Pathways shaping the mitochondrial inner membrane

MICOS and the mitochondrial inner membrane morphology – when things get out of shape

(2021) Indrani Mukherjee et al.   FEBS LETTERS

Cristae undergo continuous cycles of membrane remodelling in a MICOS ‐dependent manner

(2020) Arun Kumar Kondadi et al.   EMBO REPORTS

Shaping the mitochondrial inner membrane in health and disease

(2020) L. Colina‐Tenorio et al.   JOURNAL OF INTERNAL MEDICINE

Structural analysis of a trimeric assembly of the mitochondrial dynamin-like GTPase Mgm1

(2020) Liming Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The MICOS complex, a structural element of mitochondria with versatile functions

(2020) Siavash Khosravi et al.   BIOLOGICAL CHEMISTRY

Lipid homeostasis in mitochondria

(2020) Yasushi Tamura et al.   BIOLOGICAL CHEMISTRY

Returning to the Fold for Lessons in Mitochondrial Crista Diversity and Evolution

(2020) Tomáš Pánek et al.   CURRENT BIOLOGY

Absolute yeast mitochondrial proteome quantification reveals trade-off between biosynthesis and energy generation during diauxic shift

(2020) Francesca Di Bartolomeo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation

(2020) Till Stephan et al.   EMBO JOURNAL

Phospholipid ebb and flow makes mitochondria go

(2020) Michelle Grace Acoba et al.   JOURNAL OF CELL BIOLOGY

Quantification of cristae architecture reveals time-dependent characteristics of individual mitochondria

(2020) Mayuko Segawa et al.   Life Science Alliance

MICOS subcomplexes assemble independently on the mitochondrial inner membrane in proximity to ER contact sites

(2020) Parker S. Tirrell et al.   JOURNAL OF CELL BIOLOGY

Cristae Membrane Dynamics – A Paradigm Change

(2020) Arun Kumar Kondadi et al.   TRENDS IN CELL BIOLOGY

Maintenance of Cardiolipin and Crista Structure Requires Cooperative Functions of Mitochondrial Dynamics and Phospholipid Transport

(2019) Rieko Kojima et al.   Cell Reports

Dimers of mitochondrial ATP synthase induce membrane curvature and self-assemble into rows

(2019) Thorsten B. Blum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Mechanisms of F-Type ATP Synthases

(2019) Werner Kühlbrandt   Annual Review of Biochemistry

A MICOS-TIM22 Association Promotes Carrier Import into Human Mitochondria

(2019) Sylvie Callegari et al.   JOURNAL OF MOLECULAR BIOLOGY

Mic60 exhibits a coordinated clustered distribution along and across yeast and mammalian mitochondria

(2019) Stefan Stoldt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1

(2019) Katja Faelber et al.   NATURE

Single amino acid mutations in the Saccharomyces cerevisiae rhomboid peptidase, Pcp1p, alter mitochondrial morphology

(2019) Mary Elizabeth Huddleston et al.   CELL BIOLOGY INTERNATIONAL

Functional Interplay between Cristae Biogenesis, Mitochondrial Dynamics and Mitochondrial DNA Integrity

(2019) Arun Kumar Kondadi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent

(2019) Dane M Wolf et al.   EMBO JOURNAL

The ‘mitochondrial contact site and cristae organising system’ (MICOS) in health and human disease

(2019) Matthew J Eramo et al.   JOURNAL OF BIOCHEMISTRY

Who and how in the regulation of mitochondrial cristae shape and function

(2018) R. Quintana-Cabrera et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Eight human OPA1 isoforms, long and short: What are they for?

(2018) Valentina Del Dotto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Lipid Homeostasis Is Maintained by Dual Targeting of the Mitochondrial PE Biosynthesis Enzyme to the ER

(2018) Jonathan R. Friedman et al.   DEVELOPMENTAL CELL

­­Mitochondrial ATP synthase dimers spontaneously associate due to a long-range membrane-induced force­

(2018) Claudio Anselmi et al.   JOURNAL OF GENERAL PHYSIOLOGY

Assembly of the Mitochondrial Cristae Organizer Mic10 Is Regulated by Mic26–Mic27 Antagonism and Cardiolipin

(2018) Heike Rampelt et al.   JOURNAL OF MOLECULAR BIOLOGY

Spatial orchestration of mitochondrial translation and OXPHOS complex assembly

(2018) Stefan Stoldt et al.   NATURE CELL BIOLOGY

Integrative functions of the mitochondrial contact site and cristae organizing system

(2018) Stefan Schorr et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Porin proteins have critical functions in mitochondrial phospholipid metabolism in yeast

(2018) Non Miyata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Diverged Trypanosome MICOS Complex as a Hub for Mitochondrial Cristae Shaping and Protein Import

(2018) Iosif Kaurov et al.   CURRENT BIOLOGY

The role of nonbilayer phospholipids in mitochondrial structure and function

(2017) Writoban Basu Ball et al.   FEBS LETTERS

The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure

(2017) Hakjoo Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The MICOS component Mic60 displays a conserved membrane-bending activity that is necessary for normal cristae morphology

(2017) Daryna Tarasenko et al.   JOURNAL OF CELL BIOLOGY

Mic10, a Core Subunit of the Mitochondrial Contact Site and Cristae Organizing System, Interacts with the Dimeric F 1 F o -ATP Synthase

(2017) Heike Rampelt et al.   JOURNAL OF MOLECULAR BIOLOGY

Buckling Under Pressure: Curvature-Based Lipid Segregation and Stability Modulation in Cardiolipin-Containing Bilayers

(2017) Kevin J. Boyd et al.   LANGMUIR

Atomic model for the dimeric FOregion of mitochondrial ATP synthase

(2017) Hui Guo et al.   SCIENCE

Regulated membrane remodeling by Mic60 controls formation of mitochondrial crista junctions

(2017) Manuel Hessenberger et al.   Nature Communications

Cooperative function of Fmp30, Mdm31, and Mdm32 in Ups1-independent cardiolipin accumulation in the yeast Saccharomyces cerevisiae

(2017) Non Miyata et al.   Scientific Reports

OPA1 Isoforms in the Hierarchical Organization of Mitochondrial Functions

(2017) Valentina Del Dotto et al.   Cell Reports

Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function

(2016) Lena Pernas et al.   Annual Review of Physiology

Evolution and structural organization of the mitochondrial contact site (MICOS) complex and the mitochondrial intermembrane space bridging (MIB) complex

(2016) Martijn A. Huynen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The MICOS complex of human mitochondria

(2016) Vera Kozjak-Pavlovic   CELL AND TISSUE RESEARCH

AtMic60 Is Involved in Plant Mitochondria Lipid Trafficking and Is Part of a Large Complex

(2016) Morgane Michaud et al.   CURRENT BIOLOGY

Phosphatidylserine transport by Ups2–Mdm35 in respiration-active mitochondria

(2016) Non Miyata et al.   JOURNAL OF CELL BIOLOGY

MICOS and phospholipid transfer by Ups2–Mdm35 organize membrane lipid synthesis in mitochondria

(2016) Mari J. Aaltonen et al.   JOURNAL OF CELL BIOLOGY

Distinct Roles of Mic12 and Mic27 in the Mitochondrial Contact Site and Cristae Organizing System

(2016) Ralf M. Zerbes et al.   JOURNAL OF MOLECULAR BIOLOGY

Specific requirements of nonbilayer phospholipids in mitochondrial respiratory chain function and formation

(2016) Charli D. Baker et al.   MOLECULAR BIOLOGY OF THE CELL

Magnetosome biogenesis in magnetotactic bacteria

(2016) René Uebe et al.   NATURE REVIEWS MICROBIOLOGY

Mitochondrial Cristae: Where Beauty Meets Functionality

(2016) Sara Cogliati et al.   TRENDS IN BIOCHEMICAL SCIENCES

An evidence based hypothesis on the existence of two pathways of mitochondrial crista formation

(2016) Max E Harner et al.   eLife

Mic10 Oligomerizes to Bend Mitochondrial Inner Membranes at Cristae Junctions

(2015) Mariam Barbot et al.   Cell Metabolism

Central Role of Mic10 in the Mitochondrial Contact Site and Cristae Organizing System

(2015) Maria Bohnert et al.   Cell Metabolism

Ancient Homology of the Mitochondrial Contact Site and Cristae Organizing System Points to an Endosymbiotic Origin of Mitochondrial Cristae

(2015) Sergio A. Muñoz-Gómez et al.   CURRENT BIOLOGY

Mitochondrial Genome Maintenance 1 (Mgm1) Protein Alters Membrane Topology and Promotes Local Membrane Bending

(2015) Jarungjit Rujiviphat et al.   JOURNAL OF MOLECULAR BIOLOGY

The Oxidation Status of Mic19 Regulates MICOS Assembly

(2015) Paulina Sakowska et al.   MOLECULAR AND CELLULAR BIOLOGY

Interaction of MDM33 with mitochondrial inner membrane homeostasis pathways in yeast

(2015) Till Klecker et al.   Scientific Reports

Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure

(2015) Chengli Ding et al.   Scientific Reports

MICOS coordinates with respiratory complexes and lipids to establish mitochondrial inner membrane architecture

(2015) Jonathan R Friedman et al.   eLife

Phosphatidylcholine Supply to Peroxisomes of the Yeast Saccharomyces cerevisiae

(2015) Vid V. Flis et al.   PLoS One

Determinants and Functions of Mitochondrial Behavior

(2014) Katherine Labbé et al.   Annual Review of Cell and Developmental Biology

Yeast lipid metabolism at a glance

(2014) Lisa Klug et al.   FEMS YEAST RESEARCH

Uniform nomenclature for the mitochondrial contact site and cristae organizing system

(2014) Nikolaus Pfanner et al.   JOURNAL OF CELL BIOLOGY

Thei-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission

(2014) Ruchika Anand et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial form and function

(2014) Jonathan R. Friedman et al.   NATURE

Lipid landscapes and pipelines in membrane homeostasis

(2014) Joost C.M. Holthuis et al.   NATURE

Aim24 and MICOS modulate respiratory function, tafazzin-related cardiolipin modification and mitochondrial architecture

(2014) Max Emanuel Harner et al.   eLife

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

(2013) Sara Cogliati et al.   CELL

Mia40 and MINOS act in parallel with Ccs1 in the biogenesis of mitochondrial Sod1

(2013) Aksana Varabyova et al.   FEBS Journal

Unremodeled and Remodeled Cardiolipin Are Functionally Indistinguishable in Yeast

(2013) Matthew G. Baile et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of Fcj1-Mos1 and mitochondrial division on aggregation of mitochondrial DNA nucleoids and organelle morphology

(2013) Kie Itoh et al.   MOLECULAR BIOLOGY OF THE CELL

Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain

(2013) E. Lapuente-Brun et al.   SCIENCE

Bioenergetic role of mitochondrial fusion and fission

(2012) Benedikt Westermann   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mechanistic perspective of mitochondrial fusion: Tubulation vs. fragmentation

(2012) Mafalda Escobar-Henriques et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Metabolism and Regulation of Glycerolipids in the Yeast Saccharomyces cerevisiae

(2012) Susan A. Henry et al.   GENETICS

Membrane Tethering and Nucleotide-dependent Conformational Changes Drive Mitochondrial Genome Maintenance (Mgm1) Protein-mediated Membrane Fusion

(2012) Inbal Abutbul-Ionita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHCM1/CHCHD6, Novel Mitochondrial Protein Linked to Regulation of Mitofilin and Mitochondrial Cristae Morphology

(2012) Jie An et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role for Two Conserved Intermembrane Space Proteins, Ups1p and Up2p, in Intra-mitochondrial Phospholipid Trafficking

(2012) Yasushi Tamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of MINOS in Mitochondrial Membrane Architecture: Cristae Morphology and Outer Membrane Interactions Differentially Depend on Mitofilin Domains

(2012) Ralf M. Zerbes et al.   JOURNAL OF MOLECULAR BIOLOGY

The C-terminal domain of Fcj1 is required for formation of crista junctions and interacts with the TOB/SAM complex in mitochondria

(2012) Christian Körner et al.   MOLECULAR BIOLOGY OF THE CELL

Role of mitochondrial inner membrane organizing system in protein biogenesis of the mitochondrial outer membrane

(2012) Maria Bohnert et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial DNA Mutations Provoke Dominant Inhibition of Mitochondrial Inner Membrane Fusion

(2012) Cécile Sauvanet et al.   PLoS One

Structure of the yeast F1Fo-ATP synthase dimer and its role in shaping the mitochondrial cristae

(2012) K. M. Davies et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intramitochondrial Transport of Phosphatidic Acid in Yeast by a Lipid Transfer Protein

(2012) M. Connerth et al.   SCIENCE

Role of MINOS in mitochondrial membrane architecture and biogenesis

(2012) Martin van der Laan et al.   TRENDS IN CELL BIOLOGY

Dual Role of Mitofilin in Mitochondrial Membrane Organization and Protein Biogenesis

(2011) Karina von der Malsburg et al.   DEVELOPMENTAL CELL

The mitochondrial contact site complex, a determinant of mitochondrial architecture

(2011) Max Harner et al.   EMBO JOURNAL

A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria

(2011) Suzanne Hoppins et al.   JOURNAL OF CELL BIOLOGY

MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization

(2011) Alwaleed K. Alkhaja et al.   MOLECULAR BIOLOGY OF THE CELL

Saccharomyces Genome Database: the genomics resource of budding yeast

(2011) J. M. Cherry et al.   NUCLEIC ACIDS RESEARCH

Macromolecular organization of ATP synthase and complex I in whole mitochondria

(2011) K. M. Davies et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mdm35p imports Ups proteins into the mitochondrial intermembrane space by functional complex formation

(2010) Yasushi Tamura et al.   EMBO JOURNAL

Regulation of mitochondrial phospholipids by Ups1/PRELI-like proteins depends on proteolysis and Mdm35

(2010) Christoph Potting et al.   EMBO JOURNAL

Structure of Dimeric F1F0-ATP Synthase

(2010) Sergio J. Couoh-Cardel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane invagination in Rhodobacter sphaeroides is initiated at curved regions of the cytoplasmic membrane, then forms both budded and fully detached spherical vesicles

(2010) Jaimey D. Tucker et al.   MOLECULAR MICROBIOLOGY

Mitochondrial fusion and fission in cell life and death

(2010) Benedikt Westermann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Dynamin-Related Protein Mgm1p Assembles into Oligomers and Hydrolyzes GTP To Function in Mitochondrial Membrane Fusion†

(2009) Gabriela Meglei et al.   BIOCHEMISTRY

Row-like organization of ATP synthase in intact mitochondria determined by cryo-electron tomography

(2009) Natalya V. Dudkina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Distinct roles of the two isoforms of the dynamin-like GTPase Mgm1 in mitochondrial fusion

(2009) Michael Zick et al.   FEBS LETTERS

Mitochondrial F1F0-ATP synthase and organellar internal architecture

(2009) Jean Velours et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Phospholipid Association Is Essential for Dynamin-related Protein Mgm1 to Function in Mitochondrial Membrane Fusion

(2009) Jarungjit Rujiviphat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a Cardiolipin-specific Phospholipase Encoded by the GeneCLD1(YGR110W) in Yeast

(2009) Andreas Beranek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner membrane fusion

(2009) Rachel M. DeVay et al.   JOURNAL OF CELL BIOLOGY

Ups1p and Ups2p antagonistically regulate cardiolipin metabolism in mitochondria

(2009) Yasushi Tamura et al.   JOURNAL OF CELL BIOLOGY

The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria

(2009) Christof Osman et al.   JOURNAL OF CELL BIOLOGY

Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Sue/g

(2009) Regina Rabl et al.   JOURNAL OF CELL BIOLOGY

Mitofusins and OPA1 Mediate Sequential Steps in Mitochondrial Membrane Fusion

(2009) Zhiyin Song et al.   MOLECULAR BIOLOGY OF THE CELL

An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

(2009) Benoît Kornmann et al.   SCIENCE

Cristae formation—linking ultrastructure and function of mitochondria

(2008) Michael Zick et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Assembly of F0 in Saccharomyces cerevisiae

(2008) Malgorzata Rak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Supramolecular organization of the yeast F1Fo-ATP synthase

(2008) Daniel Thomas et al.   BIOLOGY OF THE CELL

Membrane Deformation under Local pH Gradient: Mimicking Mitochondrial Cristae Dynamics

(2008) Nada Khalifat et al.   BIOPHYSICAL JOURNAL

Dimer ribbons of ATP synthase shape the inner mitochondrial membrane

(2008) Mike Strauss et al.   EMBO JOURNAL

Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria

(2008) C. Merkwirth et al.   GENES & DEVELOPMENT

Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria

(2008) Devrim Acehan et al.   MITOCHONDRION

Characterization of Domain Interfaces in Monomeric and Dimeric ATP Synthase

(2008) Ilka Wittig et al.   MOLECULAR & CELLULAR PROTEOMICS

The Cardiolipin Transacylase, Tafazzin, Associates with Two Distinct Respiratory Components Providing Insight into Barth Syndrome

(2008) Steven M. Claypool et al.   MOLECULAR BIOLOGY OF THE CELL

The m-AAA Protease Processes Cytochrome c Peroxidase Preferentially at the Inner Boundary Membrane of Mitochondria

(2008) Ida E. Suppanz et al.   MOLECULAR BIOLOGY OF THE CELL

Caenorhabditis elegans drp-1 and fis-2 Regulate Distinct Cell-Death Execution Pathways Downstream of ced-3 and Independent of ced-9

(2008) David G. Breckenridge et al.   MOLECULAR CELL

Respiratory Active Mitochondrial Supercomplexes

(2008) Rebeca Acín-Pérez et al.   MOLECULAR CELL

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The C. elegans Opa1 Homologue EAT-3 Is Essential for Resistance to Free Radicals

(2008) Takayuki Kanazawa et al.   PLoS Genetics