Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits

Diversity amongst human cortical pyramidal neurons revealed via their sag currents and frequency preferences

(2021) Homeira Moradi Chameh et al.   Nature Communications

GABA-mediated tonic inhibition differentially modulates gain in functional subtypes of cortical interneurons

(2020) Alexander Bryson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic action potentials and computation in human layer 2/3 cortical neurons

(2020) Albert Gidon et al.   SCIENCE

Altered GABA-mediated information processing and cognitive dysfunctions in depression and other brain disorders

(2020) Thomas Prévot et al.   MOLECULAR PSYCHIATRY

Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation

(2020) Thomas D Prevot et al.   CEREBRAL CORTEX

Innovations present in the primate interneuron repertoire

(2020) Fenna M. Krienen et al.   NATURE

Relocation of an Extrasynaptic GABAA Receptor to Inhibitory Synapses Freezes Excitatory Synaptic Strength and Preserves Memory

(2020) Christopher M. Davenport et al.   NEURON

A Disinhibitory Circuit for Contextual Modulation in Primary Visual Cortex

(2020) Andreas J. Keller et al.   NEURON

The spectral exponent of the resting EEG indexes the presence of consciousness during unresponsiveness induced by propofol, xenon, and ketamine

(2019) Michele Angelo Colombo et al.   NEUROIMAGE

Using computational models to predict in vivo synaptic inputs to interneuron specific 3 (IS3) cells of CA1 hippocampus that also allow their recruitment during rhythmic states

(2019) Alexandre Guet-McCreight et al.   PLoS One

Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments

(2019) Ronald S. Duman et al.   NEURON

Loss of Glutamate Decarboxylase 67 in Somatostatin-Expressing Neurons Leads to Anxiety-Like Behavior and Alteration in the Akt/GSK3β Signaling Pathway

(2019) Shigeo Miyata et al.   Frontiers in Behavioral Neuroscience

Conserved cell types with divergent features in human versus mouse cortex

(2019) Rebecca D. Hodge et al.   NATURE

Recruitment of GABAergic Interneurons in the Barrel Cortex during Active Tactile Behavior

(2019) Jianing Yu et al.   NEURON

Hierarchical organization of cortical and thalamic connectivity

(2019) Julie A. Harris et al.   NATURE

The generation and propagation of the human alpha rhythm

(2019) Milan Halgren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-throughput microcircuit analysis of individual human brains through next-generation multineuron patch-clamp

(2019) Yangfan Peng et al.   eLife

Layer 5 Callosal Parvalbumin-Expressing Neurons: A Distinct Functional Group of GABAergic Neurons

(2018) Hector Zurita et al.   Frontiers in Cellular Neuroscience

Systematic generation of biophysically detailed models for diverse cortical neuron types

(2018) Nathan W. Gouwens et al.   Nature Communications

Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABAA receptors

(2018) Jan M. Schulz et al.   Nature Communications

Sparse recurrent excitatory connectivity in the microcircuit of the adult mouse and human cortex

(2018) Stephanie C Seeman et al.   eLife

Enhanced Dendritic Compartmentalization in Human Cortical Neurons

(2018) Lou Beaulieu-Laroche et al.   CELL

Alterations in Schizophrenia-Associated Genes Can Lead to Increased Power in Delta Oscillations

(2018) Tuomo Mäki-Marttunen et al.   CEREBRAL CORTEX

Lateral inhibition by Martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex

(2018) Joshua Obermayer et al.   Nature Communications

Multimodal Modeling of Neural Network Activity: Computing LFP, ECoG, EEG, and MEG Signals With LFPy 2.0

(2018) Espen Hagen et al.   Frontiers in Neuroinformatics

Local field potentials primarily reflect inhibitory neuron activity in human and monkey cortex

(2017) Bartosz Teleńczuk et al.   Scientific Reports

Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state

(2016) T Fuchs et al.   MOLECULAR PSYCHIATRY

GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits

(2016) Robin Tremblay et al.   NEURON

Low-frequency electrical stimulation enhances the effectiveness of phenobarbital on GABAergic currents in hippocampal slices of kindled rats

(2016) Azam Asgari et al.   NEUROSCIENCE

Plasticity in Single Axon Glutamatergic Connection to GABAergic Interneurons Regulates Complex Events in the Human Neocortex

(2016) Viktor Szegedi et al.   PLOS BIOLOGY

Human pyramidal to interneuron synapses are mediated by multi-vesicular release and multiple docked vesicles

(2016) Gábor Molnár et al.   eLife

Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABAA Receptor Positive Allosteric Modulator

(2016) Sean C. Piantadosi et al.   Frontiers in Pharmacology

Reconstruction and Simulation of Neocortical Microcircuitry

(2015) Henry Markram et al.   CELL

Characterizing VIP Neurons in the Barrel Cortex of VIPcre/tdTomato Mice Reveals Layer-Specific Differences

(2015) Alvar Prönneke et al.   CEREBRAL CORTEX

Dendritic and Axonal Architecture of Individual Pyramidal Neurons across Layers of Adult Human Neocortex

(2015) Hemanth Mohan et al.   CEREBRAL CORTEX

Somatostatin, neuronal vulnerability and behavioral emotionality

(2015) L C Lin et al.   MOLECULAR PSYCHIATRY

Laminar and cellular analyses of reduced somatostatin gene expression in the subgenual anterior cingulate cortex in major depression

(2015) Marianne L. Seney et al.   NEUROBIOLOGY OF DISEASE

Dendritic Excitability and Gain Control in Recurrent Cortical Microcircuits

(2014) Etay Hay et al.   CEREBRAL CORTEX

Why are cortical GABA neurons relevant to internal focus in depression? A cross-level model linking cellular, biochemical and neural network findings

(2014) G Northoff et al.   MOLECULAR PSYCHIATRY

Equalizing excitation–inhibition ratios across visual cortical neurons

(2014) Mingshan Xue et al.   NATURE

In Vitro Recordings of Human Neocortical Oscillations

(2013) C.M. Florez et al.   CEREBRAL CORTEX

Preserving axosomatic spiking features despite diverse dendritic morphology

(2013) Etay Hay et al.   JOURNAL OF NEUROPHYSIOLOGY

Serotonin and beyond: therapeutics for major depression

(2013) P. Blier et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Methods for recording and measuring tonic GABAA receptor-mediated inhibition

(2013) Damian P. Bright et al.   Frontiers in Neural Circuits

Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?

(2013) Li-Chun Lin et al.   Frontiers in Pharmacology

Linking Microcircuit Dysfunction to Cognitive Impairment: Effects of Disinhibition Associated with Schizophrenia in a Cortical Working Memory Model

(2012) J. D. Murray et al.   CEREBRAL CORTEX

Fluoxetine (Prozac) and Serotonin Act on Excitatory Synaptic Transmission to Suppress Single Layer 2/3 Pyramidal Neuron-Triggered Cell Assemblies in the Human Prefrontal Cortex

(2012) G. Komlosi et al.   JOURNAL OF NEUROSCIENCE

An anatomically comprehensive atlas of the adult human brain transcriptome

(2012) Michael J. Hawrylycz et al.   NATURE

Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

(2012) Hyo Jung Kang et al.   NATURE MEDICINE

Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex

(2012) Luc J Gentet et al.   NATURE NEUROSCIENCE

Interneuron dysfunction in psychiatric disorders

(2012) Oscar Marín   NATURE REVIEWS NEUROSCIENCE

Somatostatinergic systems: an update on brain functions in normal and pathological aging

(2012) Guillaume Martel et al.   Frontiers in Endocrinology

Cell atrophy and loss in depression: reversal by antidepressant treatment

(2011) Mounira Banasr et al.   CURRENT OPINION IN CELL BIOLOGY

Models of Neocortical Layer 5b Pyramidal Cells Capturing a Wide Range of Dendritic and Perisomatic Active Properties

(2011) Etay Hay et al.   PLoS Computational Biology

The Largest Group of Superficial Neocortical GABAergic Interneurons Expresses Ionotropic Serotonin Receptors

(2010) S. Lee et al.   JOURNAL OF NEUROSCIENCE

Nicotinic acetylcholine receptors and depression: a review of the preclinical and clinical literature

(2010) Noah S. Philip et al.   PSYCHOPHARMACOLOGY

The functional neuroanatomy of depression: Distinct roles for ventromedial and dorsolateral prefrontal cortex

(2009) Michael Koenigs et al.   BEHAVIOURAL BRAIN RESEARCH

Evidence of Cortical Inhibitory Deficits in Major Depressive Disorder

(2009) Andrea J. Levinson et al.   BIOLOGICAL PSYCHIATRY

A meta-analysis of depression severity and cognitive function

(2009) Lisa M. McDermott et al.   JOURNAL OF AFFECTIVE DISORDERS

EEG Power Spectra at Early Stages of Depressive Disorders

(2009) Vera A. Grin-Yatsenko et al.   JOURNAL OF CLINICAL NEUROPHYSIOLOGY

Anxiolytic and antidepressant effects of intracerebroventricularly administered somatostatin: Behavioral and neurophysiological evidence

(2008) E. Engin et al.   NEUROSCIENCE