Overcoming Antigenic Diversity by Enhancing the Immunogenicity of Conserved Epitopes on the Malaria Vaccine Candidate Apical Membrane Antigen-1

Diversity Covering AMA1-MSP119Fusion Proteins as Malaria Vaccines

(2013) Bart W. Faber et al.   INFECTION AND IMMUNITY

Overcoming Allelic Specificity by Immunization with Five Allelic Forms of Plasmodium falciparum Apical Membrane Antigen 1

(2013) Kazutoyo Miura et al.   INFECTION AND IMMUNITY

Immunogenicity of single versus mixed allele vaccines of Plasmodium vivax Duffy binding protein region II

(2013) Francis B. Ntumngia et al.   VACCINE

Controlled Human Blood Stage Malaria Infection: Current Status and Potential Applications

(2012) Christopher J. A. Duncan et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Measurement of the plasma levels of antibodies against the polymorphic vaccine candidate apical membrane antigen 1 in a malaria-exposed population

(2012) Kwadwo A Kusi et al.   BMC INFECTIOUS DISEASES

Molecular Basis of Allele-Specific Efficacy of a Blood-Stage Malaria Vaccine: Vaccine Development Implications

(2012) Amed Ouattara et al.   JOURNAL OF INFECTIOUS DISEASES

1976 and 2009 H1N1 Influenza Virus Vaccines Boost Anti-Hemagglutinin Stalk Antibodies in Humans

(2012) Matthew S. Miller et al.   JOURNAL OF INFECTIOUS DISEASES

Hemagglutinin Stalk-Reactive Antibodies Are Boosted following Sequential Infection with Seasonal and Pandemic H1N1 Influenza Virus in Mice

(2012) F. Krammer et al.   JOURNAL OF VIROLOGY

HIV-1 Neutralization Coverage Is Improved by Combining Monoclonal Antibodies That Target Independent Epitopes

(2012) N. A. Doria-Rose et al.   JOURNAL OF VIROLOGY

Evolution of an HIV glycan–dependent broadly neutralizing antibody epitope through immune escape

(2012) Penny L Moore et al.   NATURE MEDICINE

Humoral Immune Responses to a Single Allele PfAMA1 Vaccine in Healthy Malaria-Naïve Adults

(2012) Edmond J. Remarque et al.   PLoS One

Defining the Antigenic Diversity of Plasmodium falciparum Apical Membrane Antigen 1 and the Requirements for a Multi-Allele Vaccine against Malaria

(2012) Damien R. Drew et al.   PLoS One

Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells

(2012) G.-M. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hemagglutinin stalk antibodies elicited by the 2009 pandemic influenza virus as a mechanism for the extinction of seasonal H1N1 viruses

(2012) N. Pica et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Evolutionary Consequences of Blood-Stage Vaccination on the Rodent Malaria Plasmodium chabaudi

(2012) Victoria C. Barclay et al.   PLOS BIOLOGY

Structural and Functional Insights into the Malaria Parasite Moving Junction Complex

(2012) Brigitte Vulliez-Le Normand et al.   PLoS Pathogens

Enhancing Blockade of Plasmodium falciparum Erythrocyte Invasion: Assessing Combinations of Antibodies against PfRH5 and Other Merozoite Antigens

(2012) Andrew R. Williams et al.   PLoS Pathogens

Immunization with different PfAMA1 alleles in sequence induces clonal imprint humoral responses that are similar to responses induced by the same alleles as a vaccine cocktail in rabbits

(2011) Kwadwo A Kusi et al.   MALARIA JOURNAL

Safety and immunogenicity of multi-antigen AMA1-based vaccines formulated with CoVaccine HT™ and Montanide ISA 51 in rhesus macaques

(2011) Kwadwo A Kusi et al.   MALARIA JOURNAL

A Field Trial to Assess a Blood-Stage Malaria Vaccine

(2011) Mahamadou A. Thera et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vaccination with Plasmodium knowlesi AMA1 Formulated in the Novel Adjuvant Co-Vaccine HT™ Protects against Blood-Stage Challenge in Rhesus Macaques

(2011) Muzamil Mahdi Abdel Hamid et al.   PLoS One

Adenovirus 5-Vectored P. falciparum Vaccine Expressing CSP and AMA1. Part A: Safety and Immunogenicity in Seronegative Adults

(2011) Martha Sedegah et al.   PLoS One

Revealing a Parasite's Invasive Trick

(2011) J. Baum et al.   SCIENCE

Host Cell Invasion by Apicomplexan Parasites: Insights from the Co-Structure of AMA1 with a RON2 Peptide

(2011) M. L. Tonkin et al.   SCIENCE

Erythrocyte and reticulocyte binding-like proteins of Plasmodium falciparum

(2011) Wai-Hong Tham et al.   TRENDS IN PARASITOLOGY

The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody

(2011) Alexander D. Douglas et al.   Nature Communications

Juxtamembrane Shedding of Plasmodium falciparum AMA1 Is Sequence Independent and Essential, and Helps Evade Invasion-Inhibitory Antibodies

(2011) Anna Olivieri et al.   PLoS Pathogens

Structural Characterization of Apical Membrane Antigen 1 (AMA1) fromToxoplasma gondii

(2010) Joanna Crawford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction betweenPlasmodium falciparumApical Membrane Antigen 1 and the Rhoptry Neck Protein Complex Defines a Key Step in the Erythrocyte Invasion Process of Malaria Parasites

(2010) Dave Richard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Advances and challenges in malaria vaccine development

(2010) Peter D. Crompton et al.   JOURNAL OF CLINICAL INVESTIGATION

Development of fluorescent Plasmodium falciparum for in vitro growth inhibition assays

(2010) Danny W Wilson et al.   MALARIA JOURNAL

Antibodies against multiple merozoite surface antigens of the human malaria parasite Plasmodium falciparum inhibit parasite maturation and red blood cell invasion

(2010) Ute Woehlbier et al.   MALARIA JOURNAL

Generation of Humoral Immune Responses to Multi-Allele PfAMA1 Vaccines; Effect of Adjuvant and Number of Component Alleles on the Breadth of Response

(2010) Kwadwo A. Kusi et al.   PLoS One

Adenovectors induce functional antibodies capable of potent inhibition of blood stage malaria parasite growth

(2010) Joseph T. Bruder et al.   VACCINE

Alanine Mutagenesis of the Primary Antigenic Escape Residue Cluster, C1, of Apical Membrane Antigen 1

(2009) S. Dutta et al.   INFECTION AND IMMUNITY

In Vitro Growth-Inhibitory Activity and Malaria Risk in a Cohort Study in Mali

(2009) P. D. Crompton et al.   INFECTION AND IMMUNITY

Immunoglobulin G Subclass-Specific Responses against Plasmodium falciparum Merozoite Antigens Are Associated with Control of Parasitemia and Protection from Symptomatic Illness

(2009) D. I. Stanisic et al.   INFECTION AND IMMUNITY

Phase 1/2a Study of the Malaria Vaccine Candidate Apical Membrane Antigen-1 (AMA-1) Administered in Adjuvant System AS01B or AS02A

(2009) Michele D. Spring et al.   PLoS One

Humoral Immune Response to Mixed PfAMA1 Alleles; Multivalent PfAMA1 Vaccines Induce Broad Specificity

(2009) Kwadwo A. Kusi et al.   PLoS One

High Antibody Titer against Apical Membrane Antigen-1 Is Required to Protect against Malaria in the Aotus Model

(2009) Sheetij Dutta et al.   PLoS One

Extreme Polymorphism in a Vaccine Antigen and Risk of Clinical Malaria: Implications for Vaccine Development

(2009) S. L. Takala et al.   Science Translational Medicine

A randomized controlled phase 2 trial of the blood stage AMA1-C1/Alhydrogel malaria vaccine in children in Mali

(2009) Issaka Sagara et al.   VACCINE

Evaluation of the safety and immunogenicity of Plasmodium falciparum apical membrane antigen 1, merozoite surface protein 1 or RTS,S vaccines with adjuvant system AS02A administered alone or concurrently in rhesus monkeys

(2009) S. Pichyangkul et al.   VACCINE

An Inhibitory Antibody Blocks Interactions between Components of the Malarial Invasion Machinery

(2009) Christine R. Collins et al.   PLoS Pathogens

A Diversity-Covering Approach to Immunization with Plasmodium falciparum Apical Membrane Antigen 1 Induces Broader Allelic Recognition and Growth Inhibition Responses in Rabbits

(2008) E. J. Remarque et al.   INFECTION AND IMMUNITY

Rhoptry neck protein RON2 forms a complex with microneme protein AMA1 in Plasmodium falciparum merozoites

(2008) Jun Cao et al.   PARASITOLOGY INTERNATIONAL

Population structure of the genes encoding the polymorphic Plasmodium falciparum apical membrane antigen 1: Implications for vaccine design

(2008) J. Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apical membrane antigen 1: a malaria vaccine candidate in review

(2008) Edmond J. Remarque et al.   TRENDS IN PARASITOLOGY