Identification of Novel Malaria Transmission-Blocking Vaccine Candidates

Structural vaccinology of malaria transmission-blocking vaccines

(2021) Palak N. Patel et al.   Expert Review of Vaccines

Transmission-Blocking Vaccines: Harnessing Herd Immunity for Malaria Elimination

(2021) Patrick E. Duffy   Expert Review of Vaccines

Pfs230 yields higher malaria transmission–blocking vaccine activity than Pfs25 in humans but not mice

(2021) Sara A. Healy et al.   JOURNAL OF CLINICAL INVESTIGATION

Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled trial

(2021) Mehreen S Datoo et al.   LANCET

Immunofocusing humoral immunity potentiates the functional efficacy of the AnAPN1 malaria transmission-blocking vaccine antigen

(2021) Nicole G. Bender et al.   npj Vaccines

Targeting Gametocytes of the Malaria Parasite Plasmodium falciparum in a Functional Genomics Era: Next Steps

(2021) Jyotsna Chawla et al.   Pathogens

Evidence of Artemisinin-Resistant Malaria in Africa

(2021) Betty Balikagala et al.   NEW ENGLAND JOURNAL OF MEDICINE

WHO gives first malaria vaccine the green light

(2021) Gretchen Vogel   SCIENCE

Characterization of Naturally Acquired Immunity to a Panel of Antigens Expressed in Mature P. falciparum Gametocytes

(2021) Michelle K. Muthui et al.   Frontiers in Cellular and Infection Microbiology

Evaluation of Plasmodium vivax HAP2 as a transmission-blocking vaccine candidate

(2020) Yue Qiu et al.   VACCINE

The C-terminal region of the Plasmodium yoelii microgamete surface antigen PyMiGS induces potent anti-malarial transmission-blocking immunity in mice

(2020) Mayumi Tachibana et al.   VACCINE

Current Challenges in the Identification of Pre-Erythrocytic Malaria Vaccine Candidate Antigens

(2020) Paulo Bettencourt   Frontiers in Immunology

Preparedness is essential for malaria-endemic regions during the COVID-19 pandemic

(2020) Jigang Wang et al.   LANCET

Development and validation of serological markers for detecting recent Plasmodium vivax infection

(2020) Rhea J. Longley et al.   NATURE MEDICINE

A conserved malaria parasite antigen Pb22 plays a critical role in male gametogenesis in Plasmodium berghei

(2020) Fei Liu et al.   CELLULAR MICROBIOLOGY

Leveraging the wheat germ cell-free protein synthesis system to accelerate malaria vaccine development

(2020) Bernard N. Kanoi et al.   PARASITOLOGY INTERNATIONAL

RTS,S malaria vaccine pilots in three African countries

(2019) Paul Adepoju   LANCET

Malaria transmission-blocking vaccines: wheat germ cell-free technology can accelerate vaccine development

(2019) Kazutoyo Miura et al.   Expert Review of Vaccines

Immunity against sexual stage Plasmodium falciparum and Plasmodium vivax parasites

(2019) Roos M. Jong et al.   IMMUNOLOGICAL REVIEWS

A male gametocyte osmiophilic body and microgamete surface protein of the rodent malaria parasite Plasmodium yoelii (PyMiGS) plays a critical role in male osmiophilic body formation and exflagellation

(2018) Mayumi Tachibana et al.   CELLULAR MICROBIOLOGY

Characterization of Plasmodium berghei Pbg37 as Both Pre- and Post-Fertilization Antigen with Transmission-Blocking Potential

(2018) Fei Liu et al.   INFECTION AND IMMUNITY

Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity

(2018) Will J. R. Stone et al.   Nature Communications

Antibody targeting of a specific region of Pfs47 blocks Plasmodium falciparum malaria transmission

(2018) Gaspar E. Canepa et al.   npj Vaccines

Safety and immunogenicity of Pfs25H-EPA/Alhydrogel, a transmission-blocking vaccine against Plasmodium falciparum: a randomised, double-blind, comparator-controlled, dose-escalation study in healthy Malian adults

(2018) Issaka Sagara et al.   LANCET INFECTIOUS DISEASES

Comprehensive analysis of antibody responses to Plasmodium falciparum erythrocyte membrane protein 1 domains

(2018) Bernard N. Kanoi et al.   VACCINE

Probabilistic data integration identifies reliable gametocyte-specific proteins and transcripts in malaria parasites

(2018) Lisette Meerstein-Kessel et al.   Scientific Reports

The Plasmodium yoelii microgamete surface antigen (PyMiGS) induces anti-malarial transmission blocking immunity that reduces microgamete motility/release from activated male gametocytes

(2018) Mayumi Tachibana et al.   VACCINE

Blood-stage malaria vaccines: post-genome strategies for the identification of novel vaccine candidates

(2017) Edward H. Ntege et al.   Expert Review of Vaccines

Characterization of Pb51 in Plasmodium berghei as a malaria vaccine candidate targeting both asexual erythrocytic proliferation and transmission

(2017) Jian Wang et al.   MALARIA JOURNAL

Functional characterization and comparison of Plasmodium falciparum proteins as targets of transmission-blocking antibodies

(2017) Daria Nikolaeva et al.   MOLECULAR & CELLULAR PROTEOMICS

Functional characterization of Plasmodium berghei PSOP25 during ookinete development and as a malaria transmission-blocking vaccine candidate

(2017) Wenqi Zheng et al.   Parasites & Vectors

Targeting the Conserved Fusion Loop of HAP2 Inhibits the Transmission of Plasmodium berghei and falciparum

(2017) Fiona Angrisano et al.   Cell Reports

Immunoscreening of Plasmodium falciparum proteins expressed in a wheat germ cell-free system reveals a novel malaria vaccine candidate

(2017) Masayuki Morita et al.   Scientific Reports

Structural and Immunological Characterization of Recombinant 6-Cysteine Domains of thePlasmodium falciparumSexual Stage Protein Pfs230

(2016) Nicholas J. MacDonald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic Analysis of thePlasmodium bergheiGametocyte Egressome and Vesicular bioID of Osmiophilic Body Proteins Identifies Merozoite TRAP-like Protein (MTRAP) as an Essential Factor for Parasite Transmission

(2016) Jessica Kehrer et al.   MOLECULAR & CELLULAR PROTEOMICS

Integrated transcriptomic and proteomic analyses ofP. falciparumgametocytes: molecular insight into sex-specific processes and translational repression

(2016) Edwin Lasonder et al.   NUCLEIC ACIDS RESEARCH

Characterization of a Plasmodium berghei sexual stage antigen PbPH as a new candidate for malaria transmission-blocking vaccine

(2016) Xu Kou et al.   Parasites & Vectors

Identification of three ookinete-specific genes and evaluation of their transmission-blocking potentials in Plasmodium berghei

(2016) Wenqi Zheng et al.   VACCINE

Safety and Immunogenicity of Pfs25-EPA/Alhydrogel®, a Transmission Blocking Vaccine against Plasmodium falciparum: An Open Label Study in Malaria Naïve Adults

(2016) Kawsar R. Talaat et al.   PLoS One

Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial

(2015)   LANCET

Immunogenicity of the RTS,S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial

(2015) Michael T White et al.   LANCET INFECTIOUS DISEASES

The Plasmodium berghei sexual stage antigen PSOP12 induces anti-malarial transmission blocking immunity both in vivo and in vitro

(2015) K.A. Sala et al.   VACCINE

Plasmodium vivax gametocyte proteins, Pvs48/45 and Pvs47, induce transmission-reducing antibodies by DNA immunization

(2015) Mayumi Tachibana et al.   VACCINE

Recombinant Pvs48/45 Antigen Expressed in E. coli Generates Antibodies that Block Malaria Transmission in Anopheles albimanus Mosquitoes

(2015) Myriam Arévalo-Herrera et al.   PLoS One

Antibodies to a Single, Conserved Epitope in Anopheles APN1 Inhibit Universal Transmission of Plasmodium falciparum and Plasmodium vivax Malaria

(2013) Jennifer S. Armistead et al.   INFECTION AND IMMUNITY

Functional Comparison of Plasmodium falciparum Transmission-Blocking Vaccine Candidates by the Standard Membrane-Feeding Assay

(2013) Kazutoyo Miura et al.   INFECTION AND IMMUNITY

Malaria vaccine technology roadmap

(2013) Vasee S Moorthy et al.   LANCET

Qualification of Standard Membrane-Feeding Assay with Plasmodium falciparum Malaria and Potential Improvements for Future Assays

(2013) Kazutoyo Miura et al.   PLoS One

Transposon mutagenesis identifies genes essential for Plasmodium falciparum gametocytogenesis

(2013) H. Ikadai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasmodium vivax gametocyte protein Pvs230 is a transmission-blocking vaccine candidate

(2012) Mayumi Tachibana et al.   VACCINE

Three Members of the 6-cys Protein Family of Plasmodium Play a Role in Gamete Fertility

(2010) Melissa R. van Dijk et al.   PLoS Pathogens

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Plasmodium berghei HAP2 induces strong malaria transmission-blocking immunity in vivo and in vitro

(2009) Andrew M. Blagborough et al.   VACCINE

Male Fertility of Malaria Parasites Is Determined by GCS1, a Plant-Type Reproduction Factor

(2008) Makoto Hirai et al.   CURRENT BIOLOGY

The conserved plant sterility gene HAP2 functions after attachment of fusogenic membranes in Chlamydomonas and Plasmodium gametes

(2008) Y. Liu et al.   GENES & DEVELOPMENT

Correctly folded Pfs48/45 protein of Plasmodium falciparum elicits malaria transmission-blocking immunity in mice

(2008) N. S. Outchkourov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA