Treatment in a Rat Model of Focal Cerebral Ischemia

(2009) Wenlan Liu et al.   STROKE

Normobaric hyperoxia attenuates early blood-brain barrier disruption by inhibiting MMP-9-mediated occludin degradation in focal cerebral ischemia

(2008) Wenlan Liu et al.   JOURNAL OF NEUROCHEMISTRY

Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke

(2008) Werner Hacke et al.   NEW ENGLAND JOURNAL OF MEDICINE

PKC  regulates occludin phosphorylation and epithelial tight junction integrity

(2008) T. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA