Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo

Inhibition of complement C5a receptor protects lung cells and tissues against lipopolysaccharide-induced injury via blocking pyroptosis

(2021) Renying Wang et al.   Aging-US

Protective Effects of Thymoquinone, an Active Compound of Nigella sativa, on Rats with Benzo(a)pyrene-Induced Lung Injury through Regulation of Oxidative Stress and Inflammation

(2021) Mohammad A. Alzohairy et al.   MOLECULES

Inhibition of ERRα Aggravates Sepsis-Induced Acute Lung Injury in Rats via Provoking Inflammation and Oxidative Stress

(2020) Wenfang Xia et al.   Oxidative Medicine and Cellular Longevity

Role of Nrf2 in Lipopolysaccharide-Induced Acute Kidney Injury: Protection by Human Umbilical Cord Blood Mononuclear Cells

(2020) Li-Xin Feng et al.   Oxidative Medicine and Cellular Longevity

Madecassoside protects retinal pigment epithelial cells against hydrogen peroxide-induced oxidative stress and apoptosis through the activation of Nrf2/HO-1 pathway

(2020) Jinzi Zhou et al.   BIOSCIENCE REPORTS

Activating Nrf2 signalling alleviates osteoarthritis development by inhibiting inflammasome activation

(2020) Zijian Yan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The NLRP3 inflammasome: Mechanism of action, role in disease and therapies

(2020) Li Wang et al.   MOLECULAR ASPECTS OF MEDICINE

Phillyrin Mitigates Apoptosis and Oxidative Stress in Hydrogen Peroxide-Treated RPE Cells through Activation of the Nrf2 Signaling Pathway

(2020) Yuanyuan Du et al.   Oxidative Medicine and Cellular Longevity

Protein S is Protective in Acute Lung Injury by Inhibiting Cell Apoptosis

(2019) Prince Baffour Tonto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mangiferin alleviates arsenic induced oxidative lung injury via upregulation of the Nrf2-HO1 axis

(2019) Sushweta Mahalanobish et al.   FOOD AND CHEMICAL TOXICOLOGY

PKR suppress NLRP3-pyroptosis pathway in lipopolysaccharide-induced acute lung injury model of mice

(2019) Yanjun Zeng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Honokiol Alleviates Oxidative Stress-Induced Neurotoxicity via Activation of Nrf2

(2018) Yanan Hou et al.   ACS Chemical Neuroscience

Dl-3-n-Butylphthalide Inhibits NLRP3 Inflammasome and Mitigates Alzheimer's-Like Pathology via Nrf2-TXNIP-TrX Axis

(2018) Chun-Yan Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury

(2018) Yanghao Hou et al.   BEHAVIOURAL BRAIN RESEARCH

FABP4 inhibitors suppress inflammation and oxidative stress in murine and cell models of acute lung injury

(2018) Yuanqi Gong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Honokiol protects hepatocytes from oxidative injury through mitochondrial deacetylase SIRT3

(2018) Jing-Xin Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Honokiol alleviates the degeneration of intervertebral disc via suppressing the activation of TXNIP-NLRP3 inflammasome signal pathway

(2018) Pan Tang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Juglanin suppresses fibrosis and inflammation response caused by LPS in acute lung injury

(2018) Ze-Wu Dong et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Protective Effects of a Synthetic Geranyl Acetophenone in a Cellular Model of TNF-α-Induced Pulmonary Epithelial Barrier Dysfunction

(2018) Tee Sim et al.   MOLECULES

Honokiol Ameliorates Myocardial Ischemia/Reperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway

(2018) Bin Zhang et al.   Oxidative Medicine and Cellular Longevity

Anti-inflammatory properties of Honokiol in activated primary microglia and astrocytes

(2018) Uta Rickert et al.   JOURNAL OF NEUROIMMUNOLOGY

Calcitriol inhibits ROS-NLRP3-IL-1β signaling axis via activation of Nrf2-antioxidant signaling in hyperosmotic stress stimulated human corneal epithelial cells

(2018) Yiqin Dai et al.   Redox Biology

Nrf2/ARE pathway inhibits ROS-induced NLRP3 inflammasome activation in BV2 cells after cerebral ischemia reperfusion

(2017) Xiujian Xu et al.   INFLAMMATION RESEARCH

Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-κB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway

(2017) Jun Zeng et al.   Journal of Neuroinflammation

Acute Respiratory Distress Syndrome

(2017) B. Taylor Thompson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Acute Lung Injury: A Clinical and Molecular Review

(2016) Yasmeen Butt et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

The suppression of bromodomain and extra-terminal domain inhibits vascular inflammation by blocking NF-κB and MAPK activation

(2016) Mingcheng Huang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Protection of Nrf2 against arsenite-induced oxidative damage is regulated by the cyclic guanosine monophosphate-protein kinase G signaling pathway

(2016) Chengzhi Chen et al.   ENVIRONMENTAL TOXICOLOGY

The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation

(2016) Deepika Sharma et al.   JOURNAL OF CELL BIOLOGY

Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome

(2016) Yong Zhang et al.   JOURNAL OF PINEAL RESEARCH

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Tight junctions in pulmonary epithelia during lung inflammation

(2016) Oliver H. Wittekindt   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Pulmonary epithelial barrier function: some new players and mechanisms

(2015) Kieran Brune et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

NLRP3 inflammasome and its inhibitors: a review

(2015) Bo-Zong Shao et al.   Frontiers in Pharmacology

Homocysteine downregulates gene expression of heme oxygenase-1 in hepatocytes

(2014) Xiaoqin Luo et al.   Nutrition & Metabolism

Novel concepts of acute lung injury and alveolar-capillary barrier dysfunction

(2013) Susanne Herold et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

An Official American Thoracic Society Workshop Report: Features and Measurements of Experimental Acute Lung Injury in Animals

(2011) Gustavo Matute-Bello et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Mechanism of the Nrf2/Keap1/ARE signaling system

(2011) V. O. Tkachev et al.   BIOCHEMISTRY-MOSCOW

Antioxidant signaling via Nrf2 counteracts lipopolysaccharide-mediated inflammatory responses in foam cell macrophages

(2011) Anne-Marie Kuhn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Honokiol rescues sepsis-associated acute lung injury and lethality via the inhibition of oxidative stress and inflammation

(2011) Te I. Weng et al.   INTENSIVE CARE MEDICINE

The value of the lipopolysaccharide-induced acute lung injury model in respiratory medicine

(2010) Hong Chen et al.   Expert Review of Respiratory Medicine

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY