Emerging Roles of Ceramide in Cardiovascular Diseases

Cardiomyocyte Krüppel-like Factor 5 Promotes De Novo Ceramide Biosynthesis and Contributes to Eccentric Remodeling in Ischemic Cardiomyopathy

(2021) Matthew Hoffman et al.   CIRCULATION

The role of ceramide accumulation in human induced pluripotent stem cell-derived cardiomyocytes on mitochondrial oxidative stress and mitophagy

(2021) Mohamed Bekhite et al.   FREE RADICAL BIOLOGY AND MEDICINE

Characterizing a common CERS2 polymorphism in a mouse model of metabolic disease and in subjects from the Utah CAD Study

(2021) Rebekah J Nicholson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Altering Sphingolipid Metabolism Attenuates Cell Death and Inflammatory Response after Myocardial Infarction

(2020) Yoav Hadas et al.   CIRCULATION

Global Plasma Metabolomics to Identify Potential Biomarkers of Blood Pressure Progression

(2020) Yi-Ting Lin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

DES1: A Key Driver of Lipotoxicity in Metabolic Disease

(2020) Jeremy T. Blitzer et al.   DNA AND CELL BIOLOGY

Lipid Accumulation in Hearts Transplanted From Nondiabetic Donors to Diabetic Recipients

(2020) Raffaele Marfella et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The imbalance in the aortic ceramide/sphingosine-1-phosphate rheostat in ovariectomized rats and the preventive effect of estrogen

(2020) Yao Li et al.   Lipids in Health and Disease

Unbiased proteomics identifies plasminogen activator inhibitor-1 as a negative regulator of endothelial nitric oxide synthase

(2020) Victor Garcia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels

(2020) Elizabeth L. Johnson et al.   Nature Communications

Prediction of Residual Risk by Ceramide‐Phospholipid Score in Patients With Stable Coronary Heart Disease on Optimal Medical Therapy

(2020) Mika Hilvo et al.   Journal of the American Heart Association

Relationship between elevated plasma ceramides and plaque rupture in patients with ST-segment elevation myocardial infarction

(2020) Weili Pan et al.   ATHEROSCLEROSIS

The ceramide-S1P pathway as a druggable target to alleviate peripheral neuropathic pain

(2020) Michiel Langeslag et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Application of untargeted lipidomics based on UHPLC-high resolution tandem MS analysis to profile the lipid metabolic disturbances in the heart of diabetic cardiomyopathy mice

(2020) Xuejun Xu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Association between ceramides and coronary artery stenosis in patients with coronary artery disease

(2020) Chenchen Tu et al.   Lipids in Health and Disease

Wnt-controlled sphingolipids modulate Anthrax Toxin Receptor palmitoylation to regulate oriented mitosis in zebrafish

(2020) I. Castanon et al.   Nature Communications

Elusive Roles of the Different Ceramidases in Human Health, Pathophysiology, and Tissue Regeneration

(2020) Carolina Duarte et al.   Cells

Relation between plasma ceramides and cardiovascular death in chronic heart failure: A subset analysis of the GISSI‐HF trial

(2020) Giovanni Targher et al.   ESC Heart Failure

Sphingolipid composition of circulating extracellular vesicles after myocardial ischemia

(2020) J. Burrello et al.   Scientific Reports

Ceramides and Ceramide Scores: Clinical Applications for Cardiometabolic Risk Stratification

(2020) Mika Hilvo et al.   Frontiers in Endocrinology

Lipid Profiles and Heart Failure Risk: Results from Two Prospective Studies

(2020) Clemens Wittenbecher et al.   CIRCULATION RESEARCH

Ceramides improve atherosclerotic cardiovascular disease risk assessment beyond standard risk factors

(2020) Jeffrey W. Meeusen et al.   CLINICA CHIMICA ACTA

Prevalence, Features, and Prognosis of Artery‐to‐Artery Embolic ST‐Segment–Elevation Myocardial Infarction: An Optical Coherence Tomography Study

(2020) Masahiro Takahata et al.   Journal of the American Heart Association

Host sphingolipids: Perspective immune adjuvant for controlling SARS-CoV-2 infection for managing COVID-19 disease

(2020) Hridayesh Prakash et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Untargeted metabolomics and lipidomics uncovering the cardioprotective effects of Huanglian Jiedu Decoction on pathological cardiac hypertrophy and remodeling

(2020) Qian-Qian Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance

(2019) Sarah M. Turpin-Nolan et al.   Cell Reports

The ORMDL/Orm–serine palmitoyltransferase (SPT) complex is directly regulated by ceramide: Reconstitution of SPT regulation in isolated membranes

(2019) Deanna L. Davis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preservation of Acyl-CoA Attenuates Pathological and Metabolic Cardiac Remodeling Through Selective Lipid Trafficking

(2019) Joseph R. Goldenberg et al.   CIRCULATION

Small hairpin RNA and pharmacological targeting of neutral sphingomyelinase prevents diaphragm weakness in rats with heart failure and reduced ejection fraction

(2019) Philip D. Coblentz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Alterations in the gut microbiome and metabolism with coronary artery disease severity

(2019) Honghong Liu et al.   Microbiome

Plasma Ceramides and Sphingomyelins in Relation to Heart Failure Risk

(2019) Rozenn N. Lemaitre et al.   Circulation-Heart Failure

The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms

(2019) Jan Korbecki et al.   INFLAMMATION RESEARCH

Targeting a ceramide double bond improves insulin resistance and hepatic steatosis

(2019) Bhagirath Chaurasia et al.   SCIENCE

Effect of combined testing of ceramides with high-sensitive troponin T on the detection of acute coronary syndrome in patients with chest pain in China: a prospective observational study

(2019) Kang Yao et al.   BMJ Open

Variation in Coronary Atherosclerosis Severity Related to a Distinct LDL (Low-Density Lipoprotein) Profile

(2019) Ayla Hoogendoorn et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Adipocyte Hypoxia-Inducible Factor 2α Suppresses Atherosclerosis by Promoting Adipose Ceramide Catabolism

(2019) Xingzhong Zhang et al.   Cell Metabolism

Association of Circulating Ceramides With Cardiac Structure and Function in the Community: The Framingham Heart Study

(2019) Chike C. Nwabuo et al.   Journal of the American Heart Association

Association of Lipidomic Profiles With Progression of Carotid Artery Atherosclerosis in HIV Infection

(2019) Jin Choul Chai et al.   JAMA Cardiology

Acid sphingomyelinase downregulation alleviates vascular endothelial leptin resistance in rats

(2019) Bei-bo Cai et al.   ACTA PHARMACOLOGICA SINICA

Hypertension and Heart Failure

(2019) Katherine E. Di Palo et al.   Heart Failure Clinics

Neutrophil elastase increases airway ceramide levels via upregulation of serine palmitoyltransferase

(2018) Sophia Karandashova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Could Ceramides Become the New Cholesterol?

(2018) Scott A. Summers   Cell Metabolism

The aging heart

(2018) Vanessa Obas et al.   CLINICAL SCIENCE

Serum Metabolomics Study Based on LC-MS and Antihypertensive Effect of Uncaria on Spontaneously Hypertensive Rats

(2018) Ana Liu et al.   Evidence-based Complementary and Alternative Medicine

Lipotoxic very-long-chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytes

(2018) Brittany A. Law et al.   FASEB JOURNAL

Ceramide-induced BOK promotes mitochondrial fission in preeclampsia

(2018) Jonathan Ausman et al.   Cell Death & Disease

Ceramide-Protein Interactions Modulate Ceramide-Associated Lipotoxic Cardiomyopathy

(2018) Stanley M. Walls et al.   Cell Reports

Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension

(2018) Isola A.M. Brown et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Epidemic of Cardiovascular Disease in China

(2018) Chengxing Shen et al.   CIRCULATION

Identification of lipids of the stratum corneum by high performance thin layer chromatography and mass spectrometry

(2018) Emilien L Jamin et al.   EUROPEAN JOURNAL OF MASS SPECTROMETRY

Ceramides as Novel Disease Biomarkers

(2018) Jennifer Kurz et al.   TRENDS IN MOLECULAR MEDICINE

The ORMs interact with transmembrane domain 1 of Lcb1 and regulate serine palmitoyltransferase oligomerization, activity and localization

(2018) Gongshe Han et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism

(2017) Rajesh K. Singh et al.   JOURNAL OF LIPID RESEARCH

Structural insights into adiponectin receptors suggest ceramidase activity

(2017) Ieva Vasiliauskaité-Brooks et al.   NATURE

Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis

(2017) Cen Xie et al.   NATURE MEDICINE

Western diet increases cardiac ceramide content in healthy and hypertrophied hearts

(2017) T.J. Butler et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Trends for prevalence and incidence of resistant hypertension: population based cohort study in the UK 1995-2015

(2017) Sarah-Jo Sinnott et al.   BMJ-British Medical Journal

Trends for prevalence and incidence of resistant hypertension: population based cohort study in the UK 1995-2015

(2017) Sarah-Jo Sinnott et al.   BMJ-British Medical Journal

Inhibition of ceramide de novo synthesis as a postischemic strategy to reduce myocardial reperfusion injury

(2016) M. R. Reforgiato et al.   BASIC RESEARCH IN CARDIOLOGY

Role of sphingomyelinase in mitochondrial ceramide accumulation during reperfusion

(2016) I. Ramírez-Camacho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inhibitors of dihydroceramide desaturase 1: Therapeutic agents and pharmacological tools to decipher the role of dihydroceramides in cell biology

(2016) Mireia Casasampere et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Plasma Metabolic Profile Determination in Young ST-segment Elevation Myocardial Infarction Patients with Ischemia and Reperfusion: Ultra-performance Liquid Chromatography and Mass Spectrometry for Pathway Analysis

(2016) Tong Li et al.   CHINESE MEDICAL JOURNAL

Sedentary Behavior and Cardiovascular Morbidity and Mortality: A Science Advisory From the American Heart Association

(2016) et al.   CIRCULATION

Atherosclerosis

(2016) Peter Libby et al.   CIRCULATION RESEARCH

A Diet Rich in Medium-Chain Fatty Acids Improves Systolic Function and Alters the Lipidomic Profile in Patients With Type 2 Diabetes: A Pilot Study

(2016) Sophia Airhart et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lactosylceramide contributes to mitochondrial dysfunction in diabetes

(2016) Sergei A. Novgorodov et al.   JOURNAL OF LIPID RESEARCH

Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis

(2016) Xinfang Xie et al.   LANCET

Epidemiology and aetiology of heart failure

(2016) Boback Ziaeian et al.   Nature Reviews Cardiology

Downregulation of adipose triglyceride lipase promotes cardiomyocyte hypertrophy by triggering the accumulation of ceramides

(2015) Hui Gao et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Ceramide-Initiated Protein Phosphatase 2A Activation Contributes to Arterial Dysfunction In Vivo

(2015) Leena P. Bharath et al.   DIABETES

Alteration in Metabolic Signature and Lipid Metabolism in Patients with Angina Pectoris and Myocardial Infarction

(2015) Ju Yeon Park et al.   PLoS One

Ceramide Changes the Mediator of Flow-Induced Vasodilation From Nitric Oxide to Hydrogen Peroxide in the Human Microcirculation

(2014) Julie K. Freed et al.   CIRCULATION RESEARCH

Elevation of ceramide and activation of secretory acid sphingomyelinase in patients with acute coronary syndromes

(2014) Wei Pan et al.   CORONARY ARTERY DISEASE

Oxidized low-density lipoprotein as a biomarker of cardiovascular diseases

(2014) Andreja Trpkovic et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Endothelial Dysfunction and Hypertension

(2014) Ralf P. Brandes   HYPERTENSION

Dietary fish oil improves endothelial function and lowers blood pressure via suppression of sphingolipid-mediated contractions in spontaneously hypertensive rats

(2014) Lieke W.J. van den Elsen et al.   JOURNAL OF HYPERTENSION

Endogenous Ceramide Contributes to the Transcytosis of oxLDL across Endothelial Cells and Promotes Its Subendothelial Retention in Vascular Wall

(2014) Wenjing Li et al.   Oxidative Medicine and Cellular Longevity

A Gene Variant in CERS2 Is Associated with Rate of Increase in Albuminuria in Patients with Diabetes from ONTARGET and TRANSCEND

(2014) Dov Shiffman et al.   PLoS One

Ceramide: A simple sphingolipid with unique biophysical properties

(2014) Bruno M. Castro et al.   PROGRESS IN LIPID RESEARCH

TNF-induced endothelial barrier disruption: beyond actin and Rho

(2014) Beatriz Marcos-Ramiro et al.   THROMBOSIS AND HAEMOSTASIS

Ceramide synthases as potential targets for therapeutic intervention in human diseases

(2013) Joo-Won Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Apelin administration ameliorates high fat diet-induced cardiac hypertrophy and contractile dysfunction

(2013) Asli F. Ceylan-Isik et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Chemical Basis of Serine Palmitoyltransferase Inhibition by Myriocin

(2013) John M. Wadsworth et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ceramide synthases at the centre of sphingolipid metabolism and biology

(2012) Thomas D. Mullen et al.   BIOCHEMICAL JOURNAL

Carnitine Palmitoyltransferase-1b Deficiency Aggravates Pressure Overload–Induced Cardiac Hypertrophy Caused by Lipotoxicity

(2012) Lan He et al.   CIRCULATION

Cardiomyocyte Specific Deficiency of Serine Palmitoyltransferase Subunit 2 Reduces Ceramide but Leads to Cardiac Dysfunction

(2012) Su-Yeon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes

(2012) Sarah Brice Russo et al.   JOURNAL OF CLINICAL INVESTIGATION

Sphingolipids, Lipotoxic Cardiomyopathy, and Cardiac Failure

(2012) Tae-Sik Park et al.   Heart Failure Clinics

Inhibition of ceramide synthesis reverses endothelial dysfunction and atherosclerosis in streptozotocin-induced diabetic rats

(2011) Li Chun et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Hypertension Is Associated with Marked Alterations in Sphingolipid Biology: A Potential Role for Ceramide

(2011) Léon J. A. Spijkers et al.   PLoS One

Antihypertensive Treatment Differentially Affects Vascular Sphingolipid Biology in Spontaneously Hypertensive Rats

(2011) Léon J. A. Spijkers et al.   PLoS One

Dihydroceramide desaturase and dihydrosphingolipids: Debutant players in the sphingolipid arena

(2011) Gemma Fabrias et al.   PROGRESS IN LIPID RESEARCH

Activation of ceramide synthase 6 by celecoxib leads to a selective induction of C16:0-ceramide

(2010) Susanne Schiffmann et al.   BIOCHEMICAL PHARMACOLOGY

Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism

(2010) Thomas D. Mullen et al.   JOURNAL OF LIPID RESEARCH

Lipidomics reveals a remarkable diversity of lipids in human plasma,

(2010) Oswald Quehenberger et al.   JOURNAL OF LIPID RESEARCH

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

(2010) William L Holland et al.   NATURE MEDICINE

(R)-α-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria

(2010) Jeffrey S. Monette et al.   PHARMACOLOGICAL RESEARCH

Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function

(2009) Ratnadeep Basu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Link between plasma ceramides, inflammation and insulin resistance: association with serum IL-6 concentration in patients with coronary heart disease

(2009) V. D. F. de Mello et al.   DIABETOLOGIA

DGAT1 Expression Increases Heart Triglyceride Content but Ameliorates Lipotoxicity

(2009) Li Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dietary Soy Protein Reduces Cardiac Lipid Accumulation and the Ceramide Concentration in High-Fat Diet-Fed Rats and ob/ob Mice

(2009) Ivan Torre-Villalvazo et al.   JOURNAL OF NUTRITION

Effects of ceramide and other simple sphingolipids on membrane lateral structure

(2008) Félix M. Goñi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The sphingolipid salvage pathway in ceramide metabolism and signaling

(2008) Kazuyuki Kitatani et al.   CELLULAR SIGNALLING

Ceramide is a cardiotoxin in lipotoxic cardiomyopathy

(2008) Tae-Sik Park et al.   JOURNAL OF LIPID RESEARCH

Effect of Sphingomyelinase-Mediated Generation of Ceramide on Aggregation of Low-Density Lipoprotein

(2008) Michael J. Walters et al.   LANGMUIR

Ceramide: A common pathway for atherosclerosis?

(2007) Jean Bismuth et al.   ATHEROSCLEROSIS