LY395756 promotes NR2B expression via activation of AKT/CREB signaling in the juvenile methylazoxymethanol mice model of schizophrenia

Poor sleep quality and its related risk factors among university students

(2021) Xiaohong Liu et al.   Annals of Palliative Medicine

Understanding factors relevant to poor sleep and coping methods in people with schizophrenia

(2021) Yen-Ching Chang et al.   BMC Psychiatry

PKA-mediated phosphorylation of CREB and NMDA receptor 2B in the hippocampus of offspring rats is involved in transmission of mental disorders across a generation

(2019) Yuejun Huang et al.   PSYCHIATRY RESEARCH

The stem cell factor-stimulated melanogenesis in human melanocytes can be abrogated by interrupting the phosphorylation of MSK1: evidence for involvement of the p38/MSK1/CREB/MITF axis

(2018) Takao Niwano et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Dysfunction in Brain-Derived Neurotrophic Factor Signaling Pathway and Susceptibility to Schizophrenia, Parkinson's and Alzheimer's Diseases

(2018) Alireza Mohammadi et al.   CURRENT GENE THERAPY

Juvenile treatment with mGluR2/3 agonist prevents schizophrenia-like phenotypes in adult by acting through GSK3β

(2018) Bo Xing et al.   NEUROPHARMACOLOGY

Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in the MAM model for schizophrenia

(2017) Yelena Gulchina et al.   JOURNAL OF NEUROCHEMISTRY

Juvenile treatment with a novel mGluR2 agonist/mGluR3 antagonist compound, LY395756, reverses learning deficits and cognitive flexibility impairments in adults in a neurodevelopmental model of schizophrenia

(2017) Meng-Lin Li et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Emerging Roles of CREB-Regulated Transcription Coactivators in Brain Physiology and Pathology

(2017) Carlos A. Saura et al.   TRENDS IN NEUROSCIENCES

Adolescence as a period of vulnerability and intervention in schizophrenia: Insights from the MAM model

(2016) Felipe V. Gomes et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

mGluR2/3 agonist LY379268 rescues NMDA and GABAA receptor level deficits induced in a two-hit mouse model of schizophrenia

(2016) Martin Engel et al.   PSYCHOPHARMACOLOGY

Control of CREB expression in tumors: from molecular mechanisms and signal transduction pathways to therapeutic target

(2016) André Steven et al.   Oncotarget

Role of PTEN-Akt-CREB Signaling Pathway in Nervous System impairment of Rats with Chronic Arsenite Exposure

(2015) Lisha Qu et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

LY395756, an mGluR2 agonist and mGluR3 antagonist, enhances NMDA receptor expression and function in the normal adult rat prefrontal cortex, but fails to improve working memory and reverse MK801-induced working memory impairment

(2015) Meng-Lin Li et al.   EXPERIMENTAL NEUROLOGY

Perspectives on the mGluR2/3 agonists as a therapeutic target for schizophrenia: Still promising or a dead end?

(2015) Meng-Lin Li et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Dynorphin up-regulation in the dentate granule cell mossy fiber pathway following chronic inhibition of GluN2B-containing NMDAR is associated with increased CREB (Ser 133) phosphorylation, but is independent of BDNF/TrkB signaling pathways

(2014) W. Bradley Rittase et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Translating the N-methyl-d-aspartate receptor antagonist model of schizophrenia to treatments for cognitive impairment in schizophrenia

(2013) Herbert Y. Meltzer et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Alteration of cyclic-AMP response element binding protein in the postmortem brain of subjects with bipolar disorder and schizophrenia

(2013) Xinguo Ren et al.   JOURNAL OF AFFECTIVE DISORDERS

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Group II Metabotropic Glutamate Receptor Agonist LY379268 Regulates AMPA Receptor Trafficking in Prefrontal Cortical Neurons

(2013) Min-Juan Wang et al.   PLoS One

Gestational Methylazoxymethanol Exposure Leads to NMDAR Dysfunction in Hippocampus During Early Development and Lasting Deficits in Learning

(2012) Melissa A Snyder et al.   NEUROPSYCHOPHARMACOLOGY

Group II metabotropic glutamate receptor agonists and positive allosteric modulators as novel treatments for schizophrenia

(2011) Matthew J. Fell et al.   NEUROPHARMACOLOGY

CREB is a regulatory target for the protein kinase Akt/PKB in the differentiation of pancreatic ductal cells into islet β-cells mediated by hepatocyte growth factor

(2010) Xin-Yu Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rethinking schizophrenia

(2010) Thomas R. Insel   NATURE

RNA interference in hippocampus demonstrates opposing roles for CREB and PP1α in contextual and temporal long-term memory

(2009) M. Peters et al.   GENES BRAIN AND BEHAVIOR

Schizophrenia

(2009) Jim van Os et al.   LANCET

The Dopamine Hypothesis of Schizophrenia: Version III--The Final Common Pathway

(2009) O. D. Howes et al.   SCHIZOPHRENIA BULLETIN

Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia

(2008) P. Jeffrey Conn et al.   TRENDS IN PHARMACOLOGICAL SCIENCES