Indoxyl Sulfate Contributes to mTORC1-Induced Renal Fibrosis via The OAT/NADPH Oxidase/ROS Pathway
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Title
Indoxyl Sulfate Contributes to mTORC1-Induced Renal Fibrosis via The OAT/NADPH Oxidase/ROS Pathway
Authors
Keywords
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Journal
Toxins
Volume 13, Issue 12, Pages 909
Publisher
MDPI AG
Online
2021-12-20
DOI
10.3390/toxins13120909
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Note: Only part of the references are listed.- An acute phase protein α1-acid glycoprotein mitigates AKI and its progression to CKD through its anti-inflammatory action
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- (2020) Jing Lv et al. Aging-US
- Targeting the progression of chronic kidney disease
- (2020) Marta Ruiz-Ortega et al. Nature Reviews Nephrology
- SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition
- (2020) Issei Tomita et al. Cell Metabolism
- NOX4/H 2 O 2 /mTORC1 Pathway in Salt-Induced Hypertension and Kidney Injury
- (2020) Vikash Kumar et al. HYPERTENSION
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- (2020) Mickaël Bobot et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Proximal Tubule mTORC1 Is a Central Player in the Pathophysiology of Diabetic Nephropathy and Its Correction by SGLT2 Inhibitors
- (2020) Aviram Kogot-Levin et al. Cell Reports
- Indoxyl Sulfate Contributes to Adipose Tissue Inflammation through the Activation of NADPH Oxidase
- (2020) Shoma Tanaka et al. Toxins
- Uremic Toxins Affect Erythropoiesis during the Course of Chronic Kidney Disease: A Review
- (2020) Eya Hamza et al. Cells
- Indoxyl sulfate induces ROS production via the aryl hydrocarbon receptor-NADPH oxidase pathway and inactivates NO in vascular tissues
- (2020) Keisuke Nakagawa et al. LIFE SCIENCES
- Inhibition of the ERK1/2-mTORC1 axis ameliorates proteinuria and the fibrogenic action of transforming growth factor-β in adriamycin-induced glomerulosclerosis.
- (2019) Ranjan Das et al. KIDNEY INTERNATIONAL
- Indoxyl Sulfate Induces Renal Fibroblast Activation through a Targetable Heat Shock Protein 90-Dependent Pathway
- (2019) Samantha Milanesi et al. Oxidative Medicine and Cellular Longevity
- Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion
- (2019) Jitske Jansen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dual Therapeutic Effects of an Albumin-Based Nitric Oxide Donor on 2 Experimental Models of Chronic Kidney Disease
- (2018) Shun Oshiro et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- A NOX4/TRPC6 Pathway in Podocyte Calcium Regulation and Renal Damage in Diabetic Kidney Disease
- (2018) Daria V. Ilatovskaya et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Indoxyl Sulfate Induces Apoptosis and Hypertrophy in Human Kidney Proximal Tubular Cells
- (2018) Robert J. Ellis et al. TOXICOLOGIC PATHOLOGY
- Metabolism and mitochondria in polycystic kidney disease research and therapy
- (2018) Valeria Padovano et al. Nature Reviews Nephrology
- Uremic Toxin Indoxyl Sulfate Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling
- (2018) Toshiaki Nakano et al. CIRCULATION
- The MEK Inhibitor Trametinib Ameliorates Kidney Fibrosis by Suppressing ERK1/2 and mTORC1 Signaling
- (2018) Petros Andrikopoulos et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Targeting mTOR Signaling Can Prevent the Progression of FSGS
- (2017) Stefan Zschiedrich et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Oncogene-Selective Sensitivity to Synchronous Cell Death following Modulation of the Amino Acid Nutrient Cystine
- (2017) Ioannis Poursaitidis et al. Cell Reports
- Potential therapeutic interventions for chronic kidney disease-associated sarcopenia via indoxyl sulfate-induced mitochondrial dysfunction
- (2017) Yuki Enoki et al. Journal of Cachexia Sarcopenia and Muscle
- Low-protein diet for conservative management of chronic kidney disease: a systematic review and meta-analysis of controlled trials
- (2017) Connie M. Rhee et al. Journal of Cachexia Sarcopenia and Muscle
- Indoxyl sulfate, a uremic toxin in chronic kidney disease, suppresses both bone formation and bone resorption
- (2017) Kenta Watanabe et al. FEBS Open Bio
- Atg5-mediated autophagy deficiency in proximal tubules promotes cell cycle G2/M arrest and renal fibrosis
- (2016) Huiyan Li et al. Autophagy
- MicroRNA148b-3p inhibits mTORC1-dependent apoptosis in diabetes by repressing TNFR2 in proximal tubular cells
- (2016) Shogo Kuwagata et al. KIDNEY INTERNATIONAL
- Indoxyl sulfate potentiates skeletal muscle atrophy by inducing the oxidative stress-mediated expression of myostatin and atrogin-1
- (2016) Yuki Enoki et al. Scientific Reports
- Olmesartan protects endothelial cells against oxidative stress-mediated cellular injury
- (2015) Daisuke Kadowaki et al. Clinical and Experimental Nephrology
- Fatty acids are novel nutrient factors to regulate mTORC1 lysosomal localization and apoptosis in podocytes
- (2014) Mako Yasuda et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Low-Dose Rapamycin (Sirolimus) Effects in Autosomal Dominant Polycystic Kidney Disease: An Open-Label Randomized Controlled Pilot Study
- (2014) W. E. Braun et al. Clinical Journal of the American Society of Nephrology
- The Uremic Toxicity of Indoxyl Sulfate and p-Cresyl Sulfate: A Systematic Review
- (2014) R. Vanholder et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Renal Clearance and Intestinal Generation of p-Cresyl Sulfate and Indoxyl Sulfate in CKD
- (2013) R. Poesen et al. Clinical Journal of the American Society of Nephrology
- Rheb/mTORC1 Signaling Promotes Kidney Fibroblast Activation and Fibrosis
- (2013) L. Jiang et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- p -Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase
- (2013) Hiroshi Watanabe et al. KIDNEY INTERNATIONAL
- Autophagy in proximal tubules protects against acute kidney injury
- (2012) Man Jiang et al. KIDNEY INTERNATIONAL
- Indoxyl sulfate-induced epithelial-to-mesenchymal transition and apoptosis of renal tubular cells as novel mechanisms of progression of renal disease
- (2012) Su Hyun Kim et al. LABORATORY INVESTIGATION
- Redox Regulates Mammalian Target of Rapamycin Complex 1 (mTORC1) Activity by Modulating the TSC1/TSC2-Rheb GTPase Pathway
- (2011) Sei Yoshida et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Role of mTOR in podocyte function and diabetic nephropathy in humans and mice
- (2011) Markus Gödel et al. JOURNAL OF CLINICAL INVESTIGATION
- Cellular and molecular mechanisms of renal fibrosis
- (2011) Youhua Liu Nature Reviews Nephrology
- Sirolimus attenuates disease progression in an orthologous mouse model of human autosomal dominant polycystic kidney disease
- (2010) Iram Zafar et al. KIDNEY INTERNATIONAL
- p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease
- (2010) I.-W. Wu et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Sirolimus and Kidney Growth in Autosomal Dominant Polycystic Kidney Disease
- (2010) Andreas L. Serra et al. NEW ENGLAND JOURNAL OF MEDICINE
- Everolimus in Patients with Autosomal Dominant Polycystic Kidney Disease
- (2010) Gerd Walz et al. NEW ENGLAND JOURNAL OF MEDICINE
- Effect of a Carbonaceous Oral Adsorbent on the Progression of CKD: A Multicenter, Randomized, Controlled Trial
- (2009) Tadao Akizawa et al. AMERICAN JOURNAL OF KIDNEY DISEASES
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