Butylphthalide Inhibits TLR4/NF-κB Pathway by Upregulation of miR-21 to Have the Neuroprotective Effect

CiRS-126 inhibits proliferation of ovarian granulosa cells through targeting the miR-21-PDCD4-ROS axis in a polycystic ovarian syndrome model

(2020) Jiafeng Lu et al.   CELL AND TISSUE RESEARCH

Diagnosis of Hyperacute and Acute Ischaemic Stroke: The Potential Utility of Exosomal MicroRNA-21-5p and MicroRNA-30a-5p

(2018) Wei Wang et al.   CEREBROVASCULAR DISEASES

microRNA-21 Confers Neuroprotection Against Cerebral Ischemia-Reperfusion Injury and Alleviates Blood-Brain Barrier Disruption in Rats via the MAPK Signaling Pathway

(2018) Xiaofeng Yao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

miR-21 Protects Against Ischemia/Reperfusion-Induced Acute Kidney Injury by Preventing Epithelial Cell Apoptosis and Inhibiting Dendritic Cell Maturation

(2018) Nana Song et al.   Frontiers in Physiology

L-3-n-Butylphthalide reduces ischemic stroke injury and increases M2 microglial polarization

(2018) Fangfang Li et al.   METABOLIC BRAIN DISEASE

Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate ischemic neuronal death by targeting miR-21/PDCD4 signaling pathway

(2017) Honglin Yan et al.   Cell Death & Disease

Global stroke statistics

(2016) Amanda G Thrift et al.   International Journal of Stroke

Mobilization of Circulating Endothelial Progenitor Cells by dl-3-n-Butylphthalide in Acute Ischemic Stroke Patients

(2016) Hongru Zhao et al.   Journal of Stroke & Cerebrovascular Diseases

Efficacy and safety comparison of DL-3-n-butylphthalide and Cerebrolysin: Effects on neurological and behavioral outcomes in acute ischemic stroke

(2016) LI-XIA XUE et al.   Experimental and Therapeutic Medicine

Mobilization of Circulating Endothelial Progenitor Cells by dl-3-n-Butylphthalide in Acute Ischemic Stroke Patients

(2016) Hongru Zhao et al.   Journal of Stroke & Cerebrovascular Diseases

dl-3-n-butylphthalide inhibits platelet activation via inhibition of cPLA2-mediated TXA2synthesis and phosphodiesterase

(2015) Jianqin Ye et al.   PLATELETS

The Effect of Butylphthalide on the Brain Edema, Blood–Brain Barrier of Rats After Focal Cerebral Infarction and the Expression of Rho A

(2014) Jinyang Hu et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Identification of miRNA-21 and miRNA-24 in plasma as potential early stage markers of acute cerebral infarction

(2014) JIANSUO ZHOU et al.   Molecular Medicine Reports

3-N-Butylphthalide (NBP) Attenuates the Amyloid-�-Induced Inflammatory Responses in Cultured Astrocytes via the Nuclear Factor-κB Signaling Pathway

(2013) Hong-Mei Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Ischemic Postconditioning Diminishes Matrix Metalloproteinase 9 Expression and Attenuates Loss of the Extracellular Matrix Proteins in Rats Following Middle Cerebral Artery Occlusion and Reperfusion

(2012) Xiang-Rong Liu et al.   CNS Neuroscience & Therapeutics

DL-3-n-Butylphthalide, an Anti-Oxidant Agent, Prevents Neurological Deficits and Cerebral Injury Following Stroke per Functional Analysis, Magnetic Resonance Imaging and Histological Assessment

(2012) Lihong Zhang et al.   CURRENT NEUROVASCULAR RESEARCH

Effects of DL-3-n-Butylphthalide on Vascular Dementia and Angiogenesis

(2012) Lihong Zhang et al.   NEUROCHEMICAL RESEARCH

dl-3-n-Butylphthalide prevents neuronal cell death after focal cerebral ischemia in mice via the JNK pathway

(2010) Jimei Li et al.   BRAIN RESEARCH

MicroRNA-21 protects neurons from ischemic death

(2010) Ben Buller et al.   FEBS Journal