Article
Biochemistry & Molecular Biology
Li Cui, Xueneng Guan, Wenbo Ding, Yi Luo, Wei Wang, Weiquan Bu, Jie Song, Xiaobin Tan, E. Sun, Qing Ning, Guoguang Liu, Xiaobin Jia, Liang Feng
Summary: SP2-1 polysaccharide from Scutellaria baicalensis Georgi shows protective effects against ulcerative colitis by improving pathological damage, reducing weight loss, and repairing intestinal barrier. Additionally, it significantly increases beneficial bacteria and inhibits the growth of harmful bacteria.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Fisheries
Yi-Teng Xia, Edwin Hok-Chi Cheng, Huai-You Wang, Lynn Hoi-Lam Zhang, Sheng-Ying Lin, Tina Ting-Xia Dong, Ran Duan, Qi-Wei Qin, Wen-Xiong Wang, Karl Wah-Keung Tsim
Summary: The root of Scutellaria baicalensis is used as herbal medicine, while its stem and leaf are considered waste. The extract of its aerial part, SBA, has been shown to replace antibiotics in rabbit fish farming to fight against marine pathogenic bacteria. The intake of SBA extract showed strong anti-bacterial effect and promoted the growth of probiotics.
Review
Medicine, Research & Experimental
Wanying Feng, Zhihua Yang, Yangxi Liu, Rui Chen, Zhihui Song, Guiyun Pan, Yuhang Zhang, Zehui Guo, Xinya Ding, Lu Chen, Yi Wang
Summary: All species have a physiological need for sleep, which plays a crucial role in preserving and restoring physiological processes. Recent research points to the influence of gut microbiota on brain function, revealing their relationship. Dysregulation of the gut-brain axis is found to be linked to insomnia, with certain gut microbiota metabolites and disturbances worsening the condition. Traditional Chinese medicine offers unique advantages in treating insomnia, and exploring its scientific relevance to gut microbiota may lead to new concepts and improved therapeutics.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Yiqing Guan, Kai Chen, Dongling Quan, Liangqi Kang, Danni Yang, Huanxian Wu, Mengqiu Yan, Shaoyu Wu, Lin Lv, Guohua Zhang
Summary: The combination of Scutellaria baicalensis Georgi (SB) and Sophora japonica L. (SJ) demonstrates renal protective effects against hypertensive nephropathy by improving intestinal barrier function, increasing SCFAs, reducing inflammation, decreasing IS accumulation, and inhibiting oxidative stress reactions in kidneys.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Veterinary Sciences
Hong Jiang, Zixia Bai, Ziheng Xu, Jian Sun, Hatungimana Francoise, Zuxiang Luan, Hongjun Wang
Summary: The traditional Chinese medicinal plants Rheum palmatum L., Scutellaria baicalensis Georgi, and Houttuynia cordata Thunb can inhibit and kill Escherichia coli and Salmonella in fish and shrimp aquaculture. The semi-biomimetic extract of the compound Dahuang Qinyu San (DQS) contains active ingredients such as quercetin, emodin, baicalin, and aloe-emodin. This study investigates the antibacterial mechanism of the extract against Salmonella.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Immunology
Chenxi Zhang, Peng Xue, Haiyan Zhang, Chenxi Tan, Shiyao Zhao, Xudong Li, Lihui Sun, Huihui Zheng, Jun Wang, Baoling Zhang, Weiya Lang
Summary: This review provides an overview of the role of the gut microbiota in adult neurogenesis and proposes the potential effects of traditional Chinese medicine on neurogenesis through regulation of the gut microbiota.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Agricultural Engineering
Yumeng Lu, Bo Cao, Yiyang Su, Jingjing Yang, Ying Xue, Meng Zhang, Lingyu Che, Pufan Gao, Xia Li, Xiaofang Zhou, Lianjin Liu, Shuanghong Song, Guishuang Li, Chengke Bai
Summary: This study compared the accumulation and synthesis mechanism of bioactive products in Huangqin (Scutellaria baicalensis Georgi) and Nianmao-Huangqin (Scutellaria viscidula Bge), and found significant differences in bioactive product content between the two species. The expression of key enzyme genes showed spatiotemporal specificities and was significantly correlated with the content of bioactive products. These findings suggest that the expression of key enzyme genes is the main reason for the difference in bioactive products.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Review
Chemistry, Medicinal
Bingjie Yue, Gangfan Zong, Ruizhi Tao, Zhonghong Wei, Yin Lu
Summary: This article discusses the extraction and pharmacological effects of traditional Chinese medicine polysaccharides, the functions of the gut microbiota, and the interactions between polysaccharides and the gut microbiota. It elucidates the mechanisms of how polysaccharides modulate host physiology via the gut microbiota.
PHYTOTHERAPY RESEARCH
(2022)
Review
Integrative & Complementary Medicine
Hui Zhao, Man He, Meng Zhang, Qiang Sun, Sha Zeng, Li Chen, Han Yang, Maolun Liu, Shan Ren, Xianli Meng, Haibo Xu
Summary: The text discusses the pathogenesis of colorectal cancer, the types and functions of gut microbiota, and the research on traditional Chinese medicine in treating colorectal cancer by regulating the gut microbiota. It emphasizes the importance of regulating the gut microbiota for disease treatment.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Plant Sciences
Boru Li, Meijing Xu, Yu Wang, Lijin Feng, Hang Xing, Kuo Zhang
Summary: This article summarizes the pharmacological effects, targets, and mechanisms of traditional Chinese medicine (TCM) in improving depression by regulating the gut microbiota. It provides evidence that TCMs are safe and effective in the treatment of depression and may offer a new therapeutic approach.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Environmental Sciences
Hui Wang, Yunyan Kang, Ni Yang, Hui Li, Sirui Huang, Zishan Liang, Guiling Zeng, Yi Huang, Wei Li, Mingtao Zheng, Riming Huang, Bingfu Lei, Xian Yang
Summary: This study synthesized carbon dots with enzyme-like activity via a hydrothermal method and found that these carbon dots can enhance the resistance of lettuce seedlings to UV-B stress by regulating the activities of antioxidant enzymes and activating the antioxidant metabolism pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Endocrinology & Metabolism
Donghui Li, Weiwei Tang, Yanyan Wang, Qi Gao, Hongwei Zhang, Yu Zhang, Yuliang Wang, Yongyi Yang, Yingming Zhou, Yike Zhang, Haonan Li, Shuo Li, Hong Zhao
Summary: Obesity is a chronic metabolic disease caused by multiple factors. High-fat diets disrupt the gut microbiota and impair gut barrier function in obese individuals. This leads to an imbalance in energy metabolism and inflammatory response, contributing to the development of chronic diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Agriculture, Dairy & Animal Science
Baishuang Yin, Wei Li, Hongyu Qin, Jinyan Yun, Xuezhao Sun
Summary: Scutellaria baicalensis, a common Chinese medicinal herb, contains bioactive compounds such as baicalein and baicalin with multiple biological functions. It has been used in animal production to effectively improve production performance, reduce stress and inflammation, and treat diseases caused by pathogens. Natural products like medicinal herbs, including S. baicalensis, have become increasingly popular due to their safety and lack of drug resistance.
Review
Medicine, Research & Experimental
Zhihua Yang, Yangxi Liu, Lin Wang, Shanshan Lin, Xiangdong Dai, Haifeng Yan, Zhao Ge, Qiuan Ren, Hui Wang, Feng Zhu, Shuping Wang
Summary: COVID-19 can cause gastrointestinal symptoms due to disruption of the gut microbiota. Traditional Chinese medicine has advantages in regulating the gut microbiota and has shown significant efficacy in the prevention and treatment of COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Plant Sciences
Yingying Li, Xinyu Ji, Haonan Wu, Xiang Li, Huamin Zhang, Danli Tang
Summary: This study reviewed the regulation of lipid metabolism by microbial metabolites in Traditional Chinese Medicine (TCM). It was found that TCM can effectively improve lipid metabolism through various mechanisms such as increasing SCFA levels, regulating BA metabolism, and reducing TMAO production. The findings suggest a potential new approach for better management of dyslipidemia in future clinical treatments.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Weidong Zhang, Yong Zhao, Pengfei Zhang, Yanan Hao, Shuai Yu, Lingjiang Min, Lan Li, Dongxue Ma, Liang Chen, Bao Yi, Xiangfang Tang, Qingshi Meng, Lei Liu, Shukun Wang, Wei Shen, Hongfu Zhang
Article
Multidisciplinary Sciences
Bao Yi, Liang Chen, Renna Sa, Ruqing Zhong, Huan Xing, Hongfu Zhang
Article
Agriculture, Dairy & Animal Science
Shanlong Tang, Jingjing Xie, Sheng Zhang, Weida Wu, Bao Yi, Hongfu Zhang
Article
Environmental Sciences
Shanlong Tang, Jingjing Xie, Weida Wu, Bao Yi, Lei Liu, Hongfu Zhang
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Review
Agriculture, Multidisciplinary
Ming Liu, Lei Liu, Zhang Hong-fu, Bao Yi, Nadia Everaert
Summary: Alginate oligosaccharides (AOS) are a class of functional marine oligosaccharides with low viscosity and good water solubility, possessing antioxidant, immune regulation, antibacterial, and anti-inflammatory activities. As new bio-feed additives, AOS have broad potential applications in animal husbandry. This review summarizes the sources of alginate, chemical structure and preparation methods of AOS, and their biological activities and applications in livestock and poultry.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2021)
Article
Infectious Diseases
Shunfen Zhang, Ruqing Zhong, Hui Han, Bao Yi, Jie Yin, Liang Chen, Hongfu Zhang
Article
Nutrition & Dietetics
Mengyu Wang, Shunfen Zhang, Ruqing Zhong, Fan Wan, Liang Chen, Lei Liu, Bao Yi, Hongfu Zhang
Summary: In summary, the study demonstrated that treatment with 100 mg/kg body weight polyphenol-rich OE could significantly enhance the antioxidant capacity in mice by increasing serum antioxidative enzyme activities and altering the colonic microbiota community.
FRONTIERS IN NUTRITION
(2021)
Review
Food Science & Technology
Hui Han, Yi Jiang, Mengyu Wang, Mebratu Melaku, Lei Liu, Yong Zhao, Nadia Everaert, Bao Yi, Hongfu Zhang
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disorder that is closely related to gut dysfunction. The bidirectional communication between the gut and liver, mediated by metabolites, plays a role in the pathogenesis of NAFLD.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Microbiology
Hui Han, Bao Yi, Ruqing Zhong, Mengyu Wang, Shunfen Zhang, Jie Ma, Yulong Yin, Jie Yin, Liang Chen, Hongfu Zhang
Summary: Feelings of hunger and satiety play crucial roles in maintaining life; gut microbiota have been implicated in appetite control, potentially affecting host metabolic health and leading to various metabolic disorders.
Review
Biochemistry & Molecular Biology
Mebratu Melaku, Ruqing Zhong, Hui Han, Fan Wan, Bao Yi, Hongfu Zhang
Summary: Intestinal dysfunction in farm animals is a critical issue affecting welfare and profitability. China has banned the use of antibiotics for improved feed efficiency, turning to organic acids as a promising alternative. Butyric and citric acids positively impact growth, welfare, and intestinal health by reducing pathogenic bacteria and maintaining GIT pH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Fan Wan, Xueying Cai, Mengyu Wang, Liang Chen, Ruqing Zhong, Lei Liu, Bao Yi, Fujiang Hou, Hongfu Zhang
Summary: Chlorogenic acid supplementation can effectively ameliorate DSS-induced colitis by activating the Nrf-2/HO-1 pathway to suppress oxidative stress and inflammatory responses, and promoting gut barrier.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Hui Han, Mengyu Wang, Ruqing Zhong, Bao Yi, Martine Schroyen, Hongfu Zhang
Summary: This study investigates the mechanism through which the gut microbiota influences hepatic lipid metabolism in high-fat diet-fed mice. Gut microbiota depletion was found to reduce body weight, fat deposition, glucose levels, cholesterol levels, insulin levels, and leptin levels in these mice. Additionally, it inhibited excessive hepatic lipid accumulation and changed the expression of genes involved in cholesterol and fatty acid metabolism. The abundance of bacteria associated with abnormal metabolism and inflammation was also reduced. There was a strong correlation between the altered gut microbiota abundance and the serum cholesterol level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fan Wan, Hui Han, Ruqing Zhong, Mengyu Wang, Shanlong Tang, Shunfen Zhang, Fujiang Hou, Bao Yi, Hongfu Zhang
Summary: The study found that dietary dihydroquercetin (DHQ) supplementation alleviated DSS-induced colitis in mice, potentially through its modulation of fecal microbiota communities. By increasing the relative abundance of beneficial bacteria such as Lactobacillus and Dubosiella, decreasing the relative abundance of Bacteroidetes, and restoring fecal concentrations of acetic acid and butyric acid, it improved the pathophysiological features of colitis.
Article
Biochemistry & Molecular Biology
Xiaochun Xu, Shengyue Ji, Weili Li, Bao Yi, Hengxin Li, Hongfu Zhang, Wenping Ma
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2017)