Pyruvate Kinase M2 Mediates Glycolysis Contributes to Psoriasis by Promoting Keratinocyte Proliferation

2′-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice

(2021) Lihua Hao et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Bruton’s tyrosine kinase inhibitor suppresses imiquimod-induced psoriasis-like inflammation in mice through regulation of IL-23/IL-17A in innate immune cells

(2020) Ahmed Nadeem et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Therapeutic treatment with Ibrutinib attenuates imiquimod-induced psoriasis-like inflammation in mice through downregulation of oxidative and inflammatory mediators in neutrophils and dendritic cells

(2020) Naif O. Al-Harbi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibiting protein kinase activity of pyruvate kinase M2 by sirtuin 2 deacetylase attenuates psoriasis

(2020) Lihua Hao et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

EZH2-dependent epigenetic modulation of histone H3 lysine-27 contributes to psoriasis by promoting keratinocyte proliferation

(2020) Tongmei Zhang et al.   Cell Death & Disease

Inhibition of interleukin-2-inducible T-cell kinase causes reduction in imiquimod-induced psoriasiform inflammation through reduction of Th17 cells and enhancement of Treg cells in mice

(2020) Ahmed Nadeem et al.   BIOCHIMIE

Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers

(2018) Michael J Curtis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Research Techniques Made Simple: Murine Models of Human Psoriasis

(2018) Jason E. Hawkes et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Pyruvate kinase M2 fuels multiple aspects of cancer cells: from cellular metabolism, transcriptional regulation to extracellular signaling

(2018) Ming-Chuan Hsu et al.   Molecular Cancer

Systemic inflammation in asocial BTBR T + tf/J mice predisposes them to increased psoriatic inflammation

(2018) Ahmed Nadeem et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The Interplay Between Keratinocytes and Immune Cells in the Pathogenesis of Psoriasis

(2018) Cristina Albanesi et al.   Frontiers in Immunology

Pathogenesis of psoriasis and development of treatment

(2017) Eisaku Ogawa et al.   JOURNAL OF DERMATOLOGY

Recent Highlights in Psoriasis Research

(2017) Samuel T. Hwang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

NLRP3 inflammasome activation mediates radiation-induced pyroptosis in bone marrow-derived macrophages

(2017) Yan-gang Liu et al.   Cell Death & Disease

PKM2 in carcinogenesis and oncotherapy

(2017) Xia He et al.   Oncotarget

Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis

(2017) William R. Swindell et al.   Genome Medicine

Exploration of candidate biomarkers for human psoriasis based on gas chromatography-mass spectrometry serum metabolomics

(2016) H. Kang et al.   BRITISH JOURNAL OF DERMATOLOGY

Risk of Serious Infections in Patients with Psoriasis on Biologic Therapies: A Systematic Review and Meta-Analysis

(2016) Zenas Z.N. Yiu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Immunology of Psoriasis

(2014) Michelle A. Lowes et al.   Annual Review of Immunology

Effect of psoriasis activity on epidermal growth factor (EGF) and the concentration of soluble EGF receptor in serum and plaque scales

(2014) I. Flisiak et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Guselkumab (an IL-23–specific mAb) demonstrates clinical and molecular response in patients with moderate-to-severe psoriasis

(2014) Howard Sofen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of Kir6.2 subunits of ATP-sensitive potassium channels in endotoxemia-induced cardiac dysfunction

(2013) Zhong-Wei Yang et al.   Cardiovascular Diabetology

TLRs to cytokines: Mechanistic insights from the imiquimod mouse model of psoriasis

(2013) Barry Flutter et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pharmacological Properties of Shikonin – A Review of Literature since 2002

(2013) Isabel Andújar et al.   PLANTA MEDICA

The Emerging Role of IL-17 in the Pathogenesis of Psoriasis: Preclinical and Clinical Findings

(2012) David A. Martin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

(2012) Xueliang Gao et al.   MOLECULAR CELL

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

(2012) Weiwei Yang et al.   NATURE CELL BIOLOGY

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

(2012) Dimitrios Anastasiou et al.   Nature Chemical Biology

SAICAR Stimulates Pyruvate Kinase Isoform M2 and Promotes Cancer Cell Survival in Glucose-Limited Conditions

(2012) K. E. Keller et al.   SCIENCE

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Differential modulation of stress-inflammation responses by plant polyphenols in cultured normal human keratinocytes and immortalized HaCaT cells

(2011) Saveria Pastore et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2

(2011) J Chen et al.   ONCOGENE

Incidental Finding of F-18 FDG Skin Uptake in a Patient With Psoriasis During the Evaluation of a Recurrent Papillary Thyroid Carcinoma

(2010) Claire Bruna-Muraille et al.   CLINICAL NUCLEAR MEDICINE

Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis

(2009) L. van der Fits et al.   JOURNAL OF IMMUNOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells

(2008) Michelle A. Lowes et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE