Article
Chemistry, Applied
Long Chen, Xiao-Yan Liu, Jing Zhang, Li Duan, Zhong Wen, Hai-Liang Ni
Summary: The one-pot phospha-Michael addition/5-exo-dig cyclization/isomerization reaction catalyzed by relay Cu(I)/Brønsted base successfully synthesized C3-phosphorylated indoles from in situ generated aza-alkynyl o-quinone methides (N-o-AQMs) and P(O)-compounds. The study demonstrated that the 1,4-conjugate addition adduct from N-o-AQMs could undergo further cyclization with the tethered alkyne moiety to afford N-heterocyclic compounds.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Organic
Si-Si Ning, Dan Meng, Jie-Yun Zhang, Shi-Lei Liu, Ni-Ni Zhou, Xiaojie Jin, Hai-Tao Zhu
Summary: A metal-free intramolecular [3+2] cycloaddtion of benzene-linked propynol-ynes in AcOH/H2O has provided a greener and more practical route to functionalized naphtho[1,2-c]furan-5-ones with high regioselectivity. Additionally, regioselective alpha-deuteration of the naphtho[1,2-c]furan-5-ones showed excellent deuterium incorporation and yields. The fluorescent properties of the naphtho[1,2-c]furan-5-one products were also investigated in solution.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Ziyang Wang, Yuyu Cheng, Zhibin Yue, Xuling Chen, Pengfei Li, Wenjun Li
Summary: In this study, a chiral phosphoric acid-catalyzed 1,10-conjugate addition reaction was developed, enabling the organocatalytic asymmetric 3-allenylation of indoles. This approach provides a new method for the synthesis of axially chiral tetrasubstituted allenes.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Ying-Pong Lam, Jingxian Huang, Xiaojian Jiang, Ying-Yeung Yeung
Summary: A class of cinchona alkaloid-derived zwitterions has been successfully used to achieve highly enantioselective Steglich rearrangement and the same catalytic protocol was found applicable in the asymmetric aldol reaction. Studies were conducted to elucidate a clearer mechanism.
Article
Chemistry, Multidisciplinary
Qing-Qing Hang, Shu-Fang Wu, Shuang Yang, Xue Wang, Zhen Zhong, Yu-Chen Zhang, Feng Shi
Summary: The catalytic atroposelective synthesis of axially chiral isochromenone-indoles has been achieved using homophthalic anhydride-based indole derivatives as a new platform molecule for dynamic kinetic resolution. A wide range of axially chiral isochromenone-indoles were synthesized in high yields and excellent enantioselectivities using chiral quaternary ammonium salt as a phase-transfer catalyst in the catalytic asymmetric sulfonylation reaction.
SCIENCE CHINA-CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Seitaro Koshino, Tohru Taniguchi, Kenji Monde, Eunsang Kwon, Yujiro Hayashi
Summary: A one-pot synthesis of biaryls was developed using a catalytic amount of a single chiral source, allowing for an enantiodivergent chirality conversion from central-to-axial chirality with excellent enantioselectivity. Both enantiomers of biaryls were obtained in a single reaction vessel, with a proposed plausible reaction mechanism for the enantiodivergence.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Xiu-Ning Hu, Dong-Ping Wu, Ye-Peng Xu, Pei-Qiang Huang
Summary: The first organocatalytic asymmetric synthesis of an advanced intermediate of (+)-sarain A was achieved by combining organocatalytic asymmetric Michael addition reaction and a nitrogen-to-carbon chirality transfer. This method allows for the construction of three chiral centers and chemoselective reduction of a key lactam intermediate, providing a tricyclic intermediate with all necessary functionalities for further elaboration into (+)-sarain A.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Organic
Kun Guo, Qian Zeng, Alba Villar-Yanez, Carles Bo, Arjan W. Kleij
Summary: A Ni-catalyzed decarboxylative silylation of alkynyl cyclic carbonates has been reported, which serves as versatile propargylic surrogates and affords a wide range of highly substituted 2,3- and 3,4-allenol products in good yields. The formal cross-coupling between a tentative intermediate Ni(allenyl) and the silyl reagent can be further extended to enantiospecific conversions providing access to chiral allene synthons. This study is of significance as it represents the first Ni-catalyzed propargylic silylation proceeding through an S(N)2' manifold.
Article
Chemistry, Multidisciplinary
Esteban Matador, Javier Iglesias-Siguenza, David Monge, Pedro Merino, Rosario Fernandez, Jose M. Lassaletta
Summary: A highly enantio- and diastereoselective thiourea-catalyzed dearomatization of isoquinolines has been developed using N-tert-butylhydrazones as key neutral reagents, leading to the formation of appealing dihydroisoquinoline derivatives with excellent stereocontrol. Experimental and computational data support the generation of highly ordered complexes that play a crucial role in the selective and high-yielding transformations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Qian Shang, Haifang Tang, Yongping Liu, Mingming Yin, Lebin Su, Shimin Xie, Lixin Liu, Wen Yang, Yi Chen, Jianyu Dong, Yongbo Zhou, Shuang-Feng Yin
Summary: The selective condensation/bicycloaromatization of two different arylalkynes was achieved under ligand-free copper (I) catalysis, allowing for the direct synthesis of C-N axial biaryl compounds in high yields with excellent selectivity and functional group tolerance. The use of Cu (I) catalyst and HFIP played critical roles in suppressing undesired reactions and constructing coupled five-six aromatic rings through the selective formation of C(sp(2))-N(sp(2)) bonds and C(sp(2))-C(sp(2)) bonds. This unique reaction has the potential to lead to the simplest asymmetric synthesis of atropoisomeric biaryls, with promising applications in various fields such as biology and pharmaceuticals.
Article
Chemistry, Multidisciplinary
Soumen Barik, Sayan Shee, Soumik Das, Rajesh G. Gonnade, Garima Jindal, Subrata Mukherjee, Akkattu T. Biju
Summary: This study describes the atroposelective synthesis of N-aryl succinimides with axially chiral C-N bonds catalyzed by N-heterocyclic carbenes, achieving good yields and ee values. Preliminary investigations were also conducted on the rotation barrier for the C-N bond, temperature dependence, and detailed DFT studies on the mechanism.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Ke-Wei Chen, Zhi-Han Chen, Shuang Yang, Shu-Fang Wu, Yu-Chen Zhang, Feng Shi
Summary: A new strategy has been developed for the highly atroposelective synthesis of N-N axially chiral indole scaffolds and bispyrroles, which can be used as chiral organocatalysts and exhibit potent anticancer activity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Applied
Zaneta A. Mala, Mikolaj J. Janicki, Robert W. Gora, Krzysztof A. Konieczny, Rafal Kowalczyk
Summary: Dithiomalonates have been shown to be active nucleophiles in stereoselective additions, with Cinchona squaramides facilitating chirality transfer and mechanochemical approach proving to be effective.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Jun Kee Cheng, Bin Tan
Summary: This article introduces the wide applications and importance of indole compounds in designing new axially chiral scaffolds. The rich reactivity and N-H functionality of indole compounds allow chemical derivatization for enhanced medicinal, material, and catalytic properties. The research group successfully synthesized chiral biaryl compounds through the design of novel organocatalytic arylation reactions. Indole compounds showed reliable reactivity with azoarenes, nitrosonapthalenes, and quinone derivatives, which, in combination with chiral phosphoric acid catalyst, enabled excellent control of stereo-, chemo-, and regioselectivity to furnish diverse scaffolds. Additionally, indole compounds can also act as nucleophiles in the desymmetrization of 1,2,4-triazole-3,5-diones. This account provides a succinct illustration of these developments.
Article
Chemistry, Organic
Ibuki Tanaka, Masaya Sawamura, Yohei Shimizu
Summary: A reductive alkynylation of aldehydes using the Umpolung approach was developed with a photoredox catalyst under blue LED irradiation. Bulky aldehydes reacted smoothly under these conditions, and the alkynylation proceeded chemoselectively even in the presence of other carbonyl groups.
Article
Endocrinology & Metabolism
Hardy Kornfeld, Elizabeth Procter-Gray, Satyavani Kumpatla, Kevin Kane, Wenjun Li, Matthew J. Magee, Subash Babu, Vijay Viswanathan
Summary: This study aimed to investigate the impact of pulmonary TB on glycemic status, as well as the associations of glycemic trends with antidiabetic therapy and TB outcomes. Data from two prospective cohort studies in Chennai, India were analyzed and it was found that baseline A1C levels decreased after TB treatment initiation in all groups. However, in patients with baseline diabetes, rising A1C levels during and after treatment were significantly associated with adverse TB outcomes.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Geochemistry & Geophysics
Wenjun Li, Jing Wang, Mengmeng Cui, Xia Liu, Lihui Jia, Kaiyun Chen, Shitou Wu, Bingyu Gao, Dingshuai Xue, Yanhong Liu, Chao Li, Yang Luo, Benxun Su
Summary: Two clinopyroxene megacrysts, DMP-2 and DMP-3, from Cenozoic alkali basalts in Hannuoba region of China were characterized for major and trace element compositions through in situ microanalysis. Both clinopyroxene samples showed homogeneity in element mass fractions based on EPMA and LA-ICP-MS analyses. Bulk analyses using XRF, ICP-OES and solution ICP-MS techniques also revealed consistent major and trace element data. Thus, these samples can serve as potential reference materials for elemental in situ microanalysis, with recommended element mass fractions for thirty-two elements.
GEOSTANDARDS AND GEOANALYTICAL RESEARCH
(2023)
Review
Environmental Sciences
Yuanming Zhang, Akash Tariq, Alice C. Hughes, Deyuan Hong, Fuwen Wei, Hang Sun, Jordi Sardans, Josep Penuelas, Gad Perry, Jianfang Qiao, Alishir Kurban, Xiaoxia Jia, Domitilla Raimondo, Borong Pan, Weikang Yang, Daoyuan Zhang, Wenjun Li, Zeeshan Ahmed, Carl Beierkuhnlein, Georgy Lazkov, Kristina Toderich, Shirin Karryeva, Davron Dehkonov, Hikmat Hisoriev, Liliya Dimeyeva, Dmitry Milko, Ahmedou Soule, Malgozhata Suska-Malawska, Jumamurat Saparmuradov, Alilov Bekzod, Paul Allin, Sidy Dieye, Birane Cissse, Wondmagegne Whibesilassie, Keping Ma
Summary: The strategic goals of the United Nations and the Aichi Targets for biodiversity conservation have not been met. Instead, biodiversity has continued to rapidly decrease, especially in developing countries.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Plant Sciences
Guangzhao Jin, Wenjun Li, Feng Song, Lei Yang, Zhibin Wen, Ying Feng
Summary: This study sequenced and compared the chloroplast genomes of 16 species within the subgenus Seriphidium, revealing genetic consistency and variation in the subgenus. It also identified repetitive sequences and highly variable loci, and found inconsistencies between the molecular phylogeny and traditional taxonomy of subgenus Seriphidium. The whole chloroplast genomes can serve as molecular markers to infer interspecific relationships in this taxon.
Article
Microbiology
Chun-Yan Lu, Lei Dong, Shuai Li, Wen-Hui Lian, Zhi-Liang Lin, Zhuo-Huan Zheng, Lei Gao, Bao-Zhu Fang, Wen-Jun Li
Summary: A new actinobacterium, SYSU T00001(T), was isolated from a tidal flat sediment sample from Guangdong province, China. The isolate exhibited unique characteristics and showed highest similarity to Salinibacterium hongtaonis 194(T) based on phylogenetic analyses. Therefore, a novel species of the genus Salinibacterium, Salinibacterium sedimenticola sp. nov., is proposed, with SYSU T00001(T) as the type strain.
CURRENT MICROBIOLOGY
(2023)
Article
Fisheries
Chong Han, Wenwei Huang, Suhan Peng, Jiangwei Zhou, Huawei Zhan, Wenjun Li, Jian Gong, Qiang Li
Summary: In this study, 11 members of IRFs were identified and their expression patterns in different tissues were analyzed in the zig-zag eel. The results provide valuable information for understanding the antibacterial mechanism of IRFs in teleosts.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Substance Abuse
Thomas J. Stopka, Marc R. Larochelle, Xiaona Li, Dana Bernson, Wenjun Li, Leland K. Ackerson, Ric Bayly, Olaf Dammann, Cici Bauer
Summary: The study identified significant variations in fatal overdose rates of opioid-related drugs among different populations and geographical locations. These variations and clusters changed over time, providing valuable information to develop targeted public health strategies for high-risk subpopulations.
DRUG AND ALCOHOL DEPENDENCE
(2023)
Article
Materials Science, Textiles
Wenjun Li, Hui Zhang, Pei Chen, Jiale Yao, Xiangzhi Dong
Summary: In this study, Ag-doped g-C3N4-TiO2 nanocomposite photocatalysts were deposited on cotton fabric surface, significantly improving the photodegradation rate of MO dye under visible light irradiation. The introduction of highly dispersed Ag nanoparticles into g-C3N4-TiO2 composites was found to exhibit excellent photocatalytic properties due to narrowed band gap and faster separation and transfer of charge carriers. The Ag nanoparticle doping site had a significant influence on the photocatalytic activity. Moreover, the modified cotton fabric showed good reusability and stability for MO dye degradation after multiple cycles.
FIBERS AND POLYMERS
(2023)
Article
Chemistry, Multidisciplinary
Meiwen Liu, Boming Shen, Chang Liu, Peiyuan Yu, Pengfei Li
Summary: In this study, an organocatalytic asymmetric synthesis of chiral tetraarylmethanes was reported. Through the use of a chiral phosphoric acid catalyst, chiral tetraarylmethanes were synthesized from racemic tertiary alcohols. The method involved stereoselective 1,8-conjugate addition reactions, yielding the tetraarylmethanes with high enantioselectivity.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Cell Biology
Yan-Ni Qu, Yang-Zhi Rao, Yan-Ling Qi, Yu-Xian Li, Andrew Li, Marike Palmer, Brian P. Hedlund, Wen-Sheng Shu, Paul N. Evans, Guo-Xing Nie, Zheng-Shuang Huo, Wen-Jun Li
Summary: By reconstructing 10 closely related metagenome-assembled genomes from hot spring habitats, we discovered a new species, Panguiarchaeum symbiosum. Our functional investigations revealed that Panguiarchaeum symbiosum is an anaerobic organism that exclusively grows in thermal habitats by fermenting peptides and producing sulfide and hydrogen. The species likely lives in a symbiotic lifestyle similar to DPANN archaea. Population metagenomics and metatranscriptomic analyses supported the proposed proteolytic catabolism and symbiotic lifestyle of Panguiarchaeum symbiosum. This study provides insights into the metabolism, evolution, and potential symbiotic lifestyle of this unique archaeon within the TACK superphylum.
Article
Microbiology
Kun Zhang, Yanling Zhang, Maocheng Deng, Pengcheng Wang, Xiu Yue, Pandeng Wang, Wenjun Li
Summary: In this study, the dynamics of microbial and viral communities in an expanded granular sludge bed (EGSB) reactor were investigated. The results showed that COD, VSS/TSS ratio, and temperature were the main factors affecting the microbial community structure. The study also identified key genes involved in nitrogen cycling, with the dissimilatory nitrate reduction to ammonia (DNRA) and denitrification pathways dominating in the anaerobic system. The findings provide insights for the optimization of engineered systems.
FRONTIERS IN MICROBIOLOGY
(2023)
Editorial Material
Microbiology
Hongchen Jiang, Wen-Jun Li, Nils-Kare Birkeland, Dilfuza Egamberdieva
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Qian Du, Xin Xi, Jie Dong, Tongyan Zhang, Dongxuan Li, Yuzhu Dong, Wenjun Li, Guili Huang, Jun Zhu, Hailong Ran, Jinghui Gou, Cheng Chen, Zhanfeng Bai, Qinglong Liu, Wei Yao, Lei Zhang, Yutian Bi, Songqing Liu
Summary: This study found that early active pharmacy infectious disease consultation can reduce 30-day all-cause mortality and improve clinical outcomes in multidrug-resistant organism patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Microbiology
Cale O. Seymour, Marike Palmer, Eric D. Becraft, Ramunas Stepanauskas, Ariel D. Friel, Frederik Schulz, Tanja Woyke, Emiley Eloe-Fadrosh, Dengxun Lai, Jian-Yu Jiao, Zheng-Shuang Hua, Lan Liu, Zheng-Han Lian, Wen-Jun Li, Maria Chuvochina, Brianna K. Finley, Benjamin J. Koch, Egbert Schwartz, Paul Dijkstra, Duane P. Moser, Bruce A. Hungate, Brian P. Hedlund
Summary: The candidate bacterial phylum Omnitrophota is poorly studied. By analyzing genomes and data from the Earth Microbiome Project, researchers found that Omnitrophota are ultra-small cells mainly found in water, sediments, and soils. These bacteria have reduced genomes but retain key metabolic pathways and symbiotic gene clusters, indicating a host-associated lifestyle. Additionally, stable-isotope probing identified certain Omnitrophota families as potential obligate bacterial predators. Overall, most Omnitrophota inhabit various ecosystems as predators or parasites.
NATURE MICROBIOLOGY
(2023)
Article
Microbiology
Yang-Zhi Rao, Yu-Xian Li, Ze-Wei Li, Yan-Ni Qu, Yan-Ling Qi, Jian-Yu Jiao, Wen-Sheng Shu, Zheng-Shuang Hua, Wen-Jun Li
Summary: By using genome-resolved metagenomics, researchers discovered 28 Parvarchaeales-associated metagenome-assembled genomes (MAGs) and identified metabolic differences between Jingweiarchaeales and Parvarchaeales, as well as the adaptation of Parvarchaeales to acidic environments. The study also revealed unique genomic features of Jingweiarchaeum and Haiyanarchaeum that may contribute to their adaptation to high-temperature environments. Overall, this research is important for understanding the strategies and processes of how Candidatus Parvarchaeales microbes adapt to extreme environments.
