Immunological causes of obsessive-compulsive disorder: is it time for the concept of an “autoimmune OCD” subtype?

PANDAS: Too Narrow a View of the Neuroimmune Landscape

(2021) Steven E. Hyman   AMERICAN JOURNAL OF PSYCHIATRY

Probable Autoimmune Catatonia With Antibodies Against Cilia on Hippocampal Granule Cells and Highly Suspicious Cerebral FDG-Positron Emission Tomography Findings

(2020) Dominique Endres et al.   BIOLOGICAL PSYCHIATRY

Monoamine oxidase A hypomethylation in obsessive-compulsive disorder - reversibility by successful psychotherapy?

(2020) Miriam A Schiele et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

18F-FDG-PET/MRI in the diagnostic work-up of limbic encephalitis

(2020) Cornelius Deuschl et al.   PLoS One

The gut microbiome and inflammation in obsessive‐compulsive disorder patients compared to age‐ and sex‐matched controls: a pilot study

(2020) J. Turna et al.   ACTA PSYCHIATRICA SCANDINAVICA

Autoimmune encephalitis as a differential diagnosis of schizophreniform psychosis: clinical symptomatology, pathophysiology, diagnostic approach, and therapeutic considerations

(2020) Dominique Endres et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Th17 lymphocytes drive vascular and neuronal deficits in a mouse model of postinfectious autoimmune encephalitis

(2020) Maryann P. Platt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low-dose IL-2 in children with recently diagnosed type 1 diabetes: a Phase I/II randomised, double-blind, placebo-controlled, dose-finding study

(2020) Michelle Rosenzwajg et al.   DIABETOLOGIA

Associations Between Subclinical Inflammatory Markers and OCD: A Retrospective Study

(2020) Oğuzhan Herdi et al.   PSYCHIATRY RESEARCH

Cerebrospinal fluid, antineuronal autoantibody, EEG, and MRI findings from 992 patients with schizophreniform and affective psychosis

(2020) Dominique Endres et al.   Translational Psychiatry

Autoantibody Biomarkers for Basal Ganglia Encephalitis in Sydenham Chorea and Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infections

(2020) Jennifer L. Chain et al.   Frontiers in Psychiatry

Understanding the genetic contribution of the human leukocyte antigen system to common major psychiatric disorders in a world pandemic context

(2020) Ryad Tamouza et al.   BRAIN BEHAVIOR AND IMMUNITY

Benchmarking of T cell receptor repertoire profiling methods reveals large systematic biases

(2020) Pierre Barennes et al.   NATURE BIOTECHNOLOGY

New insights into the role of antinuclear antibodies in systemic lupus erythematosus

(2020) David S. Pisetsky et al.   Nature Reviews Rheumatology

Autoantibody-associated psychiatric syndromes: a systematic literature review resulting in 145 cases

(2020) Dominique Endres et al.   PSYCHOLOGICAL MEDICINE

Co-occurrence, Assessment and Treatment of Obsessive Compulsive Disorder in Children and Adults With Autism Spectrum Disorder

(2020) Saashi A. Bedford et al.   Current Psychiatry Reports

The Challenge of Assessing Mild Neuroinflammation in Severe Mental Disorders

(2020) Karl Bechter   Frontiers in Psychiatry

Diagnosing Organic Causes of Schizophrenia Spectrum Disorders: Findings from a One-Year Cohort of the Freiburg Diagnostic Protocol in Psychosis (FDPP)

(2020) Dominique Endres et al.   Diagnostics

Serotonin transporter gene promoter hypomethylation in obsessive-compulsive disorder – Predictor of impaired response to exposure treatment?

(2020) Miriam A. Schiele et al.   JOURNAL OF PSYCHIATRIC RESEARCH

The Cunningham Panel is an unreliable biological measure

(2019) Susanne Bejerot et al.   Translational Psychiatry

Clinical-Serological Characterization and Treatment Outcome of a Large Cohort of Italian Children with Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection and Pediatric Acute Neuropsychiatric Syndrome

(2019) Gemma Lepri et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

Obsessive-Compulsive Disorder: Puzzles and Prospects

(2019) Trevor W. Robbins et al.   NEURON

Reliability of the Cunningham Panel

(2019) Richard E. Frye et al.   Translational Psychiatry

Systemic Lupus Erythematosus With Isolated Psychiatric Symptoms and Antinuclear Antibody Detection in the Cerebrospinal Fluid

(2019) Eva M. Lüngen et al.   Frontiers in Psychiatry

Immune-Related Comorbidities in Childhood-Onset Obsessive Compulsive Disorder: Lifetime Prevalence in the Obsessive Compulsive Disorder Collaborative Genetics Association Study

(2019) Clara Westwell-Roper et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

Obsessive–compulsive disorder

(2019) Dan J. Stein et al.   Nature Reviews Disease Primers

Obsessive-Compulsive Disorder: Autoimmunity and Neuroinflammation

(2019) Mona Gerentes et al.   Current Psychiatry Reports

The Cunningham Panel: concerns remain

(2019) Susanne Bejerot et al.   Translational Psychiatry

Neural circuits in goal-directed and habitual behavior: Implications for circuit dysfunction in obsessive-compulsive disorder

(2019) Linda D. Simmler et al.   NEUROCHEMISTRY INTERNATIONAL

Evaluation of the Cunningham Panel™ in pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS) and pediatric acute-onset neuropsychiatric syndrome (PANS): Changes in antineuronal antibody titers parallel changes in patient symptoms

(2019) Craig Shimasaki et al.   JOURNAL OF NEUROIMMUNOLOGY

Altered cerebral glucose metabolism normalized in a patient with a pediatric autoimmune neuropsychiatric disorder after streptococcal infection (PANDAS)-like condition following treatment with plasmapheresis: a case report

(2018) A. H. Nave et al.   BMC Neurology

Differential binding of antibodies in PANDAS patients to cholinergic interneurons in the striatum

(2018) Luciana R. Frick et al.   BRAIN BEHAVIOR AND IMMUNITY

Association between TNF-α-238G/A gene polymorphism and OCD susceptibility

(2018) Caixiao Jiang et al.   MEDICINE

Treatment of PANDAS and PANS: a systematic review

(2018) Sofia Sigra et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Chronic obsessive–compulsive disorder: prognostic factors

(2018) Lucas J. B. van Oudheusden et al.   PSYCHOLOGICAL MEDICINE

Immune system and obsessive-compulsive disorder

(2018) Donatella Marazziti et al.   PSYCHONEUROENDOCRINOLOGY

Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex encephalitis: a prospective observational study and retrospective analysis

(2018) Thaís Armangue et al.   LANCET NEUROLOGY

Intravenous immunoglobulin for the treatment of autoimmune encephalopathy in children with autism

(2018) Kathleen Connery et al.   Translational Psychiatry

Immune Aberrations in Obsessive-Compulsive Disorder: a Systematic Review and Meta-analysis

(2018) Theodore D. Cosco et al.   MOLECULAR NEUROBIOLOGY

Regulatory T cells in the treatment of disease

(2018) Amir Sharabi et al.   NATURE REVIEWS DRUG DISCOVERY

Systemic autoimmune diseases are associated with an increased risk of obsessive–compulsive disorder: a nationwide population-based cohort study

(2018) Ling-Yi Wang et al.   SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY

Obsessive-Compulsive Disorder

(2017) Matthew E. Hirschtritt et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Overview of Treatment of Pediatric Acute-Onset Neuropsychiatric Syndrome

(2017) Susan E. Swedo et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

Clinical Management of Pediatric Acute-Onset Neuropsychiatric Syndrome: Part I–Psychiatric and Behavioral Interventions

(2017) Margo Thienemann et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

A Double-Blind Randomized Placebo-Controlled Pilot Study of Azithromycin in Youth with Acute-Onset Obsessive–Compulsive Disorder

(2017) Tanya K. Murphy et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

Biomarkers for diagnosis of Pediatric Acute Neuropsychiatric Syndrome (PANS) – Sensitivity and specificity of the Cunningham Panel

(2017) Eva Hesselmark et al.   JOURNAL OF NEUROIMMUNOLOGY

A total-population multigenerational family clustering study of autoimmune diseases in obsessive–compulsive disorder and Tourette’s/chronic tic disorders

(2017) D Mataix-Cols et al.   MOLECULAR PSYCHIATRY

Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System

(2017) Josep Dalmau et al.   PHYSIOLOGICAL REVIEWS

Human-leukocyte antigen class II genes in early-onset obsessive-compulsive disorder

(2017) Natalia Rodriguez et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Association of Streptococcal Throat Infection With Mental Disorders

(2017) Sonja Orlovska et al.   JAMA Psychiatry

Inflammation in the Neurocircuitry of Obsessive-Compulsive Disorder

(2017) Sophia Attwells et al.   JAMA Psychiatry

Primary Sjogren’s Syndrome Associated With Treatment-Resistant Obsessive–Compulsive Disorder

(2017) Lawrence T. C. Ong et al.   Frontiers in Psychiatry

Steroid-Responsive Chronic Schizophreniform Syndrome in the Context of Mildly Increased Antithyroid Peroxidase Antibodies

(2017) Dominique Endres et al.   Frontiers in Psychiatry

Red Flags: Clinical Signs for Identifying Autoimmune Encephalitis in Psychiatric Patients

(2017) Julia Herken et al.   Frontiers in Psychiatry

Human cerebrospinal fluid monoclonalN-methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis

(2016) Jakob Kreye et al.   BRAIN

Obsessive-Compulsive Disorder Related to Mycoplasma-Associated Autoimmune Encephalopathy with Basal Ganglia Involvement

(2016) Yangsik Kim et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

New feasible treatment for refractory autoimmune encephalitis: Low-dose interleukin-2

(2016) Jung-Ah Lim et al.   JOURNAL OF NEUROIMMUNOLOGY

Randomized, Controlled Trial of Intravenous Immunoglobulin for Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections

(2016) Kyle A. Williams et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

A clinical approach to diagnosis of autoimmune encephalitis

(2016) Francesc Graus et al.   LANCET NEUROLOGY

The link between autoimmune diseases and obsessive-compulsive and tic disorders: A systematic review

(2016) Ana Pérez-Vigil et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Biological markers for anxiety disorders, OCD and PTSD – a consensus statement. Part I: Neuroimaging and genetics

(2016) Borwin Bandelow et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Whole-exome sequencing in obsessive-compulsive disorder identifies rare mutations in immunological and neurodevelopmental pathways

(2016) C Cappi et al.   Translational Psychiatry

Exon-focused genome-wide association study of obsessive-compulsive disorder and shared polygenic risk with schizophrenia

(2016) J Costas et al.   Translational Psychiatry

Beyond the association.Toxoplasma gondiiin schizophrenia, bipolar disorder, and addiction: systematic review and meta-analysis

(2015) A. L. Sutterland et al.   ACTA PSYCHIATRICA SCANDINAVICA

Hypoglutamatergic state is associated with reduced cerebral glucose metabolism in anti-NMDA receptor encephalitis: a case report

(2015) Dominique Endres et al.   BMC Psychiatry

Immunogenetics of type 1 diabetes: A comprehensive review

(2015) Janelle A. Noble   JOURNAL OF AUTOIMMUNITY

Antineuronal Antibodies in a Heterogeneous Group of Youth and Young Adults with Tics and Obsessive-Compulsive Disorder

(2015) Carol J. Cox et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

Clinical Evaluation of Youth with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS): Recommendations from the 2013 PANS Consensus Conference

(2015) Kiki Chang et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

Group A Streptococcus intranasal infection promotes CNS infiltration by streptococcal-specific Th17 cells

(2015) Thamotharampillai Dileepan et al.   JOURNAL OF CLINICAL INVESTIGATION

Antibodies to GABAA receptor  1 and  2 subunits: Clinical and serologic characterization

(2015) P. Pettingill et al.   NEUROLOGY

Anti-basal ganglia antibodies in primary obsessive–compulsive disorder: systematic review and meta-analysis

(2014) Daniel M. Pearlman et al.   BRITISH JOURNAL OF PSYCHIATRY

Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: an overview

(2014) S. Esposito et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Neurocognitive Functioning in Youth With Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcus

(2014) Adam B. Lewin et al.   JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES

Obsessive–Compulsive Disorder

(2014) Jon E. Grant   NEW ENGLAND JOURNAL OF MEDICINE

Anti-streptococcal, tubulin, and dopamine receptor 2 antibodies in children with PANDAS and Tourette syndrome: Single-point and longitudinal assessments

(2013) C.M. Morris-Berry et al.   JOURNAL OF NEUROIMMUNOLOGY

Cerebral FDG-PET and MRI findings in autoimmune limbic encephalitis: correlation with autoantibody types

(2013) Annette Baumgartner et al.   JOURNAL OF NEUROLOGY

N-methyl-D-aspartate receptor antibodies in herpes simplex encephalitis

(2012) Harald Prüss et al.   ANNALS OF NEUROLOGY

Fluorodeoxyglucose positron emission tomography in anti-N-methyl-D-aspartate receptor encephalitis: distinct pattern of disease

(2012) Frank Leypoldt et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Behavioral, Pharmacological and Immunological Abnormalities after Streptococcal Exposure: A Novel Rat Model of Sydenham Chorea and Related Neuropsychiatric Disorders

(2012) Lior Brimberg et al.   NEUROPSYCHOPHARMACOLOGY

Systematic Review of Proinflammatory Cytokines in Obsessive-Compulsive Disorder

(2012) Simon M. Gray et al.   Current Psychiatry Reports

Stressful life events at onset of obsessive-compulsive disorder are associated with a distinct clinical pattern

(2011) Eva Real et al.   DEPRESSION AND ANXIETY

Genome-wide association study identifies five new schizophrenia loci

(2011)   NATURE GENETICS

Glutamate abnormalities in obsessive compulsive disorder: Neurobiology, pathophysiology, and treatment

(2011) Christopher Pittenger et al.   PHARMACOLOGY & THERAPEUTICS

Obsessive–compulsive disorder in the community: 12-month prevalence, comorbidity and impairment

(2011) Yuki Adam et al.   SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY

The rheumatoid arthritis HLA–DRB1 shared epitope

(2010) Joseph Holoshitz   CURRENT OPINION IN RHEUMATOLOGY

Obsessive-compulsive disorder

(2009) Jonathan S Abramowitz et al.   LANCET

Anti-Brain Autoantibodies and Altered Excitatory Neurotransmitters in Obsessive–Compulsive Disorder

(2009) Sagnik Bhattacharyya et al.   NEUROPSYCHOPHARMACOLOGY

Executive and Attention Functioning Among Children in the PANDAS Subgroup

(2008) Matthew E. Hirschtritt et al.   CHILD NEUROPSYCHOLOGY

The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication

(2008) A M Ruscio et al.   MOLECULAR PSYCHIATRY

Obsessive–compulsive disorder and immunology: A review

(2008) Felipe Filardi da Rocha et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY