Global diversity and balancing selection of 23 leading Plasmodium falciparum candidate vaccine antigens

Whole-genome analysis of Malawian Plasmodium falciparum isolates identifies possible targets of allele-specific immunity to clinical malaria

(2021) Zalak Shah et al.   PLoS Genetics

A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver TRM Cell-Mediated Immunity against Malaria in Mice

(2020) Ana Maria Valencia-Hernandez et al.   Cell Host & Microbe

A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial

(2020) Raffael Nachbagauer et al.   NATURE MEDICINE

Challenges and strategies for developing efficacious and long-lasting malaria vaccines

(2019) James G. Beeson et al.   Science Translational Medicine

Targets of complement-fixing antibodies in protective immunity against malaria in children

(2019) Linda Reiling et al.   Nature Communications

Neutralising antibodies block the function of Rh5/Ripr/CyRPA complex during invasion of Plasmodium falciparum into human erythrocytes

(2019) Julie Healer et al.   CELLULAR MICROBIOLOGY

Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies

(2019) Daniel G.W. Alanine et al.   CELL

Protective Immunity against Severe Malaria in Children Is Associated with a Limited Repertoire of Antibodies to Conserved PfEMP1 Variants

(2019) Sofonias K. Tessema et al.   Cell Host & Microbe

Chromatin Accessibility-Based Characterization of the Gene Regulatory Network Underlying Plasmodium falciparum Blood-Stage Development

(2018) Christa Geeke Toenhake et al.   Cell Host & Microbe

Complex signatures of natural selection at GYPA

(2018) Abigail W. Bigham et al.   HUMAN GENETICS

Structural patterns of selection and diversity for Plasmodium vivax antigens DBP and AMA1

(2018) Andrew J. Guy et al.   MALARIA JOURNAL

Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections

(2018) Angela M. Early et al.   Nature Communications

RTS,S/AS01 malaria vaccine mismatch observed among Plasmodium falciparum isolates from southern and central Africa and globally

(2018) Julia C. Pringle et al.   Scientific Reports

Proteome-wide mapping of immune features onto Plasmodium protein three-dimensional structures

(2018) Andrew J. Guy et al.   Scientific Reports

Identity-by-descent analyses for measuring population dynamics and selection in recombining pathogens

(2018) Lyndal Henden et al.   PLoS Genetics

Structure of Plasmodium falciparum Rh5–CyRPA–Ripr invasion complex

(2018) Wilson Wong et al.   NATURE

The Immune Epitope Database (IEDB): 2018 update

(2018) Randi Vita et al.   NUCLEIC ACIDS RESEARCH

Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial

(2015)   LANCET

A novel locus of resistance to severe malaria in a region of ancient balancing selection

(2015)   NATURE

Designing malaria vaccines to circumvent antigen variability

(2015) Amed Ouattara et al.   VACCINE

popart: full-feature software for haplotype network construction

(2015) Jessica W. Leigh et al.   Methods in Ecology and Evolution

Conformational Dynamics and Antigenicity in the Disordered Malaria Antigen Merozoite Surface Protein 2

(2015) Christopher A. MacRaild et al.   PLoS One

Insights into the Immunological Properties of Intrinsically Disordered Malaria Proteins Using Proteome Scale Predictions

(2015) Andrew J. Guy et al.   PLoS One

Intrinsic disorder within the erythrocyte binding-like proteins from Plasmodium falciparum

(2014) Manuel Blanc et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

DISOPRED3: precise disordered region predictions with annotated protein-binding activity

(2014) David T. Jones et al.   BIOINFORMATICS

Epitope distribution in ordered and disordered protein regions. Part B — Ordered regions and disordered binding sites are targets of T- and B-cell immunity

(2014) Mirjana D. Pavlović et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Distinct patterns of diversity, population structure and evolution in the AMA1 genes of sympatric Plasmodium falciparum and Plasmodium vivax populations of Papua New Guinea from an area of similarly high transmission

(2014) Alicia Arnott et al.   MALARIA JOURNAL

Genome-Wide Analysis of Selection on the Malaria Parasite Plasmodium falciparum in West African Populations of Differing Infection Endemicity

(2014) Victor A. Mobegi et al.   MOLECULAR BIOLOGY AND EVOLUTION

Protective Epitopes of the Plasmodium falciparum SERA5 Malaria Vaccine Reside in Intrinsically Unstructured N-Terminal Repetitive Sequences

(2014) Masanori Yagi et al.   PLoS One

A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains

(2014) Mark D. Preston et al.   Nature Communications

Multimeric Assembly of Host-Pathogen Adhesion Complexes Involved in Apicomplexan Invasion

(2014) May M. Paing et al.   PLoS Pathogens

Structure ofPlasmodium falciparumTRAP (thrombospondin-related anonymous protein) A domain highlights distinct features in apicomplexan von Willebrand factor A homologues

(2013) Tero Pihlajamaa et al.   BIOCHEMICAL JOURNAL

Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection

(2013) Lander Foquet et al.   JOURNAL OF CLINICAL INVESTIGATION

The Epitope of Monoclonal Antibodies Blocking Erythrocyte Invasion by Plasmodium falciparum Map to The Dimerization and Receptor Glycan Binding Sites of EBA-175

(2013) Xavier Ambroggio et al.   PLoS One

Vaccination with Conserved Regions of Erythrocyte-Binding Antigens Induces Neutralizing Antibodies against Multiple Strains of Plasmodium falciparum

(2013) Julie Healer et al.   PLoS One

Maximum Allowed Solvent Accessibilites of Residues in Proteins

(2013) Matthew Z. Tien et al.   PLoS One

RH5-Basigin interaction plays a major role in the host tropism of Plasmodium falciparum

(2013) M. Wanaguru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Escaping the immune system: How the malaria parasite makes vaccine development a challenge

(2013) Danielle I. Stanisic et al.   TRENDS IN PARASITOLOGY

Structural and Functional Basis for Inhibition of Erythrocyte Invasion by Antibodies that Target Plasmodium falciparum EBA-175

(2013) Edwin Chen et al.   PLoS Pathogens

Overcoming Antigenic Diversity by Enhancing the Immunogenicity of Conserved Epitopes on the Malaria Vaccine Candidate Apical Membrane Antigen-1

(2013) Sheetij Dutta et al.   PLoS Pathogens

A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff

(2012) Pablo Cingolani et al.   FLY

Antigenic Characterization of an Intrinsically Unstructured Protein, Plasmodium falciparum Merozoite Surface Protein 2

(2012) Christopher G. Adda et al.   INFECTION AND IMMUNITY

Finding the sweet spots of inhibition: Understanding the targets of a functional antibody against Plasmodium vivax Duffy binding protein

(2012) Francis B. Ntumngia et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

A review of malaria vaccine clinical projects based on the WHO rainbow table

(2012) Lauren Schwartz et al.   MALARIA JOURNAL

A Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Infants

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Shape change in the receptor for gliding motility in Plasmodium sporozoites

(2012) G. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unexpected fold in the circumsporozoite protein target of malaria vaccines

(2012) M. B. Doud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrinsically disordered proteins: a 10-year recap

(2012) Peter Tompa   TRENDS IN BIOCHEMICAL SCIENCES

Unstructural biology coming of age

(2011) Peter Tompa   CURRENT OPINION IN STRUCTURAL BIOLOGY

A framework for variation discovery and genotyping using next-generation DNA sequencing data

(2011) Mark A DePristo et al.   NATURE GENETICS

Binding ofPlasmodiummerozoite proteins RON2 and AMA1 triggers commitment to invasion

(2011) Prakash Srinivasan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An EGF-like Protein Forms a Complex with PfRh5 and Is Required for Invasion of Human Erythrocytes by Plasmodium falciparum

(2011) Lin Chen et al.   PLoS Pathogens

A Fresh Look at the Origin of Plasmodium falciparum, the Most Malignant Malaria Agent

(2011) Franck Prugnolle et al.   PLoS Pathogens

Malaria Vaccine Design: Immunological Considerations

(2010) Michael F. Good et al.   IMMUNITY

Reticulocyte and Erythrocyte Binding-Like Proteins Function Cooperatively in Invasion of Human Erythrocytes by Malaria Parasites

(2010) Sash Lopaticki et al.   INFECTION AND IMMUNITY

The Relationship between Anti-merozoite Antibodies and Incidence of Plasmodium falciparum Malaria: A Systematic Review and Meta-analysis

(2010) Freya J. I. Fowkes et al.   PLOS MEDICINE

Acquired Immunity to Malaria

(2009) D. L. Doolan et al.   CLINICAL MICROBIOLOGY REVIEWS

Vaccine Potentials of an Intrinsically Unstructured Fragment Derived from the Blood Stage-Associated Plasmodium falciparum Protein PFF0165c

(2009) S. Olugbile et al.   INFECTION AND IMMUNITY

Contrasting Population Structures of the Genes Encoding Ten Leading Vaccine-Candidate Antigens of the Human Malaria Parasite, Plasmodium falciparum

(2009) Alyssa E. Barry et al.   PLoS One

Extreme Polymorphism in a Vaccine Antigen and Risk of Clinical Malaria: Implications for Vaccine Development

(2009) S. L. Takala et al.   Science Translational Medicine

A generic method for assignment of reliability scores applied to solvent accessibility predictions

(2009) Bent Petersen et al.   BMC STRUCTURAL BIOLOGY

Function and structure of inherently disordered proteins

(2008) A Keith Dunker et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY