Curcumin activation of a bacterial mechanosensitive channel underlies its membrane permeability and adjuvant properties

Life with Bacterial Mechanosensitive Channels, from Discovery to Physiology to Pharmacological Target

(2020) Paul Blount et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Novel MscL agonists that allow multiple antibiotics cytoplasmic access activate the channel through a common binding site

(2020) Robin Wray et al.   PLoS One

Regulation of Streptococcus pneumoniae  FtsZ assembly by divalent cations: Paradoxical effects of Ca 2+ on the nucleation and bundling of FtsZ polymers

(2019) Hemendra Pal Singh Dhaked et al.   FEBS Journal

An agonist of the MscL channel affects multiple bacterial species and increases membrane permeability and potency of common antibiotics

(2019) Robin Wray et al.   MOLECULAR MICROBIOLOGY

Understanding Interactions of Curcumin with Lipid Bilayers: A Coarse-Grained Molecular Dynamics Study

(2019) Nazar Ileri Ercan   Journal of Chemical Information and Modeling

Bacterial Mechanosensors

(2018) Charles D. Cox et al.   Annual Review of Physiology

Novel compounds that specifically bind and modulate MscL: insights into channel gating mechanisms

(2018) Robin Wray et al.   FASEB JOURNAL

The Essential Medicinal Chemistry of Curcumin

(2017) Kathryn M. Nelson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Curcumin, an antibiotic resistance breaker against a multiresistant clinical isolate of Mycobacterium abscessus

(2017) Emanuela Marini et al.   PHYTOTHERAPY RESEARCH

Construction and Analysis of Two Genome-Scale Deletion Libraries for Bacillus subtilis

(2017) Byoung-Mo Koo et al.   Cell Systems

Antibacterial activity of curcumin via apoptosis-like response in Escherichia coli

(2016) Dae Gyu Yun et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Dihydrostreptomycin Directly Binds to, Modulates, and Passes through the MscL Channel Pore

(2016) Robin Wray et al.   PLOS BIOLOGY

A new antibiotic with potent activity targets MscL

(2015) Irene Iscla et al.   JOURNAL OF ANTIBIOTICS

Bactericidal Activity of Curcumin I Is Associated with Damaging of Bacterial Membrane

(2015) Poonam Tyagi et al.   PLoS One

Scanning MscL Channels with Targeted Post-Translational Modifications for Functional Alterations

(2015) Irene Iscla et al.   PLoS One

Phytochemicals Perturb Membranes and Promiscuously Alter Protein Function

(2014) Helgi I. Ingólfsson et al.   ACS Chemical Biology

Streptomycin potency is dependent on MscL channel expression

(2014) Irene Iscla et al.   Nature Communications

Synergistic antibacterial effect of curcumin against methicillin-resistant Staphylococcus aureus

(2013) Su-Hyun Mun et al.   PHYTOMEDICINE

Differential effects of lipids and lyso-lipids on the mechanosensitivity of the mechanosensitive channels MscL and MscS

(2012) T. Nomura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

YbdG inEscherichia coliis a threshold-setting mechanosensitive channel with MscM activity

(2010) Ulrike Schumann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Curcumin inhibits FtsZ assembly: an attractive mechanism for its antibacterial activity

(2008) Dipti Rai et al.   BIOCHEMICAL JOURNAL

The Membrane Lateral Pressure-Perturbing Capacity of Parabens and Their Effects on the Mechanosensitive Channel Directly Correlate with Hydrophobicity†

(2008) Kishore Kamaraju et al.   BIOCHEMISTRY

On the Structure of the N-Terminal Domain of the MscL Channel: Helical Bundle or Membrane Interface

(2008) Irene Iscla et al.   BIOPHYSICAL JOURNAL

Gating-associated conformational changes in the mechanosensitive channel MscL

(2008) K. Yoshimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Curcumin as “Curecumin”: From kitchen to clinic

(2007) Ajay Goel et al.   BIOCHEMICAL PHARMACOLOGY