Carfilzomib Treatment Causes Molecular and Functional Alterations of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes

Heart Failure With Targeted Cancer Therapies

(2021) Virginia S. Hahn et al.   CIRCULATION RESEARCH

Pkm2 Regulates Cardiomyocyte Cell Cycle and Promotes Cardiac Regeneration

(2020) Ajit Magadum et al.   CIRCULATION

Association of GSTM1 null variant with anthracycline‐related cardiomyopathy after childhood cancer—A Children's Oncology Group ALTE03N1 report

(2020) Purnima Singh et al.   CANCER

Proteomic Profiling Reveals Roles of Stress Response, Ca 2+ Transient Dysregulation, and Novel Signaling Pathways in Alcohol‐Induced Cardiotoxicity

(2020) Rui Liu et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Optical mapping of human embryonic stem cell-derived cardiomyocyte graft electrical activity in injured hearts

(2020) Dominic Filice et al.   Stem Cell Research & Therapy

Ion Channel Conformations Regulate Integrin-Dependent Signaling

(2019) Andrea Becchetti et al.   TRENDS IN CELL BIOLOGY

Off-target effects of carfilzomib that cause cardiotoxicity

(2019) Jan S. Moreb   BLOOD

Concise Review: Precision Matchmaking: Induced Pluripotent Stem Cells Meet Cardio‐Oncology

(2019) Pooja Nair et al.   Stem Cells Translational Medicine

Cardiovascular Organ Damage and Blood Pressure Levels Predict Adverse Events in Multiple Myeloma Patients Undergoing Carfilzomib Therapy

(2019) Giulia Bruno et al.   Cancers

NDUFAB1 confers cardio-protection by enhancing mitochondrial bioenergetics through coordination of respiratory complex and supercomplex assembly

(2019) Tingting Hou et al.   CELL RESEARCH

DNA probes that store mechanical information reveal transient piconewton forces applied by T cells

(2019) Rong Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Elimination of Tumorigenic Human Pluripotent Stem Cells Using Suicide-Inducing Virus-like Particles

(2018) Antonio Rampoldi et al.   ACS Chemical Biology

Cardiovascular Complications of Proteasome Inhibitors Used in Multiple Myeloma

(2018) Daniel C. Cole et al.   Cardiology in Review

Cardiotoxicity associated with carfilzomib: systematic review and meta-analysis

(2018) Chintan Shah et al.   LEUKEMIA & LYMPHOMA

Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials

(2018) Marsha C. Lampi et al.   Science Translational Medicine

Carfilzomib-Associated Cardiovascular Adverse Events

(2018) Adam J. Waxman et al.   JAMA Oncology

Carfilzomib-associated cardiovascular adverse events in a non-Caucasian cohort of patients with multiple myeloma: A real-world experience

(2018) Ankit Mangla et al.   HEMATOLOGICAL ONCOLOGY

The HSP90 Family: Structure, Regulation, Function, and Implications in Health and Disease

(2018) Abdullah Hoter et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular mechanisms of Carfilzomib-induced cardiotoxicity in mice and the emerging cardioprotective role of Metformin

(2018) Panagiotis Efentakis et al.   BLOOD

Human CLEC16A regulates autophagy through modulating mTOR activity

(2017) Rachel Chun Yee Tam et al.   EXPERIMENTAL CELL RESEARCH

Clathrin-mediated integrin αIIbβ3 trafficking controls platelet spreading

(2017) Wen Gao et al.   PLATELETS

Systolic dysfunction associated with carfilzomib use in patients with multiple myeloma

(2017) Tania Jain et al.   Blood Cancer Journal

Cardiac spheroids as promising in vitro models to study the human heart microenvironment

(2017) Liudmila Polonchuk et al.   Scientific Reports

Molecular Mechanisms of the Cardiotoxicity of the Proteasomal-Targeted Drugs Bortezomib and Carfilzomib

(2016) Brian B. Hasinoff et al.   Cardiovascular Toxicology

The Effect of Substrate Stiffness on Cardiomyocyte Action Potentials

(2016) Sean D. Boothe et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Inherited heart disease - what can we expect from the second decade of human iPS cell research?

(2016) Milena Bellin et al.   FEBS LETTERS

DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity

(2016) Yang Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bortezomib-induced heat shock response protects multiple myeloma cells and is activated by heat shock factor 1 serine 326 phosphorylation

(2016) Shardule P. Shah et al.   Oncotarget

Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes

(2016) Agnes Maillet et al.   Scientific Reports

Simulated Microgravity and 3D Culture Enhance Induction, Viability, Proliferation and Differentiation of Cardiac Progenitors from Human Pluripotent Stem Cells

(2016) Rajneesh Jha et al.   Scientific Reports

From ATP to PTP and Back: A Dual Function for the Mitochondrial ATP Synthase

(2015) P. Bernardi et al.   CIRCULATION RESEARCH

Effect of Substrate Mechanics on Cardiomyocyte Maturation and Growth

(2015) Marwa Tallawi et al.   TISSUE ENGINEERING PART B-REVIEWS

Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales

(2015) Nathaniel Huebsch et al.   TISSUE ENGINEERING PART C-METHODS

The novel proteasome inhibitor carfilzomib activates and enhances extrinsic apoptosis involving stabilization of death receptor 5

(2015) Bo Han et al.   Oncotarget

Therapeutic Targets in Heart Failure

(2014) Erik B. Schelbert et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Carfilzomib

(2013) K. M. Kortuem et al.   BLOOD

p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents

(2013) Xinbing Sui et al.   CANCER LETTERS

Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells

(2013) Feng Lan et al.   Cell Stem Cell

Induced Pluripotent Stem Cells in Cardiovascular Drug Discovery

(2013) Mark Mercola et al.   CIRCULATION RESEARCH

Where the endoplasmic reticulum and the mitochondrion tie the knot: The mitochondria-associated membrane (MAM)

(2012) Arun Raturi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Proteasome inhibitors in multiple myeloma: 10 years later

(2012) P. Moreau et al.   BLOOD

Effects of doxorubicin cancer therapy on autophagy and the ubiquitin-proteasome system in long-term cultured adult rat cardiomyocytes

(2012) Polychronis Dimitrakis et al.   CELL AND TISSUE RESEARCH

A Review of Human Pluripotent Stem Cell-Derived Cardiomyocytes for High-Throughput Drug Discovery, Cardiotoxicity Screening, and Publication Standards

(2012) Nicholas M. Mordwinkin et al.   Journal of Cardiovascular Translational Research

Hsp90 inhibitors and drug resistance in cancer: The potential benefits of combination therapies of Hsp90 inhibitors and other anti-cancer drugs

(2011) Xiangyi Lu et al.   BIOCHEMICAL PHARMACOLOGY

The Role of Mitochondria in Reactive Oxygen Species Metabolism and Signaling

(2010) Anatoly A. Starkov   Annals of the New York Academy of Sciences

Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage

(2010) William B Pratt et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Introducing a new entity: chemotherapy-induced arrhythmia

(2009) M. Guglin et al.   EUROPACE

Heat shock proteins: essential proteins for apoptosis regulation

(2008) D. Lanneau et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE