Subcellular proteomics of dopamine neurons in the mouse brain

Essential role for autophagy protein VMP1 in maintaining neuronal homeostasis and preventing axonal degeneration

(2021) Panpan Wang et al.   Cell Death & Disease

Proteomic Profiling of the Substantia Nigra to Identify Determinants of Lewy Body Pathology and Dopaminergic Neuronal Loss

(2021) Vladislav A. Petyuk et al.   JOURNAL OF PROTEOME RESEARCH

Cell-type and subcellular compartment-specific APEX2 proximity labeling reveals activity-dependent nuclear proteome dynamics in the striatum

(2021) V. Dumrongprechachan et al.   Nature Communications

Refining the Identity and Role of Kv4 Channels in Mouse Substantia Nigra Dopaminergic Neurons

(2021) Alexis Haddjeri-Hopkins et al.   eNeuro

Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics

(2020) Guoxia Liu et al.   NATURE

Synaptotagmin-1 is the Ca2+ sensor for fast striatal dopamine release

(2020) Aditi Banerjee et al.   eLife

A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders

(2020) Devika Agarwal et al.   Nature Communications

Axonal mechanisms mediating γ-aminobutyric acid receptor type A (GABA-A) inhibition of striatal dopamine release

(2020) Paul F Kramer et al.   eLife

The Gene Ontology resource: enriching a GOld mine

(2020) et al.   NUCLEIC ACIDS RESEARCH

Poor transcript-protein correlation in the brain: negatively correlating gene products reveal neuronal polarity as a potential cause

(2019) Christian P. Moritz et al.   JOURNAL OF NEUROCHEMISTRY

α6-Containing Nicotinic Acetylcholine Receptor Reconstitution Involves Mechanistically Distinct Accessory Components

(2019) Shenyan Gu et al.   Cell Reports

Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development

(2019) Katarína Tiklová et al.   Nature Communications

Multiplexed peroxidase-based electron microscopy labeling enables simultaneous visualization of multiple cell types

(2019) Qiyu Zhang et al.   NATURE NEUROSCIENCE

De novo gene signature identification from single‐cell RNA‐seq with hierarchical Poisson factorization

(2019) Hanna Mendes Levitin et al.   Molecular Systems Biology

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse

(2019) Frank Koopmans et al.   NEURON

Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways

(2019) David A. Ruhl et al.   Nature Communications

Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease

(2019) Peter A. Szabo et al.   Nature Communications

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

(2019) Mike A Nalls et al.   LANCET NEUROLOGY

Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain

(2019) Steven M. Graves et al.   NATURE NEUROSCIENCE

DCC Receptors Drive Prefrontal Cortex Maturation by Determining Dopamine Axon Targeting in Adolescence

(2018) Lauren M. Reynolds et al.   BIOLOGICAL PSYCHIATRY

Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites

(2018) Changliang Liu et al.   CELL

Unbiased Proteomic Study of the Axons of Cultured Rat Cortical Neurons

(2018) Chih-Fan Chuang et al.   JOURNAL OF PROTEOME RESEARCH

Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain

(2018) Arpiar Saunders et al.   CELL

T-complex protein 1-ring complex enhances retrograde axonal transport by modulating tau phosphorylation

(2018) Xu-Qiao Chen et al.   TRAFFIC

Inhibition of nigrostriatal dopamine release by striatal GABAA and GABAB receptors

(2018) Emanuel F. Lopes et al.   JOURNAL OF NEUROSCIENCE

Dimensionality reduction for visualizing single-cell data using UMAP

(2018) Etienne Becht et al.   NATURE BIOTECHNOLOGY

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

BioSITe: A Method for Direct Detection and Quantitation of Site-Specific Biotinylation

(2017) Dae In Kim et al.   JOURNAL OF PROTEOME RESEARCH

An Anatomically Resolved Mouse Brain Proteome Reveals Parkinson Disease-relevant Pathways

(2017) Sung Yun Jung et al.   MOLECULAR & CELLULAR PROTEOMICS

Labeling and identifying cell-specific proteomes in the mouse brain

(2017) Toke P Krogager et al.   NATURE BIOTECHNOLOGY

Cell-type-specific metabolic labeling of nascent proteomes in vivo

(2017) Beatriz Alvarez-Castelao et al.   NATURE BIOTECHNOLOGY

Antibodies to biotin enable large-scale detection of biotinylation sites on proteins

(2017) Namrata D Udeshi et al.   NATURE METHODS

Selective neuronal vulnerability in Parkinson disease

(2017) D. James Surmeier et al.   NATURE REVIEWS NEUROSCIENCE

The nano-architecture of the axonal cytoskeleton

(2017) Christophe Leterrier et al.   NATURE REVIEWS NEUROSCIENCE

GLUT4 Mobilization Supports Energetic Demands of Active Synapses

(2017) Ghazaleh Ashrafi et al.   NEURON

Generation and characterization of a mouse line for monitoring translation in dopaminergic neurons

(2017) Joseph D. Dougherty   Scientific Reports

The chaperonin CCT inhibits assembly of α-synuclein amyloid fibrils by a specific, conformation-dependent interaction

(2017) Begoña Sot et al.   Scientific Reports

Proteomic mapping of cytosol-facing outer mitochondrial and ER membranes in living human cells by proximity biotinylation

(2017) Victoria Hung et al.   eLife

Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts

(2016) Ken H. Loh et al.   CELL

Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics

(2016) Karthik Shekhar et al.   CELL

Shank3 is localized in axons and presynaptic specializations of developing hippocampal neurons and involved in the modulation of NMDA receptor levels at axon terminals

(2016) Sonja Halbedl et al.   JOURNAL OF NEUROCHEMISTRY

Spatially resolved proteomic mapping in living cells with the engineered peroxidase APEX2

(2016) Victoria Hung et al.   Nature Protocols

Glycolytic Enzymes Localize to Synapses under Energy Stress to Support Synaptic Function

(2016) SoRi Jang et al.   NEURON

Selective Ablation of GIRK Channels in Dopamine Neurons Alters Behavioral Effects of Cocaine in Mice

(2016) Nora M McCall et al.   NEUROPSYCHOPHARMACOLOGY

TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington’s disease

(2016) Xiaobei Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of an elaborate complex mediating postsynaptic inhibition

(2016) A. Uezu et al.   SCIENCE

Self-propelling vesicles define glycolysis as the minimal energy machinery for neuronal transport

(2016) María-Victoria Hinckelmann et al.   Nature Communications

Reconstruction of genetically identified neurons imaged by serial-section electron microscopy

(2016) Maximilian Joesch et al.   eLife

SLC10A4 Is a Vesicular Amine-Associated Transporter Modulating Dopamine Homeostasis

(2015) Martin Larhammar et al.   BIOLOGICAL PSYCHIATRY

Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis

(2015) Jacob H. Levine et al.   CELL

Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons

(2015) Consiglia Pacelli et al.   CURRENT BIOLOGY

The Mechanism and Function of Group II Chaperonins

(2015) Tom Lopez et al.   JOURNAL OF MOLECULAR BIOLOGY

Extending the Limits of Quantitative Proteome Profiling with Data-Independent Acquisition and Application to Acetaminophen-Treated Three-Dimensional Liver Microtissues

(2015) Roland Bruderer et al.   MOLECULAR & CELLULAR PROTEOMICS

Identification of neurodegenerative factors using translatome–regulatory network analysis

(2015) Lars Brichta et al.   NATURE NEUROSCIENCE

Proteomic mapping in liveDrosophilatissues using an engineered ascorbate peroxidase

(2015) Chiao-Lin Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

fastcluster: Fast Hierarchical, Agglomerative Clustering Routines forRandPython

(2015) Daniel Müllner   Journal of Statistical Software

Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons

(2014) Elena Dragicevic et al.   BRAIN

Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting

(2014) Christoph Biesemann et al.   EMBO JOURNAL

Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin

(2014) Ghazaleh Ashrafi et al.   JOURNAL OF CELL BIOLOGY

Proteomic Mapping of the Human Mitochondrial Intermembrane Space in Live Cells via Ratiometric APEX Tagging

(2014) Victoria Hung et al.   MOLECULAR CELL

Directed evolution of APEX2 for electron microscopy and proximity labeling

(2014) Stephanie S Lam et al.   NATURE METHODS

Axonal Transport: Cargo-Specific Mechanisms of Motility and Regulation

(2014) Sandra Maday et al.   NEURON

The role of D2-autoreceptors in regulating dopamine neuron activity and transmission

(2014) C.P. Ford   NEUROSCIENCE

COMPARTMENTS: unification and visualization of protein subcellular localization evidence

(2014) J. X. Binder et al.   Database-The Journal of Biological Databases and Curation

Defining Midbrain Dopaminergic Neuron Diversity by Single-Cell Gene Expression Profiling

(2014) Jean-Francois Poulin et al.   Cell Reports

Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease

(2013) Jeffrey H. Kordower et al.   BRAIN

Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport

(2013) Diana Zala et al.   CELL

Seeing the Unseen

(2013) Subhojit Roy   NEUROSCIENTIST

Spatial Distribution of DARPP-32 in Dendritic Spines

(2013) Hans Blom et al.   PLoS One

Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging

(2013) H.-W. Rhee et al.   SCIENCE

The energy cost of action potential propagation in dopamine neurons: clues to susceptibility in Parkinson's disease

(2013) Eleftheria K. Pissadaki et al.   Frontiers in Computational Neuroscience

Axon degeneration in Parkinson's disease

(2012) Robert E. Burke et al.   EXPERIMENTAL NEUROLOGY

Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons

(2012) Sandra Maday et al.   JOURNAL OF CELL BIOLOGY

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

(2012) Kyle J. Roux et al.   JOURNAL OF CELL BIOLOGY

GIRK2 expression in dopamine neurons of the substantia nigra and ventral tegmental area

(2012) Stefanie Reyes et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Glutamate Corelease Promotes Growth and Survival of Midbrain Dopamine Neurons

(2012) G. M. Fortin et al.   JOURNAL OF NEUROSCIENCE

Living on the edge with too many mouths to feed: Why dopamine neurons die

(2012) J. Paul Bolam et al.   MOVEMENT DISORDERS

Regulation of Presynaptic Neurotransmission by Macroautophagy

(2012) Daniela Hernandez et al.   NEURON

Actin, Spectrin, and Associated Proteins Form a Periodic Cytoskeletal Structure in Axons

(2012) K. Xu et al.   SCIENCE

Somatodendritic Dopamine Release Requires Synaptotagmin 4 and 7 and the Participation of Voltage-gated Calcium Channels

(2011) Jose Alfredo Mendez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mProphet: automated data processing and statistical validation for large-scale SRM experiments

(2011) Lukas Reiter et al.   NATURE METHODS

Role of Kv1 Potassium Channels in Regulating Dopamine Release and Presynaptic D2 Receptor Function

(2011) Philippe Martel et al.   PLoS One

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

Glutamate Controls Growth Rate and Branching of Dopaminergic Axons

(2009) Y. Schmitz et al.   JOURNAL OF NEUROSCIENCE

Single Nigrostriatal Dopaminergic Neurons Form Widely Spread and Highly Dense Axonal Arborizations in the Neostriatum

(2009) W. Matsuda et al.   JOURNAL OF NEUROSCIENCE

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

(2009) Stephen Tam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Presynaptic nicotinic receptors: a dynamic and diverse cholinergic filter of striatal dopamine neurotransmission

(2007) R Exley et al.   BRITISH JOURNAL OF PHARMACOLOGY