Structural vaccinology of malaria transmission-blocking vaccines

A C-terminal Pfs48/45 malaria transmission-blocking vaccine candidate produced in the baculovirus expression system

(2020) Shwu-Maan Lee et al.   Scientific Reports

Comparison of carrier proteins to conjugate malaria transmission blocking vaccine antigens, Pfs25 and Pfs230

(2020) Puthupparampil V. Scaria et al.   VACCINE

Malaria vaccines since 2000: progress, priorities, products

(2020) Patrick E. Duffy et al.   npj Vaccines

Structure and function of a malaria transmission blocking vaccine targeting Pfs230 and Pfs230-Pfs48/45 proteins

(2020) Kavita Singh et al.   Communications Biology

Structural basis for neutralization of Plasmodium vivax by naturally acquired human antibodies that target DBP

(2019) Darya Urusova et al.   Nature Microbiology

Pfs230 and Pfs48/45 Fusion Proteins Elicit Strong Transmission-Blocking Antibody Responses Against Plasmodium falciparum

(2019) Susheel K. Singh et al.   Frontiers in Immunology

Outer membrane protein complex as a carrier for malaria transmission blocking antigen Pfs230

(2019) Puthupparampil V. Scaria et al.   npj Vaccines

Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25

(2019) Brandon McLeod et al.   Nature Communications

Malaria Vaccines: Recent Advances and New Horizons

(2018) Simon J. Draper et al.   Cell Host & Microbe

A Neutralizing Antibody Recognizing Primarily N -Linked Glycan Targets the Silent Face of the HIV Envelope

(2018) Tongqing Zhou et al.   IMMUNITY

Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity

(2018) Will J. R. Stone et al.   Nature Communications

Antibody targeting of a specific region of Pfs47 blocks Plasmodium falciparum malaria transmission

(2018) Gaspar E. Canepa et al.   npj Vaccines

Glycan Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies

(2018) Hongying Duan et al.   IMMUNITY

Safety and immunogenicity of a plant-produced Pfs25 virus-like particle as a transmission blocking vaccine against malaria: A Phase 1 dose-escalation study in healthy adults

(2018) Jessica A. Chichester et al.   VACCINE

Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody

(2018) Frank Lennartz et al.   Nature Communications

Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45

(2018) Prasun Kundu et al.   Nature Communications

Towards clinical development of a Pfs48/45-based transmission blocking malaria vaccine

(2017) Michael Theisen et al.   Expert Review of Vaccines

The s48/45 six-cysteine proteins: mediators of interaction throughout the Plasmodium life cycle

(2017) Silvia A. Arredondo et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Protein-protein conjugate nanoparticles for malaria antigen delivery and enhanced immunogenicity

(2017) Puthupparampil V. Scaria et al.   PLoS One

Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25

(2017) Stephen W. Scally et al.   Nature Communications

Targeting the Conserved Fusion Loop of HAP2 Inhibits the Transmission of Plasmodium berghei and falciparum

(2017) Fiona Angrisano et al.   Cell Reports

Structural and Immunological Characterization of Recombinant 6-Cysteine Domains of thePlasmodium falciparumSexual Stage Protein Pfs230

(2016) Nicholas J. MacDonald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assessment of Pfs25 expressed from multiple soluble expression platforms for use as transmission-blocking vaccine candidates

(2016) Shwu-Maan Lee et al.   MALARIA JOURNAL

Naturally acquired immunity to sexual stage P. falciparum parasites

(2016) WILL J. R. STONE et al.   PARASITOLOGY

Broadly neutralizing epitopes in thePlasmodium vivaxvaccine candidate Duffy Binding Protein

(2016) Edwin Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transmission-blocking activity is determined by transmission-reducing activity and number of control oocysts in Plasmodium falciparum standard membrane-feeding assay

(2016) Kazutoyo Miura et al.   VACCINE

Safety and Immunogenicity of Pfs25-EPA/Alhydrogel®, a Transmission Blocking Vaccine against Plasmodium falciparum: An Open Label Study in Malaria Naïve Adults

(2016) Kawsar R. Talaat et al.   PLoS One

Toward the development of effective transmission-blocking vaccines for malaria

(2015) Daria Nikolaeva et al.   Expert Review of Vaccines

Naturally acquired antibody responses to recombinant Pfs230 and Pfs48/45 transmission blocking vaccine candidates

(2015) Sophie Jones et al.   JOURNAL OF INFECTION

Transmission-blocking activity of antibodies to Plasmodium falciparum GLURP.10C chimeric protein formulated in different adjuvants

(2015) Will Roeffen et al.   MALARIA JOURNAL

Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection

(2015) Hadi M Yassine et al.   NATURE MEDICINE

A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen

(2015) A. Impagliazzo et al.   SCIENCE

A Plasmodium falciparum 48/45 single epitope R0.6C subunit protein elicits high levels of transmission blocking antibodies

(2015) Susheel K. Singh et al.   VACCINE

The Structure of Plasmodium falciparum Blood-Stage 6-Cys Protein Pf41 Reveals an Unexpected Intra-Domain Insertion Required for Pf12 Coordination

(2015) Michelle L. Parker et al.   PLoS One

Comparative Assessment of Transmission-Blocking Vaccine Candidates against Plasmodium falciparum

(2015) M. C. Kapulu et al.   Scientific Reports

Proof of principle for epitope-focused vaccine design

(2014) Bruno E. Correia et al.   NATURE

A multi-stage malaria vaccine candidate targeting both transmission and asexual parasite life-cycle stages

(2014) Michael Theisen et al.   VACCINE

Functional Comparison of Plasmodium falciparum Transmission-Blocking Vaccine Candidates by the Standard Membrane-Feeding Assay

(2013) Kazutoyo Miura et al.   INFECTION AND IMMUNITY

Structural and Biochemical Characterization ofPlasmodium falciparum12 (Pf12) Reveals a Unique Interdomain Organization and the Potential for an Antiparallel Arrangement withPf41

(2013) Michelle L. Tonkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies

(2013) Masaru Kanekiyo et al.   NATURE

A Plant-Produced Pfs25 VLP Malaria Vaccine Candidate Induces Persistent Transmission Blocking Antibodies against Plasmodium falciparum in Immunized Mice

(2013) R. Mark Jones et al.   PLoS One

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

(2013) J. S. McLellan et al.   SCIENCE

The Human Malaria Parasite Pfs47 Gene Mediates Evasion of the Mosquito Immune System

(2013) A. Molina-Cruz et al.   SCIENCE

Development of a Pfs25-EPA malaria transmission blocking vaccine as a chemically conjugated nanoparticle

(2013) Richard L. Shimp et al.   VACCINE

Structural and Functional Basis for Inhibition of Erythrocyte Invasion by Antibodies that Target Plasmodium falciparum EBA-175

(2013) Edwin Chen et al.   PLoS Pathogens

Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing

(2012) Magnus Manske et al.   NATURE

Structure of the Plasmodium 6-cysteine s48/45 domain

(2012) S. A. Arredondo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-Terminal Prodomain of Pfs230 Synthesized Using a Cell-Free System Is Sufficient To Induce Complement-Dependent Malaria Transmission-Blocking Activity

(2011) Mayumi Tachibana et al.   Clinical and Vaccine Immunology

Blood-stage malaria vaccines — recent progress and future challenges

(2010) A. L. Goodman et al.   ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY

From the circumsporozoite protein to the RTS,S/AS candidate vaccine

(2010) Joe Cohen et al.   Human vaccines & immunotherapeutics

The Dynamics of Naturally Acquired Immune Responses to Plasmodium falciparum Sexual Stage Antigens Pfs230 & Pfs48/45 in a Low Endemic Area in Tanzania

(2010) Teun Bousema et al.   PLoS One

The IC50 of anti-Pfs25 antibody in membrane-feeding assay varies among species

(2010) Lediya Cheru et al.   VACCINE

Three Members of the 6-cys Protein Family of Plasmodium Play a Role in Gamete Fertility

(2010) Melissa R. van Dijk et al.   PLoS Pathogens

A Potent Malaria Transmission Blocking Vaccine Based on Codon Harmonized Full Length Pfs48/45 Expressed in Escherichia coli

(2009) Debabani Roy Chowdhury et al.   PLoS One

Plasmodium berghei HAP2 induces strong malaria transmission-blocking immunity in vivo and in vitro

(2009) Andrew M. Blagborough et al.   VACCINE

Male Fertility of Malaria Parasites Is Determined by GCS1, a Plant-Type Reproduction Factor

(2008) Makoto Hirai et al.   CURRENT BIOLOGY

The conserved plant sterility gene HAP2 functions after attachment of fusogenic membranes in Chlamydomonas and Plasmodium gametes

(2008) Y. Liu et al.   GENES & DEVELOPMENT

Phase 1 Trial of Malaria Transmission Blocking Vaccine Candidates Pfs25 and Pvs25 Formulated with Montanide ISA 51

(2008) Yimin Wu et al.   PLoS One

Correctly folded Pfs48/45 protein of Plasmodium falciparum elicits malaria transmission-blocking immunity in mice

(2008) N. S. Outchkourov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA