Hypusination Orchestrates the Antimicrobial Response of Macrophages

Recessive Rare Variants in Deoxyhypusine Synthase, an Enzyme Involved in the Synthesis of Hypusine, Are Associated with a Neurodevelopmental Disorder

(2019) Mythily Ganapathi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The role of polyamines in the regulation of macrophage polarization and function

(2019) Yvonne L. Latour et al.   AMINO ACIDS

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

(2019) Daniel J. Puleston et al.   Cell Metabolism

Induction of autophagy through CLEC4E in combination with TLR4: an innovative strategy to restrict the survival of Mycobacterium tuberculosis

(2019) Susanta Pahari et al.   Autophagy

Polyamines reverse immune senescence via the translational control of autophagy

(2019) Hanlin Zhang et al.   Autophagy

Bacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway

(2019) Alain P. Gobert et al.   mBio

IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors To Restrict Intracellular Replication of Legionella pneumophila

(2019) Jordan V. Price et al.   mBio

Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis

(2019) Esther M. Levasseur et al.   Science Signaling

Spermidine in health and disease

(2018) Frank Madeo et al.   SCIENCE

Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection

(2018) Alain P. Gobert et al.   Frontiers in Immunology

Hypusine, a polyamine-derived amino acid critical for eukaryotic translation

(2018) Myung Hee Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Carcinogenic Helicobacter pylori strains selectively dysregulate the in vivo gastric proteome, which may be associated with stomach cancer progression

(2018) Jennifer M. Noto et al.   MOLECULAR & CELLULAR PROTEOMICS

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Dynamics ofHelicobacter pyloriinfection as a determinant of progression of gastric precancerous lesions: 16-year follow-up of an eradication trial

(2017) Robertino M Mera et al.   GUT

Epidermal growth factor receptor inhibition downregulatesHelicobacter pylori-induced epithelial inflammatory responses, DNA damage and gastric carcinogenesis

(2017) Johanna C Sierra et al.   GUT

eIF5A Functions Globally in Translation Elongation and Termination

(2017) Anthony P. Schuller et al.   MOLECULAR CELL

eIF5A facilitates translation termination globally and promotes the elongation of many non polyproline-specific tripeptide sequences

(2017) Vicent Pelechano et al.   NUCLEIC ACIDS RESEARCH

Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications

(2017) Dana M. Hardbower et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the polyamine-hypusine circuit for the prevention and treatment of cancer

(2016) Shima Nakanishi et al.   AMINO ACIDS

Functions of Polyamines in Mammals

(2016) Anthony E. Pegg   JOURNAL OF BIOLOGICAL CHEMISTRY

EGFR regulates macrophage activation and function in bacterial infection

(2016) Dana M. Hardbower et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A

(2016) Metin Aksu et al.   Nature Communications

Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution

(2016) Wook-Bin Lee et al.   Nature Communications

Global quantitative proteomics reveal up-regulation of endoplasmic reticulum stress response proteins upon depletion of eIF5A in HeLa cells

(2016) Ajeet Mandal et al.   Scientific Reports

ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts

(2016) Yongmei Qi et al.   Scientific Reports

Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels

(2015) Ken Fujimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation

(2014) H. Sievert et al.   Disease Models & Mechanisms

Heme Oxygenase-1 Dysregulates Macrophage Polarization and the Immune Response toHelicobacter pylori

(2014) Alain P. Gobert et al.   JOURNAL OF IMMUNOLOGY

Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation

(2013) Elisabeth Mémin et al.   CANCER RESEARCH

eIF5A Promotes Translation of Polyproline Motifs

(2013) Erik Gutierrez et al.   MOLECULAR CELL

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

(2013) A. Michelucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of a novel polyclonal anti-hypusine antibody

(2013) Yurika Nishiki et al.   SpringerPlus

Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway

(2012) Robert O. Watson et al.   CELL

Sustained Generation of Nitric Oxide and Control of Mycobacterial Infection Requires Argininosuccinate Synthase 1

(2012) Joseph E. Qualls et al.   Cell Host & Microbe

A tumour suppressor network relying on the polyamine–hypusine axis

(2012) Claudio Scuoppo et al.   NATURE

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

(2011) Eugenia Morselli et al.   JOURNAL OF CELL BIOLOGY

Itaconic Acid Is a Mammalian Metabolite Induced during Macrophage Activation

(2011) Cheryl L. Strelko et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production

(2010) Rupesh Chaturvedi et al.   GASTROENTEROLOGY

Tolerance Rather Than Immunity Protects From Helicobacter pylori–Induced Gastric Preneoplasia

(2010) Isabelle C. Arnold et al.   GASTROENTEROLOGY

The unique hypusine modification of eIF5A promotes islet β cell inflammation and dysfunction in mice

(2010) Bernhard Maier et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of Innate Immunity in Helicobacter pylori-Induced Gastric Malignancy

(2010) Richard M. Peek et al.   PHYSIOLOGICAL REVIEWS

Mammalian polyamine metabolism and function

(2009) Anthony E. Pegg   IUBMB LIFE

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

IFN-γ-Inducible Irga6 Mediates Host Resistance against Chlamydia trachomatis via Autophagy

(2009) Munir A. Al-Zeer et al.   PLoS One

The Proinflammatory Cytokine-Induced IRG1 Protein Associates with Mitochondria

(2008) Daniel Degrandi et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens

(2008) Karim C El Kasmi et al.   NATURE IMMUNOLOGY